Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)

Pilot Study of Minocycline in Relapsing-Remitting Multiple Sclerosis

(2014) Yunyan Zhang et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Swift Entry of Myelin-Specific T Lymphocytes into the Central Nervous System in Spontaneous Autoimmune Encephalomyelitis

(2014) G. C. Furtado et al.   JOURNAL OF IMMUNOLOGY

Fast Progression of Recombinant Human Myelin/Oligodendrocyte Glycoprotein (MOG)-Induced Experimental Autoimmune Encephalomyelitis in Marmosets Is Associated with the Activation of MOG34-56-Specific Cytotoxic T Cells

(2014) Y. S. Kap et al.   JOURNAL OF IMMUNOLOGY

Pentoxifylline inhibits experimental allergic encephalomyelitis

(2010) S. Nataf et al.   ACTA NEUROLOGICA SCANDINAVICA

Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

(2010) Dimitrios Karussis et al.   ARCHIVES OF NEUROLOGY

Hematopoietic Stem Cell Transplantation for Multiple Sclerosis: Collaboration of the CIBMTR and EBMT to Facilitate International Clinical Studies

(2010) Marcelo C. Pasquini et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Multiple sclerosis: a practical overview for clinicians

(2010) K. Rejdak et al.   BRITISH MEDICAL BULLETIN

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Update on emerging therapies for multiple sclerosis

(2010) Eppie M Yiu et al.   Expert Review of Neurotherapeutics

Fingolimod (FTY720), sphingosine 1-phosphate receptor modulator, shows superior efficacy as compared with interferon-β in mouse experimental autoimmune encephalomyelitis

(2010) Kenji Chiba et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Current and future disease-modifying therapies in multiple sclerosis

(2010) S. Y. Lim et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

N-type Calcium Channel in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

(2010) Naoki Tokuhara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Late B Cell Depletion with a Human Anti-Human CD20 IgG1  Monoclonal Antibody Halts the Development of Experimental Autoimmune Encephalomyelitis in Marmosets

(2010) Y. S. Kap et al.   JOURNAL OF IMMUNOLOGY

Are current disease-modifying therapeutics in multiple sclerosis justified on the basis of studies in experimental autoimmune encephalomyelitis?

(2010) Nasr Farooqi et al.   JOURNAL OF NEUROCHEMISTRY

Epstein–Barr Virus Infection and Multiple Sclerosis: A Review

(2010) Alberto Ascherio et al.   Journal of Neuroimmune Pharmacology

The TLR7 agonist, imiquimod, increases IFN-β production and reduces the severity of experimental autoimmune encephalomyelitis

(2010) Kate O'Brien et al.   JOURNAL OF NEUROIMMUNOLOGY

Laquinimod interferes with migratory capacity of T cells and reduces IL-17 levels, inflammatory demyelination and acute axonal damage in mice with experimental autoimmune encephalomyelitis

(2010) Christiane Wegner et al.   JOURNAL OF NEUROIMMUNOLOGY

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study

(2010) Bassem Yamout et al.   JOURNAL OF NEUROIMMUNOLOGY

Human Mesenchymal Stem Cells Infiltrate the Spinal Cord, Reduce Demyelination, and Localize to White Matter Lesions in Experimental Autoimmune Encephalomyelitis

(2010) David Gordon et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases

(2010) David B Clifford et al.   LANCET NEUROLOGY

Oral laquinimod in patients with relapsing-remitting multiple sclerosis: 36-week double-blind active extension of the multi-centre, randomized, double-blind, parallel-group placebo-controlled study

(2010) G. Comi et al.   Multiple Sclerosis Journal

The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group

(2010) Mark S Freedman et al.   Multiple Sclerosis Journal

Autoimmune associations in multiple sclerosis

(2010) Cris S. Constantinescu et al.   Nature Reviews Neurology

Histamine and histamine receptors in pathogenesis and treatment of multiple sclerosis

(2010) Farhad Jadidi-Niaragh et al.   NEUROPHARMACOLOGY

A Placebo-Controlled Trial of Oral Cladribine for Relapsing Multiple Sclerosis

(2010) Gavin Giovannoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis

(2010) Ludwig Kappos et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis

(2010) Jeffrey A. Cohen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human neural stem cells ameliorate autoimmune encephalomyelitis in non-human primates

(2009) Stefano Pluchino et al.   ANNALS OF NEUROLOGY

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

T-cell clones persisting in the circulation after autologous hematopoietic SCT are undetectable in the peripheral CD34+ selected graft

(2009) A N Dubinsky et al.   BONE MARROW TRANSPLANTATION

Variable effects of cyclophosphamide in rodent models of experimental allergic encephalomyelitis

(2009) K. Mangano et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Curing CNS autoimmune disease with myelin-reactive Foxp3+Treg

(2009) Leigh A. Stephens et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

B cells from glatiramer acetate-treated mice suppress experimental autoimmune encephalomyelitis

(2009) Mrinalini Kala et al.   EXPERIMENTAL NEUROLOGY

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis

(2009) Lianhua Bai et al.   GLIA

Investigation of the mechanism of action of alemtuzumab in a human CD52 transgenic mouse model

(2009) Yanping Hu et al.   IMMUNOLOGY

Adult neural stem cells expressing IL-10 confer potent immunomodulation and remyelination in experimental autoimmune encephalitis

(2009) Jingxian Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

(2009) Moutih Rafei et al.   JOURNAL OF IMMUNOLOGY

Helminth Antigens Modulate Immune Responses in Cells from Multiple Sclerosis Patients through TLR2-Dependent Mechanisms

(2009) J. Correale et al.   JOURNAL OF IMMUNOLOGY

Neuroprotection and neurogeneration in MS and its animal model EAE effected by glatiramer acetate

(2009) Ruth Arnon et al.   JOURNAL OF NEURAL TRANSMISSION

Neuroprotective mesenchymal stem cells are endowed with a potent antioxidant effectin vivo

(2009) Cristina Lanza et al.   JOURNAL OF NEUROCHEMISTRY

Increasing CNS Noradrenaline Reduces EAE Severity

(2009) Maria Vittoria Simonini et al.   Journal of Neuroimmune Pharmacology

Experimental Autoimmune Encephalomyelitis in the Common Marmoset, a Bridge Between Rodent EAE and Multiple Sclerosis for Immunotherapy Development

(2009) Yolanda S. Kap et al.   Journal of Neuroimmune Pharmacology

Modulation of Cannabinoid Receptor Activation as a Neuroprotective Strategy for EAE and Stroke

(2009) Ming Zhang et al.   Journal of Neuroimmune Pharmacology

Small but powerful: Short peptide hormones and their role in autoimmune inflammation

(2009) F. Lühder et al.   JOURNAL OF NEUROIMMUNOLOGY

Luteolin as a therapeutic option for multiple sclerosis

(2009) Theoharis C Theoharides   Journal of Neuroinflammation

FTY720 ameliorates MOG-induced experimental autoimmune encephalomyelitis by suppressing both cellular and humoral immune responses

(2009) Dimitrios Papadopoulos et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Anakinra for Rheumatoid Arthritis: A Systematic Review

(2009) M. MERTENS et al.   JOURNAL OF RHEUMATOLOGY

Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study

(2009) Eva Havrdova et al.   LANCET NEUROLOGY

Autologous non-myeloablative haemopoietic stem cell transplantation in relapsing-remitting multiple sclerosis: a phase I/II study

(2009) Richard K Burt et al.   LANCET NEUROLOGY

Evaluating potential therapies for bladder dysfunction in a mouse model of multiple sclerosis with high-resolution ultrasonography

(2009) S Al-Izki et al.   Multiple Sclerosis Journal

Glatiramer acetate in combination with minocycline in patients with relapsing—remitting multiple sclerosis: results of a Canadian, multicenter, double-blind, placebo-controlled trial

(2009) LM Metz et al.   Multiple Sclerosis Journal

Mixed results with modulation of TH-17 cells in human autoimmune diseases

(2009) Lawrence Steinman   NATURE IMMUNOLOGY

Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis

(2009) Manjit Braitch et al.   NEUROIMMUNOMODULATION

Emerging multiple sclerosis oral therapies

(2009) K. W. Rammohan et al.   NEUROLOGY

Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system

(2009) J. Stegbauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple sclerosis – a response-to-damage model

