Immune Cells After Ischemic Stroke Onset: Roles, Migration, and Target Intervention

The role of KATP channels in cerebral ischemic stroke and diabetes

(2018) Vivian Szeto et al.   ACTA PHARMACOLOGICA SINICA

Peripheral immune cells infiltrate into sites of secondary neurodegeneration after ischemic stroke

(2018) K.A. Jones et al.   BRAIN BEHAVIOR AND IMMUNITY

Ginkgolide K promotes astrocyte proliferation and migration after oxygen-glucose deprivation via inducing protective autophagy through the AMPK/mTOR/ULK1 signaling pathway

(2018) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microglia and macrophages differ in their inflammatory profile after permanent brain ischemia

(2018) Juan G. Zarruk et al.   EXPERIMENTAL NEUROLOGY

Neuronal IL-4Rα modulates neuronal apoptosis and cell viability during the acute phases of cerebral ischemia

(2018) Han Kyu Lee et al.   FEBS Journal

Peroxiredoxin 2 activates microglia by interacting with Toll-like receptor 4 after subarachnoid hemorrhage

(2018) Yue Lu et al.   Journal of Neuroinflammation

Targeted intracerebral delivery of the anti-inflammatory cytokine IL13 promotes alternative activation of both microglia and macrophages after stroke

(2018) Somayyeh Hamzei Taj et al.   Journal of Neuroinflammation

Celastrol treatment protects against acute ischemic stroke-induced brain injury by promoting an IL-33/ST2 axis-mediated microglia/macrophage M2 polarization

(2018) Mei Jiang et al.   Journal of Neuroinflammation

Neutrophil to lymphocyte ratio and early clinical outcomes in patients with acute ischemic stroke

(2018) Sungwook Yu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke

(2018) David T. She et al.   MOLECULAR NEUROBIOLOGY

Axl activation attenuates neuroinflammation by inhibiting the TLR/TRAF/NF-κB pathway after MCAO in rats

(2018) Guangyong Wu et al.   NEUROBIOLOGY OF DISEASE

Stepwise impairment of neural stem cell proliferation and neurogenesis concomitant with disruption of blood-brain barrier in recurrent ischemic stroke

(2018) Ruihe Lin et al.   NEUROBIOLOGY OF DISEASE

Cell Type-Specific Mechanisms in the Pathogenesis of Ischemic Stroke: The Role of Apoptosis Signal-Regulating Kinase 1

(2018) So Yeong Cheon et al.   Oxidative Medicine and Cellular Longevity

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil—Microglia interaction during stroke in vivo

(2018) Jens Neumann et al.   PLoS One

Notch signaling and neuronal death in stroke

(2018) Thiruma V. Arumugam et al.   PROGRESS IN NEUROBIOLOGY

Autophagy in ischemic stroke

(2018) Pei Wang et al.   PROGRESS IN NEUROBIOLOGY

Brain Ischemia Induces Diversified Neuroantigen-Specific T-Cell Responses That Exacerbate Brain Injury

(2018) Wei-Na Jin et al.   STROKE

SCIL-STROKE (Subcutaneous Interleukin-1 Receptor Antagonist in Ischemic Stroke)

(2018) Craig J. Smith et al.   STROKE

Targeting NMDA receptors in stroke: new hope in neuroprotection

(2018) Qiu Jing Wu et al.   Molecular Brain

Role of mTORC1 Controlling Proteostasis after Brain Ischemia

(2018) Maria J. Perez-Alvarez et al.   Frontiers in Neuroscience

Gastrodin Attenuates Bilateral Common Carotid Artery Occlusion-Induced Cognitive Deficits via Regulating Aβ-Related Proteins and Reducing Autophagy and Apoptosis in Rats

(2018) Bo Liu et al.   Frontiers in Pharmacology

Platelet microparticles sustain autophagy-associated activation of neutrophils in systemic sclerosis

(2018) Norma Maugeri et al.   Science Translational Medicine

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging

(2017) Ainhoa Plaza-Zabala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Complex Roles of Microglial Cells in Ischemic Stroke Pathobiology: New Insights and Future Directions

(2017) Revathy Guruswamy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke

(2017) Shuang Chen et al.   Journal of Neuroinflammation

Sulfosuccinimidyl oleate sodium is neuroprotective and alleviates stroke-induced neuroinflammation

(2017) Hiramani Dhungana et al.   Journal of Neuroinflammation

Infiltration and persistence of lymphocytes during late-stage cerebral ischemia in middle cerebral artery occlusion and photothrombotic stroke models

(2017) Yan Feng et al.   Journal of Neuroinflammation

The Subventricular Zone Response to Stroke Is Not a Therapeutic Target of Anti-Nogo-A Immunotherapy

(2017) Daniel J. Shepherd et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Curcumin prevents reperfusion injury following ischemic stroke in rats via inhibition of NF-κB, ICAM-1, MMP-9 and caspase-3 expression

(2017) Wei Li et al.   Molecular Medicine Reports

Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury

(2017) Hee Ra Park et al.   MOLECULAR NEUROBIOLOGY

Past, present and future of preserving and restoring function in the visual system: removing galectin-3 as a promising treatment

(2017) AnaM. Blanco Martinez et al.   Neural Regeneration Research

Lymphocyte-to-monocyte ratio on day 7 is associated with outcomes in acute ischemic stroke

(2017) Min-Gyu Park et al.   NEUROLOGICAL SCIENCES

Pathogenic mechanisms following ischemic stroke

(2017) Seyed Esmaeil Khoshnam et al.   NEUROLOGICAL SCIENCES

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

(2017) Zongjian Liu et al.   Frontiers in Aging Neuroscience

Regulation of Microglia and Macrophage Polarization via Apoptosis Signal-Regulating Kinase 1 Silencing after Ischemic/Hypoxic Injury

(2017) So Yeong Cheon et al.   Frontiers in Molecular Neuroscience

Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke

(2017) Johanna Ruhnau et al.   Journal of Immunology Research

Role of Interleukin-10 in Acute Brain Injuries

(2017) Joshua M. Garcia et al.   Frontiers in Neurology

Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke

(2017) Masataka Nakajima et al.   Molecular Therapy-Methods & Clinical Development

M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain

(2017) Ja Yong Choi et al.   Experimental Neurobiology

Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis

(2017) Sara Brilha et al.   Scientific Reports

Cell therapy centered on IL-1Ra is neuroprotective in experimental stroke

(2016) Bettina Hjelm Clausen et al.   ACTA NEUROPATHOLOGICA

Amelioration of Ischemic Brain Injury in Rats with Human Umbilical Cord Blood Stem Cells: Mechanisms of Action

(2016) Laura L. Hocum Stone et al.   CELL TRANSPLANTATION

Postarrest stalling rather than crawling favors CD8+ over CD4+ T-cell migration across the blood-brain barrier under flow in vitro

(2016) Henriette Rudolph et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Natalizumab: a new therapy for acute ischemic stroke?

(2016) Alba Simats et al.   Expert Review of Neurotherapeutics

ALCAM (CD166) is involved in extravasation of monocytes rather than T cells across the blood–brain barrier

(2016) Ruth Lyck et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Cerebral ischemia-induced angiogenesis is dependent on tumor necrosis factor receptor 1-mediated upregulation of α5β1 and αVβ3 integrins

(2016) Heng Huang et al.   Journal of Neuroinflammation

Monocyte-Derived Macrophages Contribute to Spontaneous Long-Term Functional Recovery after Stroke in Mice

(2016) S. Wattananit et al.   JOURNAL OF NEUROSCIENCE

Recombinant tissue plasminogen activator enhances microparticle release from mouse brain-derived endothelial cells through plasmin

(2016) Marie Garraud et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Activation of Alpha-7 Nicotinic Acetylcholine Receptor Reduces Brain Edema in Mice with Ischemic Stroke and Bone Fracture

(2016) Dingquan Zou et al.   MOLECULAR NEUROBIOLOGY

Th17 Cells Induce Dopaminergic Neuronal Death via LFA-1/ICAM-1 Interaction in a Mouse Model of Parkinson’s Disease

(2016) Zhan Liu et al.   MOLECULAR NEUROBIOLOGY

Astrocytic response to cerebral ischemia is influenced by sex differences and impaired by aging

(2016) Nioka C. Chisholm et al.   NEUROBIOLOGY OF DISEASE

Role of Interleukin-10 (-1082A/G) gene polymorphism with the risk of ischemic stroke: a meta-analysis

(2016) Pradeep Kumar et al.   NEUROLOGICAL RESEARCH

Inhibition of chemokine-like factor 1 improves blood-brain barrier dysfunction in rats following focal cerebral ischemia

(2016) Ling-Lei Kong et al.   NEUROSCIENCE LETTERS

Neuroimmune Response in Ischemic Preconditioning

(2016) Ashley McDonough et al.   Neurotherapeutics

Microglia and Monocyte-Derived Macrophages in Stroke

(2016) Eunhee Kim et al.   Neurotherapeutics

Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity

(2016) Minshu Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-Derived Pentraxin 3 Supports Blood–Brain Barrier Integrity Under Acute Phase of Stroke

(2016) Akihiro Shindo et al.   STROKE

Modeling Ischemic Stroke In Vitro: Status Quo and Future Perspectives

(2016) Paul M. Holloway et al.   STROKE

Natalizumab: a new therapy for acute ischemic stroke?

(2016) Alba Simats et al.   Expert Review of Neurotherapeutics

Role of Homocysteine in the Ischemic Stroke and Development of Ischemic Tolerance

(2016) Ján Lehotský et al.   Frontiers in Neuroscience

IL-1β, TNF-α, and IL-6 levels in gingival fluid and serum of patients with ischemic stroke

(2016) Anna Wytrykowska et al.   Journal of Oral Science

Imaging of Leukocyte Trafficking in Alzheimer’s Disease

(2016) Enrica Pietronigro et al.   Frontiers in Immunology

Inflammation after Ischemic Stroke: The Role of Leukocytes and Glial Cells

(2016) Jong Youl Kim et al.   Experimental Neurobiology

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Interaction of astrocytes and T cells in physiological and pathological conditions

