Article
Microbiology
Bo Wen, Lulu Yang, Jiaona Guo, Wenchi Chang, Shaopeng Wei, Shengmeng Yu, Xuefeng Qi, Qinghong Xue, Jingyu Wang
Summary: In this study, it was found that Peste des petits ruminants virus (PPRV) infection induces endoplasmic reticulum stress (ERS) and activates autophagy. Virus replication is necessary for the induction of ERS-mediated autophagy and PERK pathway activation. Furthermore, it was shown that the viral nucleocapsid (N) or nonstructural protein C is sufficient to induce ERS and enhance autophagy.
VETERINARY MICROBIOLOGY
(2022)
Article
Clinical Neurology
Diede Witkamp, Ellen Oudejans, Gino V. Hu-A-Ng, Leoni Hoogterp, Aleksandra M. Krzywanska, Milo Znidarsic, Kevin Marinus, Christina F. de Veij Mestdagh, Imke Bartelink, Marianna Bugiani, Marjo S. van Der Knaap, Truus E. M. Abbink
Summary: The study found that guanabenz is a viable treatment option for vanishing white matter (VWM), improving pathological symptoms and regulating the cellular stress response. However, the exact mechanism of guanabenz's impact on VWM still requires further research. Additionally, a guanabenz analog called Sephin1 lacks the alpha 2-adrenergic effects of guanabenz.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2022)
Article
Fisheries
Ruoying Hu, Shiyu Wang, Lin Feng, Weidan Jiang, Pei Wu, Yang Liu, Xiaowan Jin, Shengyao Kuang, Ling Tang, Lu Zhang, Xiaoqiu Zhou
Summary: Tea tree oil (TTO) supplementation can prevent damage to the grass carp gill from hypoxia stress. TTO alleviates deterioration of serum parameters, reduces oxidative damage and apoptosis, improves structural integrity of the gills, and relieves gill endoplasmic reticulum stress (ERS) and autophagy. TTO reduces gill damage caused by hypoxia stress by mitigating oxidative damage, ERS, and autophagy.
Article
Genetics & Heredity
Parith Wongkittichote, Soe Soe Mar, Robert C. McKinstry, Hoanh Nguyen
Summary: This article presents a case of CACH/VWM and emphasizes the importance of genetic testing in patients with leukodystrophies.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Shi-Zheng Jia, Xin-Wen Xu, Zhong-Hao Zhang, Chen Chen, Yu-Bin Chen, Shao-Ling Huang, Qiong Liu, Peter R. Hoffmann, Guo-Li Song
Summary: Selenoprotein K plays a critical role in regulating intracellular calcium flux, degradation pathways, and response to stress in neurons. Knockout of SELENOK in neurons leads to increased apoptosis, activated cascade pathways, and decreased cognitive ability and increased anxiety in older mice.
Article
Chemistry, Medicinal
Yan Guo, Suxing Jin, Hao Yuan, Tao Yang, Kun Wang, Zijian Guo, Xiaoyong Wang
Summary: Mono-Pt kills cancer cells through a mitophagic pathway by stimulating endoplasmic reticulum stress and activating the unfolded protein response, severely impairing mitochondrial structure and function.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Environmental Sciences
Yiqi Wang, Lian Duan, Xing Zhang, Yang Jiao, Ying Liu, Lingling Dai, Hong Yan
Summary: The study demonstrated that chronic exposure to ACR can impair motor skills, muscle strength, and coordination in rats, as well as damage the morphology of the cerebellum, leading to increased apoptosis and initiation of autophagy.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Chemistry, Multidisciplinary
Yasaman Esmaeili, Zahra Yarjanli, Fatemeh Pakniya, Elham Bidram, Marek J. Los, Mehdi Eshraghi, Daniel J. Klionsky, Saeid Ghavami, Ali Zarrabi
Summary: Protein homeostasis is crucial for cell function, and disruption of the molecular mechanisms involved in this process may contribute to neurodegenerative diseases. Autophagy disruption, oxidative stress, and ER stress are the main molecular mechanisms underlying neurodegeneration, and they have synergistic effects on each other. Therefore, targeting the crosstalk between these pathways may play a critical role in healing neurodegenerative diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Noriyoshi Ogino, Koichiro Miyagawa, Kenjiro Nagaoka, Kazuhiro Sumida, Masashi Kusanaga, Shinji Oe, Yuichi Honma, Michihiko Shibata, Masaru Harada, Narufumi Suganuma, Keiki Ogino
Summary: The study found that atmospheric particulate matter in Japan can stimulate lipogenesis in hepatocytes and inhibit autophagic degradation, indicating potential effects on liver health.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2021)
Article
Cell Biology
Cailing Wen, Yuheng Zhou, Yanting Xu, Huijing Tan, Caixia Pang, Haiqian Liu, Kaifei Liu, Linlin Wei, Hui Luo, Tian Qin, Chonghua He, Cuiling Liu, Chun Zhou
Summary: The lack of GBF1 affects osteoclast differentiation, leading to cell swelling and reduced formation; GBF1 inhibition can intensify cellular stress and excessive autophagy, ultimately leading to cell apoptosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Yue Gu, Huan Xia, Xiao Chen, Jing Li
Summary: This study demonstrated that CUR-loaded nanoparticles can protect cardiomyocytes from lipotoxic injury induced by palmitate, reverse the decrease in cell proliferation, inhibit apoptosis, and activate the autophagy pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Yuting Ren, Xueying Yu, Bin Chen, Hefei Tang, Songtao Niu, Xingao Wang, Hua Pan, Zaiqiang Zhang
Summary: This study provides a detailed description of clinical symptoms, disease characteristics, and MRI findings of adult-onset VWM, as well as identifies new gene mutations. These findings contribute to a better understanding of the pathogenesis and diagnosis of VWM.
NEUROLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dongmei Liu, Muriel Mari, Xia Li, Fulvio Reggiori, Susan Ferro-Novick, Peter Novick
Summary: This study discovered a process called ER-phagy, which selectively delivers fragments of the endoplasmic reticulum to the lysosome or vacuole in response to starvation or the accumulation of misfolded proteins. The loss of specific genes and proteins blocks the association between the autophagy receptor and the assembly scaffold protein, and a membrane contact site module is also found to be involved in ER-phagy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Zaiwei Wu, Fang Wang, Liwen Hu, Jianrong Zhang, Daojun Chen, Sujuan Zhao
Summary: This study demonstrates that MCLR causes damage to the male reproductive system and enhances autophagy, indicating the essential role of autophagy in MCLR-induced cell death. Furthermore, the study reveals the involvement of ER stress-related autophagy pathway in MCLR-induced apoptosis and injury in the male reproductive system.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Environmental Sciences
Yu Wang, Hongjing Zhao, Mengyao Mu, Menghao Guo, Mingwei Xing
Summary: Arsenic accumulation in the spleen due to environmental exposure can cause severe injuries, while zinc treatment may offer protection against arsenic-induced splenic toxicity in common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)