Microglial activation in stroke: Therapeutic targets

Glutamate induces neurotrophic factor production from microglia via protein kinase C pathway

(2010) Jianfeng Liang et al.   BRAIN RESEARCH

A Telestroke Network Enhances Recruitment into Acute Stroke Clinical Trials

(2010) Jeffrey A. Switzer et al.   STROKE

Role of SIRT1 in regulation of LPS- or two ethanol metabolites-induced TNF-α production in cultured macrophage cell lines

(2009) Zheng Shen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of metabotropic glutamate receptor 5 improves recovery after spinal cord injury in rodents

(2009) Kimberly R. Byrnes et al.   ANNALS OF NEUROLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

TREM-2 (triggering receptor expressed on myeloid cells 2) is a phagocytic receptor for bacteria

(2009) Elsa-Noah N'Diaye et al.   JOURNAL OF CELL BIOLOGY

Inhibition of Poly(ADP-Ribose) Polymerase Suppresses Inflammation and Promotes Recovery after Ischemic Injury

(2009) Tiina M Kauppinen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion

(2009) Hai Chen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice

(2009) Fangfang Yin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An engineered CX3CR1 antagonist endowed with anti-inflammatory activity

(2009) Karim Dorgham et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Microglial phagocytosis attenuated by short-term exposure to exogenous ATP through P2X7receptor action

(2009) Kuan-Min Fang et al.   JOURNAL OF NEUROCHEMISTRY

Toll-like receptor 4 is involved in neuroprotection afforded by ischemic preconditioning

(2009) Jesús M. Pradillo et al.   JOURNAL OF NEUROCHEMISTRY

A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia

(2009) Christine L. Hsieh et al.   JOURNAL OF NEUROCHEMISTRY

The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor

(2009) Luisa Stefano et al.   JOURNAL OF NEUROCHEMISTRY

The P2X7 Receptor Drives Microglial Activation and Proliferation: A Trophic Role for P2X7R Pore

(2009) M. Monif et al.   JOURNAL OF NEUROSCIENCE

Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

(2009) B. Marsh et al.   JOURNAL OF NEUROSCIENCE

Pyruvate protects against experimental stroke via an anti-inflammatory mechanism

(2009) Qing Wang et al.   NEUROBIOLOGY OF DISEASE

Doxycycline inhibits matrix metalloproteinase-9 and laminin degradation after transient global cerebral ischemia

(2009) Hyung Lee et al.   NEUROBIOLOGY OF DISEASE

Nicotinamide Prevents NAD+ Depletion and Protects Neurons Against Excitotoxicity and Cerebral Ischemia: NAD+ Consumption by SIRT1 may Endanger Energetically Compromised Neurons

(2009) Dong Liu et al.   NEUROMOLECULAR MEDICINE

Resveratrol pretreatment protects rat brain from cerebral ischemic damage via a sirtuin 1–uncoupling protein 2 pathway

(2009) D. Della-Morte et al.   NEUROSCIENCE

Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury

(2009) W. Peng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of PGE2 receptors in models of neurological disease

(2009) Katrin Andreasson   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

Inhibition of nitric oxide production by the carbazole compound LCY-2-CHO via blockade of activator protein-1 and CCAAT/enhancer-binding protein activation in microglia

(2008) Ling-Chu Chang et al.   BIOCHEMICAL PHARMACOLOGY

Possible Involvement of P2X7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats

(2008) Daijiro Yanagisawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Therapeutic Targets in Prostaglandin E2 Signaling for Neurologic Disease

(2008) P. Cimino et al.   CURRENT MEDICINAL CHEMISTRY

Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation

(2008) W Lee Kraus   CURRENT OPINION IN CELL BIOLOGY

Inflammation as Therapeutic Objective in Stroke

(2008) Joaquin Jordan et al.   CURRENT PHARMACEUTICAL DESIGN

Blockade of microglial glutamate release protects against ischemic brain injury

(2008) Hideyuki Takeuchi et al.   EXPERIMENTAL NEUROLOGY

TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia

(2008) Espen J. Walker et al.   EXPERIMENTAL NEUROLOGY

Metabotropic glutamate receptor 5 activation inhibits microglial associated inflammation and neurotoxicity

(2008) Kimberly R. Byrnes et al.   GLIA

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

(2008) Ádám Dénes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation

(2008) Nirmal K. Phulwani et al.   JOURNAL OF NEUROCHEMISTRY

Myelin-induced microglial neurotoxicity can be controlled by microglial metabotropic glutamate receptors

(2008) Fleur Pinteaux-Jones et al.   JOURNAL OF NEUROCHEMISTRY

A Vicious Cycle Involving Release of Heat Shock Protein 60 from Injured Cells and Activation of Toll-Like Receptor 4 Mediates Neurodegeneration in the CNS

(2008) S. Lehnardt et al.   JOURNAL OF NEUROSCIENCE

Zinc Triggers Microglial Activation

(2008) T. M. Kauppinen et al.   JOURNAL OF NEUROSCIENCE

TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

(2008) Ulkan Kilic et al.   NEUROBIOLOGY OF DISEASE

Neuroprotection for ischemic stroke: Past, present and future

(2008) Myron D. Ginsberg   NEUROPHARMACOLOGY

Apocynin improves outcome in experimental stroke with a narrow dose range

(2008) X.N. Tang et al.   NEUROSCIENCE

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

(2008) E. Candelario-Jalil et al.   NEUROSCIENCE

Luteolin reduces IL-6 production in microglia by inhibiting JNK phosphorylation and activation of AP-1

(2008) S. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Glial Cell Functions by PPAR- Natural and Synthetic Agonists

(2008) Antonietta Bernardo et al.   PPAR Research

Neuroprotective effects of the selective type 1 metabotropic glutamate receptor antagonist YM-202074 in rat stroke models

(2007) Atsuyuki Kohara et al.   BRAIN RESEARCH