Article
Biochemistry & Molecular Biology
Nadia Papini, Roberta Todisco, Paola Giussani, Michele Dei Cas, Rita Paroni, Chiara Giallanza, Cristina Tringali
Summary: Autophagic impairment is observed in lysosomal storage diseases and adult neurodegenerative diseases, and it may contribute to worsen metabolite accumulation and lysosomal distress. In Krabbe disease, autophagy alterations were also identified. In this study, the inhibitory AKT-mediated phosphorylation of beclin-1 and the BCL2-beclin-1 complex were found to reduce autophagosomes formation in response to starvation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Multidisciplinary
Shasha Bai, Sainan Cui, Wenhao Wen, Elaine Lai-Han Leung, Jing Bai, Huiyuan Lin, Yongfei Cui, Lei Yang, Zhongqiu Liu, Yuan Zheng, Rong Zhang
Summary: Tan IIA, an active ingredient of Salvia miltiorrhiza, inhibits lung cancer growth by inducing autophagic apoptosis.
Article
Biochemistry & Molecular Biology
Leilei Zang, Yanmei Song, Yanhua Tian, Ning Hu
Summary: TAT-Beclin 1, as an autophagic promoter, can inhibit the tumorigenesis of DUSP4-positive PTC by regulating autophagy. The expression levels of autophagic proteins decreased with the increase of DUSP4 expression in PTC tissues. In PTC cells, the inhibitory effects of DUSP4 overexpression on autophagic activity and cell proliferation and migration were reversed by TAT-Beclin 1 administration. In vivo assays also showed that TAT-Beclin 1 could block the tumorigenic ability and restore autophagic activity in DUSP4-overexpressed PTC cells.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Reynold I. I. Lopez-Soler, Azadeh Nikouee, Matthew Kim, Saman Khan, Lakshmi Sivaraman, Xiangzhong Ding, Qun Sophia Zang
Summary: This study found that enhancing autophagy can reduce fibrosis caused by renal injury. By observing mice after kidney surgery, it was found that the use of active mutant Beclin-1 can inhibit the fibrosis process, alleviate inflammation and cellular stress response caused by kidney injury. These findings provide new methods for treating fibrosis after kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Masataka Sano, Yasuhiro Maejima, Shun Nakagama, Yuka Shiheido-Watanabe, Natsuko Tamura, Kenzo Hirao, Mitsuaki Isobe, Tetsuo Sasano
Summary: An increasing body of evidence suggests that neutrophil extracellular traps (NETs) play a critical role in the development of atherosclerosis. This study further reveals that NETs promote atherosclerosis by modulating the autophagy activity in macrophages.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Hongmei Zhou, Hong Ling, Yunlong Li, Xuejun Jiang, Shuqun Cheng, Golamaully Mohammad Zubeir, Yinyin Xia, Xia Qin, Jun Zhang, Zhen Zou, Chengzhi Chen
Summary: Exposure to arsenite causes brain damage, induces autophagy, and impairs autophagic flux. Downregulation of beclin 1 can restore impaired autophagic flux by improving lysosomal function.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Ahlam M. M. Alhusaini, Sara A. A. Alhumaidan, Ghaida M. M. Alharbi, Eman A. A. Alzahrani, WedadS S. Sarawi, Hatun A. A. Alomar, Abeer M. M. Alanazi, Dareen S. S. Mattar, Iman H. H. Hasan
Summary: This study investigated the protective effects of vitamin E and lactobacillus plantarum against mercuric chloride-induced kidney injury. The results showed that both vitamin E and lactobacillus plantarum provided protection against kidney damage by regulating autophagy and apoptosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
A. Movaqar, A. Abdoli, E. Aryan, Z. Meshkat
Summary: The study demonstrates that autophagy activation can significantly reduce virus yield in neuroblastoma cells while decreasing HSV-1 propagation in HeLa cells. However, HSV-1 proliferation increases in both cell types and maintains its ability to propagate even under high autophagic activity. Overactivation of autophagy only slows down the rate of virus replication.
MICROBIAL PATHOGENESIS
(2021)
Article
Biotechnology & Applied Microbiology
Zhiyang Huang, Xiaobin Luo, Yifan Zhang, Yibo Ying, Xiong Cai, Wenjie Lu, Juan Zhao, Yutian Wang, Wenwei Lin, Yurong Tu, Ziyue Xiang, Qiuji Wu, Shengwu Yang, Sipin Zhu, Xiaoyang Li
Summary: Notoginseng triterpenes (NT) can improve the survival rate of random flaps by promoting cell proliferation and migration, and by activating autophagy.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Haorui Qin, Zhiqiang Han, Wenkai Zhang, Rongquan He, Shuhua Zeng, Chunhui Qi, Shuting Zhou, Yingchun Chen
Summary: CTCF is involved in the regulation of autophagy and lipolysis, and it cooperates with PPAR gamma to modulate the transcription of BECLIN 1, thereby regulating autophagy and enhancing adipocyte lipolysis.
CELLULAR SIGNALLING
(2024)
Article
Neurosciences
Danyang Li, Qizhong Qin, Yinyin Xia, Shuqun Cheng, Jun Zhang, Xinhao Duan, Xia Qin, Xin Tian, Lejiao Mao, Jingfu Qiu, Xuejun Jiang, Zhen Zou, Chengzhi Chen
Summary: Arsenite, a common neurotoxicant, affects neurological functions through mechanisms not fully understood. This study investigated the role of autophagy in arsenite neurotoxicity using beclin 1(+/+) and beclin 1(+/-) mice. The results showed that arsenite exposure caused cognitive impairment, anxiety-like behavior, and motor coordination disorder in beclin 1(+/+) mice, accompanied by morphological and electrophysiological changes in cortical tissues. Heterozygous disruption of beclin 1 attenuated these neurotoxic effects, suggesting that regulating autophagy through beclin 1 may be a potential therapeutic approach against arsenite neurotoxicity.
Article
Biochemistry & Molecular Biology
Miray Turk, Ozge Tatli, Hamza Furkan Alkan, Pelin Ozfiliz Kilbas, Gizem Alkurt, Gizem Dinler Doganay
Summary: Expression levels of Beclin 1 and its interaction with Bcl-2 regulate the balance between autophagic cell survival and apoptotic cell death pathways. Bag-1 indirectly interacts with Beclin 1, influencing the crosstalk between Bcl-2 and Beclin 1 and participating in the regulation of early autophagy, ultimately impacting cell survival and proliferation.
Article
Biochemistry & Molecular Biology
Nobuyuki Fujiwara, Shusaku Shibutani, Takashi Ohama, Koichi Sato
Summary: Autophagy is regulated by the Beclin 1/Vps34 complex, and the protein phosphatase 6 (PP6) inhibits autophagy by binding to Beclin 1 and causing dissociation of Vps34. The phosphatase activity of PP6 is not involved in this regulatory mechanism.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Pathology
Chenghe Fan, Yilin Zhang, Yu Tian, Xinyu Zhao, Junfang Teng
Summary: Phloretin induces autophagy in cells through the AKT/mTOR and JNK-mediated pathways, playing a role in its anticancer effects. Upregulation of Beclin-1 and inhibition of autophagy can reduce phloretin-induced cytotoxicity and protect neurons.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Hamza Malik Okuyan, Serdar Dogan, Tayibe Bal, Mehmet Cabalak
Summary: The study reveals that serum BECN1 levels are elevated in COVID-19 patients compared to healthy controls, with significantly higher concentrations in severe cases. BECN1 levels show significant positive correlations with coagulation markers, inflammation markers, and biochemical markers.
