LRRK2 is involved in the pathogenesis of system lupus erythematosus through promoting pathogenic antibody production

Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S-Parkinson’s disease

(2018) Diana Luz Juárez-Flores et al.   Journal of Translational Medicine

Plasmacytoid pre-dendritic cells (pDC): from molecular pathways to function and disease association

(2018) Solana Alculumbre et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Type I Interferons, Autophagy and Host Metabolism in Leprosy

(2018) Thiago Gomes Toledo Pinto et al.   Frontiers in Immunology

Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus

(2018) Susan Malkiel et al.   Frontiers in Immunology

LRRK2 promotes the activation of NLRC4 inflammasome duringSalmonellaTyphimurium infection

(2017) Weiwei Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD19hi B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseases

(2017) Zhicui Liu et al.   Scientific Reports

Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

(2016) Makoto Kubo et al.   JOURNAL OF NEUROIMMUNOLOGY

Fn14-Fc suppresses germinal center formation and pathogenic B cells in a lupus mouse model via inhibition of the TWEAK/Fn14 Pathway

(2016) Hong-Ki Min et al.   Journal of Translational Medicine

LRRK2 dephosphorylation increases its ubiquitination

(2015) Jing Zhao et al.   BIOCHEMICAL JOURNAL

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

(2015) João P. L. Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease

(2015) Kyoko Koshibu et al.   PHARMACOLOGY

Rituximab in Systemic Lupus Erythematosus and Lupus Nephritis

(2015) Hannah Beckwith et al.   NEPHRON CLINICAL PRACTICE

Association of the LRRK2 genetic polymorphisms with leprosy in Han Chinese from Southwest China

(2014) D Wang et al.   GENES AND IMMUNITY

Genetic susceptibility to SLE: Recent progress from GWAS

(2013) Yong Cui et al.   JOURNAL OF AUTOIMMUNITY

Prevalence of cancer in Parkinson's disease related to R1441G and G2019S mutations inLRRK2

(2013) Javier Ruiz-Martínez et al.   MOVEMENT DISORDERS

The Neurobiology of LRRK2 and its Role in the Pathogenesis of Parkinson’s Disease

(2013) Hardy J. Rideout et al.   NEUROCHEMICAL RESEARCH

GSK2578215A; A potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

(2012) Alastair D. Reith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of LRRK2 in inflammatory bowel disease

(2012) Zhihua Liu et al.   CELL RESEARCH

Germinal center selection and the development of memory B and plasma cells

(2012) Mark J. Shlomchik et al.   IMMUNOLOGICAL REVIEWS

Chemoproteomics-Based Design of Potent LRRK2-Selective Lead Compounds That Attenuate Parkinson’s Disease-Related Toxicity in Human Neurons

(2011) Nigel Ramsden et al.   ACS Chemical Biology

Disturbed Th1, Th2, Th17 and Treg balance in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   CLINICAL IMMUNOLOGY

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Systemic Lupus Erythematosus

(2011) George C. Tsokos   NEW ENGLAND JOURNAL OF MEDICINE

Mechanisms of B cell autoimmunity in SLE

(2011) Thomas Dörner et al.   ARTHRITIS RESEARCH & THERAPY

Age-dependent and cell-population-restricted LRRK2 expression in normal mouse spleen

(2010) Tatsunori Maekawa et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Rituximab is effective in the treatment of nephritis in lupus patients, refractory to conventional immunosuppressive therapy

(2010) R Martínez et al.   Journal of Translational Medicine

Emerging roles of TLR7 and TLR9 in murine SLE

(2009) Marie-Laure Santiago-Raber et al.   JOURNAL OF AUTOIMMUNITY

The complement system in systemic autoimmune disease

(2009) Min Chen et al.   JOURNAL OF AUTOIMMUNITY

Induction of autoimmunity by pristane and other naturally occurring hydrocarbons

(2009) Westley H. Reeves et al.   TRENDS IN IMMUNOLOGY

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE

(2008) Matilda W. Nicholas et al.   CLINICAL IMMUNOLOGY