Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

Organ- and cell-specific immune responses are associated with the outcomes of intracerebral hemorrhage

(2018) Jing Zhang et al.   FASEB JOURNAL

Stroke-induced immunosuppression and poststroke infection

(2018) Kaibin Shi et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations

(2017) Qiang Liu et al.   IMMUNITY

Rationale and design of combination of an immune modulator Fingolimod with Alteplase bridging with Mechanical Thrombectomy in Acute Ischemic Stroke (FAMTAIS) trial

(2017) Sheng Zhang et al.   International Journal of Stroke

Absent Filling of Ipsilateral Superficial Middle Cerebral Vein Is Associated With Poor Outcome After Reperfusion Therapy

(2017) Sheng Zhang et al.   STROKE

Fingolimod (FTY720) Reduces Cortical Infarction and Neurological Deficits During Ischemic Stroke Through Potential Maintenance of Microvascular Patency

(2016) Michael K. Schuhmann et al.   CURRENT NEUROVASCULAR RESEARCH

European Cooperative Acute Stroke Study-4: Extending the time for thrombolysis in emergency neurological deficits ECASS-4: ExTEND

(2016) Hemasse Amiri et al.   International Journal of Stroke

Endovascular thrombectomy after large-vessel ischaemic stroke: a meta-analysis of individual patient data from five randomised trials

(2016) Mayank Goyal et al.   LANCET

How temporal evolution of intracranial collaterals in acute stroke affects clinical outcomes

(2016) Leonard L.L. Yeo et al.   NEUROLOGY

Defining Core and Penumbra in Ischemic Stroke: A Voxel- and Volume-Based Analysis of Whole Brain CT Perfusion

(2016) Yannan Yu et al.   Scientific Reports

Combination of the Immune Modulator Fingolimod With Alteplase in Acute Ischemic StrokeCLINICAL PERSPECTIVE

(2015) Zilong Zhu et al.   CIRCULATION

Future directions of acute ischaemic stroke therapy

(2015) Marc Fisher et al.   LANCET NEUROLOGY

Alteplase versus tenecteplase for thrombolysis after ischaemic stroke (ATTEST): a phase 2, randomised, open-label, blinded endpoint study

(2015) Xuya Huang et al.   LANCET NEUROLOGY

Safety and efficacy of desmoteplase given 3–9 h after ischaemic stroke in patients with occlusion or high-grade stenosis in major cerebral arteries (DIAS-3): a double-blind, randomised, placebo-controlled phase 3 trial

(2015) Gregory W Albers et al.   LANCET NEUROLOGY

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

Randomized Assessment of Rapid Endovascular Treatment of Ischemic Stroke

(2015) Mayank Goyal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiphase CT Angiography: A New Tool for the Imaging Triage of Patients with Acute Ischemic Stroke

(2015) Bijoy K. Menon et al.   RADIOLOGY

Combined Multimodal Computed Tomography Score Correlates With Futile Recanalization After Thrombectomy in Patients With Acute Stroke

(2015) Mariano Espinosa de Rueda et al.   STROKE

Reperfusion Within 6 Hours Outperforms Recanalization in Predicting Penumbra Salvage, Lesion Growth, Final Infarct, and Clinical Outcome

(2015) Tae-Hee Cho et al.   STROKE

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of an immune modulator fingolimod on acute ischemic stroke

(2014) Ying Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fingolimod for the Treatment of Intracerebral Hemorrhage

(2014) Ying Fu et al.   JAMA Neurology

Protocol for the Perfusion and Angiography Imaging Sub-Study of the Third International Stroke Trial (IST-3) of Alteplase Treatment within Six-Hours of Acute Ischemic Stroke

(2013) Joanna M. Wardlaw et al.   International Journal of Stroke

Failure of Collateral Blood Flow is Associated with Infarct Growth in Ischemic Stroke

(2013) Bruce CV Campbell et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

FTY720 Ameliorates Acute Ischemic Stroke in Mice by Reducing Thrombo-Inflammation but Not by Direct Neuroprotection

(2013) Peter Kraft et al.   STROKE

Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation

(2012) F. Langhauser et al.   BLOOD

Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature

(2012) C. Kleinschnitz et al.   BLOOD

A Randomized Trial of Tenecteplase versus Alteplase for Acute Ischemic Stroke

(2012) Mark Parsons et al.   NEW ENGLAND JOURNAL OF MEDICINE

The neurovascular unit and combination treatment strategies for stroke

(2012) Li Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A Multicentre, Randomized, Double-Blinded, Placebo-Controlled Phase III Study to Investigate Extending the Time for Thrombolysis in Emergency Neurological Deficits (EXTEND)

(2011) Henry Ma et al.   International Journal of Stroke

The Benefits of Intravenous Thrombolysis Relate to the Site of Baseline Arterial Occlusion in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET)

(2010) Deidre A. De Silva et al.   STROKE

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

(2009) Muge Yemisci et al.   NATURE MEDICINE

Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment

(2008) G. Stoll et al.   BLOOD

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial

(2008) Stephen M Davis et al.   LANCET NEUROLOGY