Article
Neurosciences
Daniela Buonvicino, Giuseppe Ranieri, Daniele Guasti, Alessandra Pistolesi, Antonino Iurato La Rocca, Elena Rapizzi, Alberto Chiarugi
Summary: This study found that axonal-restricted derangement of mitochondrial homeostasis occurs during the asymptomatic state in a mouse model of progressive multiple sclerosis (PMS). These findings further our understanding of the neurobiology of PMS and provide insights into potential therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Materials Science, Multidisciplinary
Kangqiang Qiu, Aditya Yadav, Zhiqi Tian, Ziyuan Guo, Donglu Shi, Chayan K. Nandi, Jiajie Diao
Summary: In this study, biocompatible protein-modified noble-metal nanoclusters were used to image lysosomes under structured illumination microscopy. The nanoclusters exhibited excellent performance in pH fluctuation resistance and antiphotobleaching, allowing for the observation of lysosomal events and the interplay between lysosomes and mitochondria. This research opens up new possibilities for long-term bioimaging with nanoclusters.
ACS MATERIALS LETTERS
(2022)
Article
Immunology
Xian Jiang, Yifan Song, Jie Fang, Xiaosheng Yang, Shuhua Mu, Jian Zhang
Summary: The study found that Vesatolimod, a toll-like receptor 7 agonist, has significant therapeutic effects on Experimental autoimmune encephalomyelitis (EAE) mice. It reduces clinical symptoms, inflammatory cytokine levels, demyelination, and immune cell infiltration in the spinal cords. These findings suggest that Vesatolimod could be a promising treatment for multiple sclerosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Maryam Akhavan Tavakoli, Maryam Soleimani, Hassan Marzban, Ronak Shabani, Fatemeh Moradi, Marziyeh Ajdary, Mehdi Mehdizadeh
Summary: The interaction between autophagy and apoptosis plays a crucial role in cell death, particularly in neurodegenerative diseases. This study investigated the effects of fluoxetine (FLX) and cannabidiol (CBD) on demyelination rate in a mouse model of experimental autoimmune encephalomyelitis (EAE). The results showed that FLX and CBD increased autophagic markers and reduced pro-apoptotic markers, leading to a significant decrease in demyelination. Combined treatment with these agents may be a potential strategy for further investigations.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Chemistry, Analytical
Jianhua Guo, Li Fan, Qi Zan, Jianhua Wang, Zhenhua Yang, Wenjing Lu, Yongming Yang, Xihua Yang, Chuan Dong, Shaomin Shuang
Summary: In this study, self-targetable orange-red emissive carbon dots (OR-CDs) were designed and developed for monitoring lysosomal viscosity fluctuations. The fluorescence of OR-CDs increased significantly as viscosity increased. OR-CDs could quickly enter cells for lysosome-targeting imaging and visualize viscosity variations in living cells and zebrafish. Moreover, OR-CDs successfully traced variations in lysosomal viscosity during the autophagy process and were effectively utilized for cancer imaging.
ANALYTICAL CHEMISTRY
(2023)
Article
Geriatrics & Gerontology
Haiming Liu, Pu Zang, Ian (In-gi) Lee, Barbara Anderson, Anthony Christiani, Lena Strait-Bodey, Beatrice A. Breckheimer, Mackenzie Storie, Alison Tewnion, Kora Krumm, Theresa Li, Brynn Irwin, Jose M. Garcia
Summary: The study found that the growth hormone secretagogue receptor-1a mediates the effects of ghrelin in attenuating weakness induced by LLC by modulating the autophagy-lysosome pathway, mitophagy, and mitochondrial respiration, but not reducing muscle mass loss.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Review
Cell Biology
Petra Teresak, Ana Lapao, Nemanja Subic, Patricia Boya, Zvulun Elazar, Anne Simonsen
Summary: Mitochondria are essential for cellular homeostasis, with mitophagy being a prominent mechanism to maintain a healthy mitochondrial pool. While the PINK1-PRKN pathway is well-studied for mitophagy, there are also alternative pathways involving different proteins and lipids. The significance of PRKN-independent mitophagy pathways in various physiological and pathophysiological processes highlights the need for further research into their regulation and interactions.
Article
Biochemistry & Molecular Biology
Lea P. Wilhelm, Juan Zapata-Munoz, Beatriz Villarejo-Zori, Stephanie Pellegrin, Catarina Martins Freire, Ashley M. Toye, Patricia Boya, Ian G. Ganley
Summary: This study reveals that both mitophagy and pexophagy are activated upon iron chelation in a BNIP3L/NIX-dependent manner. The NIX protein, known as a mitophagy receptor, is also found to localize to peroxisomes and drive pexophagy independently.
Article
Chemistry, Analytical
Xinru Wang, Qi Chen, Kun Dong, Chuan Sun, Yinliang Huang, Zeming Qiang, Baoqian Chen, Man Chen, Yan Feng, Xiangming Meng
Summary: Mitophagy is crucial in maintaining cellular functions, and in this research, a multifunctional two-photon fluorescent probe Mito-PV was developed for tracking changes in polarity, viscosity, and morphology of mitochondria. The probe successfully enabled real-time and accurate monitoring of mitophagy, showing potential as a tool for evaluating mitophagy-related processes and drug effects.
ANALYTICAL CHEMISTRY
(2021)
Editorial Material
Cell Biology
Shree Padma Metur, Daniel J. Klionsky
Summary: Maintaining mitochondrial quality control is crucial for neuronal homeostasis, and dysregulation of this process has been implicated in neurodegenerative diseases. This study demonstrates that neurons sustain axonal mitophagy by locally translating Pink1 mRNA that is co-transported with mitochondria to the distal axons, providing a continuous supply of PINK1 protein.
