Inhibition of mTOR suppresses IFNα production and the STING pathway in monocytes from systemic lupus erythematosus patients

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

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Attenuation of cGAS‐STING signaling is mediated by a p62/SQSTM1‐dependent autophagy pathway activated by TBK1

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Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

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Elevated IFIT3 Contributes to Abnormal Overactive cGAS-STING Signaling in Human Systemic Lupus Erythematosus Monocytes

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IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

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Expression of Cyclic GMP-AMP Synthase in Patients With Systemic Lupus Erythematosus

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Activation of the Mechanistic Target of Rapamycin in SLE: Explosion of Evidence in the Last Five Years

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Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases

(2015) Andras Perl   Nature Reviews Rheumatology

Suppression of systemic autoimmunity by the innate immune adaptor STING

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Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

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Type I Interferon in the Pathogenesis of Lupus

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Activated STING in a Vascular and Pulmonary Syndrome

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mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

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The type I interferon system in the development of lupus

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An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

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The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

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The S1P1-mTOR axis directs the reciprocal differentiation of TH1 and Treg cells

(2010) Guangwei Liu et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Age‐ and sex‐related patterns of serum interferon‐α activity in lupus families

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The innate immune system in SLE: type I interferons and dendritic cells

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Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

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