Early sirtuin 2 inhibition prevents age-related cognitive decline in a senescence-accelerated mouse model

Sirtuins in Alzheimer’s Disease: SIRT2-Related GenoPhenotypes and Implications for PharmacoEpiGenetics

(2019) Ramón Cacabelos et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Biomarkers for Alzheimer´s disease

(2019) Leonardo Guzman-Martinez et al.   Current Alzheimer Research

Understanding Epigenetics in the Neurodegeneration of Alzheimer’s Disease: SAMP8 Mouse Model

(2018) Christian Griñán-Ferré et al.   JOURNAL OF ALZHEIMERS DISEASE

Dietary Total Prenylflavonoids from the Fruits of Psoralea corylifolia L. Prevents Age-Related Cognitive Deficits and Down-Regulates Alzheimer’s Markers in SAMP8 Mice

(2018) Zhi-Jing Chen et al.   MOLECULES

Nucleocytoplasmic export of HDAC5 and SIRT2 downregulation: two epigenetic mechanisms by which antidepressants enhance synaptic plasticity markers

(2018) I. Muñoz-Cobo et al.   PSYCHOPHARMACOLOGY

Acetylation as a major determinant to microtubule-dependent autophagy: Relevance to Alzheimer's and Parkinson disease pathology

(2018) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alterations in the Expression of Amyloid Precursor Protein Cleaving Enzymes mRNA in Alzheimer Peripheral Blood

(2018) Prapimpun Wongchitrat et al.   Current Alzheimer Research

Temporal Integrative Analysis of mRNA and microRNAs Expression Profiles and Epigenetic Alterations in Female SAMP8, a Model of Age-Related Cognitive Decline

(2018) Marta Cosín-Tomás et al.   Frontiers in Genetics

Tubulin Post-Translational Modifications and Microtubule Dynamics

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of the oral administration of nanoencapsulated quercetin on a mouse model of Alzheimer’s disease

(2017) Lina Clara Gayoso e Ibiapina Moreno et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Protective effect of xanthohumol against age-related brain damage

(2017) Lisa Rancán et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

SIRT2 inhibition modulate glutamate and serotonin systems in the prefrontal cortex and induces antidepressant-like action

(2017) Mercedes Erburu et al.   NEUROPHARMACOLOGY

The mechanism of sirtuin 2–mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease

(2017) Rita Machado de Oliveira et al.   PLOS BIOLOGY

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)

(2017) Merce Pallas et al.   JOURNAL OF ALZHEIMERS DISEASE

Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 status

(2016) Tarique Anwar et al.   CELL CYCLE

Sirtuin 2 Inhibition Improves Cognitive Performance and Acts on Amyloid-β Protein Precursor Processing in Two Alzheimer’s Disease Mouse Models

(2016) Gloria Biella et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology

(2016) D. F. Silva et al.   MOLECULAR NEUROBIOLOGY

The aging memory: Modulating epigenetic modifications to improve cognitive function

(2016) Rosalina Fonseca   NEUROBIOLOGY OF LEARNING AND MEMORY

SIRT2 Plays Significant Roles in Lipopolysaccharides-Induced Neuroinflammation and Brain Injury in Mice

(2016) Ban Wang et al.   NEUROCHEMICAL RESEARCH

Application of Targeted Mass Spectrometry for the Quantification of Sirtuins in the Central Nervous System

(2016) T. Jayasena et al.   Scientific Reports

Environmental Enrichment Modified Epigenetic Mechanisms in SAMP8 Mouse Hippocampus by Reducing Oxidative Stress and Inflammaging and Achieving Neuroprotection

(2016) Christian Griñan-Ferré et al.   Frontiers in Aging Neuroscience

Reversal of aging-related emotional memory deficits by norepinephrine via regulating the stability of surface AMPA receptors

(2015) Yi Luo et al.   AGING CELL

Selective Inhibition of SIRT2 Improves Outcomes in a Lethal Septic Model

(2015) T. Zhao et al.   CURRENT MOLECULAR MEDICINE

SIRT2 inhibition exacerbates neuroinflammation and blood-brain barrier disruption in experimental traumatic brain injury by enhancing NF-κB p65 acetylation and activation

(2015) Fang Yuan et al.   JOURNAL OF NEUROCHEMISTRY

Environmental Enrichment Improves Behavior, Cognition, and Brain Functional Markers in Young Senescence-Accelerated Prone Mice (SAMP8)

(2015) Christian Griñan-Ferré et al.   MOLECULAR NEUROBIOLOGY

SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia

(2015) Heyu Chen et al.   NEUROREPORT

Histone deacetylase 3 inhibition re-establishes synaptic tagging and capture in aging through the activation of nuclear factor kappa B

(2015) Mahima Sharma et al.   Scientific Reports

SIRT2 ameliorates lipopolysaccharide-induced inflammation in macrophages

(2014) Ae Sin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

SIRT2knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors

(2014) Toshiaki Inoue et al.   FEBS Journal

Sildenafil Decreases BACE1 and Cathepsin B Levels and Reduces APP Amyloidogenic Processing in the SAMP8 Mouse

(2014) Lourdes Orejana et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Epigenetics of Aging and Aging-related Disease

(2014) A. Brunet et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Sodium butyrate, a histone deacetylase Inhibitor, ameliorates SIRT2-induced memory impairment, reduction of cell proliferation, and neuroblast differentiation in the dentate gyrus

(2014) Dae Young Yoo et al.   NEUROLOGICAL RESEARCH

The SIRT2 Polymorphism rs10410544 and Risk of Alzheimer’s Disease: A Meta-analysis

(2014) Wenjin Wei et al.   NEUROMOLECULAR MEDICINE

Intervening in ageing to prevent the diseases of ageing

(2014) Linda Partridge   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sirtuin modulators control reactive gliosis in an in vitro model of Alzheimer’s disease

(2014) Caterina Scuderi et al.   Frontiers in Pharmacology

The Potential of HDAC Inhibitors as Cognitive Enhancers

(2013) Johannes Gräff et al.   Annual Review of Pharmacology and Toxicology

The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation

(2013) Teresa Faria Pais et al.   EMBO JOURNAL

Implication of JNK pathway on tau pathology and cognitive decline in a senescence-accelerated mouse model

(2013) Lourdes Orejana et al.   EXPERIMENTAL GERONTOLOGY

Neurobiological and pharmacological validity of curcumin in ameliorating memory performance of senescence-accelerated mice

(2013) Chen Y. Sun et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuroprotective Sirtuin ratio reversed by ApoE4

(2013) V. Theendakara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role for SIRT2-Dependent Histone H3K18 Deacetylation in Bacterial Infection

(2013) H. A. Eskandarian et al.   SCIENCE

Epigenetic Determinants of Healthy and Diseased Brain Aging and Cognition

(2013) Schahram Akbarian et al.   JAMA Neurology

Dietary resveratrol prevents Alzheimer’s markers and increases life span in SAMP8

(2012) David Porquet et al.   AGE

The SIRT2 polymorphism rs10410544 and risk of Alzheimer’s disease in two Caucasian case–control cohorts

(2012) Letizia Polito et al.   Alzheimers & Dementia

Memory in aged mice is rescued by enhanced expression of the GluN2B subunit of the NMDA receptor

(2012) B.L. Brim et al.   BEHAVIOURAL BRAIN RESEARCH

Design, Synthesis, and Biological Activity of a Novel Series of Human Sirtuin-2-Selective Inhibitors

(2012) Takayoshi Suzuki et al.   JOURNAL OF MEDICINAL CHEMISTRY

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

The Sirtuin 2 Inhibitor AK-7 Is Neuroprotective in Huntington’s Disease Mouse Models

(2012) Vanita Chopra et al.   Cell Reports

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

(2012) Tara L. Spires-Jones et al.   Frontiers in Pharmacology

SIRT2 activity is required for the survival of C6 glioma cells

(2011) Xin He et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Sirtuin 2 microtubule deacetylase is an abundant neuronal protein that accumulates in the aging CNS

(2011) Michele M. Maxwell et al.   HUMAN MOLECULAR GENETICS

Epigenetic mechanisms in Alzheimer's disease

(2011) Diego Mastroeni et al.   NEUROBIOLOGY OF AGING

Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model

(2011) Lourdes Orejana et al.   NEUROBIOLOGY OF AGING

SIRT2 down-regulation in HeLa can induce p53 accumulation via p38 MAPK activation-dependent p300 decrease, eventually leading to apoptosis

(2010) Yanze Li et al.   GENES TO CELLS

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

Neurochemistry, Neuropathology, and Heredity in SAMP8: A Mouse Model of Senescence

(2009) Koji Tomobe et al.   NEUROCHEMICAL RESEARCH

SIRT2 is a negative regulator of anoxia-reoxygenation tolerance via regulation of 14-3-3 ζ and BAD in H9c2 cells

(2008) Edward G. Lynn et al.   FEBS LETTERS

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

Opposing Effects of Sirtuins on Neuronal Survival: SIRT1-Mediated Neuroprotection Is Independent of Its Deacetylase Activity

(2008) Jason A. Pfister et al.   PLoS One