Article
Pharmacology & Pharmacy
Sha Huang, Luping Lin, Yifei Ma, Qing Zhu, Ningna Weng
Summary: This study demonstrates that scoparone inhibits the growth of colorectal cancer cells both in vitro and in vivo, and induces autophagy in these cells. The underlying molecular mechanism involves the reduction of PAK1 expression and subsequent repression of the AKT/mTOR signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Oncology
Man-Yuan Li, Jiao Zhang, Xiao Lu, Dong Zhou, Xu-Feng Deng, Quan-Xing Liu, Ji-Gang Dai, Hong Zheng
Summary: Ivermectin treatment showed significant inhibitory effects on colony formation, cell viability, proliferation, apoptosis, and autophagy flux in LUAD cells. This inhibitory effect was achieved by downregulating PAK1 protein expression, leading to nonprotective autophagy and poor overall survival in LUAD patients with high PAK1 expression. In vivo experiments confirmed that ivermectin efficiently suppressed the growth of LUAD cells.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ganesh Pai Bellare, Birija Sankar Patro
Summary: This study proposes the usage of resveratrol as a chemosensitizer in combination with talazoparib for targeting HR proficient breast cancers. Resveratrol effectively enhances talazoparib-induced cell death in breast cancer cells and shows minimal cytotoxicity in normal cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Oncology
Alakananda Basu, Christoffer Briggs Lambring
Summary: This article discusses the importance of breast cancer in women in the United States and the role of Akt isoforms in the development of breast cancer. While Akt isoforms share similar structures, they exhibit redundant, distinct, and opposite functions in breast cancer. Understanding the isoform-specific function of Akt is critical for effectively targeting the Akt signaling pathway in cancer therapy.
Article
Biochemistry & Molecular Biology
Yuan Zhang, Tun Sun, Meng Li, Yanling Lin, Yue Liu, Shusheng Tang, Chongshan Dai
Summary: Ivermectin can induce apoptotic cell death in human neuroblastoma cells, promoting ROS production, mitochondrial dysfunction, and autophagy, while inhibiting the Akt/mTOR pathway. Autophagy inhibition improved Ivermectin-induced oxidative stress and apoptotic cell death in these cells.
Article
Pharmacology & Pharmacy
Weikang Kong, Lingxia Zhu, Tian Li, Jiao Chen, Bo Fan, Wenjing Ji, Chunli Zhang, Xueting Cai, Chunping Hu, Xiaoyan Sun, Peng Cao
Summary: The drug azeliragon was found to inhibit the activity of PAK1, promote apoptosis in pancreatic cancer cells, and significantly inhibit tumor growth. Combination with afuresertib further enhanced the antitumor efficacy of azeliragon, suggesting a novel treatment strategy for pancreatic cancer.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giulia Miglietta, Marco Russo, Renee C. Duardo, Giovanni Capranico
Summary: The study found that two unrelated G4 ligands can significantly activate innate immune genes at non-cytotoxic concentrations, triggering the activation of cytoplasmic STING signaling pathway and leading to an increase in micronuclei. Ligand activity can also induce type I interferon production and activation of innate immune genes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Mashan L. Abdullah, Othman Al-Shabanah, Zeinab K. Hassan, Mohamed M. Hafez
Summary: The use of eugenol, a phenolic phytochemical extracted from certain essential oils, shows promising anti-cancer effects against triple-negative and HER2-positive breast cancer cells by targeting the caspase pathway and inducing autophagic cell death. Jurat et al. demonstrated that eugenol inhibits cell proliferation, increases protein levels associated with apoptosis, and induces autophagy in cancer cells, suggesting its potential as a natural anti-cancer agent.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Liu Yang, Qijun Wang, Qian Zhao, Fan Yang, Tingjiao Liu, Xiaohua Huang, Qiu Yan, Xuesong Yang
Summary: This study demonstrates that deglycosylated EpCAM promotes autophagy, inhibits proliferation, and induces apoptosis in breast cancer cells by activating the Akt/mTOR signaling pathway. These findings reveal a novel mechanism of deglycosylated EpCAM in breast cancer and suggest that a combination of autophagy modulation and EpCAM targeted therapy could be a promising therapeutic strategy.
