Article
Medicine, Research & Experimental
Hongcheng Luo, Deyou Huang, Xionglin Tang, Yu Liu, Qisheng Luo, Chunhong Liu, Huatuo Huang, Wencheng Chen, Zhongquan Qi
Summary: This study found that Beclin-1 protects neurons from damage in cerebral ischemia-reperfusion through non-autophagy-dependent DNA repair processes. Autophagy inhibitors can decrease brain tissue damage and cell apoptosis, but the decrease is not highly correlated with changes in autophagy.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Zhiwei Kong, Tingting Yao
Summary: This study investigated the expression of Beclin-1 and LC3 in endometriosis and found that their downregulation is negatively correlated with the stage of the disease.
Article
Pharmacology & Pharmacy
Jia Zhang, Wei Mao, Yuying Liu, Jian Ding, Jie Wang, Ziwei Yu, Ruofei Huang, Sen Yang, Ying Sun, Pin Dong
Summary: Enhanced autophagy is a crucial factor contributing to cisplatin resistance in FaDu cells. The use of 3-MA can significantly reduce autophagy levels, arrest the cell cycle, promote apoptosis, and reverse cisplatin resistance, partly by inhibiting Beclin-1 expression. This provides a theoretical basis for 3-MA application in overcoming cisplatin resistance in hypopharyngeal cancer.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Review
Pharmacology & Pharmacy
Alexander G. Raufi, Nicholas R. Liguori, Lindsey Carlsen, Cassandra Parker, Liz Hernandez Borrero, Shengliang Zhang, Xiaobing Tian, Anna Louie, Lanlan Zhou, Attila A. Seyhan, Wafik S. El-Deiry
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with slow progress towards effective therapy, indicating an urgent need for novel treatment approaches, with autophagy potentially being a promising therapeutic target.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yun Li, Zhuofan Lei, Rodney M. Ritzel, Junyun He, Hui Li, Harry M. C. Choi, Marta M. Lipinski, Junfang Wu
Summary: Autophagy plays a crucial role in post-spinal cord injury, as inhibiting autophagy can lead to pro-inflammatory activation in microglia and worse functional outcomes, while increasing autophagy can reduce inflammation and improve outcomes.
Article
Endocrinology & Metabolism
Yuefei Wang, Ling Qin, Caixia Zhu, Fei Fan, Jingbo Xu
Summary: This study investigated the proliferation, autophagy, and mechanism of curcumin in the treatment of cervical cancer cells complicated with HPV infection. The expression of autophagy-related proteins in cervical cancer cells was regulated by curcumin.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biology
I. C. Weel, V. R. Ribeiro, M. Romao-Veiga, E. G. Fioratti, J. C. Peracoli, M. T. S. Peracoli
Summary: Autophagy, a cellular degradation pathway, is found to be deficient in the placenta of pregnant women with preeclampsia (PE). This deficiency may contribute to the pathogenesis of PE. Further studies on the interaction between autophagy and inflammatory molecular mechanisms are needed to better understand the role of autophagy in this obstetric pathology.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2022)
Article
Immunology
Yan Zhou, Yishu Xue, Aihua Bao, Lei Han, Wuping Bao, Chao Xia, Xue Tian, Min Zhang
Summary: The study suggests that early-life vitamin D deficiency may exacerbate allergic airway inflammation, and maintaining sufficient vitamin D is necessary for lung health. Vitamin D may modulate autophagy in the lungs of OVA sensitized and challenged mice, playing a protective role in OVA-induced allergic airway inflammation.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Cell Biology
Sanjana Kumariya, Vaibhave Ubba, Rajesh K. Jha, Jiaur R. Gayen
Summary: PCOS is a prevalent syndrome among women of fertile age, with the ovary being the prime affected organ. Defective autophagy in follicular cells plays a significant role in PCOS pathogenesis. Although few studies have linked autophagy with PCOS progression, detailed knowledge in this area is lacking.
Article
Oncology
Dongqing Hu, Yanming Huo, Ye Xue, Haixia Feng, Wei Sun, Huiqi Wang, Jing Wu, Xiaoyan Wang
Summary: This study evaluated the prognostic value of autophagy proteins in colorectal cancer (CRC) and found that Beclin-1, LC3B, and p62 may serve as promising prognostic biomarkers for CRC. Additionally, high expression of LC3B and p62 can be reliable tools for predicting tumor metastasis.
Article
Pathology
Zhen Zhao, Bing Hou, Li Tang, Yaping Wang, Yueqing Zhang, Zhanzhuan Ying, Jie Duo
Summary: This study found that high-altitude hypoxia can induce autophagy of alveolar cells, and that autophagy plays an important role in high-altitude hypoxia-induced lung injury. Inhibition of autophagy may be a promising strategy for the treatment of high-altitude hypoxia-induced lung injury.
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
(2022)
Review
Neurosciences
Yingying Tang, Jiaqian Xie, Xiaoping Chen, Lihong Sun, Lili Xu, Xinzhong Chen
Summary: This review examines the role of SIRT1 in cerebral ischemia and reperfusion injury, with a focus on its involvement in regulating autophagy.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ines M. Aparicio, Patricia Rojo-Dominguez, Alba Castillejo-Rufo, Fernando J. Pena, Jose A. Tapia
Summary: This study aimed to investigate the role of autophagy in stallion spermatozoa during capacitation and acrosome reaction. The activation of autophagy components, such as LC3, was observed in spermatozoa during these processes. Furthermore, the inhibition or activation of autophagy-related pathways affected the acrosome reaction. These findings suggest that noncanonical autophagy may facilitate the acrosome reaction in stallion sperm.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Yan-qing Wu, Jun Xiong, Zi-li He, Yuan Yuan, Bei-ni Wang, Jing-yu Xu, Man Wu, Su-su Zhang, Shu-fang Cai, Jia-xin Zhao, Ke Xu, Hong-yu Zhang, Jian Xiao
Summary: Metformin plays a protective role in myelin preservation during SCI recovery by promoting the autophagy level of microglial cells, regulating inflammatory responses, improving neuronal apoptosis, and enhancing locomotor function recovery.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Pharmacology & Pharmacy
Milica Kosic, Verica Paunovic, Biljana Ristic, Aleksandar Mircic, Mihajlo Bosnjak, Danijela Stevanovic, Tamara Kravic-Stevovic, Vladimir Trajkovic, Ljubica Harhaji-Trajkovic
Summary: The study showed that 3-methyladenine (3MA) can prevent cancer cell death induced by energy stress through autophagy-independent mechanisms, possibly involving JNK suppression and decrease of oxidative stress. It highlights the need for caution when using 3MA as an autophagy inhibitor.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)