Neuroprotective Properties of Linagliptin: Focus on Biochemical Mechanisms in Cerebral Ischemia, Vascular Dysfunction and Certain Neurodegenerative Diseases

Liraglutide and its Neuroprotective Properties—Focus on Possible Biochemical Mechanisms in Alzheimer’s Disease and Cerebral Ischemic Events

(2019) Michał Wiciński et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Revealing the Penumbra through Imaging Elemental Markers of Cellular Metabolism in an Ischemic Stroke Model

(2018) M. Jake Pushie et al.   ACS Chemical Neuroscience

Linagliptin and cardiovascular outcomes in type 2 diabetes after acute coronary syndrome or acute ischemic stroke

(2018) Yan-Rong Li et al.   Cardiovascular Diabetology

The effect of DPP-4 inhibition to improve functional outcome after stroke is mediated by the SDF-1α/CXCR4 pathway

(2018) Fausto Chiazza et al.   Cardiovascular Diabetology

Rationale, design, and baseline characteristics of the CArdiovascular safety and Renal Microvascular outcomE study with LINAgliptin (CARMELINA®): a randomized, double-blind, placebo-controlled clinical trial in patients with type 2 diabetes and high cardio-renal risk

(2018) Julio Rosenstock et al.   Cardiovascular Diabetology

Role of the JAK/STAT signaling pathway in regulation of innate immunity in neuroinflammatory diseases

(2018) Zhaoqi Yan et al.   CLINICAL IMMUNOLOGY

Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK/SIRT1 and JAK2/STAT3/NF-κB signalling pathway modulation

(2018) Eman M. Elbaz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Phytochemicals as modulators of M1-M2 macrophages in inflammation

(2018) Uzma Saqib et al.   Oncotarget

DPP-4 inhibitors promote proliferation and migration of rat brain microvascular endothelial cells under hypoxic/high-glucose conditions, potentially through the SIRT1/HIF-1/VEGF pathway

(2018) Dong-Hua Mi et al.   CNS Neuroscience & Therapeutics

Increased Susceptibility to Amyloid-β Toxicity in Rat Brain Microvascular Endothelial Cells under Hyperglycemic Conditions

(2018) Cristina Carvalho et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Activity of Sitagliptin via Reduction of Neuroinflammation beyond the Incretin Effect: Focus on Alzheimer’s Disease

(2018) Michał Wiciński et al.   Biomed Research International

Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions

(2018) Michał Wiciński et al.   Nutrients

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

CNS inflammation and neurodegeneration

(2017) Tanuja Chitnis et al.   JOURNAL OF CLINICAL INVESTIGATION

Stroke

(2017) Graeme J Hankey   LANCET

MCP-1-mediated activation of microglia promotes white matter lesions and cognitive deficits by chronic cerebral hypoperfusion in mice

(2017) Bangqing Yuan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Anti-atherogenic properties of resveratrol: 4-week resveratrol administration associated with serum concentrations of SIRT1, adiponectin, S100A8/A9 and VSMCs contractility in a rat model

(2017) Michał Wiciński et al.   Experimental and Therapeutic Medicine

The Role of SDF-1/CXCR4/CXCR7 in Neuronal Regeneration after Cerebral Ischemia

(2017) Xi Cheng et al.   Frontiers in Neuroscience

Correlation of hyperglycemia with mortality after acute ischemic stroke

(2017) Donghua Mi et al.   Therapeutic Advances in Neurological Disorders

Decreased Plasma and Cerebrospinal Fluid Levels of Stem Cell Factor in Patients with Early Alzheimer's Disease

(2017) Christoph Laske et al.   JOURNAL OF ALZHEIMERS DISEASE

NF-κB as a Key Mediator of Brain Inflammation in Alzheimer’s Disease

(2017) Chul Ju Hwang et al.   CNS & Neurological Disorders-Drug Targets

Vascular endothelium – Gatekeeper of vessel health

(2016) Paul A. Cahill et al.   ATHEROSCLEROSIS

Vascular effects of linagliptin in non-obese diabetic mice are glucose-independent and involve positive modulation of the endothelial nitric oxide synthase (eNOS)/caveolin-1 (CAV-1) pathway

(2016) Valentina Vellecco et al.   DIABETES OBESITY & METABOLISM

Gliptin-mediated neuroprotection against stroke requires chronic pretreatment and is independent of glucagon-like peptide-1 receptor

(2016) V. Darsalia et al.   DIABETES OBESITY & METABOLISM

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

(2016) George B. Stefano et al.   EUROPEAN JOURNAL OF NUTRITION

Preconditioning-induced CXCL12 upregulation minimizes leukocyte infiltration after stroke in ischemia-tolerant mice

(2016) Uma Maheswari Selvaraj et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Acute Effects of Linagliptin on Progenitor Cells, Monocyte Phenotypes, and Soluble Mediators in Type 2 Diabetes

(2016) Gian Paolo Fadini et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Hyperglycemia in Stroke Impairs Polarization of Monocytes/Macrophages to a Protective Noninflammatory Cell Type