Article
Plant Sciences
Nana Xu, Yunyun Zhao, Huimin Bu, Shirui Tan, Guokai Dong, Jinjuan Liu, Meng Wang, Jihong Jiang, Bo Yuan, Rongpeng Li
Summary: This study demonstrated the inhibitory effect of CoB1 on lung cancer cells by inducing cytostatic autophagy both in vitro and in vivo. CoB1 exerted its effects by blocking the PI3K/Akt1/mTOR signaling pathway, activating the TAK1/MKK4/JNK/Smad axis, inducing miR-125b expression, reducing Foxp3 expression, and ultimately inducing autophagy.
Review
Biochemistry & Molecular Biology
Hye Min Kim, Ja Seung Koo
Summary: Patient morbidity and mortality are significantly increased in metastatic breast cancer. The metastasis process of breast cancer is very complicated and controlled by various factors. Autophagy is an important regulatory factor affecting metastasis in breast cancer, involving cell mobility, metabolic adaptation, tumor dormancy, and cancer stem cells. In this article, we discuss the effects of autophagy on breast cancer metastasis and evaluate the potential use of autophagy modulators for metastasis treatment.
Article
Oncology
Omar Elakad, Bjoern Haeupl, Vera Labitzky, Sha Yao, Stefan Kueffer, Alexander von Hammerstein-Equord, Bernhard C. Danner, Manfred Juecker, Henning Urlaub, Tobias Lange, Philipp Stroebel, Thomas Oellerich, Hanibal Bohnenberger
Summary: This study identified a CD44/PAK1/AKT signaling axis as a common resistance mechanism to FGFR1 inhibition in lung cancer. The activation levels of CD44/PAK1/AKT could help predict response to FGFR1 inhibition, and the combination of AKT and FGFR1 inhibitors may be effective in treating patients with FGFR1-dependent lung cancer.
NPJ PRECISION ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Anette M. Skjervold, Marit Valla, Borgny Ytterhus, Anna Bofin
Summary: This study aimed to assess the association between PAK1 gene copy number and proliferation status, molecular subtype, and prognosis in breast cancer. The results showed that PAK1 copy number increase is associated with high proliferation and high histological grade, but not with prognosis. PAK1 copy number increase is most frequent in the HER2 type and Luminal B (HER2(-)) subtype and is associated with CCND1 copy number increase.
Article
Oncology
Chunmei Wen, Qingqing Ruan, Zhaofeng Li, Xiang Zhou, Xuezhi Yang, Pingwei Xu, Percy David Papa Akuetteh, Zheng Xu, Jie Deng
Summary: This study found that Cory inhibited the proliferation of pancreatic cancer cells, induced apoptosis, and promoted cell death by generating intracellular reactive oxygen species (ROS) and activating the p38 signaling pathway. Cory also exerted an anti-tumor effect by inducing endoplasmic reticulum stress.
BRITISH JOURNAL OF CANCER
(2022)
Article
Gastroenterology & Hepatology
Hai-Ning Chen, Yang Shu, Fei Liao, Xue Liao, Hongying Zhang, Yun Qin, Zhu Wang, Maochao Luo, Qiuluo Liu, Zhinan Xue, Minyuan Cao, Shouyue Zhang, Wei-Han Zhang, Qianqian Hou, Xuyang Xia, Han Luo, Yan Zhang, Lie Yang, Jian-Kun Hu, Xianghui Fu, Bo Liu, Hongbo Hu, Canhua Huang, Yong Peng, Wei Cheng, Lunzhi Dai, Li Yang, Wei Zhang, Biao Dong, Yuan Li, Yuquan Wei, Heng Xu, Zong-Guang Zhou
Summary: The study provides insights into the genomic evolution and metastatic patterns of colorectal cancer, suggesting that biopsy/sequencing of metastases should be considered for patients with multiorgan or late postoperative metastasis.
