Pathogenic mechanisms following ischemic stroke

HMGB1 as a Key Mediator of Immune Mechanisms in Ischemic Stroke

(2016) Vikramjeet Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

(2016) Weifei Zhu et al.   CELL

The Future of Vascular Biology and Medicine

(2016) Scott Kinlay et al.   CIRCULATION

Inflammatory Disequilibrium in Stroke

(2016) Danica Petrovic-Djergovic et al.   CIRCULATION RESEARCH

Location of cerebral atherosclerosis: Why is there a difference between East and West?

(2016) Jong S Kim et al.   International Journal of Stroke

Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke

(2016) V. Singh et al.   JOURNAL OF NEUROSCIENCE

Relation of cerebral vessel disease to Alzheimer's disease dementia and cognitive function in elderly people: a cross-sectional study

(2016) Zoe Arvanitakis et al.   LANCET NEUROLOGY

Neuroprotection by Combined Administration with Maslinic Acid, a Natural Product from Olea europaea, and MK-801 in the Cerebral Ischemia Model

(2016) Yisong Qian et al.   MOLECULES

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

(2016) Corinne Benakis et al.   NATURE MEDICINE

Regulation of therapeutic hypothermia on inflammatory cytokines, microglia polarization, migration and functional recovery after ischemic stroke in mice

(2016) Jin Hwan Lee et al.   NEUROBIOLOGY OF DISEASE

Inflammation and Stroke: An Overview

(2016) Josef Anrather et al.   Neurotherapeutics

Prevalence of Intracranial Atherosclerotic Stenosis Using High-Resolution Magnetic Resonance Angiography in the General Population

(2016) Muhammad Fareed K. Suri et al.   STROKE

Angiogenesis in Ischemic Stroke and Angiogenic Effects of Chinese Herbal Medicine

(2016) Sai-Wang Seto et al.   Journal of Clinical Medicine

Neurovascular Regulation in the Ischemic Brain

(2015) Katherine Jackman et al.   ANTIOXIDANTS & REDOX SIGNALING

Reduced cerebral monocarboxylate transporters and lactate levels by ethanol and normobaric oxygen therapy in severe transient and permanent ischemic stroke

(2015) Xiaokun Geng et al.   BRAIN RESEARCH

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Neuroprotective Mechanisms of Oxygen and Ethanol: A Potential Combination Therapy in Stroke

(2015) Sweena Parmar et al.   CURRENT MEDICINAL CHEMISTRY

Immune interventions in stroke

(2015) Ying Fu et al.   Nature Reviews Neurology

The role of microglia and myeloid immune cells in acute cerebral ischemia

(2015) Corinne Benakis et al.   Frontiers in Cellular Neuroscience

Regulation of Bim in Health and Disease

(2015) Ronit Vogt Sionov et al.   Oncotarget

Microglia and inflammation: conspiracy, controversy or control?

(2014) Adelaide Fernandes et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cause and Mechanisms of Intracranial Atherosclerosis

(2014) Katja Ritz et al.   CIRCULATION

Up-regulation of brain-enrichedmiR-107promotes excitatory neurotoxicity through down-regulation of glutamate transporter-1 expression following ischaemic stroke

(2014) Zhong-Bao Yang et al.   CLINICAL SCIENCE

Door-to-Needle Times for Tissue Plasminogen Activator Administration and Clinical Outcomes in Acute Ischemic Stroke Before and After a Quality Improvement Initiative

(2014) Gregg C. Fonarow et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

miR-134 Regulates Ischemia/Reperfusion Injury-Induced Neuronal Cell Death by Regulating CREB Signaling

(2014) Weidong Huang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

CCR2+Ly6Chi Inflammatory Monocyte Recruitment Exacerbates Acute Disability Following Intracerebral Hemorrhage

(2014) M. D. Hammond et al.   JOURNAL OF NEUROSCIENCE

Therapeutic Effects of Pharmacologically Induced Hypothermia against Traumatic Brain Injury in Mice

(2014) Jin Hwan Lee et al.   JOURNAL OF NEUROTRAUMA

Ischemic neurons recruit natural killer cells that accelerate brain infarction

(2014) Y. Gan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reprogramming the Response to Stroke by Preconditioning

(2014) Susan L. Stevens et al.   STROKE

Novel Humanized Recombinant T Cell Receptor Ligands Protect the Female Brain After Experimental Stroke

(2014) Jie Pan et al.   Translational Stroke Research

Effect of Pulsed Electromagnetic Field (PEMF) on Infarct Size and Inflammation After Cerebral Ischemia in Mice

(2014) Juan Carlos Pena-Philippides et al.   Translational Stroke Research

Remote Ischemic Postconditioning: Harnessing Endogenous Protection in a Murine Model of Vascular Cognitive Impairment

