Potential molecular targets of peroxynitrite in mediating blood–brain barrier damage and haemorrhagic transformation in acute ischaemic stroke with delayed tissue plasminogen activator treatment

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

(2018) Han-sen Chen et al.   ACTA PHARMACOLOGICA SINICA

Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis

(2018) Tatsuya Fukuta et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Improved Reperfusion and Vasculoprotection by the Poly(ADP-Ribose)Polymerase Inhibitor PJ34 After Stroke and Thrombolysis in Mice

(2018) Mohamad El Amki et al.   MOLECULAR NEUROBIOLOGY

Early Treatment with Poly(ADP-Ribose) Polymerase-1 Inhibitor (JPI-289) Reduces Infarct Volume and Improves Long-Term Behavior in an Animal Model of Ischemic Stroke

(2018) Youngchul Kim et al.   MOLECULAR NEUROBIOLOGY

Reactive nitrogen species as therapeutic targets for autophagy: implication for ischemic stroke

(2017) Jinghan Feng et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke

(2017) Tatsuya Fukuta et al.   FASEB JOURNAL

Adjunctive Therapy Approaches for Ischemic Stroke: Innovations to Expand Time Window of Treatment

(2017) Talia Knecht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Strategies to Attenuate Hemorrhagic Transformation After Tissue Plasminogen Activator Treatment for Acute Ischemic Stroke

(2017) Masato Kanazawa et al.   Journal of Atherosclerosis and Thrombosis

Role of glycogen synthase kinase 3 in ischemia-induced blood-brain barrier disruption in aged female rats

(2017) Han Xiao et al.   JOURNAL OF NEUROCHEMISTRY

Peroxynitrite-Induced Tyrosine Nitration Contributes to Matrix Metalloprotease-3 Activation: Relevance to Hyperglycemic Ischemic Brain Injury and Tissue Plasminogen Activator

(2017) Sherif Hafez et al.   NEUROCHEMICAL RESEARCH

Salvianolic acid A inhibits calpain activation and eNOS uncoupling during focal cerebral ischemia in mice

(2017) Qaisar Mahmood et al.   PHYTOMEDICINE

12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke

(2017) Yu Liu et al.   STROKE

Toll-Like Receptor 4 Mediates Hemorrhagic Transformation After Delayed Tissue Plasminogen Activator Administration in In Situ Thromboembolic Stroke

(2017) Alicia García-Culebras et al.   STROKE

Annexin A2 Plus Low-Dose Tissue Plasminogen Activator Combination Attenuates Cerebrovascular Dysfunction After Focal Embolic Stroke of Rats

(2017) Xiang Fan et al.   Translational Stroke Research

Worse Outcome in Stroke Patients Treated with rt-PA Without Early Reperfusion: Associated Factors

(2017) Ramón Iglesias-Rey et al.   Translational Stroke Research

Stroke Cytoprotection: Can Repeating History with New Expectations Really Be the Path to Success in Stroke Research?

(2017) Paul A. Lapchak et al.   Translational Stroke Research

Sodium Tanshinone IIA Sulfonate Enhances Effectiveness Rt-PA Treatment in Acute Ischemic Stroke Patients Associated with Ameliorating Blood-Brain Barrier Damage

(2017) Biying Ji et al.   Translational Stroke Research

Diabetes Worsens Functional Outcomes in Young Female Rats: Comparison of Stroke Models, Tissue Plasminogen Activator Effects, and Sexes

(2017) Weiguo Li et al.   Translational Stroke Research

Translational Stroke Research Guideline Projections: The 20/20 Standards

(2017) Paul A. Lapchak et al.   Translational Stroke Research

Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats

(2017) Hongfei Sang et al.   Translational Stroke Research

Baicalin Attenuates Blood-Brain Barrier Disruption and Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke Rats with Delayed t-PA Treatment: Involvement of ONOO−-MMP-9 Pathway

(2017) Hansen Chen et al.   Translational Stroke Research

The Role of Astrocytes in Neuroprotection after Brain Stroke: Potential in Cell Therapy

(2017) Andrea Becerra-Calixto et al.   Frontiers in Molecular Neuroscience

Strategies to Extend Thrombolytic Time Window for Ischemic Stroke Treatment: An Unmet Clinical Need