Article
Medicine, Research & Experimental
Zhe Zhang, Siyuan Qin, Yan Chen, Li Zhou, Mei Yang, Yongquan Tang, Jing Zuo, Jian Zhang, Atsushi Mizokami, Edouard C. Nice, Hai-Ning Chen, Canhua Huang, Xiawei Wei
Summary: The study identified a drug-tolerant persister (DTP) state in multidrug-resistant (MDR) cancer cells as a tolerance response to combination treatment, partially preventing chemotherapy-induced oxidative stress by promoting vitamin E uptake. The NRF2 transcriptionally regulated NPC1L1 by binding to its promoter, and decreased DNA methylation was also related to this process. Triple-combination therapy with chemotherapeutic agents, verapamil, and ezetimibe demonstrated significant anti-tumor effects and prevented tumor recurrence in mice.
EMBO MOLECULAR MEDICINE
(2022)
Article
Oncology
Xin Liao, Xuyang Xia, Wei Su, Huayun Yan, Yingfang Ma, Lian Xu, Han Luo, Wanting Liu, Dandan Yin, Wei-Han Zhang, Hai-Ning Chen, Yiqi Deng, Zhixiang Ren, Zehui Yu, Fei Liao, Keling Chen, Minyuan Cao, Yiguan Zhang, Wei Zhang, Wei Wang, Jun-Ning Zhao, Heng Xu, Yang Shu
Summary: The study investigated the genomic alterations and prognostic value of gastric-type cervical adenocarcinoma (GCA) in Chinese patients. Mutations were commonly observed in GCA-related driver genes, and the alteration of APOBEC3B was found to be associated with favorable prognosis.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Huafeng Wang, Qianhui Dou, Kyung Jo Jeong, Jungmin Choi, Vadim N. Gladyshev, Jean-Ju Chung
Summary: This study reveals the important role of TXNRD3, a member of the thioredoxin reductase family, in sperm development and maturation. The deficiency of TXNRD3 impairs sperm morphology and motility, as well as mitochondrial ultrastructure and activity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Qianhui Dou, Anton A. Turanov, Marco Mariotti, Jae Yeon Hwang, Huafeng Wang, Sang -Goo Lee, Joao A. Paulo, Sun Hee Yim, Stephen P. Gygi, Jean-Ju Chung, Vadim N. Gladyshev
Summary: TXNRD3 plays a critical role in male reproduction by controlling spermatogenesis through thiol redox regulation.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Meiwen Guo, Shuang Chen, Jitong Lao, Jiantang Liang, Hao Chen, Jingyi Tong, Yonghao Huang, Dandan Jia, Qifu Li
Summary: This study investigated the effects of 3BDO on autophagy regulation and its impact on seizures and cognitive function in a PTZ-kindled epileptic mice model. The results showed that 3BDO can regulate autophagy by activating the mTOR signaling pathway, thereby reducing hippocampal neuronal loss and astrocyte proliferation, decreasing seizures, and significantly improving cognitive function.
NEUROCHEMICAL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Han Luo, Xuyang Xia, Li-Bin Huang, Hyunsu An, Minyuan Cao, Gyeong Dae Kim, Hai-Ning Chen, Wei-Han Zhang, Yang Shu, Xiangyu Kong, Zhixiang Ren, Pei-Heng Li, Yang Liu, Huairong Tang, Ronghao Sun, Chao Li, Bing Bai, Weiguo Jia, Yi Liu, Wei Zhang, Li Yang, Yong Peng, Lunzhi Dai, Hongbo Hu, Yong Jiang, Yiguo Hu, Jingqiang Zhu, Hong Jiang, Zhihui Li, Carlos Caulin, Jihwan Park, Heng Xu
Summary: This study conducts pan-cancer analysis on 226 samples across 10 solid cancer types, illustrating the commonalities and plasticity of heterogeneous CAFs. It reveals that the activation trajectory of major CAF types is divided into three states, showing distinct interactions with other cell components and correlation with immunotherapy prognosis. Additionally, minor CAF components may originate from other TME components such as endothelial cells and macrophages.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Jingyu Zhou, Xiao Guo, Xiaoli Liu, Yuling Luo, Xin Chang, Hui He, Mingjun Duan, Shicai Li, Qifu Li, Ying Tan, Gang Yao, Dezhong Yao, Cheng Luo
Summary: Components of metabolic syndrome may predict the therapeutic outcome of psychiatric symptoms in schizophrenia, but clinical results are inconsistent and the intrinsic therapeutic link between weaker psychiatric symptoms and emergent metabolic syndrome remains unclear.
Review
Oncology
Qiu-Luo Liu, Huijie Zhou, Zong-Guang Zhou, Hai-Ning Chen
Summary: Colorectal cancer (CRC) patients often suffer from liver metastases, resulting in high mortality rates. The molecular basis and management of colorectal liver metastases (CRLMs) pose significant challenges in the clinic. Recent genomic evidence has revealed liver tropism in CRC and a stricter evolutionary bottleneck in the liver compared to lymph nodes. This organ-specific bottleneck challenges CRC cells and necessitates adaptation at both the genetic and phenotypic levels to interact with the hepatic microenvironment. Here, we review emerging evidence on the clonal evolution of CRLM and discuss recent insights into the molecular mechanisms behind the bidirectional interactions between metastatic CRC cells and the unique liver microenvironment.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Yan Wang, Zhongyv Xiong, Chang Li, Dong Liu, Xiaogang Li, Junyv Xu, Niangen Chen, Xuesong Wang, Qifu Li, Youbin Li
Summary: Aloesone from Aloe vera has been shown to have antioxidant, anti-inflammatory, and anti-apoptotic effects on macrophages by inhibiting ROS production, reducing NO release, and modulating the expression of inflammation-related genes. It also affects the activation of core genes and inhibits the protein expression of TLR4.
Review
Oncology
Zihao Wang, Xingyun Wu, Hai-Ning Chen, Kui Wang
Summary: Metastasis is the major cause of cancer death as cancer cells can colonize in distant organs. Metastases reprogram their metabolic states to adapt to new environments, displaying different metabolic properties compared with primary lesions. Amino acid metabolic reprogramming plays a crucial role in cancer metastasis, providing energy supply and maintaining homeostasis. This review summarizes the role of amino acid metabolism in cancer cell colonization in common metastatic organs and discusses the potential of targeting organ-specific metastasis for cancer treatment.
FRONTIERS IN ONCOLOGY
(2023)
Review
Dermatology
Xin-Yu Ben, Meng-Si Tian, Hui-Hui Zheng, Ya-Ru Wang, Tian-Wei Cui, Rui Ren, Xi-Nan Yi, Qi-Fu Li
Summary: The skin, as the largest organ, is vulnerable to various injuries. However, the use of MSCs-EVs can promote wound healing and reduce scar formation.
DERMATOLOGIC THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Yan Wang, Youbin Li, Dong Liu, Danyang Zheng, Xiaogang Li, Chang Li, Caihui Huang, Yun Wang, Xuesong Wang, Qifu Li, Junyu Xu
Summary: The anti-glioblastoma effect of a novel pyrimidin-2-amine, LH20, was evaluated in this study. LH20 significantly inhibited the proliferation and migration of primary GBM cell lines U87MG and U251, induced apoptosis and cell cycle arrest. The mechanism of action involved the inhibition of CDK4 and CDK6 activities by decreasing the phosphorylation of Rb.
Article
Biochemistry & Molecular Biology
Jingwen Jiang, Hai-Ning Chen, Ping Jin, Li Zhou, Liyuan Peng, Zhao Huang, Siyuan Qin, Bowen Li, Hui Ming, Maochao Luo, Na Xie, Wei Gao, Edouard C. Nice, Qiang Yu, Canhua Huang
Summary: The codon 72-Pro variant of p53 interacts with PSAT1, leading to nuclear translocation of PGC-1 alpha and activation of oxidative phosphorylation and TCA cycle, which impacts tumor metastasis. Targeting the PSAT1-p53(72P) interaction with AOA provides a precision strategy to treat tumors carrying p53(72P) variant.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Letter
Surgery
Qiu-Luo Liu, Hai-Ning Chen
BRITISH JOURNAL OF SURGERY
(2022)