(2014) Mohammad Badruzzaman Khan et al.   Translational Stroke Research

Crosstalk between apoptosis, necrosis and autophagy

(2013) Vassiliki Nikoletopoulou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Factors that determine penumbral tissue loss in acute ischaemic stroke

(2013) Simon Jung et al.   BRAIN

Preconditioning and post-treatment with cobalt chloride in rat model of perinatal hypoxic–ischemic encephalopathy

(2013) Ying Dai et al.   BRAIN & DEVELOPMENT

Reduced apoptosis by combining normobaric oxygenation with ethanol in transient ischemic stroke

(2013) Xiaokun Geng et al.   BRAIN RESEARCH

Gomisin A inhibits lipopolysaccharide-induced inflammatory responses in N9 microglia via blocking the NF-κB/MAPKs pathway

(2013) Xiaoxiao Wang et al.   FOOD AND CHEMICAL TOXICOLOGY

Inhibition of microRNA-181 Reduces Forebrain Ischemia-Induced Neuronal Loss

(2013) Jeong-mi Moon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Spectratype analysis of clonal T cell expansion in murine experimental stroke

(2013) Arthur Liesz et al.   JOURNAL OF NEUROIMMUNOLOGY

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Histamine up-regulates astrocytic glutamate transporter 1 and protects neurons against ischemic injury

(2013) Qi Fang et al.   NEUROPHARMACOLOGY

Ischemic postconditioning protects against focal cerebral ischemia by inhibiting brain inflammation while attenuating peripheral lymphopenia in mice

(2013) S.P. Joo et al.   NEUROSCIENCE

Excitotoxicity and stroke: Identifying novel targets for neuroprotection

(2013) Ted Weita Lai et al.   PROGRESS IN NEUROBIOLOGY

Remote Limb Perconditioning and Postconditioning

(2013) David C. Hess et al.   STROKE

Synergetic Neuroprotection of Normobaric Oxygenation and Ethanol in Ischemic Stroke Through Improved Oxidative Mechanism

(2013) Xiaokun Geng et al.   STROKE

Brain Inflammation and Microglia: Facts and Misconceptions

(2013) Hey-Kyeong Jeong et al.   Experimental Neurobiology

BCL2L11/BIM

(2012) Shouqing Luo et al.   Autophagy

Postischemic Brain Infiltration of Leukocyte Subpopulations Differs among Murine Permanent and Transient Focal Cerebral Ischemia Models

(2012) Wei Zhou et al.   BRAIN PATHOLOGY

A novel stroke therapy of pharmacologically induced hypothermia after focal cerebral ischemia in mice

(2012) Ko-Eun Choi et al.   FASEB JOURNAL

Interleukin-6, a Major Cytokine in the Central Nervous System

(2012) María Erta et al.   International Journal of Biological Sciences

CCL2 upregulation triggers hypoxic preconditioning-induced protection from stroke

(2012) Ann M Stowe et al.   Journal of Neuroinflammation

Toll-like receptor 2 deficiency leads to delayed exacerbation of ischemic injury

(2012) Ivan Bohacek et al.   Journal of Neuroinflammation

The benefits and harms of intravenous thrombolysis with recombinant tissue plasminogen activator within 6 h of acute ischaemic stroke (the third international stroke trial [IST-3]): a randomised controlled trial

(2012)   LANCET

Peroxiredoxin sets the brain on fire after stroke

(2012) Lidia Garcia-Bonilla et al.   NATURE MEDICINE

The immunology of acute stroke

(2012) Ángel Chamorro et al.   Nature Reviews Neurology

Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis

(2012) R. Meng et al.   NEUROLOGY

Myrislignan Attenuates Lipopolysaccharide-induced Inflammation Reaction in Murine Macrophage Cells Through Inhibition of NF-κB Signalling Pathway Activation

(2012) Hong Jin et al.   PHYTOTHERAPY RESEARCH

MicroRNA-223 is neuroprotective by targeting glutamate receptors

(2012) M. M. Harraz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection

(2012) Meijuan Zhang et al.   PROGRESS IN NEUROBIOLOGY

Cellular resolution of inflammation-catabasis

(2012) Alan D. Widgerow   WOUND REPAIR AND REGENERATION

Symptomatic atherosclerosis is associated with an altered gut metagenome

(2012) Fredrik H. Karlsson et al.   Nature Communications

Repetitive hypoxia extends endogenous neurovascular protection for stroke

(2011) Ann M. Stowe et al.   ANNALS OF NEUROLOGY

Toll-like receptors 2 and 4 in ischemic stroke: Outcome and therapeutic values

(2011) David Brea et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Uridine 5'-Diphosphate Induces Chemokine Expression in Microglia and Astrocytes through Activation of the P2Y6 Receptor

(2011) B. Kim et al.   JOURNAL OF IMMUNOLOGY

Nrf2 Expression by Neurons, Astroglia, and Microglia in the Cerebral Cortical Penumbra of Ischemic Rats

(2011) Jon Dang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke

(2011) X. Ren et al.   JOURNAL OF NEUROSCIENCE

Protective conditioning of the brain: expressway or roadblock?