(2017) Ike dela Peña et al.   Journal of Stroke

HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease

(2017) Varun Chandrashekaran et al.   Redox Biology

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

(2016) Tao Pang et al.   ACTA PHARMACOLOGICA SINICA

RhoA/rock signaling mediates peroxynitrite-induced functional impairment of Rat coronary vessels

(2016) Zhijun Sun et al.   BMC Cardiovascular Disorders

One-Compound-Multi-Target: Combination Prospect of Natural Compounds with Thrombolytic Therapy in Acute Ischemic Stroke

(2016) Han-Sen Chen et al.   Current Neuropharmacology

Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death

(2016) Lei Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glycogen Synthase Kinase 3β Influences Injury Following Cerebral Ischemia/Reperfusion in Rats

(2016) Yixin Li et al.   International Journal of Biological Sciences

Uric acid therapy improves the outcomes of stroke patients treated with intravenous tissue plasminogen activator and mechanical thrombectomy

(2016) Ángel Chamorro et al.   International Journal of Stroke

Temporal analysis of blood–brain barrier disruption and cerebrospinal fluid matrix metalloproteinases in rhesus monkeys subjected to transient ischemic stroke

(2016) Yingqian Zhang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

(2016) William N Whiteley et al.   LANCET NEUROLOGY

GSK3β inhibition protects the immature brain from hypoxic-ischaemic insult via reduced STAT3 signalling

(2016) Barbara D'Angelo et al.   NEUROPHARMACOLOGY

The role of connexin43 in hemorrhagic transformation after thrombolysis in vivo and in vitro

(2016) Xiaobo Yang et al.   NEUROSCIENCE

Release of Matrix Metalloproteinases-2 and 9 by S-Nitrosylated Caveolin-1 Contributes to Degradation of Extracellular Matrix in tPA-Treated Hypoxic Endothelial Cells

(2016) Haoming Song et al.   PLoS One

Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke

(2016) Zhongwu Liu et al.   PROGRESS IN NEUROBIOLOGY

A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues

(2016) Tao Peng et al.   Chemical Science

Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice

(2016) Carles Justicia et al.   Translational Stroke Research

Extending the Time Window for Endovascular and Pharmacological Reperfusion

(2016) Nils Henninger et al.   Translational Stroke Research

Increased 12/15-Lipoxygenase Leads to Widespread Brain Injury Following Global Cerebral Ischemia

(2016) Kazim Yigitkanli et al.   Translational Stroke Research

Impaired vascular function in sepsis-surviving rats mediated by oxidative stress and Rho-Kinase pathway

(2016) Priscila de Souza et al.   Redox Biology

Pros and Cons of Current Approaches for Detecting Peroxynitrite and Their Applications

(2016) Xingmiao Chen et al.   Biomedical Journal

NADPH Oxidase–Derived Peroxynitrite Drives Inflammation in Mice and Human Nonalcoholic Steatohepatitis via TLR4-Lipid Raft Recruitment

(2015) Suvarthi Das et al.   AMERICAN JOURNAL OF PATHOLOGY

The Angiotensin-Converting Enzyme 2/Angiotensin (1–7)/Mas Axis Protects Against Lung Fibroblast Migration and Lung Fibrosis by Inhibiting the NOX4-Derived ROS-Mediated RhoA/Rho Kinase Pathway

(2015) Ying Meng et al.   ANTIOXIDANTS & REDOX SIGNALING

Protection of the brain following cerebral ischemia through the attenuation of PARP-1-induced neurovascular unit damage in rats

(2015) Ruixue Zhang et al.   BRAIN RESEARCH

Matrix metalloproteinases as therapeutic targets for stroke

(2015) Yi Yang et al.   BRAIN RESEARCH

S-nitrosoglutathione reduces tau hyper-phosphorylation and provides neuroprotection in rat model of chronic cerebral hypoperfusion

(2015) Je-Seong Won et al.   BRAIN RESEARCH

Peroxynitrite Decomposition Catalyst Reduces Delayed Thrombolysis-induced Hemorrhagic Transformation in Ischemia-reperfused Rat Brains

(2015) Han-Sen Chen et al.   CNS Neuroscience & Therapeutics

Bryostatin extends tPA time window to 6h following middle cerebral artery occlusion in aged female rats

(2015) Zhenjun Tan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Serum Uric Acid Is Neuroprotective in Chinese Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator

(2015) Xuan Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Serum Uric Acid Levels and Outcomes After Acute Ischemic Stroke

(2015) Zhongchao Wang et al.   MOLECULAR NEUROBIOLOGY

GSK-3β inhibitor TWS119 attenuates rtPA-induced hemorrhagic transformation and activates the Wnt/β-catenin signaling pathway after acute ischemic stroke in rats

(2015) Wei Wang et al.   MOLECULAR NEUROBIOLOGY

The role of uric acid as a potential neuroprotectant in acute ischemic stroke: a review of literature

(2015) Rong Li et al.   NEUROLOGICAL SCIENCES

Momordica charantia polysaccharides could protect against cerebral ischemia/reperfusion injury through inhibiting oxidative stress mediated c-Jun N-terminal kinase 3 signaling pathway

(2015) Juanjuan Gong et al.   NEUROPHARMACOLOGY

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats

(2015) R. Ding et al.   NEUROSCIENCE

Serum Uric Acid Is Neuroprotective in Chinese Patients with Acute Ischemic Stroke Treated with Intravenous Recombinant Tissue Plasminogen Activator

(2015) Xuan Liu et al.   Journal of Stroke & Cerebrovascular Diseases

Correlation between MMP-9 and extracellular cytokine HMGB1 in prediction of human ischemic stroke outcome

(2014) Nelly Sapojnikova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Fasudil Hydrochloride Protects Neurons in Rat Hippocampal CA1 Region through Inhibiting GluR6–MLK3–JNKs Signal Pathway

(2014) Xiu-E Wei et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Glycogen Synthase Kinase-β3 in Ischemic Neuronal Death

(2014) Pradeep Hanumanthappa et al.   CURRENT NEUROVASCULAR RESEARCH

Inhibition of Src phosphorylation reduces damage to the blood-brain barrier following transient focal cerebral ischemia in rats

(2014) YONGSHENG BAI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Calycosin-7-O-β-d-glucoside regulates nitric oxide /caveolin-1/matrix metalloproteinases pathway and protects blood–brain barrier integrity in experimental cerebral ischemia–reperfusion injury

(2014) Shuping Fu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Inhibition of Rho-kinase protects cerebral barrier from ischaemia-evoked injury through modulations of endothelial cell oxidative stress and tight junctions

(2014) Claire L. Gibson et al.   JOURNAL OF NEUROCHEMISTRY

Herbal Medicines for Ischemic Stroke: Combating Inflammation as Therapeutic Targets

(2014) Yong Gu et al.   Journal of Neuroimmune Pharmacology

Toll-Like Receptors and Ischemic Brain Injury

(2014) Raffaella Gesuete et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Estradiol and Progesterone Administration After pMCAO Stimulates the Neurological Recovery and Reduces the Detrimental Effect of Ischemia Mainly in Hippocampus

(2014) Maria Jose Perez-Alvarez et al.   MOLECULAR NEUROBIOLOGY

Src regulates angiogenic factors and vascular permeability after focal cerebral ischemia–reperfusion

(2014) L. Zan et al.   NEUROSCIENCE

Baicalin Inhibits High-Mobility Group Box 1 Release and Improves Survival in Experimental Sepsis

(2014) Hongling Wang et al.   SHOCK

Effect of HMGB1 on the Paracrine Action of EPC Promotes Post-Ischemic Neovascularization in Mice

(2014) Chao Chen et al.   STEM CELLS

Redox Modulation of HMGB1-Related Signaling

(2013) Christina Janko et al.   ANTIOXIDANTS & REDOX SIGNALING

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Pyruvate minimizes rtPA toxicity from in vitro oxygen-glucose deprivation and reoxygenation

(2013) Myoung-Gwi Ryou et al.   BRAIN RESEARCH

Acute hyperglycemia worsens ischemic stroke-induced brain damage via high mobility group box-1 in rats

(2013) Jingyang Huang et al.   BRAIN RESEARCH

Prevention of rt-PA induced blood–brain barrier component degradation by the poly(ADP-ribose)polymerase inhibitor PJ34 after ischemic stroke in mice

(2013) Fei Teng et al.   EXPERIMENTAL NEUROLOGY

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Hemorrhagic Transformation after Ischemic Stroke in Animals and Humans

(2013) Glen C Jickling et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury

(2013) Mingjing Xu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression

(2013) Ying-Na Li et al.   JOURNAL OF NEUROCHEMISTRY

MMP-9 Inhibition: a Therapeutic Strategy in Ischemic Stroke

(2013) Mayank Chaturvedi et al.   MOLECULAR NEUROBIOLOGY

Inhibition of Glycogen Synthase Kinase 3β Promotes Tight Junction Stability in Brain Endothelial Cells by Half-Life Extension of Occludin and Claudin-5

(2013) Servio H. Ramirez et al.   PLoS One

Activated Protein C Analog Protects From Ischemic Stroke and Extends the Therapeutic Window of Tissue-Type Plasminogen Activator in Aged Female Mice and Hypertensive Rats

(2013) Yaoming Wang et al.   STROKE

Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury

(2012) Xing-miao Chen et al.   ACTA PHARMACOLOGICA SINICA

Pathobiology of injury after stroke: the neurovascular unit and beyond

(2012) Ulrich Dirnagl   Annals of the New York Academy of Sciences

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

(2012) B. Niego et al.   BLOOD

Rho-Kinase Inhibitor, Fasudil, Prevents Neuronal Apoptosis via the Akt Activation and PTEN Inactivation in the Ischemic Penumbra of Rat Brain

(2012) Jianhua Wu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Enhanced Cerebral but Not Peripheral Angiogenesis in the Goto-Kakizaki Model of Type 2 Diabetes Involves VEGF and Peroxynitrite Signaling

(2012) R. Prakash et al.   DIABETES

Combined therapy with PJ34, a poly(ADP-ribose)polymerase inhibitor, reduces tissue plasminogen activator-induced hemorrhagic transformations in cerebral ischemia in mice

(2012) Marianne Haddad et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Strong neuroprotection with a novel platinum nanoparticle against ischemic stroke- and tissue plasminogen activator-related brain damages in mice

(2012) M. Takamiya et al.   NEUROSCIENCE

A broad-spectrum matrix metalloproteinase inhibitor prevents hemorrhagic complications induced by tissue plasminogen activator in mice

(2012) K. Mishiro et al.   NEUROSCIENCE

A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator

(2012) M. Ishiguro et al.   NEUROSCIENCE

Tissue plasminogen activator treatment of stroke in type-1 diabetes rats

(2012) R. Ning et al.   NEUROSCIENCE

Astrocytic high-mobility group box 1 promotes endothelial progenitor cell-mediated neurovascular remodeling during stroke recovery

(2012) K. Hayakawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Activated Protein C Analog With Reduced Anticoagulant Activity Extends the Therapeutic Window of Tissue Plasminogen Activator for Ischemic Stroke in Rodents

(2012) Yaoming Wang et al.   STROKE

The neurovascular unit and combination treatment strategies for stroke

(2012) Li Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Recommendations for Preclinical Research in Hemorrhagic Transformation

(2012) Susan C. Fagan et al.   Translational Stroke Research

GSK-3β inhibitors suppressed neuroinflammation in rat cortex by activating autophagy in ischemic brain injury

(2011) Xiaogang Zhou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia

(2011) Yasuhiro Egi et al.   BRAIN RESEARCH

MP-124, a novel poly(ADP-ribose) polymerase-1 (PARP-1) inhibitor, ameliorates ischemic brain damage in a non-human primate model

(2011) Shigeru Matsuura et al.   BRAIN RESEARCH

Oxidative species increase arginase activity in endothelial cells through the RhoA/Rho kinase pathway

(2011) S Chandra et al.   BRITISH JOURNAL OF PHARMACOLOGY

Long-lasting neuroprotection and neurological improvement in stroke models with new, potent and brain permeable inhibitors of poly(ADP-ribose) polymerase

(2011) F Moroni et al.   BRITISH JOURNAL OF PHARMACOLOGY

HMGB1 Increases Permeability of the Endothelial Cell Monolayer via RAGE and Src Family Tyrosine Kinase Pathways

(2011) Wenchang Huang et al.   INFLAMMATION

Inhibition of VEGF signaling pathway attenuates hemorrhage after tPA treatment

(2011) Masato Kanazawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Caveolin-1 regulates nitric oxide-mediated matrix metalloproteinases activity and blood-brain barrier permeability in focal cerebral ischemia and reperfusion injury

