β-Lapachone suppresses neuroinflammation by modulating the expression of cytokines and matrix metalloproteinases in activated microglia

Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease

(2015) Diana M. Norden et al.   NEUROPHARMACOLOGY

NAD(P)H:Quinone Oxidoreductase 1 Activation Reduces Blood Pressure Through Regulation of Endothelial Nitric Oxide Synthase Acetylation in Spontaneously Hypertensive Rats

(2014) Y.-H. Kim et al.   AMERICAN JOURNAL OF HYPERTENSION

β-lapachone-Induced Apoptosis of Human Gastric Carcinoma AGS Cells Is Caspase-Dependent and Regulated by the PI3K/Akt Pathway

(2014) Hai Yang Yu et al.   Biomolecules & Therapeutics

Matrix Metalloproteinase-8 Plays a Pivotal Role in Neuroinflammation by Modulating TNF-α Activation

(2014) Eun-Jung Lee et al.   JOURNAL OF IMMUNOLOGY

The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia

(2014) Eun-Jung Lee et al.   Journal of Neuroinflammation

Neuroinflammation and M2 microglia: the good, the bad, and the inflamed

(2014) Jonathan D Cherry et al.   Journal of Neuroinflammation

Microglial Dynamics and Role in the Healthy and Diseased Brain

(2014) Diego Gomez-Nicola et al.   NEUROSCIENTIST

Anti-inflammatory mechanism of exogenous C2 ceramide in lipopolysaccharide-stimulated microglia

(2013) Ji-Sun Jung et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis of quinoidal molecules: Strategies towards bioactive compounds with an emphasis on lapachones

(2013) Solange L. de Castro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protection of NAD(P)H:quinone oxidoreductase 1 against renal ischemia/reperfusion injury in mice

(2013) Gil-Tae Gang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pharmacological activation of NQO1 increases NAD+ levels and attenuates cisplatin-mediated acute kidney injury in mice

(2013) Gi-Su Oh et al.   KIDNEY INTERNATIONAL

Regulation of Nrf2-Mediated Phase II Detoxification and Anti-oxidant Genes

(2012) Young-Sam Keum   Biomolecules & Therapeutics

Potential in vitro Protective Effect of Quercetin, Catechin, Caffeic Acid and Phytic Acid against Ethanol-Induced Oxidative Stress in SK-Hep-1 Cells

(2012) Ki-Mo Lee et al.   Biomolecules & Therapeutics

Anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone)

(2012) Marília Maria Sitônio et al.   INFLAMMATION RESEARCH

β-Lapachone, a substrate of NAD(P)H:quinone oxidoreductase, induces anti-inflammatory heme oxygenase-1 via AMP-activated protein kinase activation in RAW264.7 macrophages

(2012) Seung Jae Byun et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

β-Lapachone ameliorization of experimental autoimmune encephalomyelitis

(2012) Jihong Xu et al.   JOURNAL OF NEUROIMMUNOLOGY

Beta-Lapachone, a Modulator of NAD Metabolism, Prevents Health Declines in Aged Mice

(2012) Jeong-sook Lee et al.   PLoS One

NADPH oxidases: novel therapeutic targets for neurodegenerative diseases

(2012) Hui-Ming Gao et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Prevention of salt-induced renal injury by activation of NAD(P)H:quinone oxidoreductase 1, associated with NADPH oxidase

(2011) Yong-Hoon Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids

(2011) Emilia Kansanen et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Role of Microglia in the Healthy Brain

(2011) M.-E. Tremblay et al.   JOURNAL OF NEUROSCIENCE

Metalloproteinase and stroke infarct size: role for anti-inflammatory treatment?

(2010) Anna Morancho et al.   Annals of the New York Academy of Sciences

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

 -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1

(2010) E.-J. Lee et al.   JOURNAL OF IMMUNOLOGY

Anti-inflammatory mechanism of ginsenoside Rh1 in lipopolysaccharide-stimulated microglia: critical role of the protein kinase A pathway and hemeoxygenase-1 expression

(2010) Ji-Sun Jung et al.   JOURNAL OF NEUROCHEMISTRY

Activation of NAD(P)H:Quinone Oxidoreductase 1 Prevents Arterial Restenosis by Suppressing Vascular Smooth Muscle Cell Proliferation

(2009) Sun-Yee Kim et al.   CIRCULATION RESEARCH

Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in Mice

(2009) J. H. Hwang et al.   DIABETES

Matrix metalloproteinases and their multiple roles in neurodegenerative diseases

(2009) Gary A Rosenberg   LANCET NEUROLOGY

Regulation of haeme oxygenase-1 for treatment of neuroinflammation and brain disorders

(2008) P J Syapin   BRITISH JOURNAL OF PHARMACOLOGY

Topoisomerase inhibitors as anti-arthritic agents

(2008) J. K. Jackson et al.   INFLAMMATION RESEARCH

Red Lapacho (Tabebuia impetiginosa)—A global ethnopharmacological commodity?

(2008) J. Rubén Gómez Castellanos et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia

(2008) Moon-Sook Woo et al.   JOURNAL OF NEUROCHEMISTRY

The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death

(2008) Boyoung Lee et al.   JOURNAL OF NEUROCHEMISTRY

Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse

(2008) J.P. Juncos et al.   KIDNEY INTERNATIONAL

MMPs in the central nervous system: Where the good guys go bad

(2007) S AGRAWAL et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY