MicroRNA-212-5p Prevents Dopaminergic Neuron Death by Inhibiting SIRT2 in MPTP-Induced Mouse Model of Parkinson’s Disease

Plin4-Dependent Lipid Droplets Hamper Neuronal Mitophagy in the MPTP/p-Induced Mouse Model of Parkinson’s Disease

(2018) Xiaojuan Han et al.   Frontiers in Neuroscience

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

(2017) Rita Machado de Oliveira et al.   PLOS BIOLOGY

Specific and Novel microRNAs Are Regulated as Response to Fungal Infection in Human Dendritic Cells

(2017) Andreas Dix et al.   Frontiers in Microbiology

Sirtuins, Cell Senescence, and Vascular Aging

(2016) Yujiro Kida et al.   CANADIAN JOURNAL OF CARDIOLOGY

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

(2016) Yan Zhou et al.   Molecular Neurodegeneration

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

Fluoxetine protects against IL-1β-induced neuronal apoptosis via downregulation of p53

(2016) Han Shan et al.   NEUROPHARMACOLOGY

Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death

(2015) Yi-Hui Lee et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

MicroRNA-7 Enhances Subventricular Zone Neurogenesis by Inhibiting NLRP3/Caspase-1 Axis in Adult Neural Stem Cells

(2015) Zheng Fan et al.   MOLECULAR NEUROBIOLOGY

Autophagy in neurodegenerative diseases: From pathogenic dysfunction to therapeutic modulation

(2015) Marta Martinez-Vicente   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site

(2015) Tobias Rumpf et al.   Nature Communications

The Sirtuin-2 Inhibitor AK7 Is Neuroprotective in Models of Parkinson’s Disease but Not Amyotrophic Lateral Sclerosis and Cerebral Ischemia

(2015) Xiqun Chen et al.   PLoS One

Deciphering the Function and Regulation of microRNAs in Alzheimer’s Disease and Parkinson’s Disease

(2014) Lifeng Qiu et al.   ACS Chemical Neuroscience

The role of melatonin, sirtuin2 and FoXO1 transcription factor in the aging process of colon in male rats

(2014) Kazime Gonca Akbulut et al.   BIOGERONTOLOGY

Discovery of Potent and Selective Sirtuin 2 (SIRT2) Inhibitors Using a Fragment-Based Approach

(2014) Huaqing Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Circulating MicroRNA as Potential Source for Neurodegenerative Diseases Biomarkers

(2014) Ying Zi et al.   MOLECULAR NEUROBIOLOGY

SIRT1 in Neurodevelopment and Brain Senescence

(2014) A. Zara Herskovits et al.   NEURON

SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway

(2014) Lei Liu et al.   Frontiers in Aging Neuroscience

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Parkinson disease: from pathology to molecular disease mechanisms

(2013) David T. Dexter et al.   FREE RADICAL BIOLOGY AND MEDICINE

Modulation of p53 C-Terminal Acetylation by mdm2, p14ARF, and Cytoplasmic SirT2

(2013) I. M. M. van Leeuwen et al.   MOLECULAR CANCER THERAPEUTICS

Poly(ADP-ribose) polymerase mediates both cell death and ATP decreases in SIRT2 inhibitor AGK2-treated microglial BV2 cells

(2013) Yexin Li et al.   NEUROSCIENCE LETTERS

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

The involvement of microRNAs in neurodegenerative diseases

(2013) Simona Maciotta et al.   Frontiers in Cellular Neuroscience

Advances with microRNAs in Parkinson’s disease research

(2013) Weien Yuan et al.   Drug Design Development and Therapy

Programmed Cell Death in Parkinson's Disease

(2013) K. Venderova et al.   Cold Spring Harbor Perspectives in Medicine

Sirtuins: from metabolic regulation to brain aging

(2013) Wenzhen Duan   Frontiers in Aging Neuroscience

SIRT1 Protects against  -Synuclein Aggregation by Activating Molecular Chaperones

(2012) G. Donmez et al.   JOURNAL OF NEUROSCIENCE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

The neurobiology of sirtuins and their role in neurodegeneration

(2012) Gizem Donmez   TRENDS IN PHARMACOLOGICAL SCIENCES

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

MicroRNAs in neurodegenerative diseases and their therapeutic potential

(2011) Eunsung Junn et al.   PHARMACOLOGY & THERAPEUTICS

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

(2011) B. Beirowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153

(2010) Epaminondas Doxakis   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

The Role of Sirtuins in the Control of Metabolic Homeostasis

(2009) Jiujiu Yu et al.   Annals of the New York Academy of Sciences

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Silencing of MicroRNA-122 in Primates with Chronic Hepatitis C Virus Infection

(2009) R. E. Lanford et al.   SCIENCE

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53: The Janus of autophagy?

(2008) Beth Levine et al.   NATURE CELL BIOLOGY

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY