Neuroinflammation in hemorrhagic transformation after tissue plasminogen activator thrombolysis: Potential mechanisms, targets, therapeutic drugs and biomarkers

The association between monocyte to high-density lipoprotein ratio and hemorrhagic transformation in patients with acute ischemic stroke

(2020) Yanan Wang et al.   Aging-US

A high neutrophil-to-lymphocyte ratio predicts hemorrhagic transformation of large atherosclerotic infarction in patients with acute ischemic stroke

(2020) Wen-Bo Zhang et al.   Aging-US

Human neural stem cells improve early stage stroke outcome in delayed tissue plasminogen activator-treated aged stroke brains

(2020) AustinC. Boese et al.   EXPERIMENTAL NEUROLOGY

Neutrophil-Related Oxidants Drive Heart and Brain Remodeling After Ischemia/Reperfusion Injury

(2020) Federico Carbone et al.   Frontiers in Physiology

Exogenous activation of cannabinoid-2 receptor modulates TLR4/MMP9 expression in a spinal cord ischemia reperfusion rat model

(2020) Na Jing et al.   Journal of Neuroinflammation

Neutrophil extracellular traps released by neutrophils impair revascularization and vascular remodeling after stroke

(2020) Lijing Kang et al.   Nature Communications

Microglia and macrophage metabolism in CNS injury and disease: The role of immunometabolism in neurodegeneration and neurotrauma

(2020) Nicholas A. Devanney et al.   EXPERIMENTAL NEUROLOGY

Matrix Metalloproteinase-9 Relationship With Infarct Growth and Hemorrhagic Transformation in the Era of Thrombectomy

(2020) Laura Mechtouff et al.   Frontiers in Neurology

Myosin IIA Regulated Tight Junction in Oxygen Glucose-Deprived Brain Endothelial Cells Via Activation of TLR4/PI3K/Akt/JNK1/2/14-3-3ε/NF-κB/MMP9 Signal Transduction Pathway

(2019) Yanni Lv et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neutrophil extracellular traps in thrombi retrieved during interventional treatment of ischemic arterial diseases

(2019) Ádám Z. Farkas et al.   THROMBOSIS RESEARCH

Electroacupuncture attenuated cerebral ischemic injury and neuroinflammation through α7nAChR-mediated inhibition of NLRP3 inflammasome in stroke rats

(2019) Tao Jiang et al.   MOLECULAR MEDICINE

The Neutrophil’s Role During Health and Disease

(2019) Pei Xiong Liew et al.   PHYSIOLOGICAL REVIEWS

Microglia-derived TNF-α mediates endothelial necroptosis aggravating blood brain–barrier disruption after ischemic stroke

(2019) An-Qi Chen et al.   Cell Death & Disease

Role of the S1P pathway and inhibition by fingolimod in preventing hemorrhagic transformation after stroke

(2019) Angélica Salas-Perdomo et al.   Scientific Reports

Protective effect of glycyrrhizic acid on cerebral ischemia/reperfusion (I/R) injury via inhibiting HMGB1 mediated TLR4/NF‐κB pathway

(2019) Sunhong Yan et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Temporal changes in physiological and molecular markers in various brain regions following transient global ischemia in rats

(2019) Monika Kapoor et al.   MOLECULAR BIOLOGY REPORTS

Neutrophil‐to‐lymphocyte ratio predicts hemorrhagic transformation in ischemic stroke: A meta‐analysis

(2019) Ruirui Zhang et al.   Brain and Behavior

Rosiglitazone ameliorates tissue plasminogen activator‐induced brain hemorrhage after stroke

(2019) Yan Li et al.   CNS Neuroscience & Therapeutics

All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling

(2019) Wei Cai et al.   Journal of Neuroinflammation

Microglia and macrophage phenotypes in intracerebral haemorrhage injury: therapeutic opportunities

(2019) Qian Bai et al.   BRAIN

T Cells Prevent Hemorrhagic Transformation in Ischemic Stroke by P-Selectin Binding

(2018) Angélica Salas-Perdomo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment

(2018) Zhiliang Guo et al.   BRAIN RESEARCH BULLETIN

microRNA-21 Confers Neuroprotection Against Cerebral Ischemia-Reperfusion Injury and Alleviates Blood-Brain Barrier Disruption in Rats via the MAPK Signaling Pathway

(2018) Xiaofeng Yao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

Inhibition of Toll-Like Receptor-4 (TLR-4) Improves Neurobehavioral Outcomes After Acute Ischemic Stroke in Diabetic Rats: Possible Role of Vascular Endothelial TLR-4

(2018) Yasir Abdul et al.   MOLECULAR NEUROBIOLOGY

Free Radical Damage in Ischemia-Reperfusion Injury: An Obstacle in Acute Ischemic Stroke after Revascularization Therapy

(2018) Ming-Shuo Sun et al.   Oxidative Medicine and Cellular Longevity

Blood-brain barrier dysfunction and recovery after ischemic stroke

(2018) Xiaoyan Jiang et al.   PROGRESS IN NEUROBIOLOGY

Pilot study to assess visualization and therapy of inflammatory mechanisms after vessel reopening in a mouse stroke model

(2018) Ebba Beller et al.   Scientific Reports

Release of IL-6 After Stroke Contributes to Impaired Cerebral Autoregulation and Hippocampal Neuronal Necrosis Through NMDA Receptor Activation and Upregulation of ET-1 and JNK

(2018) William M. Armstead et al.   Translational Stroke Research

Pinocembrin Protects Blood-Brain Barrier Function and Expands the Therapeutic Time Window for Tissue-Type Plasminogen Activator Treatment in a Rat Thromboembolic Stroke Model

(2018) YinZhong Ma et al.   Biomed Research International

Cell permeable HMGB1-binding heptamer peptide ameliorates neurovascular complications associated with thrombolytic therapy in rats with transient ischemic stroke

(2018) Miaodan Li et al.   Journal of Neuroinflammation

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

(2018) Zhe Gong et al.   Journal of Neuroinflammation

The role of NLRP3 inflammasome in stroke and central poststroke pain

(2018) Shao-jun Li et al.   MEDICINE

Neutrophils in tPA-induced hemorrhagic transformations: Main culprit, accomplice or innocent bystander?

(2018) Thavarak Ouk et al.   PHARMACOLOGY & THERAPEUTICS

Rosuvastatin Reduces Neuroinflammation in the Hemorrhagic Transformation After rt-PA Treatment in a Mouse Model of Experimental Stroke

(2018) Dan Lu et al.   Frontiers in Cellular Neuroscience

Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

(2018) De-Cai Tian et al.   ANNALS OF NEUROLOGY

High serum sICAM-1 is correlated with cerebral microbleeds and hemorrhagic transformation in ischemic stroke patients

(2018) Bo-Na Wu et al.   BRITISH JOURNAL OF NEUROSURGERY

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

(2018) Saeedeh Tajalli-Nezhad et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potential molecular targets of peroxynitrite in mediating blood–brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment

(2018) Hansen Chen et al.   FREE RADICAL RESEARCH

Predictive value of plasma matrix metalloproteinase-9 concentrations for spontaneous haemorrhagic transformation in patients with acute ischaemic stroke: A cohort study in Chinese patients

(2018) Ruozhen Yuan et al.   JOURNAL OF CLINICAL NEUROSCIENCE

Immune Cells After Ischemic Stroke Onset: Roles, Migration, and Target Intervention

(2018) Lu-yao Ao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

NRF2 and NF-қB interplay in cerebrovascular and neurodegenerative disorders: Molecular mechanisms and possible therapeutic approaches

(2018) Farzane Sivandzade et al.   Redox Biology

Adjunctive Therapy Approaches for Ischemic Stroke: Innovations to Expand Time Window of Treatment

(2017) Talia Knecht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke

(2017) Masato Kanazawa et al.   Journal of Atherosclerosis and Thrombosis

Anti-inflammatory approaches to ischaemic stroke prevention

(2017) Peter J Kelly et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

(2017) Alicia García-Culebras et al.   STROKE

Neutrophil extracellular traps are increased in patients with acute ischemic stroke: prognostic significance

(2017) Juana Vallés et al.   THROMBOSIS AND HAEMOSTASIS

Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats

(2017) Xiang Fan et al.   Translational Stroke Research

Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats

(2017) Hongfei Sang et al.   Translational Stroke Research

Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO−-MMP-9 Pathway

(2017) Hansen Chen et al.   Translational Stroke Research

Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke

(2017) Johanna Ruhnau et al.   Journal of Immunology Research

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

(2017) Varun Chandrashekaran et al.   Redox Biology

The plasminogen activation system in neuroinflammation

(2016) Anupriya Mehra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inflammatory Disequilibrium in Stroke

(2016) Danica Petrovic-Djergovic et al.   CIRCULATION RESEARCH

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

(2016) Han-Sen Chen et al.   Current Neuropharmacology

Activation of p38-mitogen-activated protein kinase contributes to ischemia reperfusion in rat brain

