Mitochondrial Metabolism Power SIRT2-Dependent Deficient Traffic Causing Alzheimer’s-Disease Related Pathology

Amyloid-β-Induced Mitochondrial Dysfunction Impairs the Autophagic Lysosomal Pathway in a Tubulin Dependent Pathway

(2018) Diana F.F. Silva et al.   JOURNAL OF ALZHEIMERS DISEASE

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

(2018) Xiongwei Zhu et al.   JOURNAL OF ALZHEIMERS DISEASE

Inhibitors of Mitochondrial Fission as a Therapeutic Strategy for Diseases with Oxidative Stress and Mitochondrial Dysfunction

(2018) P. Hemachandra Reddy   JOURNAL OF ALZHEIMERS DISEASE

Posttranslational modifications of α-tubulin in alzheimer disease

(2015) Fan Zhang et al.   Translational Neurodegeneration

Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration

(2014) Sandra E. Encalada et al.   Annual Review of Biophysics

Dual roles for autophagy: Degradation and secretion of Alzheimer's disease Aβ peptide

(2014) Per Nilsson et al.   BIOESSAYS

Enhancing Astrocytic Lysosome Biogenesis Facilitates A  Clearance and Attenuates Amyloid Plaque Pathogenesis

(2014) Q. Xiao et al.   JOURNAL OF NEUROSCIENCE

The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm

(2014) A. R. Esteves et al.   MOLECULAR NEUROBIOLOGY

Systemic regulation of mammalian ageing and longevity by brain sirtuins

(2014) Akiko Satoh et al.   Nature Communications

The Alzheimer's disease mitochondrial cascade hypothesis: Progress and perspectives

(2013) Russell H. Swerdlow et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

(2013) Xueqi Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Prodromal Metabolic Phenotype in MCI Cybrids: Implications for Alzheimer’s Disease

(2013) D. F. Silva et al.   Current Alzheimer Research

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines

(2013) D. F. Silva et al.   HUMAN MOLECULAR GENETICS

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Phosphorylation of tau protein at sites Ser396-404is one of the earliest events in Alzheimer's disease and Down syndrome

(2013) S. Mondragón-Rodríguez et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Aβ Secretion and Plaque Formation Depend on Autophagy

(2013) Per Nilsson et al.   Cell Reports

SIRT2 interferes with autophagy-mediated degradation of protein aggregates in neuronal cells under proteasome inhibition

(2012) Jiyeong Gal et al.   NEUROCHEMISTRY INTERNATIONAL

Axonal transport and neurodegenerative disease: Can we see the elephant?

(2012) Lawrence S.B. Goldstein   PROGRESS IN NEUROBIOLOGY

PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria

(2012) Kei Okatsu et al.   Nature Communications

Inhibition of Sirtuin 2 with Sulfobenzoic Acid Derivative AK1 is Non-Toxic and Potentially Neuroprotective in a Mouse Model of Frontotemporal Dementia

(2012) Tara L. Spires-Jones et al.   Frontiers in Pharmacology

Abnormal accumulation of autophagic vesicles correlates with axonal and synaptic pathology in young Alzheimer’s mice hippocampus

(2011) Raquel Sanchez-Varo et al.   ACTA NEUROPATHOLOGICA

Primary lysosomal dysfunction causes cargo-specific deficits of axonal transport leading to Alzheimer-like neuritic dystrophy

(2011) SooYeon Lee et al.   Autophagy

Mitochondria: The Common Upstream Driver of Amyloid-β and Tau Pathology in Alzheimers Disease

(2011) D. F.F. Silva et al.   Current Alzheimer Research

The mitochondrial intramembrane protease PARL cleaves human Pink1 to regulate Pink1 trafficking

(2011) Cathrin Meissner et al.   JOURNAL OF NEUROCHEMISTRY

Protective Effects of Positive Lysosomal Modulation in Alzheimer's Disease Transgenic Mouse Models

(2011) David Butler et al.   PLoS One

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Microtubule destruction induces tau liberation and its subsequent phosphorylation

(2010) Tomohiro Miyasaka et al.   FEBS LETTERS

Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy☆

(2010) Takafumi Hasegawa et al.   NEUROCHEMISTRY INTERNATIONAL

Regulation of Amyloid Precursor Protein Processing by the Beclin 1 Complex

(2010) Philipp A. Jaeger et al.   PLoS One

SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis

(2010) Ruth Luthi-Carter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of tau-induced neurodegeneration

(2009) Khalid Iqbal et al.   ACTA NEUROPATHOLOGICA

SIRT2-mediated protein deacetylation: An emerging key regulator in brain physiology and pathology

(2009) Kai Harting et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission

(2009) Ruben K. Dagda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Dynamin-Like Protein 1 Reduction Underlies Mitochondrial Morphology and Distribution Abnormalities in Fibroblasts from Sporadic Alzheimer's Disease Patients

(2008) Xinglong Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

(2008) Ruwin Pandithage et al.   JOURNAL OF CELL BIOLOGY

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid β accumulation in mice

(2008) Fiona Pickford et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

(2008) K. N. Green et al.   JOURNAL OF NEUROSCIENCE

Autophagy Induction and Autophagosome Clearance in Neurons: Relationship to Autophagic Pathology in Alzheimer's Disease

(2008) B. Boland et al.   JOURNAL OF NEUROSCIENCE