(2009) Bert A. ‘t Hart et al.   TRENDS IN MOLECULAR MEDICINE

NKT Cell-Dependent Amelioration of a Mouse Model of Multiple Sclerosis by Altering Gut Flora

(2008) Hiroaki Yokote et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase 2 trial of a DNA vaccine encoding myelin basic protein for multiple sclerosis

(2008) Hideki Garren et al.   ANNALS OF NEUROLOGY

Neuroprotection and Immunomodulation With Mesenchymal Stem Cells in Chronic Experimental Autoimmune Encephalomyelitis

(2008) Ibrahim Kassis et al.   ARCHIVES OF NEUROLOGY

FTY720 Rescue Therapy in the Dark Agouti Rat Model of Experimental Autoimmune Encephalomyelitis: Expression of Central Nervous System Genes and Reversal of Blood-Brain-Barrier Damage

(2008) Carolyn A. Foster et al.   BRAIN PATHOLOGY

The Use of Clinically Approved Small Particles of Iron Oxide (SPIO) for Labeling of Mesenchymal Stem Cells Aggravates Clinical Symptoms in Experimental Autoimmune Encephalomyelitis and Influences Their In Vivo Distribution

(2008) Richard Schäfer et al.   CELL TRANSPLANTATION

The antidepressant venlafaxine ameliorates murine experimental autoimmune encephalomyelitis by suppression of pro-inflammatory cytokines

(2008) Patrick Vollmar et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

The CB2Cannabinoid Receptor Controls Myeloid Progenitor Trafficking

(2008) Javier Palazuelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stem cell based delivery of IFN-β reduces relapses in experimental autoimmune encephalomyelitis☆

(2008) T MAKAR et al.   JOURNAL OF NEUROIMMUNOLOGY

Downregulation of IL-17 and IL-6 in the central nervous system by glatiramer acetate in experimental autoimmune encephalomyelitis

(2008) S BEGUMHAQUE et al.   JOURNAL OF NEUROIMMUNOLOGY

Bladder dysfunction in mice with experimental autoimmune encephalomyelitis

(2008) Cengiz Z. Altuntas et al.   JOURNAL OF NEUROIMMUNOLOGY

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss

(2008) David W. Hampton et al.   JOURNAL OF NEUROIMMUNOLOGY

Overexpression of CNTF in Mesenchymal Stem Cells reduces demyelination and induces clinical recovery in experimental autoimmune encephalomyelitis mice

(2008) Zhengqi Lu et al.   JOURNAL OF NEUROIMMUNOLOGY

Effect of laquinimod on MRI-monitored disease activity in patients with relapsing-remitting multiple sclerosis: a multicentre, randomised, double-blind, placebo-controlled phase IIb study

(2008) G Comi et al.   LANCET

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET

Refining genetic associations in multiple sclerosis

(2008)   LANCET NEUROLOGY

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

(2008) Benjamin M Segal et al.   LANCET NEUROLOGY

Loss of Na+ channel β2 subunits is neuroprotective in a mouse model of multiple sclerosis

(2008) Heather A. O'Malley et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets

(2008) May H. Han et al.   NATURE

Assessment: The use of natalizumab (Tysabri) for the treatment of multiple sclerosis (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology

(2008) D. S. Goodin et al.   NEUROLOGY

Alemtuzumab vs. Interferon Beta-1a in Early Multiple Sclerosis

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

B-Cell Depletion with Rituximab in Relapsing–Remitting Multiple Sclerosis

(2008) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Amino acid copolymer-specific IL-10-secreting regulatory T cells that ameliorate autoimmune diseases in mice

(2008) Joel N. H. Stern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-  signaling in dendritic cells is a prerequisite for the control of autoimmune encephalomyelitis

(2008) Y. Laouar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of CD4+CD25+ regulatory T cells by intravenous immunoglobulin: a critical factor in controlling experimental autoimmune encephalomyelitis

(2007) A. Ephrem et al.   BLOOD

Therapeutic vaccination with a trivalent T-cell receptor (TCR) peptide vaccine restores deficient FoxP3 expression and TCR recognition in subjects with multiple sclerosis

(2007) Arthur A. Vandenbark et al.   IMMUNOLOGY