Probing the mechanism of SIRT1 activation by a 1,4-dihydropyridine

Novel 1,4-dihydropyridine induces apoptosis in human cancer cells through overexpression of Sirtuin1

(2018) Debashri Manna et al.   APOPTOSIS

Reaching multi-nanosecond timescales in combined QM/MM molecular dynamics simulations through parallel horsetail sampling

(2017) Marilia T. C. Martins-Costa et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Update on phosphate and charged post-translationally modified amino acid parameters in the GROMOS force field

(2017) Christian Margreitter et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Resveratrol inhibits proliferation and migration through SIRT1 mediated post-translational modification of PI3K/AKT signaling in hepatocellular carcinoma cells

(2017) Rongfei Chai et al.   Molecular Medicine Reports

Synthesis and Cytotoxicity of 1,4-Dihydropyridines and an Unexpected 1,3-Oxazin-6-one

(2016) Louis Pergaud Sandjo et al.   HELVETICA CHIMICA ACTA

1,4-Dihydropyridines Active on the SIRT1/AMPK Pathway Ameliorate Skin Repair and Mitochondrial Function and Exhibit Inhibition of Proliferation in Cancer Cells

(2016) Sergio Valente et al.   JOURNAL OF MEDICINAL CHEMISTRY

1,4-Dihydropyridine Derivatives: Dihydronicotinamide Analogues—Model Compounds Targeting Oxidative Stress

(2016) Astrida Velena et al.   Oxidative Medicine and Cellular Longevity

Resveratrol serves as a protein-substrate interaction stabilizer in human SIRT1 activation

(2016) Xuben Hou et al.   Scientific Reports

Sirt1 activation by resveratrol is substrate sequence-selective

(2016) Mahadevan Lakshminarasimhan et al.   Aging-US

The Role of SIRT1 in Cancer

(2015) Melissa J. Wilking et al.   AMERICAN JOURNAL OF PATHOLOGY

GMXPBSA 2.1: A GROMACS tool to perform MM/PBSA and computational alanine scanning

(2015) C. Paissoni et al.   COMPUTER PHYSICS COMMUNICATIONS

Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol

(2015) Duanfang Cao et al.   GENES & DEVELOPMENT

Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia

(2015) Lihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Sirt1-Deficient Mice Have Hypogonadotropic Hypogonadism due to Defective GnRH Neuronal Migration

(2015) Gabriele Di Sante et al.   MOLECULAR ENDOCRINOLOGY

Crystallographic structure of a small molecule SIRT1 activator-enzyme complex

(2015) Han Dai et al.   Nature Communications

Rejuvenating SIRT1 Activators

(2013) Philipp Gut et al.   Cell Metabolism

Structural and Functional Analysis of Human SIRT1

(2013) Andrew M. Davenport et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

Sirtuin activators and inhibitors

(2012) José M. Villalba et al.   BIOFACTORS

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

USP22 Antagonizes p53 Transcriptional Activation by Deubiquitinating Sirt1 to Suppress Cell Apoptosis and Is Required for Mouse Embryonic Development

(2012) Zhenghong Lin et al.   MOLECULAR CELL

Template-based protein structure modeling using the RaptorX web server

(2012) Morten Källberg et al.   Nature Protocols

Resveratrol promotes expression of SIRT1 and StAR in rat ovarian granulosa cells: an implicative role of SIRT1 in the ovary

(2012) Yoshihiro Morita et al.   Reproductive Biology and Endocrinology

mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart

(2011) Manlio Vinciguerra et al.   AGING CELL

The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation

(2011) Sinyi Kong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol induces Sirt1-dependent apoptosis in 3T3-L1 preadipocytes by activating AMPK and suppressing AKT activity and survivin expression

(2011) Sifan Chen et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Facile Synthesis and Antibacterial, Antitubercular, and Anticancer Activities of Novel 1,4-Dihydropyridines

(2010) Kalam Sirisha et al.   ARCHIV DER PHARMAZIE

Myeloid Deletion of SIRT1 Induces Inflammatory Signaling in Response to Environmental Stress

(2010) T. T. Schug et al.   MOLECULAR AND CELLULAR BIOLOGY

Resveratrol prevents doxorubicin cardiotoxicity through mitochondrial stabilization and the Sirt1 pathway

(2009) Elizabeth D. Brookins Danz et al.   FREE RADICAL BIOLOGY AND MEDICINE

Study of 1,4-Dihydropyridine Structural Scaffold: Discovery of Novel Sirtuin Activators and Inhibitors

(2009) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1

(2009) Anna Csiszar et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Human Sirt-1: Molecular Modeling and Structure-Function Relationships of an Unordered Protein

(2009) Ida Autiero et al.   PLoS One

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Deacetylation of cortactin by SIRT1 promotes cell migration

(2008) Y Zhang et al.   ONCOGENE

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth

(2008) Ron Firestein et al.   PLoS One