The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

IL-1RA VNTR and IL-1α 4845G>T polymorphisms and risk of idiopathic male infertility in Iranian men: A case-control study and an in silico analysis

(2018) Tayyebeh Zamani-Badi et al.   ANDROLOGIA

Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1

(2018) Sepideh Etehadi Moghadam et al.   Journal of Stroke & Cerebrovascular Diseases

Prevention of the Severity of Post-ischemic Inflammation and Brain Damage by Simultaneous Knockdown of Toll-like Receptors 2 and 4

(2018) Koteswara Rao Nalamolu et al.   NEUROSCIENCE

Neuroprotective Effects of Oxytocin Hormone after an Experimental Stroke Model and the Possible Role of Calpain-1

(2018) Sepideh Etehadi Moghadam et al.   Journal of Stroke & Cerebrovascular Diseases

Role of Steroid Therapy after Ischemic Stroke by n -Methyl- d -Aspartate Receptor Gene Regulation

(2018) Abolfazl Azami Tameh et al.   Journal of Stroke & Cerebrovascular Diseases

Polymorphisms of the folate metabolizing enzymes: Association with SLE susceptibility and in silico analysis

(2017) Saeedeh Salimi et al.   GENE

Molecular mechanisms mediating the neuroprotective role of the selective estrogen receptor modulator, bazedoxifene, in acute ischemic stroke: A comparative study with 17β-estradiol

(2017) Teresa Jover-Mengual et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Association of C3953T transition in interleukin 1β gene with idiopathic male infertility in an Iranian population

(2017) Tayyebeh Zamani-Badi et al.   Human Fertility

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

NLRP3 inflammasome activation mediates estrogen deficiency-induced depression- and anxiety-like behavior and hippocampal inflammation in mice

(2016) Yongjun Xu et al.   BRAIN BEHAVIOR AND IMMUNITY

Progesterone neuroprotection: The background of clinical trial failure

(2016) Michael Schumacher et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Estrogen receptors alpha mediates postischemic inflammation in chronically estrogen-deprived mice

(2016) Pierre Cordeau et al.   NEUROBIOLOGY OF AGING

Gonadal steroids block the calpain-1-dependent intrinsic pathway of apoptosis in an experimental rat stroke model

(2016) Zeinab Vahidinia et al.   NEUROLOGICAL RESEARCH

Genetic association of Toll-like receptor 4 gene and coronary artery disease in a Chinese Han population

(2016) Liting Zhou et al.   SpringerPlus

Function and mechanism of toll-like receptors in cerebral ischemic tolerance: from preconditioning to treatment

(2015) Peng-Fei Wang et al.   Journal of Neuroinflammation

Inflammasomes are neuroprotective targets for sex steroids

(2015) Alexander Slowik et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke

(2015) Anya Turetsky et al.   Journal of Stroke & Cerebrovascular Diseases

TLR4 rs1927911, but Not TLR2 rs5743708, Is Associated With Atherosclerotic Cerebral Infarction in the Southern Han Population

(2015) Yanmin Song et al.   MEDICINE

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

(2015) Leoni Lammerding et al.   NEUROENDOCRINOLOGY

Low Serum Vitamin D Is Independently Associated with Larger Lesion Volumes after Ischemic Stroke

(2015) Anya Turetsky et al.   Journal of Stroke & Cerebrovascular Diseases

Vitamin D Prevents Hypoxia/Reoxygenation-Induced Blood-Brain Barrier Disruption via Vitamin D Receptor-Mediated NF-kB Signaling Pathways

(2015) Soonmi Won et al.   PLoS One

The Impact of Vitamin D Levels on Inflammatory Status: A Systematic Review of Immune Cell Studies

(2015) Emily K. Calton et al.   PLoS One

Chronic Estradiol Administration In Vivo Promotes the Proinflammatory Response of Macrophages to TLR4 Activation: Involvement of the Phosphatidylinositol 3-Kinase Pathway

(2014) B. Calippe et al.   JOURNAL OF IMMUNOLOGY

Comparative Analysis of Gonadal Steroid-Mediated Neuroprotection after Transient Focal Ischemia in Rats: Route of Application and Substrate Composition

(2014) Stefanie Hoffmann et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Brain-derived estrogen exerts anti-inflammatory and neuroprotective actions in the rat hippocampus

(2014) Quan-Guang Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Hypoxia-Induced Gene Expression of Aquaporin-4, Cyclooxygenase-2 and Hypoxia-Inducible Factor 1α in Rat Cortical Astroglia Is Inhibited by 17β-Estradiol and Progesterone

