Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation

(2015) Jessica L. Feldman et al.   BIOCHEMISTRY

Safety, pharmacokinetics, pharmacogenomics and QT concentration−effect modelling of the SirT1 inhibitor selisistat in healthy volunteers

(2015) Goran Westerberg et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

An exploratory double-blind, randomized clinical trial with selisistat, a SirT1 inhibitor, in patients with Huntington's disease

(2015) Sigurd D. Süssmuth et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The deacetylase Sirt1 is an essential regulator of Aire-mediated induction of central immunological tolerance

(2015) Anna Chuprin et al.   NATURE IMMUNOLOGY

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

Efficient Demyristoylase Activity of SIRT2 Revealed by Kinetic and Structural Studies

(2015) Yan-Bin Teng et al.   Scientific Reports

Integrative Chemical Biology Approaches for Identification and Characterization of “Erasers” for Fatty-Acid-Acylated Lysine Residues within Proteins

(2014) Zheng Liu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Lysine Glutarylation Is a Protein Posttranslational Modification Regulated by SIRT5

(2014) Minjia Tan et al.   Cell Metabolism

A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease

(2014) Marianne R. Smith et al.   HUMAN MOLECULAR GENETICS

Structural Basis for Potent Inhibition of SIRT2 Deacetylase by a Macrocyclic Peptide Inducing Dynamic Structural Change

(2014) Kenichiro Yamagata et al.   STRUCTURE

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

Microseed matrix screening for optimization in protein crystallization: what have we learned?

(2014) Allan D'Arcy et al.   Acta Crystallographica Section F-Structural Biology Communications

Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+and SRT1720: binding details and inhibition mechanism

(2013) Giang Thi Tuyet Nguyen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

How good are my data and what is the resolution?

(2013) Philip R. Evans et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Crystal Structures of Sirt3 Complexes with 4′-Bromo-Resveratrol Reveal Binding Sites and Inhibition Mechanism

(2013) Giang Thi Tuyet Nguyen et al.   CHEMISTRY & BIOLOGY

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins

(2013) Jessica L. Feldman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural and Functional Analysis of Human SIRT1

(2013) Andrew M. Davenport et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structure analysis of human Sirt2 and its ADP-ribose complex

(2013) Sébastien Moniot et al.   JOURNAL OF STRUCTURAL BIOLOGY

HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS

(2013) M. H. Yang et al.   MOLECULAR CANCER RESEARCH

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Schistosoma mansoni Sirtuins: Characterization and Potential as Chemotherapeutic Targets

(2013) Julien Lancelot et al.   PLoS Neglected Tropical Diseases

The histone deacetylase SIRT2 stabilizes Myc oncoproteins

(2012) P Y Liu et al.   CELL DEATH AND DIFFERENTIATION

Synthesis of Carba-NAD and the Structures of Its Ternary Complexes with SIRT3 and SIRT5

(2012) Bruce G. Szczepankiewicz et al.   JOURNAL OF ORGANIC CHEMISTRY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

SIRT2 Maintains Genome Integrity and Suppresses Tumorigenesis through Regulating APC/C Activity

(2011) Hyun-Seok Kim et al.   CANCER CELL

Structure and Biochemical Functions of SIRT6

(2011) Patricia W. Pan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension

(2011) P. Di Tommaso et al.   NUCLEIC ACIDS RESEARCH

SirT3 suppresses hypoxia inducible factor 1α and tumor growth by inhibiting mitochondrial ROS production

(2011) E L Bell et al.   ONCOGENE

Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase

(2011) J. Du et al.   SCIENCE

Promoting crystallization of antibody–antigen complexesviamicroseed matrix screening

(2010) Galina Obmolova et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer

(2010) Turki Y. Alhazzazi et al.   CANCER

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

Molecular replacement withMOLREP

(2009) Alexei Vagin et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Investigating the ADP-ribosyltransferase Activity of Sirtuins with NAD Analogues and32P-NAD†

(2009) Jintang Du et al.   BIOCHEMISTRY

Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes

(2009) Lei Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NAD+-dependent histone deacetylases (sirtuins) as novel therapeutic targets

(2009) Jörg Schemies et al.   MEDICINAL RESEARCH REVIEWS

Iterative-build OMIT maps: map improvement by iterative model building and refinement without model bias

(2008) Thomas C. Terwilliger et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY