Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis

Prognostic implication of NQO1 overexpression in hepatocellular carcinoma

(2017) Lijuan Lin et al.   HUMAN PATHOLOGY

The NQO1 bioactivatable drug, β-lapachone, alters the redox state of NQO1+ pancreatic cancer cells, causing perturbation in central carbon metabolism

(2017) Molly A. Silvers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacokinetics and tolerability of MB12066, a beta-lapachone derivative targeting NAD(P)H:quinone oxidoreductase 1: two independent, double-blind, placebo-controlled, combined single and multiple ascending dose first-in-human clinical trials

(2017) Seokuee Kim et al.   Drug Design Development and Therapy

Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors

(2016) Xiumei Huang et al.   CANCER CELL

Esterase-activatable β-lapachone prodrug micelles for NQO1-targeted lung cancer therapy

(2015) Xinpeng Ma et al.   JOURNAL OF CONTROLLED RELEASE

Depleting Tumor-NQO1 Potentiates Anoikis and Inhibits Growth of NSCLC

(2015) B. Madajewski et al.   MOLECULAR CANCER RESEARCH

β-Lapachone and Paclitaxel Combination Micelles with Improved Drug Encapsulation and Therapeutic Synergy as Novel Nanotherapeutics for NQO1-Targeted Cancer Therapy

(2015) Ling Zhang et al.   MOLECULAR PHARMACEUTICS

NAMPT inhibition sensitizes pancreatic adenocarcinoma cells to tumor-selective, PAR-independent metabolic catastrophe and cell death induced by β-lapachone

(2015) Z Moore et al.   Cell Death & Disease

Clinical implications of high NQO1 expression in breast cancers

(2014) Yang Yang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Methemoglobinemia: A Review and Recommendations for Management

(2013) Jessica A. Cortazzo et al.   JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA

Catalase Abrogates  -Lapachone-Induced PARP1 Hyperactivation-Directed Programmed Necrosis in NQO1-Positive Breast Cancers

(2013) E. A. Bey et al.   MOLECULAR CANCER THERAPEUTICS

An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis

(2012) X. Huang et al.   CANCER RESEARCH

β-Lapachone Significantly Increases the Effect of Ionizing Radiation to Cause Mitochondrial Apoptosis via JNK Activation in Cancer Cells

(2011) Moon-Taek Park et al.   PLoS One

 -Lapachone Micellar Nanotherapeutics for Non-Small Cell Lung Cancer Therapy

(2010) E. Blanco et al.   CANCER RESEARCH

Intratumoral Delivery of  -Lapachone via Polymer Implants for Prostate Cancer Therapy

(2008) Y. Dong et al.   CLINICAL CANCER RESEARCH

New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1)

(2008) E.A. Eisenhauer et al.   EUROPEAN JOURNAL OF CANCER

Methemoglobinemia and hemolytic anemia caused by rasburicase administration in a newly diagnosed child with Burkitt lymphoma/leukemia

(2007) Scott C. Borinstein et al.   PEDIATRIC BLOOD & CANCER