(2011) Philipp Mergenthaler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke

(2011) Alessio Alfieri et al.   JOURNAL OF PHYSIOLOGY-LONDON

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target

(2011) Ashfaq Shuaib et al.   LANCET NEUROLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

Stroke intervention pathways: NMDA receptors and beyond

(2011) Ted Weita Lai et al.   TRENDS IN MOLECULAR MEDICINE

Oxidative Stress and Energy Crises in Neuronal Dysfunction

(2010) David G. Nicholls   Annals of the New York Academy of Sciences

The Nrf2-ARE Pathway

(2010) Jeffrey A. Johnson et al.   Annals of the New York Academy of Sciences

Regulation of Neuronal Oxidative and Nitrosative Stress by Endogenous Protective Pathways and Disease Processes

(2010) Giles E. Hardingham et al.   ANTIOXIDANTS & REDOX SIGNALING

DAPK1 Interaction with NMDA Receptor NR2B Subunits Mediates Brain Damage in Stroke

(2010) Weihong Tu et al.   CELL

Blocking the Deadly Effects of the NMDA Receptor in Stroke

(2010) Henry G.S. Martin et al.   CELL

Nonresolving Inflammation

(2010) Carl Nathan et al.   CELL

Thrombolysis at 3–4.5 Hours after Acute Ischemic Stroke Onset – Evidence from the Canadian Alteplase for Stroke Effectiveness Study (CASES) Registry

(2010) Nandavar Shobha et al.   CEREBROVASCULAR DISEASES

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia

(2010) Lijun Xu et al.   GLIA

Activation of NR2A Receptors Induces Ischemic Tolerance through CREB Signaling

(2010) Yasukazu Terasaki et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Astrocytes in injury states rapidly produce anti-inflammatory factors and attenuate microglial inflammatory responses

(2010) Jong-hyeon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Gender and Stroke Symptoms

(2010) Claudia C. Beal   JOURNAL OF NEUROSCIENCE NURSING

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Fashioning drugs for stroke

(2010) Ted Weita Lai et al.   NATURE MEDICINE

Treatment of cerebral ischemia by disrupting ischemia-induced interaction of nNOS with PSD-95

(2010) Li Zhou et al.   NATURE MEDICINE

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Long-term depression in the CNS

(2010) Graham L. Collingridge et al.   NATURE REVIEWS NEUROSCIENCE

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

(2010) Rong Jin et al.   NEUROBIOLOGY OF DISEASE

miR-497 regulates neuronal death in mouse brain after transient focal cerebral ischemia

(2010) Ke-Jie Yin et al.   NEUROBIOLOGY OF DISEASE

The Science of Stroke: Mechanisms in Search of Treatments

(2010) Michael A. Moskowitz et al.   NEURON

Review: Leucocyte-endothelial cell crosstalk at the blood-brain barrier: A prerequisite for successful immune cell entry to the brain

(2010) J. Greenwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Organization of NMDA receptors at extrasynaptic locations

(2010) R.S. Petralia et al.   NEUROSCIENCE

Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

(2010) K. Hyakkoku et al.   NEUROSCIENCE

Nitric oxide and oxidative stress in vascular disease

(2010) Ulrich Förstermann   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Glutamate Receptor Ion Channels: Structure, Regulation, and Function

(2010) S. F. Traynelis et al.   PHARMACOLOGICAL REVIEWS

The Pattern of Leptomeningeal Collaterals on CT Angiography Is a Strong Predictor of Long-Term Functional Outcome in Stroke Patients With Large Vessel Intracranial Occlusion

(2010) Fabricio O. Lima et al.   STROKE

Microglia: biology and pathology

(2009) Manuel B. Graeber et al.   ACTA NEUROPATHOLOGICA

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

Brain dendritic cells in ischemic stroke: Time course, activation state, and origin

(2009) Jennifer C. Felger et al.   BRAIN BEHAVIOR AND IMMUNITY

The role of CC chemokine receptor 2 on microglia activation and blood-borne cell recruitment after transient focal cerebral ischemia in mice