(2011) Yong Gu et al.   JOURNAL OF NEUROCHEMISTRY

Glycogen synthase kinase-3 inhibition reduces ischemic cerebral damage, restores impaired mitochondrial biogenesis and prevents ROS production

(2011) Alessandra Valerio et al.   JOURNAL OF NEUROCHEMISTRY

Toll-like receptors in cerebral ischemic inflammatory injury

(2011) Yan-Chun Wang et al.   Journal of Neuroinflammation

Protein kinase C mediates peroxynitrite toxicity to oligodendrocytes

(2011) Shihe Li et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

17β-estradiol attenuates breakdown of blood–brain barrier and hemorrhagic transformation induced by tissue plasminogen activator in cerebral ischemia

(2011) Mingchang Li et al.   NEUROBIOLOGY OF DISEASE

Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: Correlations with angiogenesis and cerebral edema

(2011) Likun Zan et al.   NEUROCHEMISTRY INTERNATIONAL

Anti-high Mobility Group Box-1 Monoclonal Antibody Protects the Blood–Brain Barrier From Ischemia-Induced Disruption in Rats

(2011) Jiyong Zhang et al.   STROKE

Etoposide Reduces Peroxynitrite-Induced Cytotoxicity via Direct Scavenging Effect

(2011) In-Young Choi et al.   Experimental Neurobiology

High-Mobility Group Box 1, Oxidative Stress, and Disease

(2010) Daolin Tang et al.   ANTIOXIDANTS & REDOX SIGNALING

Lentivirus-mediated transfer of MMP-9 shRNA provides neuroprotection following focal ischemic brain injury in rats

(2010) Qin Hu et al.   BRAIN RESEARCH

Peroxynitrite induces HMGB1 release by cardiac cells in vitro and HMGB1 upregulation in the infarcted myocardium in vivo

(2010) N. Loukili et al.   CARDIOVASCULAR RESEARCH

RhoA/Rho-kinase and vascular diseases: what is the link?

(2010) Kenia Pedrosa Nunes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Linking oxidative stress to inflammation: Toll-like receptors

(2010) Roop Gill et al.   FREE RADICAL BIOLOGY AND MEDICINE

Src redox regulation: Again in the front line

(2010) Elisa Giannoni et al.   FREE RADICAL BIOLOGY AND MEDICINE

The perivascular astroglial sheath provides a complete covering of the brain microvessels: An electron microscopic 3D reconstruction

(2010) Thomas Misje Mathiisen et al.   GLIA

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Matrix Metalloproteinase-9 Mediates Hypoxia-Induced Vascular Leakage in the Brain via Tight Junction Rearrangement

(2010) Alexander T Bauer et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice

(2010) Kazuhide Hayakawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

HMBG1 Mediates Ischemia—Reperfusion Injury by TRIF-Adaptor Independent Toll-Like Receptor 4 Signaling

(2010) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Peroxynitrite decomposition catalyst prevents matrix metalloproteinase activation and neurovascular injury after prolonged cerebral ischemia in rats

(2010) Yalikun Suofu et al.   JOURNAL OF NEUROCHEMISTRY

Matrix Metalloproteinase-9 as a Marker for Acute Ischemic Stroke: A Systematic Review

(2010) Maria Ramos-Fernandez et al.   Journal of Stroke & Cerebrovascular Diseases

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury

(2010) M. Lv et al.   NEUROSCIENCE

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells

(2010) D Tang et al.   ONCOGENE

Reactive oxygen species signaling in pulmonary vascular smooth muscle

(2010) Francisco Perez-Vizcaino et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

High-Mobility Group Box 1 Promotes Metalloproteinase-9 Upregulation Through Toll-Like Receptor 4 After Cerebral Ischemia

(2010) Jianhua Qiu et al.   STROKE

Blood-brain barrier breakdown and repair by Src after thrombin-induced injury

(2009) Da-Zhi Liu et al.   ANNALS OF NEUROLOGY

Role of Nrf2-mediated heme oxygenase-1 upregulation in adaptive survival response to nitrosative stress

(2009) Young-Joon Surh et al.   ARCHIVES OF PHARMACAL RESEARCH

Oxidation of the alarmin high-mobility group box 1 protein (HMGB1) during apoptosis

(2009) Vilma Urbonaviciute et al.   AUTOIMMUNITY

Tissue-type plasminogen activator (t-PA) induces stromelysin-1 (MMP-3) in endothelial cells through activation of lipoprotein receptor-related protein

(2009) Y. Suzuki et al.   BLOOD

Dissociation and Protection of the Neurovascular Unit after Thrombolysis and Reperfusion in Ischemic Rat Brain

(2009) Toru Yamashita et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of Src Activity Decreases Tyrosine Phosphorylation of Occludin in Brain Capillaries and Attenuates Increase in Permeability of the Blood-Brain Barrier after Transient Focal Cerebral Ischemia

(2009) Yuji Takenaga et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High-Mobility Group Protein Box-1 and its Relevance to Cerebral Ischemia

(2009) Qing-Wu Yang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The neurovascular unit in the setting of stroke

(2009) G. J. del Zoppo   JOURNAL OF INTERNAL MEDICINE

Course of matrix metalloproteinase-9 isoforms after the administration of uric acid in patients with acute stroke

(2009) Sergio Amaro et al.   JOURNAL OF NEUROLOGY

The Free Radical Scavenger Edaravone Rescues Rats from Cerebral Infarction by Attenuating the Release of High-Mobility Group Box-1 in Neuronal Cells

(2009) K. Kikuchi et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reactive oxygen species mediate RhoA/Rho kinase-induced Ca2+ sensitization in pulmonary vascular smooth muscle following chronic hypoxia

(2008) Nikki L. Jernigan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Inhibition of GSK-3 reduces infarct volume and improves neurobehavioral functions

(2008) Seong-Ho Koh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Role of inducible nitric oxide synthase in induction of RhoA expression in hearts from diabetic rats

(2008) Hesham Soliman et al.   CARDIOVASCULAR RESEARCH

Structure and dynamic regulation of Src-family kinases

(2008) J. R. Engen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Neuroprotective Potential of Fasudil Mesylate in Brain Ischemia-Reperfusion Injury of Rats

(2008) Qin Li et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Reduction of hemorrhagic transformation by PJ34, a poly(ADP-ribose)polymerase inhibitor, after permanent focal cerebral ischemia in mice

(2008) Marianne Haddad et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model

(2008) Qin Hu et al.   EXPERIMENTAL NEUROLOGY

Oxidative stress-induced disruption of epithelial and endothelial tight junctions

(2008) Radhakrishna Rao   Frontiers in Bioscience-Landmark

The HMGB1 Receptor RAGE Mediates Ischemic Brain Damage

(2008) S. Muhammad et al.   JOURNAL OF NEUROSCIENCE

Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke

(2008) Enming J Su et al.   NATURE MEDICINE

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

(2008) Da-Zhi Liu et al.   NEUROBIOLOGY OF DISEASE

Accumulation of beta-amyloid in the brain microvessels accompanies increased hyperphosphorylated tau proteins following microsphere embolism in aged rats

(2008) F. Han et al.   NEUROSCIENCE

TREATMENT WITH THE GLYCOGEN SYNTHASE KINASE-3β INHIBITOR, TDZD-8, AFFECTS TRANSIENT CEREBRAL ISCHEMIA/REPERFUSION INJURY IN THE RAT HIPPOCAMPUS

(2008) Massimo Collino et al.   SHOCK

Reperfusion-Associated Hemorrhagic Transformation in SHR Rats

(2008) Erica C. Henning et al.   STROKE

Extension of the Thrombolytic Time Window With Minocycline in Experimental Stroke

(2008) Yoshihiro Murata et al.   STROKE

MMP-9–Positive Neutrophil Infiltration Is Associated to Blood–Brain Barrier Breakdown and Basal Lamina Type IV Collagen Degradation During Hemorrhagic Transformation After Human Ischemic Stroke

(2008) Anna Rosell et al.   STROKE

Edaravone, a Free Radical Scavenger, Inhibits MMP-9–Related Brain Hemorrhage in Rats Treated With Tissue Plasminogen Activator

(2008) Kenji Yagi et al.   STROKE

Induction and subcellular localization of high-mobility group box–1 (HMGB1) in the postischemic rat brain

(2007) Jung-Bin Kim et al.   JOURNAL OF NEUROSCIENCE RESEARCH