(2014) Pardes Habib et al.   NEUROENDOCRINOLOGY

Anti-Inflammatory Effects of Progesterone in Lipopolysaccharide-Stimulated BV-2 Microglia

(2014) Beilei Lei et al.   PLoS One

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

WS-SNPs&GO: a web server for predicting the deleterious effect of human protein variants using functional annotation

(2013) Emidio Capriotti et al.   BMC GENOMICS

RNAsnp: Efficient Detection of Local RNA Secondary Structure Changes Induced by SNPs

(2013) Radhakrishnan Sabarinathan et al.   HUMAN MUTATION

Vitamin D Receptor Inhibits Nuclear Factor κB Activation by Interacting with IκB Kinase β Protein

(2013) Yunzi Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1,25-Dihydroxyvitamin D Promotes Negative Feedback Regulation of TLR Signaling via Targeting MicroRNA-155-SOCS1 in Macrophages

(2013) Y. Chen et al.   JOURNAL OF IMMUNOLOGY

Neuroprotective effect of calcitriol on ischemic/reperfusion injury through the NR3A/CREB pathways in the rat hippocampus

(2013) JUN FU et al.   Molecular Medicine Reports

Innate immune detection of microbial nucleic acids

(2013) Claudia Gürtler et al.   TRENDS IN MICROBIOLOGY

Immuno-modulatory effects of vitamin D3 in human monocyte and macrophages

(2012) M. Di Rosa et al.   CELLULAR IMMUNOLOGY

Vitamin D Deficiency Exacerbates Experimental Stroke Injury and Dysregulates Ischemia-Induced Inflammation in Adult Rats

(2012) Robyn Balden et al.   ENDOCRINOLOGY

A clinical/translational perspective: Can a developmental hormone play a role in the treatment of traumatic brain injury?

(2012) Donald G. Stein   HORMONES AND BEHAVIOR

Progesterone and neuroprotection

(2012) Meharvan Singh et al.   HORMONES AND BEHAVIOR

Sex, stroke, and inflammation: The potential for estrogen-mediated immunoprotection in stroke

(2012) Rodney M. Ritzel et al.   HORMONES AND BEHAVIOR

Different Patterns of Toll-Like Receptor 2 Polymorphisms in Populations of Various Ethnic and Geographic Origins

(2012) M. Ioana et al.   INFECTION AND IMMUNITY

Involvement of Mitogen-Activated Protein Kinase Pathways in Expression of the Water Channel Protein Aquaporin-4 after Ischemia in Rat Cortical Astrocytes

(2012) Chikako Nito et al.   JOURNAL OF NEUROTRAUMA

Neuroprotection by gonadal steroid hormones in acute brain damage requires cooperation with astroglia and microglia

(2012) Sonja Johann et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: The role of BDNF/TrkB/Erk1/2 signaling in neuroprotection

(2012) Fahim Atif et al.   NEUROPHARMACOLOGY

The Effects of Estrogen in Ischemic Stroke

(2012) Edward C. Koellhoffer et al.   Translational Stroke Research

Post-Ischemic Inflammation in the Brain

(2012) Takashi Shichita et al.   Frontiers in Immunology

Evaluating the role of Toll-like receptors in diseases of the central nervous system

(2011) Michael Carty et al.   BIOCHEMICAL PHARMACOLOGY

Gonadal steroids prevent cell damage and stimulate behavioral recovery after transient middle cerebral artery occlusion in male and female rats

(2011) Jon Dang et al.   BRAIN BEHAVIOR AND IMMUNITY

Toll-like receptors 7 and 8 expression is associated with poor outcome and greater inflammatory response in acute ischemic stroke

(2011) David Brea et al.   CLINICAL IMMUNOLOGY

Mechanisms of Estrogens’ Dose-Dependent Neuroprotective and Neurodamaging Effects in Experimental Models of Cerebral Ischemia

(2011) Jakob O. Strom et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone

(2011) Fang Hua et al.   Journal of Neuroinflammation

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

Stroke and the immune system: from pathophysiology to new therapeutic strategies

(2011) Richard Macrez et al.   LANCET NEUROLOGY

Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats

(2011) Zhong Wang et al.   MEDIATORS OF INFLAMMATION

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants

(2011) G. De Baets et al.   NUCLEIC ACIDS RESEARCH

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

The Structural Biology of Toll-like Receptors

(2011) Istvan Botos et al.   STRUCTURE

Toll-like receptor signaling in neural plasticity and disease

(2011) Eitan Okun et al.   TRENDS IN NEUROSCIENCES

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

(2010) Kazuhide Hayakawa et al.   Annals of the New York Academy of Sciences

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Deciphering the complexity of Toll-like receptor signaling

