Piperlongumine induces apoptosis and autophagy in human lung cancer cells through inhibition of PI3K/Akt/mTOR pathway

Piperlongumine, an alkaloid causes inhibition of PI3 K/Akt/mTOR signaling axis to induce caspase-dependent apoptosis in human triple-negative breast cancer cells

(2014) Shweta Shrivastava et al.   APOPTOSIS

Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death

(2014) P Makhov et al.   BRITISH JOURNAL OF CANCER

Biodegradable nanoassemblies of piperlongumine display enhanced anti-angiogenesis and anti-tumor activities

(2014) Yuanyuan Liu et al.   Nanoscale

Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer

(2014) U Bharadwaj et al.   ONCOGENE

Piperlongumine Induces Apoptosis and Synergizes with Cisplatin or Paclitaxel in Human Ovarian Cancer Cells

(2014) Li-Hua Gong et al.   Oxidative Medicine and Cellular Longevity

Arenobufagin, a natural bufadienolide from toad venom, induces apoptosis and autophagy in human hepatocellular carcinoma cells through inhibition of PI3K/Akt/mTOR pathway

(2013) Dong-Mei Zhang et al.   CARCINOGENESIS

Piperlongumine induces autophagy by targeting p38 signaling

(2013) Y Wang et al.   Cell Death & Disease

Autophagy in tumorigenesis and cancer therapy: Dr. Jekyll or Mr. Hyde?

(2012) Shengtao Zhou et al.   CANCER LETTERS

Tumor Cell Autophagy as an Adaptive Response Mediating Resistance to Treatments Such as Antiangiogenic Therapy

(2012) Y.-L. Hu et al.   CANCER RESEARCH

Autophagy and cancer

(2012) Kyeong Sook Choi   EXPERIMENTAL AND MOLECULAR MEDICINE

Piperlongumine inhibits proliferation and survival of Burkitt lymphoma in vitro

(2012) Seong-Su Han et al.   LEUKEMIA RESEARCH

Grape Proanthocyanidin Inhibit Pancreatic Cancer Cell Growth In Vitro and In Vivo through Induction of Apoptosis and by Targeting the PI3K/Akt Pathway

(2012) Ram Prasad et al.   PLoS One

Piperlongumine induces rapid depletion of the androgen receptor in human prostate cancer cells

(2012) Konstantin V. Golovine et al.   PROSTATE

Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells

(2011) M. Danielle Bareford et al.   Autophagy

Quercetin induces protective autophagy in gastric cancer cells: Involvement of Akt-mTOR- and hypoxia-induced factor 1α-mediated signaling

(2011) Kui Wang et al.   Autophagy

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A Decade of Advances in Treatment for Advanced Non–Small Cell Lung Cancer

(2011) Scott Gettinger et al.   CLINICS IN CHEST MEDICINE

Pancreatic cancers require autophagy for tumor growth

(2011) S. Yang et al.   GENES & DEVELOPMENT

Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis

(2011) J. Y. Guo et al.   GENES & DEVELOPMENT

Cannabidiol Induces Programmed Cell Death in Breast Cancer Cells by Coordinating the Cross-talk between Apoptosis and Autophagy

(2011) A. Shrivastava et al.   MOLECULAR CANCER THERAPEUTICS

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Selective oxycution?

(2011) Darren J. Burgess   NATURE REVIEWS DRUG DISCOVERY

Targeting the pro-death and pro-survival functions of autophagy as novel therapeutic strategies in cancer

(2010) Kevin Dalby et al.   Autophagy

The in vitro cleavage of the hAtg proteins by cell death proteases

(2010) Joanna M. Norman et al.   Autophagy

Targeting cancer cells through autophagy for anticancer therapy

(2010) Sandra Turcotte et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy and Metabolism

(2010) J. D. Rabinowitz et al.   SCIENCE

Life and death partners: apoptosis, autophagy and the cross-talk between them

(2009) A Eisenberg-Lerner et al.   CELL DEATH AND DIFFERENTIATION

OSU-03012, a Novel Celecoxib Derivative, Induces Reactive Oxygen Species-Related Autophagy in Hepatocellular Carcinoma

(2008) M. Gao et al.   CANCER RESEARCH

Autophagy and cell death in model organisms

(2008) N Kourtis et al.   CELL DEATH AND DIFFERENTIATION

Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises

(2008) Timothy A Yap et al.   CURRENT OPINION IN PHARMACOLOGY

The efficiency of single agent docetaxel in patients with platinum-refractory non-small cell lung carcinoma

(2008) Kazım Uygun et al.   MEDICAL ONCOLOGY

In vivogrowth inhibition of sarcoma 180 by piperlonguminine, an alkaloid amide from thePiperspecies

(2007) Daniel P. Bezerra et al.   JOURNAL OF APPLIED TOXICOLOGY