Editorial Material
Cell Biology
Xu Xu, Ying Zhang, Hanhua Cheng, Rongjia Zhou
Summary: SPATA33 acts as a novel receptor for mitophagy in male germline cells, mediating the interaction of VDAC2 and ATG16L1 during the autophagic process. It plays a crucial role in priming mitochondria for degradation and promoting mitophagy, providing cargo selectivity in the process. This study sheds new light on selective autophagy and mitochondrial homeostasis.
Article
Medicine, General & Internal
Catriona Ling, Christian J. Versloot, Matilda E. Arvidsson Kvissberg, Guanlan Hu, Nathan Swain, Jose M. Horcas-Nieto, Emily Miraglia, Mehakpreet K. Thind, Amber Farooqui, Albert Gerding, Karen van Eunen, Mirjam H. Koster, Niels J. Kloosterhuis, Lijun Chi, YueYing ChenMi, Miriam Langelaar-Makkinje, Celine Bourdon, Jonathan Swann, Marieke Smit, Alain de Bruin, Sameh A. Youssef, Marjon Feenstra, Theo H. van Dijk, Kathrin Thedieck, Johan W. Jonker, Peter K. Kim, Barbara M. Bakker, Robert H. J. Bandsma
Summary: Severe malnutrition leads to structural and functional changes in the intestine, increasing the risk of infection and mortality. This study reveals the mechanisms underlying malnutrition enteropathy, including dysregulation of autophagy and mitochondrial homeostasis, as well as abnormalities in reactive oxygen species. The findings suggest that nicotinamide supplementation and modulation of SIRT1 and mTORC1 pathways may ameliorate malnutrition enteropathy in children with severe malnutrition.
Article
Cell Biology
Kayo Machihara, Sou Kageyama, Shoma Oki, Hiroki Makino, Masamichi Sasaki, Hiroyasu Iwahashi, Takushi Namba
Summary: Cell aging leads to reduced cellular functions and disruption of cellular homeostasis, with mitochondrial dysfunction playing a crucial role. The study demonstrates that lotus germ extract can rejuvenate aging fibroblasts by restoring mitochondrial function and clearing abnormal proteins.
Article
Cardiac & Cardiovascular Systems
Mingming Tong, Toshiro Saito, Peiyong Zhai, Shin-Ichi Oka, Wataru Mizushima, Michinari Nakamura, Shohei Ikeda, Akihiro Shirakabe, Junichi Sadoshima
Summary: The study found that during the chronic phase of obesity-associated cardiomyopathy, mitophagy is activated even after conventional autophagy is downregulated, serving as an essential mitochondrial quality control mechanism to protect the heart.
CIRCULATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Francesco Agostini, Marco Bisaglia, Nicoletta Plotegher
Summary: Reactive oxygen species (ROS) generated from incomplete oxygen reduction can interact with and influence the function of various targets, including DNA, lipids, and proteins. AMP-activated protein kinase (AMPK), known as a major sensor of intracellular energy status, has been shown to play a crucial role in regulating cellular processes such as autophagy and lysosomal function. Through its modulation, AMPK can participate in the crosstalk between mitochondria and lysosomes by perceiving signals related to mitochondrial dynamics and transducing them to lysosomes, thereby impacting autophagic flux. Future studies should focus on the specific contribution of different AMPK subpopulations to the autophagic pathway, considering the tissue-specific regulation and localization of AMPK.
Article
Pathology
Quan-Cheng Kan, Qing-xia Pan, Xiao-Jian Zhang, Yao-juan Chu, Nan Liu, Peng Lv, Guang-Xian Zhang, Lin Zhu
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2015)
Article
Pathology
Lin Zhu, Qing-xia Pan, Xiao-Jian Zhang, Yu -Ming Xu, Yao-juan Chu, Nan Liu, Peng Lv, Guang-Xian Zhang, Quan-Cheng Kan
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2016)
Article
Immunology
Xiaoyu Zhao, Xiaojian Zhang, Ying Lv, Yuming Xu, Menglong Li, Qingxia Pan, Yaojuan Chu, Nan Liu, Guang-Xian Zhang, Lin Zhu
IMMUNOLOGY LETTERS
(2016)
Article
Neurosciences
Quan-Cheng Kan, Hui-Jun Zhang, Yuan Zhang, Xing Li, Yu-Ming Xu, Rodolfo Thome, Ming-Liang Zhang, Nan Liu, Yao-Juan Chu, Guang-Xian Zhang, Lin Zhu
MOLECULAR NEUROBIOLOGY
(2017)
Article
Immunology
Yao-Juan Chu, Wen-Di Ma, Rodolfo Thome, Jie-Dan Ping, Fang-Zhou Liu, Meng-Ru Wang, Ming-Liang Zhang, Guangxian Zhang, Lin Zhu
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Yilei Jing, Rui Ma, Yaojuan Chu, Mengmeng Dou, Mengru Wang, Xinyu Li, Lin Zhu
Summary: In this study, it was found that treatment with matrine (MAT) inhibited the generation of neurotoxic A1 astrocytes and promoted the formation of neuroprotective A2 astrocytes in the CNS of EAE, primarily by inhibiting the production of cytokines that induce A1 cells. Additionally, MAT protected the BBB from damage caused by CNS inflammation and promoted astrocyte tight junction formation at the glia limitans, limiting immune cell invasion into the CNS parenchyma.
JOURNAL OF CHEMICAL NEUROANATOMY
(2021)