(2015) Luokun Xie et al.   BRAIN RESEARCH

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier

(2015) Michael Abadier et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate Immunity and Inflammation Post-Stroke: An α7-Nicotinic Agonist Perspective

(2015) Silke Neumann et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuronal Interleukin-4 as a Modulator of Microglial Pathways and Ischemic Brain Damage

(2015) X. Zhao et al.   JOURNAL OF NEUROSCIENCE

Inhibition of Peripheral TNF-α and Downregulation of Microglial Activation by Alpha-Lipoic Acid and Etanercept Protect Rat Brain Against Ischemic Stroke

(2015) Ming-Hsiu Wu et al.   MOLECULAR NEUROBIOLOGY

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

miR-Let7A Modulates Autophagy Induction in LPS-Activated Microglia

(2015) Juhyun Song et al.   Experimental Neurobiology

Sublime Microglia: Expanding Roles for the Guardians of the CNS

(2014) Michael W. Salter et al.   CELL

Targeting Microglial Activation in Stroke Therapy: Pharmacological Tools and Gender Effects

(2014) Y. Chen et al.   CURRENT MEDICINAL CHEMISTRY

Antagonists of the Vasopressin V1 Receptor and of the β1-Adrenoceptor Inhibit Cytotoxic Brain Edema in Stroke by Effects on Astrocytes – but the Mechanisms Differ

(2014) Leif Hertz et al.   Current Neuropharmacology

PSGL-1 and E/P-selectins are essential for T-cell rolling in inflamed CNS microvessels but dispensable for initiation of EAE

(2014) Karthik Sathiyanadan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

(2014) Mingjin Jiang et al.   Journal of Neuroinflammation

Antigen Dependently Activated Cluster of Differentiation 8-Positive T Cells Cause Perforin-Mediated Neurotoxicity in Experimental Stroke

(2014) E. Mracsko et al.   JOURNAL OF NEUROSCIENCE

Anti-inflammatory Effect of Tanshinone I in Neuroprotection Against Cerebral Ischemia–Reperfusion Injury in the Gerbil Hippocampus

(2014) Joon Ha Park et al.   NEUROCHEMICAL RESEARCH

Proton-sensitive cation channels and ion exchangers in ischemic brain injury: New therapeutic targets for stroke?

(2014) Tiandong Leng et al.   PROGRESS IN NEUROBIOLOGY

Blocking of α4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice

(2014) Friederike Langhauser et al.   STROKE

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke

(2013) Yi-Lin Cheng et al.   NEUROBIOLOGY OF DISEASE

Lymphocyte-mediated neuroprotection in in vitro models of excitotoxicity involves astrocytic activation and the inhibition of MAP kinase signalling pathways

(2013) Rajeev Shrestha et al.   NEUROPHARMACOLOGY

Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy

(2012) Daniela S. Arroyo et al.   FASEB JOURNAL

Going Against the Tide – How Encephalitogenic T Cells Breach the Blood-Brain Barrier

(2012) Ruth Lyck et al.   JOURNAL OF VASCULAR RESEARCH

Progesterone is neuroprotective against ischemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway

(2012) T. Ishrat et al.   NEUROSCIENCE

Capture, crawl, cross: the T cell code to breach the blood–brain barriers

(2012) Britta Engelhardt et al.   TRENDS IN IMMUNOLOGY

Proliferative and Survival Effects of PUMA Promote Angiogenesis

(2012) Fan Zhang et al.   Cell Reports

Role of ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions

(2011) Igal Ifergan et al.   ANNALS OF NEUROLOGY

Selectin-Mediated Recruitment of Bone Marrow Stromal Cells in the Postischemic Cerebral Microvasculature

(2011) Gokhan Yilmaz et al.   STROKE

Reduced blood brain barrier breakdown in P-selectin deficient mice following transient ischemic stroke: a future therapeutic target for treatment of stroke

(2010) Albert Y Jin et al.   BMC NEUROSCIENCE

Comparison of Immortalized bEnd5 and Primary Mouse Brain Microvascular Endothelial Cells as in vitro Blood–Brain Barrier Models for the Study of T Cell Extravasation

(2010) Oliver Steiner et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-Resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-Brain Barrier Endothelium

(2010) O. Steiner et al.   JOURNAL OF IMMUNOLOGY

Vascular inflammation in central nervous system diseases: adhesion receptors controlling leukocyte-endothelial interactions

(2010) B. Rossi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Elevated levels of soluble P-selectin in mice alter blood-brain barrier function, exacerbate stroke, and promote atherosclerosis

(2009) J. Kisucka et al.   BLOOD

Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-Brain Barrier In Vivo in an Animal Model of Multiple Sclerosis

(2009) Caroline Coisne et al.   JOURNAL OF IMMUNOLOGY

The Activation of P2X7 Receptor Impairs Lysosomal Functions and Stimulates the Release of Autophagolysosomes in Microglial Cells

(2009) T. Takenouchi et al.   JOURNAL OF IMMUNOLOGY

Endothelial basement membrane laminin α5 selectively inhibits T lymphocyte extravasation into the brain

(2009) Chuan Wu et al.   NATURE MEDICINE