(2016) Y.Q. Song et al.   GENETICS AND MOLECULAR RESEARCH

Regulatory T cells ameliorate intracerebral hemorrhage-induced inflammatory injury by modulating microglia/macrophage polarization through the IL-10/GSK3β/PTEN axis

(2016) Kai Zhou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly

(2016) Florian I. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway as a Discovery Target in Stroke

(2016) Jing Sun et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dynamic change of neutrophil to lymphocyte ratio and hemorrhagic transformation after thrombolysis in stroke

(2016) Zhiliang Guo et al.   Journal of Neuroinflammation

Curcumin by down-regulating NF-kB and elevating Nrf2, reduces brain edema and neurological dysfunction after cerebral I/R

(2016) Wei Li et al.   MICROVASCULAR RESEARCH

p38 MAPK Participates in the Mediation of GLT-1 Up-regulation During the Induction of Brain Ischemic Tolerance by Cerebral Ischemic Preconditioning

(2016) Min Zhang et al.   MOLECULAR NEUROBIOLOGY

A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model

(2016) Norio Fujiwara et al.   NEUROSCIENCE LETTERS

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

Combining Growth Factor and Bone Marrow Cell Therapy Induces Bleeding and Alters Immune Response After Stroke in Mice

(2016) Jan-Kolja Strecker et al.   STROKE

High-Sensitive C-Reactive Protein Predicts Recurrent Stroke and Poor Functional Outcome

(2016) Jiejie Li et al.   STROKE

Thromboinflammation in Stroke Brain Damage

(2016) Simon F. De Meyer et al.   STROKE

Implications of MMP9 for Blood Brain Barrier Disruption and Hemorrhagic Transformation Following Ischemic Stroke

(2016) Renée J. Turner et al.   Frontiers in Cellular Neuroscience

Cell Signaling and Stress Responses

(2016) Gökhan S. Hotamisligil et al.   Cold Spring Harbor Perspectives in Biology

Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells

(2016) Jong Youl Kim et al.   Experimental Neurobiology

Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats

(2015) Soonmi Won et al.   BRAIN BEHAVIOR AND IMMUNITY

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE

(2015) Zilong Zhu et al.   CIRCULATION

Peroxynitrite Decomposition Catalyst Reduces Delayed Thrombolysis-induced Hemorrhagic Transformation in Ischemia-reperfused Rat Brains

(2015) Han-Sen Chen et al.   CNS Neuroscience & Therapeutics

Targeting Neutrophils in Ischemic Stroke: Translational Insights from Experimental Studies

(2015) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia

(2015) Ker Zhing Lok et al.   Journal of Neuroinflammation

The Natural Flavonoid Pinocembrin: Molecular Targets and Potential Therapeutic Applications

(2015) Xi Lan et al.   MOLECULAR NEUROBIOLOGY

Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway

(2015) Juanjuan Gong et al.   NEUROPHARMACOLOGY

Elevated neuronal α-synuclein promotes microglia activation after spinal cord ischemic/reperfused injury

(2015) Hongfei Qiao et al.   NEUROREPORT

Assessment of Blood–Brain Barrier Disruption in Stroke

(2015) Andrea Kassner et al.   STROKE

Treatment with recombinant tissue plasminogen activator (r-TPA) induces neutrophil degranulation in vitro via defined pathways

(2015) Federico Carbone et al.   VASCULAR PHARMACOLOGY

The Architecture of the TIR Domain Signalosome in the Toll-like Receptor-4 Signaling Pathway

(2015) Emine Guven-Maiorov et al.   Scientific Reports

Neutrophil recruitment to the brain in mouse and human ischemic stroke

(2014) Isabel Perez-de-Puig et al.   ACTA NEUROPATHOLOGICA

Prion-like Polymerization Underlies Signal Transduction in Antiviral Immune Defense and Inflammasome Activation

(2014) Xin Cai et al.   CELL

Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects

(2014) Y. Chen et al.   CURRENT MEDICINAL CHEMISTRY

Inhibition of mitogen-activated protein kinase phosphatase-1 (MKP-1) increases experimental stroke injury

(2014) Lin Liu et al.   EXPERIMENTAL NEUROLOGY

BDNF expression of macrophages and angiogenesis after myocardial infarction

(2014) Jun-Hee Hong et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Transplanted Neural Stem Cells Modulate Regulatory T, γδ T Cells and Corresponding Cytokines after Intracerebral Hemorrhage in Rats

(2014) Lu Gao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NLRP3 Deficiency Ameliorates Neurovascular Damage in Experimental Ischemic Stroke

(2014) Fan Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Upregulation of ICAM-1 in diabetic rats after transient forebrain ischemia and reperfusion injury

(2014) Li Jing et al.   Journal of Inflammation-London

Impact of the neutrophil response to granulocyte colony-stimulating factor on the risk of hemorrhage when used in combination with tissue plasminogen activator during the acute phase of experimental stroke

(2014) Sophie Gautier et al.   Journal of Neuroinflammation

Pinocembrin Protects the Brain against Ischemia-Reperfusion Injury and Reverses the Autophagy Dysfunction in the Penumbra Area

(2014) Gang Zhao et al.   MOLECULES

Synergy of Combined tPA-Edaravone Therapy in Experimental Thrombotic Stroke

(2014) Yu-Yo Sun et al.   PLoS One

Immunological consequences of ischemic stroke

(2013) A. Vogelgesang et al.   ACTA NEUROLOGICA SCANDINAVICA

Redox Modulation of HMGB1-Related Signaling

(2013) Christina Janko et al.   ANTIOXIDANTS & REDOX SIGNALING

Cellular signalling of the receptor for advanced glycation end products (RAGE)

(2013) Jianling Xie et al.   CELLULAR SIGNALLING

Microglial Responses after Ischemic Stroke and Intracerebral Hemorrhage

(2013) Roslyn A. Taylor et al.   Clinical & Developmental Immunology

Differential Effects of Paracrine Factors on the Survival of Cells of the Neurovascular Unit during Oxygen Glucose Deprivation

(2013) Zoran B. Redzic et al.   International Journal of Stroke

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

MRI of ICAM-1 Upregulation After Stroke: the Importance of Choosing the Appropriate Target-Specific Particulate Contrast Agent

(2013) Lisette H. Deddens et al.   MOLECULAR IMAGING AND BIOLOGY

Structures and interface mapping of the TIR domain-containing adaptor molecules involved in interferon signaling

(2013) Y. Enokizono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-density Lipoprotein–based Therapy Reduces the Hemorrhagic Complications Associated With Tissue Plasminogen Activator Treatment in Experimental Stroke

(2013) Bertrand Lapergue et al.   STROKE

N2 Neutrophils, Novel Players in Brain Inflammation After Stroke

(2013) María Isabel Cuartero et al.   STROKE

Toll-Like Receptor Signaling

(2013) K.-H. Lim et al.   Cold Spring Harbor Perspectives in Biology

Macrophages prevent hemorrhagic infarct transformation in murine stroke models

(2012) Michael Gliem et al.   ANNALS OF NEUROLOGY

The Classification of Microglial Activation Phenotypes on Neurodegeneration and Regeneration in Alzheimer’s Disease Brain

(2012) Megan M. Varnum et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Multiple atherosclerosis-related biomarkers associated with short- and long-term mortality after stroke

(2012) Cangel Pui-yee Chan et al.   CLINICAL BIOCHEMISTRY

Integrins regulate centrosome integrity and astrocyte polarization following a wound

(2012) Huashan Peng et al.   Developmental Neurobiology

Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506

(2012) Takayuki Ishii et al.   FASEB JOURNAL

Matrix metalloprotein-9 activation under cell-to-cell interaction between endothelial cells and monocytes: possible role of hypoxia and tumor necrosis factor-α

(2012) Yuko Yamamoto et al.   HEART AND VESSELS

Microglial Cell Activation is a Source of Metalloproteinase Generation during Hemorrhagic Transformation

(2012) Gregory J del Zoppo et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Early steps of microglial activation are directly affected by neuroprotectant FK506 in both in vitro inflammation and in rat model of stroke

(2012) Malgorzata Zawadzka et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Preserved vascular integrity and enhanced survival following neuropilin-1 inhibition in a mouse model of CD8 T cell-initiated CNS vascular permeability

(2012) Georgette L Suidan et al.   Journal of Neuroinflammation

Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke

(2012) R. Khatri et al.   NEUROLOGY

Distinctive Effects of T Cell Subsets in Neuronal Injury Induced by Cocultured Splenocytes In Vitro and by In Vivo Stroke in Mice

(2012) Lijuan Gu et al.   STROKE

Secondary Intracerebral Hemorrhage Due to Early Initiation of Oral Anticoagulation After Ischemic Stroke

(2012) Michael Gliem et al.   STROKE

Microglia/Macrophage Polarization Dynamics Reveal Novel Mechanism of Injury Expansion After Focal Cerebral Ischemia

(2012) Xiaoming Hu et al.   STROKE

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

HMGB1, TLR and RAGE: a functional tripod that leads to diabetic inflammation

(2011) José Augusto Nogueira-Machado et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Effect of Baicalin on Matrix Metalloproteinase-9 Expression and Blood–Brain Barrier Permeability Following Focal Cerebral Ischemia in Rats

(2011) Xian-kun Tu et al.   NEUROCHEMICAL RESEARCH

Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Ischemic Stroke

(2011) Jeffrey A. Switzer et al.   STROKE

Increased Brain Injury and Worsened Neurological Outcome in Interleukin-4 Knockout Mice After Transient Focal Cerebral Ischemia

(2011) Xiaoxing Xiong et al.   STROKE

Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor κB p65 activation

(2010) Xia Xue et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Tanshinone II A down-regulates HMGB1, RAGE, TLR4, NF-κB expression, ameliorates BBB permeability and endothelial cell function, and protects rat brains against focal ischemia

(2010) Lina Wang et al.   BRAIN RESEARCH

Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome

(2010) Vanessa H. Brait et al.   BRAIN RESEARCH

Meta-analysis of lineage-specific gene expression signatures in mouse leukocyte populations

(2010) Neil A. Mabbott et al.   IMMUNOBIOLOGY

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

The TAK1–TRAF6 signalling pathway

(2010) Marene Landström   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Molecular Intercommunication between the Complement and Coagulation Systems

(2010) U. Amara et al.   JOURNAL OF IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglial activation in stroke: Therapeutic targets

(2010) Midori A. Yenari et al.   Neurotherapeutics

Development of Monocytes, Macrophages, and Dendritic Cells

(2010) F. Geissmann et al.   SCIENCE

Plasma VAP-1/SSAO Activity Predicts Intracranial Hemorrhages and Adverse Neurological Outcome After Tissue Plasminogen Activator Treatment in Stroke

(2010) Mar Hernandez-Guillamon et al.   STROKE

Protective Effect of High-Density Lipoprotein-Based Therapy in a Model of Embolic Stroke

(2010) Bertrand Lapergue et al.   STROKE

Neutrophils contribute to intracerebral haemorrhages after treatment with recombinant tissue plasminogen activator following cerebral ischaemia

(2009) Sophie Gautier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Atorvastatin Extends the Therapeutic Window for tPA to 6 h after the Onset of Embolic Stroke in Rats

(2009) Li Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Rosiglitazone Alone Or in Combination with Tissue Plasminogen Activator Improves Ischemic Brain Injury in an Embolic Model in Rats

(2009) Chen Xu Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Monocyte Subtypes Predict Clinical Course and Prognosis in Human Stroke

(2009) Xabier Urra et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

CD8 T Cell-Initiated Vascular Endothelial Growth Factor Expression Promotes Central Nervous System Vascular Permeability under Neuroinflammatory Conditions

(2009) G. L. Suidan et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Effects of monocyte chemoattractant protein 1 on blood-borne cell recruitment after transient focal cerebral ischemia in mice

(2009) M. Schilling et al.   NEUROSCIENCE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model

(2008) Masashi Maeda et al.   BRAIN RESEARCH

Ambivalent Aspects of Interleukin-6 in Cerebral Ischemia: Inflammatory versus Neurotrophic Aspects

(2008) Shigeaki Suzuki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tissue plasminogen activator (t-PA) promotes neutrophil degranulation and MMP-9 release

(2008) Eloy Cuadrado et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

(2008) Bettina H Clausen et al.   Journal of Neuroinflammation

Blood-brain barrier tight junction permeability and ischemic stroke

(2008) Karin E. Sandoval et al.   NEUROBIOLOGY OF DISEASE

Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase

(2008) M. O. Breckwoldt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke

(2008) Anna Rosell et al.   STROKE

Edaravone, a Free Radical Scavenger, Inhibits MMP-9–Related Brain Hemorrhage in Rats Treated With Tissue Plasminogen Activator

(2008) Kenji Yagi et al.   STROKE

VAP-1 and CD73, Endothelial Cell Surface Enzymes in Leukocyte Extravasation

(2007) Sirpa Jalkanen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Oxidative Stress and Matrix Metalloproteinase-9 in Acute Ischemic Stroke

(2007) Peter J. Kelly et al.   STROKE