(2009) Matthias Schilling et al.   BRAIN RESEARCH

Classification of Stroke Subtypes

(2009) P. Amarenco et al.   CEREBROVASCULAR DISEASES

Transient decrease in circulating dendritic cell precursors after acute stroke: potential recruitment into the brain

(2009) Atilla Yilmaz et al.   CLINICAL SCIENCE

Blockade of adrenoreceptors inhibits the splenic response to stroke

(2009) Craig T. Ajmo et al.   EXPERIMENTAL NEUROLOGY

Oxidative Stress and Its Role in the Pathogenesis of Ischaemic Stroke

(2009) C. L. Allen et al.   International Journal of Stroke

Kidins220/ARMS downregulation by excitotoxic activation of NMDARs reveals its involvement in neuronal survival and death pathways

(2009) C. Lopez-Menendez et al.   JOURNAL OF CELL SCIENCE

NMDA Receptor Activation Increases Free Radical Production through Nitric Oxide and NOX2

(2009) H. Girouard et al.   JOURNAL OF NEUROSCIENCE

Extrasynaptic NMDA Receptors Couple Preferentially to Excitotoxicity via Calpain-Mediated Cleavage of STEP

(2009) J. Xu et al.   JOURNAL OF NEUROSCIENCE

Inflammatory mechanisms in ischemic stroke: therapeutic approaches

(2009) Shaheen E Lakhan et al.   Journal of Translational Medicine

Role of NMDA receptor–dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries

(2009) Changiz Taghibiglou et al.   NATURE MEDICINE

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Pivotal role of cerebral interleukin-17–producing γδT cells in the delayed phase of ischemic brain injury

(2009) Takashi Shichita et al.   NATURE MEDICINE

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

(2009) Angela M Brennan et al.   NATURE NEUROSCIENCE

According to GOSPEL: Filling in the GAP(DH) of NO-Mediated Neurotoxicity

(2009) Tomohiro Nakamura et al.   NEURON

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

Expansion of the Time Window for Treatment of Acute Ischemic Stroke With Intravenous Tissue Plasminogen Activator

(2009) Gregory J. del Zoppo et al.   STROKE

Withdrawal of fenofibrate treatment partially abrogates preventive neuroprotection in stroke via loss of vascular protection

(2009) Thavarak Ouk et al.   VASCULAR PHARMACOLOGY

Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

(2008) Sang Won Suh et al.   ANNALS OF NEUROLOGY

Mechanisms underlying the loss of mitochondrial membrane potential in glutamate excitotoxicity

(2008) Andrey Y. Abramov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evolution of NMDA receptor cytoplasmic interaction domains: implications for organisation of synaptic signalling complexes

(2008) Tomás J Ryan et al.   BMC NEUROSCIENCE

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Post-ischemic brain damage: pathophysiology and role of inflammatory mediators

(2008) Diana Amantea et al.   FEBS Journal

Post-ischemic brain damage: effect of ischemic preconditioning and postconditioning and identification of potential candidates for stroke therapy

(2008) Giuseppe Pignataro et al.   FEBS Journal

Two-Photon Imaging of Stroke Onset In Vivo Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines

(2008) T. H. Murphy et al.   JOURNAL OF NEUROSCIENCE

Cell adhesion molecules and ischemic stroke

(2008) Gokhan Yilmaz et al.   NEUROLOGICAL RESEARCH

Electrophysiology of cerebral ischemia

(2008) Krešimir Krnjević   NEUROPHARMACOLOGY

Mechanisms of ischemic brain damage

(2008) Kristian P. Doyle et al.   NEUROPHARMACOLOGY

A novel calpain inhibitor, ((1S)-1((((1S)-1-benzyl-3-cyclopropylamino-2,3-di-oxopropyl)amino)carbonyl)-3-methylbutyl) carbamic acid 5-methoxy-3-oxapentyl ester, protects neuronal cells from cerebral ischemia-induced damage in mice

(2008) A. Koumura et al.   NEUROSCIENCE

Systemic infection, inflammation and acute ischemic stroke

(2008) B.W. McColl et al.   NEUROSCIENCE

NF-κB signaling in cerebral ischemia

(2008) D.A. Ridder et al.   NEUROSCIENCE

Toll-like receptor signaling in endogenous neuroprotection and stroke

(2008) B.J. Marsh et al.   NEUROSCIENCE

Differential Roles of NMDA Receptor Subtypes in Ischemic Neuronal Cell Death and Ischemic Tolerance

(2008) Min Chen et al.   STROKE

Beyond NMDA and AMPA glutamate receptors: emerging mechanisms for ionic imbalance and cell death in stroke

(2008) Elaine Besancon et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases

(2007) B MARSH et al.   CURRENT OPINION IN PHARMACOLOGY

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY