mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis

PTEN Inhibition to Facilitate Intrinsic Regenerative Outgrowth of Adult Peripheral Axons

(2013) K. J. Christie et al.   JOURNAL OF NEUROSCIENCE

Rapamycin reduces clinical signs and neuropathic pain in a chronic model of experimental autoimmune encephalomyelitis

(2012) L. Lisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

Dopaminergic pathway reconstruction by Akt/Rheb-induced axon regeneration

(2011) Sang Ryong Kim et al.   ANNALS OF NEUROLOGY

Erythropoietin and Wnt1 Govern Pathways of mTOR, Apaf-1, and XIAP in Inflammatory Microglia

(2011) Yan Chen Shang et al.   CURRENT NEUROVASCULAR RESEARCH

Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiation

(2011) William A. Tyler et al.   GLIA

Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiation

(2011) Hebe M. Guardiola-Diaz et al.   GLIA

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The mTOR kinase inhibitor rapamycin decreases iNOS mRNA stability in astrocytes

(2011) Lucia Lisi et al.   Journal of Neuroinflammation

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways

(2011) Cheng-Che Lee et al.   NEUROPHARMACOLOGY

Akt/mammalian target of rapamycin signaling pathway regulates neurite outgrowth in cerebellar granule neurons stimulated by methylcobalamin

(2011) Kiyoshi Okada et al.   NEUROSCIENCE LETTERS

PI3K/Akt/mTOR signaling regulates glutamate transporter 1 in astrocytes

(2010) Xiaofeng Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic Progressive Multiple Sclerosis – Pathogenesis of Neurodegeneration and Therapeutic Strategies

(2010) Dirk Fitzner et al.   Current Neuropharmacology

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide

(2010) Won Jun Oh et al.   EMBO JOURNAL

TOR on the brain

(2010) Michael G. Garelick et al.   EXPERIMENTAL GERONTOLOGY

New treatment strategies in multiple sclerosis

(2010) Joanne L. Jones et al.   EXPERIMENTAL NEUROLOGY

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

(2010) Muhammet F. Gulen et al.   IMMUNITY

Receptor signaling in immune cell development and function

(2010) Xiao-Ping Zhong et al.   IMMUNOLOGIC RESEARCH

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Target of Rapamycin (mTOR) Activation Increases Axonal Growth Capacity of Injured Peripheral Nerves

(2010) Namiko Abe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rapamycin inhibits relapsing experimental autoimmune encephalomyelitis by both effector and regulatory T cells modulation

(2010) Marianna Esposito et al.   JOURNAL OF NEUROIMMUNOLOGY

Rapamycin Activates Autophagy and Improves Myelination in Explant Cultures from Neuropathic Mice

(2010) S. Rangaraju et al.   JOURNAL OF NEUROSCIENCE

Elevated Phosphatidylinositol 3,4,5-Trisphosphate in Glia Triggers Cell-Autonomous Membrane Wrapping and Myelination

(2010) S. Goebbels et al.   JOURNAL OF NEUROSCIENCE

Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

(2010) Calvin K. Yip et al.   MOLECULAR CELL

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Rapamycin inhibits mTORC1, but not completely

(2009) Carson C. Thoreen et al.   Autophagy

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

(2009) Timothy R. Peterson et al.   CELL

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

(2009) E.A. Dunlop et al.   CELLULAR SIGNALLING

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Treatment with rapamycin ameliorates clinical and histological signs of protracted relapsing experimental allergic encephalomyelitis in Dark Agouti rats and induces expansion of peripheral CD4+CD25+Foxp3+ regulatory T cells

(2009) Marco Donia et al.   JOURNAL OF AUTOIMMUNITY

mTOR/S6 Kinase Pathway Contributes to Astrocyte Survival during Ischemia

(2009) María Dolores Pastor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-derived Neurotrophic Factor Enhances the Basal Rate of Protein Synthesis by Increasing Active Eukaryotic Elongation Factor 2 Levels and Promoting Translation Elongation in Cortical Neurons

(2009) Nobuyuki Takei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways

(2009) Olivia Bibollet-Bahena et al.   JOURNAL OF NEUROCHEMISTRY

The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

(2009) S. Codeluppi et al.   JOURNAL OF NEUROSCIENCE

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

(2009) W. A. Tyler et al.   JOURNAL OF NEUROSCIENCE

Akt Signals through the Mammalian Target of Rapamycin Pathway to Regulate CNS Myelination

(2009) S. P. Narayanan et al.   JOURNAL OF NEUROSCIENCE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pituitary adenylyl cyclase-activating polypeptide is an intrinsic regulator of Treg abundance and protects against experimental autoimmune encephalomyelitis

(2009) Yossan-Var Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The multiple facets of mTOR in immunity

(2009) Thomas Weichhart et al.   TRENDS IN IMMUNOLOGY

mTOR signaling: At the crossroads of plasticity, memory and disease

(2009) Charles A. Hoeffer et al.   TRENDS IN NEUROSCIENCES

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

Role of TSC–mTOR pathway in diabetic nephropathy

(2008) Ken Inoki   DIABETES RESEARCH AND CLINICAL PRACTICE

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Constitutively Active Akt Induces Enhanced Myelination in the CNS

(2008) A. I. Flores et al.   JOURNAL OF NEUROSCIENCE

Response of a Neuronal Model of Tuberous Sclerosis to Mammalian Target of Rapamycin (mTOR) Inhibitors: Effects on mTORC1 and Akt Signaling Lead to Improved Survival and Function

(2008) L. Meikle et al.   JOURNAL OF NEUROSCIENCE

Cellular localization of metabotropic glutamate receptors in cortical tubers and subependymal giant cell tumors of tuberous sclerosis complex

(2008) K. Boer et al.   NEUROSCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

Pain associated with multiple sclerosis: Systematic review and proposed classification

(2007) Alec B. O’Connor et al.   PAIN