(2010) Renato Ostuni et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Progesterone and 17 -Estradiol Enhance Regulatory Responses to Human Papillomavirus Type 16 Virus-Like Particles in Peripheral Blood Mononuclear Cells from Healthy Women

(2010) M. A. Marks et al.   Clinical and Vaccine Immunology

Vitamin D: modulator of the immune system

(2010) Femke Baeke et al.   CURRENT OPINION IN PHARMACOLOGY

Progesterone and allopregnanolone attenuate blood–brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases

(2010) Tauheed Ishrat et al.   EXPERIMENTAL NEUROLOGY

Innate Immune Signaling in the Myelodysplastic Syndromes

(2010) Daniel T. Starczynowski et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Blocking TLR2 in vivo Protects against Accumulation of Inflammatory Cells and Neuronal Injury in Experimental Stroke

(2010) Gina Ziegler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity

(2010) Diane L. Kamen et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

A method and server for predicting damaging missense mutations

(2010) Ivan A Adzhubei et al.   NATURE METHODS

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

(2010) M. Lv et al.   NEUROSCIENCE

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

(2010) E. Okun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitamin D3 down-regulates intracellular Toll-like receptor 9 expression and Toll-like receptor 9-induced IL-6 production in human monocytes

(2010) L. J. Dickie et al.   RHEUMATOLOGY

Key Role of CD36 in Toll-Like Receptor 2 Signaling in Cerebral Ischemia

(2010) Takato Abe et al.   STROKE

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

(2010) David J. Loane et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Evaluation of bazedoxifene/conjugated estrogens for the treatment of menopausal symptoms and effects on metabolic parameters and overall safety profile

(2009) Rogerio A. Lobo et al.   FERTILITY AND STERILITY

Neuroprotective effects of estrogens following ischemic stroke

(2009) Shotaro Suzuki et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Dose-Related Neuroprotective versus Neurodamaging Effects of Estrogens in Rat Cerebral Ischemia: A Systematic Analysis

(2009) Jakob O Strom et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia

(2009) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Combined 17β-Oestradiol and Progesterone Treatment Prevents Neuronal Cell Injury in Cortical but not Midbrain Neurones or Neuroblastoma Cells

(2009) L. Lorenz et al.   JOURNAL OF NEUROENDOCRINOLOGY

Essential Role of Cytoplasmic cdk5 and Prx2 in Multiple Ischemic Injury Models, In Vivo

(2009) J. Rashidian et al.   JOURNAL OF NEUROSCIENCE

Estrogen Attenuates Ischemic Oxidative Damage via an Estrogen Receptor  -Mediated Inhibition of NADPH Oxidase Activation

(2009) Q.-G. Zhang et al.   JOURNAL OF NEUROSCIENCE

Estrogen and Stroke

(2009) Erin Carwile et al.   JOURNAL OF NEUROSCIENCE NURSING

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Direct activation of protein kinases by unanchored polyubiquitin chains

(2009) Zong-Ping Xia et al.   NATURE

Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm

(2009) Prateek Kumar et al.   Nature Protocols

Sex, Sex Steroids, and Brain Injury

(2009) Paco Herson et al.   SEMINARS IN REPRODUCTIVE MEDICINE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Progestin Receptor Subtypes in the Brain: The Known and the Unknown

(2008) Shaila Mani   ENDOCRINOLOGY

Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

(2008) Sung-Chun Tang et al.   EXPERIMENTAL NEUROLOGY

Progesterone receptors: Form and function in brain

(2008) Roberta Diaz Brinton et al.   FRONTIERS IN NEUROENDOCRINOLOGY

A novel method to establish microglia-free astrocyte cultures: Comparison of matrix metalloproteinase expression profiles in pure cultures of astrocytes and microglia

(2008) Stephen J. Crocker et al.   GLIA

Progesterone and its Metabolite Allopregnanolone Differentially Regulate Hemostatic Proteins after Traumatic Brain Injury

(2008) Jacob W VanLandingham et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Brain-Region-Specific Astroglial Responses In Vitro After LPS Exposure

(2008) Markus Kipp et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Progesterone Receptor Inhibits Aromatase and Inflammatory Response Pathways in Breast Cancer Cells via Ligand-Dependent and Ligand-Independent Mechanisms

(2008) Daniel B. Hardy et al.   MOLECULAR ENDOCRINOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

(2008) Ulkan Kilic et al.   NEUROBIOLOGY OF DISEASE

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE

Inflammation and the Emerging Role of the Toll-Like Receptor System in Acute Brain Ischemia

(2008) B. J. Marsh et al.   STROKE

Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases

(2007) B MARSH et al.   CURRENT OPINION IN PHARMACOLOGY