(2016) Mahtab A. Khan et al.   JOURNAL OF NEUROSCIENCE

Linagliptin reduces effects of ET-1 and TLR2-mediated cerebrovascular hyperreactivity in diabetes

(2016) Trevor Hardigan et al.   LIFE SCIENCES

Role of neuroinflammation in neurodegenerative diseases (Review)

(2016) WEI-WEI CHEN et al.   Molecular Medicine Reports

Linagliptin, a Dipeptidyl Peptidase-4 Inhibitor, Mitigates Cognitive Deficits and Pathology in the 3xTg-AD Mouse Model of Alzheimer’s Disease

(2016) Jayasankar Kosaraju et al.   MOLECULAR NEUROBIOLOGY

Neurofibrillary tangles in Alzheimer′s disease: elucidation of the molecular mechanism by immunohistochemistry and tau protein phospho-proteomics

(2016) StefanJ Kempf et al.   Neural Regeneration Research

Microglia and Monocyte-Derived Macrophages in Stroke

(2016) Eunhee Kim et al.   Neurotherapeutics

Harmful and Beneficial Role of ROS

(2016) Sergio Di Meo et al.   Oxidative Medicine and Cellular Longevity

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke

(2016) Li Zhang et al.   STROKE

Dipeptidyl peptidase-4 inhibitor, linagliptin, ameliorates endothelial dysfunction and atherogenesis in normoglycemic apolipoprotein-E deficient mice

(2016) Hotimah Masdan Salim et al.   VASCULAR PHARMACOLOGY

Linagliptin improves endothelial function in patients with type 2 diabetes: A randomized study of linagliptin effectiveness on endothelial function

(2016) Fumika Shigiyama et al.   Journal of Diabetes Investigation

Nonclassical Patrolling Monocyte Function in the Vasculature

(2015) G. Thomas et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia

(2015) Hyun-Yoo Joo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

DPP-4 inhibition with linagliptin ameliorates cognitive impairment and brain atrophy induced by transient cerebral ischemia in type 2 diabetic mice

(2015) MingJie Ma et al.   Cardiovascular Diabetology

Population Pharmacokinetics and Pharmacodynamics of Linagliptin in Patients with Type 2 Diabetes Mellitus

(2015) Silke Retlich et al.   CLINICAL PHARMACOKINETICS

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Design and baseline characteristics of the CARdiovascular Outcome Trial of LINAgliptin Versus Glimepiride in Type 2 Diabetes (CAROLINA®)

(2015) Nikolaus Marx et al.   Diabetes & Vascular Disease Research

Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

AMPK activation protects from neuronal dysfunction and vulnerability across nematode, cellular and mouse models of Huntington's disease

(2015) Rafael P. Vázquez-Manrique et al.   HUMAN MOLECULAR GENETICS

Recent insights into the cellular biology of atherosclerosis

(2015) Ira Tabas et al.   JOURNAL OF CELL BIOLOGY

CX3CL1/CX3CR1-Mediated Microglia Activation Plays a Detrimental Role in Ischemic Mice Brain via p38MAPK/PKC Pathway

(2015) Yong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Increased VEGF and Decreased SDF-1α in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke

(2015) Hyuk Sung Kwon et al.   Journal of Stroke & Cerebrovascular Diseases

Apolipoprotein A1, B levels, and their ratio and the risk of a first stroke: a meta-analysis and case–control study

(2015) Hongli Dong et al.   METABOLIC BRAIN DISEASE

Possible vasculoprotective role of linagliptin against sodium arsenite-induced vascular endothelial dysfunction

(2015) Uma Jyoti et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

Alzheimer-Demenz

(2015) U. Yilmaz   RADIOLOGE

Systemic inflammation as a therapeutic target in acute ischemic stroke

(2015) Tomasz Dziedzic   Expert Review of Neurotherapeutics

Increased VEGF and Decreased SDF-1α in Patients with Silent Brain Infarction Are Associated with Better Prognosis after First-Ever Acute Lacunar Stroke

(2015) Hyuk Sung Kwon et al.   Journal of Stroke & Cerebrovascular Diseases

Aberrant insulin signaling in Alzheimer's disease: current knowledge

(2015) Gaurav Bedse et al.   Frontiers in Neuroscience

The Dipeptidyl Peptidase-4 Inhibitor Linagliptin Preserves Endothelial Function in Mesenteric Arteries from Type 1 Diabetic Rats without Decreasing Plasma Glucose

(2015) Salheen M. Salheen et al.   PLoS One

Inflammatory dysregulation of blood monocytes in Parkinson’s disease patients

(2014) Veselin Grozdanov et al.   ACTA NEUROPATHOLOGICA

Patrolling monocytes play a critical role in CX3CR1-mediated neuroprotection during excitotoxicity

(2014) Marc-André Bellavance et al.   Brain Structure & Function

DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway

(2014) Yao Dai et al.   CARDIOVASCULAR DRUGS AND THERAPY

Atherosclerotic Plaque Destabilization

(2014) Carlos Silvestre-Roig et al.   CIRCULATION RESEARCH

Inflammation in Ischemic Stroke: Mechanisms, Consequences and Possible Drug Targets

(2014) Muzamil Ahmad et al.   CNS & Neurological Disorders-Drug Targets

Pleiotropic Mechanisms for the Glucose-Lowering Action of DPP-4 Inhibitors

(2014) B. Omar et al.   DIABETES

Correlations of MCP-1 −2518A>G Polymorphism and Serum Levels with Cerebral Infarction Risk: A Meta-Analysis

(2014) Hong-Hua Gao et al.   DNA AND CELL BIOLOGY

Apolipoprotein B of low-density lipoprotein impairs nitric oxide-mediated endothelium-dependent relaxation in rat mesenteric arteries

(2014) Yaping Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Effect of food and tablet-dissolution characteristics on the bioavailability of linagliptin fixed-dose combination with metformin: evidence from two randomized trials

(2014) Katrin Metzmann et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Microglial and macrophage polarization—new prospects for brain repair

(2014) Xiaoming Hu et al.   Nature Reviews Neurology

Linagliptin enhances neural stem cell proliferation after stroke in type 2 diabetic mice

(2014) Vladimer Darsalia et al.   REGULATORY PEPTIDES

Postacute Stromal Cell–Derived Factor-1α Expression Promotes Neurovascular Recovery in Ischemic Mice

(2014) Yaning Li et al.   STROKE

Linagliptin: from bench to bedside

(2014) John Doupis   Drug Design Development and Therapy

Hyperglycaemia promotes human brain microvascular endothelial cell apoptosis via induction of protein kinase C-βI and prooxidant enzyme NADPH oxidase

(2014) Beili Shao et al.   Redox Biology

Acute hyperglycemia worsens ischemic stroke-induced brain damage via high mobility group box-1 in rats

(2013) Jingyang Huang et al.   BRAIN RESEARCH

Type 2 Diabetes Mellitus and Hypertension

(2013) Guido Lastra et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

TLR2 and TLR4 in the Brain Injury Caused by Cerebral Ischemia and Reperfusion

(2013) Ying Wang et al.   MEDIATORS OF INFLAMMATION

The ischemic penumbra: how does tissue injury evolve?

(2012) Wolf-Dieter Heiss   Annals of the New York Academy of Sciences

Clinical Pharmacokinetics and Pharmacodynamics of Linagliptin

(2012) Ulrike Graefe-Mody et al.   CLINICAL PHARMACOKINETICS

The DPP-4 Inhibitor Linagliptin Counteracts Stroke in the Normal and Diabetic Mouse Brain: A Comparison With Glimepiride

(2012) V. Darsalia et al.   DIABETES

Hyperphosphorylation of Tau Induced by Naturally Secreted Amyloid-β at Nanomolar Concentrations Is Modulated by Insulin-dependent Akt-GSK3β Signaling Pathway

(2012) Takayoshi Tokutake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitric Oxide: Considerations for the Treatment of Ischemic Stroke

(2012) Nicole A Terpolilli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanism of Action of DPP-4 Inhibitors—New Insights

(2012) Adrian Vella   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial

(2012) Baptist Gallwitz et al.   LANCET

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Role of the vascular endothelium and plaque in acute ischemic stroke

(2012) J. A. Madden   NEUROLOGY

Review: Systemic inflammation and Alzheimer's disease

(2012) C. Holmes   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Inhibition of SIRT1 Impairs the Accumulation and Transcriptional Activity of HIF-1α Protein under Hypoxic Conditions

(2012) Alexander Laemmle et al.   PLoS One

CXCR4 Antagonist AMD3100 Protects Blood–Brain Barrier Integrity and Reduces Inflammatory Response After Focal Ischemia in Mice

(2012) Jun Huang et al.   STROKE

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons

(2011) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH Oxidase 4 Promotes Endothelial Angiogenesis Through Endothelial Nitric Oxide Synthase Activation

(2011) Siobhan M. Craige et al.   CIRCULATION

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Characteristics of MR Infarcts Associated with Dementia and Cognitive Function in the Elderly

(2011) Neelum T. Aggarwal et al.   NEUROEPIDEMIOLOGY

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Small Molecule Inhibitors of NF-κB and JAK/STAT Signal Transduction Pathways as Promising Anti-Inflammatory Therapeutics

(2010) Y. A. Ivanenkov et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

(2010) M. Lv et al.   NEUROSCIENCE

The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues

(2009) H. Thangarajah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers

(2009) Fernanda G. De Felice et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Inflammatory Markers and Poor Outcome after Stroke: A Prospective Cohort Study and Systematic Review of Interleukin-6

(2009) William Whiteley et al.   PLOS MEDICINE

The effect of dipeptidyl peptidase-4 inhibition on gastric volume, satiation and enteroendocrine secretion in type 2 diabetes: a double-blind, placebo-controlled crossover study

(2008) Adrian Vella et al.   CLINICAL ENDOCRINOLOGY

Rod-Shaped Monocytes Patrol the Brain Vasculature and Give Rise to Perivascular Macrophages under the Influence of Proinflammatory Cytokines and Angiopoietin-2

(2008) J. Audoy-Remus et al.   JOURNAL OF NEUROSCIENCE