Autophagy in white matter disorders of the CNS : mechanisms and therapeutic opportunities

Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients

(2020) Goh Murayama et al.   RHEUMATOLOGY

LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production

(2019) Meiyu Zhang et al.   Journal of Translational Medicine

Oligoprotective effect of metformin through the AMPK-dependent on restoration of mitochondrial hemostasis in the cuprizone-induced multiple sclerosis model

(2019) Seyed Hossein Hosseini Largani et al.   JOURNAL OF MOLECULAR HISTOLOGY

Dual Role of Autophagy in Diseases of the Central Nervous System

(2019) Tamara Bar-Yosef et al.   Frontiers in Cellular Neuroscience

Subacute sclerosing panencephalitis

(2019) Ravindra Kumar Garg et al.   REVIEWS IN MEDICAL VIROLOGY

Dynamic expression of autophagy-related factors in autoimmune encephalomyelitis and exploration of curcumin therapy

(2019) Yuan Boyao et al.   JOURNAL OF NEUROIMMUNOLOGY

Matrine protects oligodendrocytes by inhibiting their apoptosis and enhancing mitochondrial autophagy

(2019) Meng-Ru Wang et al.   BRAIN RESEARCH BULLETIN

Metformin Restores CNS Remyelination Capacity by Rejuvenating Aged Stem Cells

(2019) Björn Neumann et al.   Cell Stem Cell

Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis

(2019) Fariba Houshmand et al.   DARU-Journal of Pharmaceutical Sciences

Pathogenesis of progressive multifocal leukoencephalopathy and risks associated with treatments for multiple sclerosis: a decade of lessons learned

(2018) Eugene O Major et al.   LANCET NEUROLOGY

Early Prediction of Hypoxic-Ischemic Brain Injury by a New Panel of Biomarkers in a Population of Term Newborns

(2018) Simona Negro et al.   Oxidative Medicine and Cellular Longevity

Mir223 restrains autophagy and promotes CNS inflammation by targeting ATG16L1

(2018) Yan Li et al.   Autophagy

STING directly activates autophagy to tune the innate immune response

(2018) Dong Liu et al.   CELL DEATH AND DIFFERENTIATION

Gene therapy for lysosomal storage disorders: recent advances for metachromatic leukodystrophy and mucopolysaccaridosis I

(2017) Rachele Penati et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Binswanger's disease: biomarkers in the inflammatory form of vascular cognitive impairment and dementia

(2017) Gary A. Rosenberg   JOURNAL OF NEUROCHEMISTRY

Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy

(2017) William D Rawlinson et al.   LANCET INFECTIOUS DISEASES

Dual role of autophagy in hallmarks of cancer

(2017) Shikha Satendra Singh et al.   ONCOGENE

Emodin ameliorates cisplatin-induced apoptosis of rat renal tubular cells in vitro by activating autophagy

(2016) Hong Liu et al.   ACTA PHARMACOLOGICA SINICA

Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer

(2016) Kui Wang et al.   Autophagy

Low dose tunicamycin enhances atherosclerotic plaque stability by inducing autophagy

(2016) Meijuan Ma et al.   BIOCHEMICAL PHARMACOLOGY

Intrathecal Injection of 3-Methyladenine Reduces Neuronal Damage and Promotes Functional Recovery via Autophagy Attenuation after Spinal Cord Ischemia/Reperfusion Injury in Rats

(2016) Xing Wei et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Endoplasmic reticulum stress intolerance in EIF2B3 mutant oligodendrocytes is modulated by depressed autophagy

(2016) Na Chen et al.   BRAIN & DEVELOPMENT

U0126 attenuates ischemia/reperfusion-induced apoptosis and autophagy in myocardium through MEK/ERK/EGR-1 pathway

(2016) Anxing Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Acute disseminated encephalomyelitis

(2016) Daniela Pohl et al.   NEUROLOGY

Myelin and oligodendrocyte lineage cells in white matter pathology and plasticity after traumatic brain injury

(2016) Regina C. Armstrong et al.   NEUROPHARMACOLOGY

Novel pathologic findings in patients with Pelizaeus-Merzbacher disease

(2016) Jeremy J. Laukka et al.   NEUROSCIENCE LETTERS

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Genetic perspective on the role of the autophagy-lysosome pathway in Parkinson disease

(2015) Ziv Gan-Or et al.   Autophagy

Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers

(2015) Zhao Jing et al.   CANCER LETTERS

Different Eukaryotic Initiation Factor 2Bε Mutations Lead to Various Degrees of Intolerance to the Stress of Endoplasmic Reticulum in Oligodendrocytes

(2015) Ye Wu et al.   CHINESE MEDICAL JOURNAL

Oxidative stress, mitochondrial and proteostasis malfunction in adrenoleukodystrophy: A paradigm for axonal degeneration

(2015) Stéphane Fourcade et al.   FREE RADICAL BIOLOGY AND MEDICINE

Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway

(2015) Feng Wang et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy: a druggable process that is deregulated in aging and human disease

(2015) Guido Kroemer   JOURNAL OF CLINICAL INVESTIGATION

Rare Variants of ATG5 Are Likely to Be Associated With Chinese Patients With Systemic Lupus Erythematosus

(2015) Yue-miao Zhang et al.   MEDICINE

Compromised autophagy and neurodegenerative diseases

(2015) Fiona M. Menzies et al.   NATURE REVIEWS NEUROSCIENCE

Protective Effects of Gastrodin Against Autophagy-Mediated Astrocyte Death

(2015) Xin-shang Wang et al.   PHYTOTHERAPY RESEARCH

Baicalein Triggers Autophagy and Inhibits the Protein Kinase B/Mammalian Target of Rapamycin Pathway in Hepatocellular Carcinoma HepG2 Cells

(2015) Ya-Fang Wang et al.   PHYTOTHERAPY RESEARCH

Induction of apoptosis and autophagy via sirtuin1- and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells

(2015) Shu-Feng Zhou et al.   Drug Design Development and Therapy

Role of autophagy in the pathogenesis of multiple sclerosis

(2015) Peizhou Liang et al.   Neuroscience Bulletin

Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease

(2015) Christine M. LaPash Daniels et al.   PLoS One

Autophagy induction halts axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2014) Nathalie Launay et al.   ACTA NEUROPATHOLOGICA

A New Model of Cuprizone-Mediated Demyelination/Remyelination

(2014) Hilary H. Sachs et al.   ASN Neuro

Variants of autophagy-related gene 5 are associated with neuromyelitis optica in the Southern Han Chinese population

(2014) Ping-Ping Cai et al.   AUTOIMMUNITY

Neuroprotective Effect of Chebulagic Acid via Autophagy Induction in SH-SY5Y Cells

(2014) Hee Ju Kim et al.   Biomolecules & Therapeutics

Pinosylvin at a high concentration induces AMPK-mediated autophagy for preventing necrosis in bovine aortic endothelial cells

(2014) Jinsun Park et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Role of PI3K/Akt/mTOR and MEK/ERK pathway in Concanavalin A induced autophagy in HeLa cells

(2014) Bibhas Roy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Activating Cannabinoid Receptor 2 Alleviates Pathogenesis of Experimental Autoimmune Encephalomyelitis Via Activation of Autophagy and Inhibiting NLRP3 Inflammasome

(2014) Bo-Zong Shao et al.   CNS Neuroscience & Therapeutics

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Downregulation of PI3K/Akt/mTOR signaling pathway in curcumin-induced autophagy in APP/PS1 double transgenic mice

(2014) Chen Wang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy

(2014) Ming-Hui Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Type I Interferon in the Pathogenesis of Lupus

(2014) M. K. Crow   JOURNAL OF IMMUNOLOGY

Activation of Autophagy by Rapamycin Does Not Protect Oligodendrocytes Against Protein Aggregate Formation and Cell Death Induced by Proteasomal Inhibition

(2014) Monika Noack et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids

(2014) Gareth Pryce et al.   Journal of Neuroimmune Pharmacology

Corynoxine, a Natural Autophagy Enhancer, Promotes the Clearance of Alpha-Synuclein via Akt/mTOR Pathway

(2014) Lei-Lei Chen et al.   Journal of Neuroimmune Pharmacology

Rubella virus perturbs autophagy

(2014) Kata Pásztor et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Autophagy-related gene16L2, a potential serum biomarker of multiple sclerosis evaluated by bead-based proteomic technology

(2014) Linlin Yin et al.   NEUROSCIENCE LETTERS

Autophagy Activation and Antiviral Activity by a Licorice Triterpene

(2014) Samuela Laconi et al.   PHYTOTHERAPY RESEARCH

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Increased Carbonylation, Protein Aggregation and Apoptosis in the Spinal Cord of Mice with Experimental Autoimmune Encephalomyelitis

(2013) Anushka Dasgupta et al.   ASN Neuro

The machinery of macroautophagy

(2013) Yuchen Feng et al.   CELL RESEARCH

Targeting miR-21 Induces Autophagy and Chemosensitivity of Leukemia Cells

(2013) Hugo Seca et al.   CURRENT DRUG TARGETS

H89 (N-[2-p-bromocinnamylamino-ethyl]-5-isoquinolinesulphonamide) induces autophagy independently of protein kinase A inhibition

(2013) Hiroko Inoue et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant

(2013) C. M. Smith et al.   JOURNAL OF NEUROSCIENCE

Immune surveillance and response to JC virus infection and PML

(2013) Sarah Beltrami et al.   JOURNAL OF NEUROVIROLOGY

Autophagy Modulation for Alzheimer’s Disease Therapy

(2013) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

Estrogen receptor β ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis

(2013) Shalini Kumar et al.   NEUROBIOLOGY OF DISEASE

Angiotensin-(1–7) inhibits autophagy in the brain of spontaneously hypertensive rats

(2013) Teng Jiang et al.   PHARMACOLOGICAL RESEARCH

Chloroquine Treatment Enhances Regulatory T Cells and Reduces the Severity of Experimental Autoimmune Encephalomyelitis

(2013) Rodolfo Thomé et al.   PLoS One

A novel protoapigenone analog RY10-4 induces breast cancer MCF-7 cell death through autophagy via the Akt/mTOR pathway

(2013) Xuenong Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Sustained Autophagy Contributes to Measles Virus Infectivity

(2013) Clémence Richetta et al.   PLoS Pathogens

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LRRK2 and autophagy: a common pathway for disease

(2012) Claudia Manzoni   BIOCHEMICAL SOCIETY TRANSACTIONS

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

(2012) Marina Pierdominici et al.   FASEB JOURNAL

mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis

(2012) Cinzia Dello Russo et al.   GLIA

Molecular Mechanisms of Oligodendrocyte Injury in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis

(2012) Jilpa Patel et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy and Its Comprehensive Impact on ALS

(2012) Cheng-yuan Song et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

(2012) L. Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

X-linked adrenoleukodystrophy (X-ALD): clinical presentation and guidelines for diagnosis, follow-up and management

(2012) Marc Engelen et al.   Orphanet Journal of Rare Diseases

Bag3-Induced Autophagy Is Associated with Degradation of JCV Oncoprotein, T-Ag

(2012) Ilker Kudret Sariyer et al.   PLoS One

Treatment of neuromyelitis optica: Review and recommendations

(2012) Dorlan J. Kimbrough et al.   Multiple Sclerosis and Related Disorders

Antioxidants halt axonal degeneration in a mouse model of X-adrenoleukodystrophy

(2011) Jone López-Erauskin et al.   ANNALS OF NEUROLOGY

Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population

(2011) X.-j. Zhou et al.   ANNALS OF THE RHEUMATIC DISEASES

Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

(2011) Cris S Constantinescu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Beclin1 Controls the Levels of p53 by Regulating the Deubiquitination Activity of USP10 and USP13

(2011) Junli Liu et al.   CELL

mTOR Signaling and Metabolic Regulation of T Cells: New Potential Therapeutic Targets in Autoimmune Diseases

(2011) Marina Pierdominici et al.   CURRENT PHARMACEUTICAL DESIGN

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Incidence of Abcd1 level on the induction of cell death and organelle dysfunctions triggered by very long chain fatty acids and TNF-α on oligodendrocytes and astrocytes

(2011) Mauhamad Baarine et al.   NEUROTOXICOLOGY

BH3 mimetics activate multiple pro-autophagic pathways

(2011) S A Malik et al.   ONCOGENE

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

Autophagy and apoptosis: what is the connection?

(2011) Jacob M. Gump et al.   TRENDS IN CELL BIOLOGY

Metformin inhibits melanoma development through autophagy and apoptosis mechanisms

(2011) T Tomic et al.   Cell Death & Disease

IRGM Is a Common Target of RNA Viruses that Subvert the Autophagy Network

(2011) Isabel Pombo Grégoire et al.   PLoS Pathogens

Pathogen recognition by the cell surface receptor CD46 induces autophagy

(2010) Grégory Meiffren et al.   Autophagy

The role of the Atg1/ULK1 complex in autophagy regulation

(2010) Noboru Mizushima   CURRENT OPINION IN CELL BIOLOGY

Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease

(2010) C. Rose et al.   HUMAN MOLECULAR GENETICS

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation

(2010) Marianna Esposito et al.   JOURNAL OF NEUROIMMUNOLOGY

Rapamycin Activates Autophagy and Improves Myelination in Explant Cultures from Neuropathic Mice

(2010) S. Rangaraju et al.   JOURNAL OF NEUROSCIENCE

Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation

(2010) Jose A. Rodríguez-Navarro et al.   NEUROBIOLOGY OF DISEASE

Regulation Mechanisms and Signaling Pathways of Autophagy

(2009) Congcong He et al.   Annual Review of Genetics

A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy

(2009) Carol A. Mercer et al.   Autophagy

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Autophagy Induction by the Pathogen Receptor CD46

(2009) Pierre-Emmanuel Joubert et al.   Cell Host & Microbe

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

(2009) Marco Donia et al.   JOURNAL OF AUTOIMMUNITY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evidence for modulation of BAG3 by polyomavirus JC early protein

(2009) A. Basile et al.   JOURNAL OF GENERAL VIROLOGY

A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus

(2009) Vesela Gateva et al.   NATURE GENETICS

Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

(2009) Jian-Wen Han et al.   NATURE GENETICS

Endoplasmic reticulum stress in disorders of myelinating cells

(2009) Wensheng Lin et al.   NATURE NEUROSCIENCE

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

(2008) Michael Degtyarev et al.   JOURNAL OF CELL BIOLOGY

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Neurodegeneration in multiple sclerosis: The role of oxidative stress and excitotoxicity

(2008) R.E. Gonsette   JOURNAL OF THE NEUROLOGICAL SCIENCES

Novel targets for Huntington's disease in an mTOR-independent autophagy pathway

(2008) Andrea Williams et al.   Nature Chemical Biology

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS