Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health—Pathophysiology and Therapeutic Strategies

Establishing or Exaggerating Causality for the Gut Microbiome: Lessons from Human Microbiota-Associated Rodents

(2020) Jens Walter et al.   CELL

Nonalcoholic fatty liver disease: modulating gut microbiota to improve severity?

(2020) Judith Aron-Wisnewsky et al.   GASTROENTEROLOGY

Commensal Hafnia alvei strain reduces food intake and fat mass in obese mice—a new potential probiotic for appetite and body weight management

(2020) Romain Legrand et al.   INTERNATIONAL JOURNAL OF OBESITY

Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment

(2020) Zhigang Liu et al.   Nature Communications

Gut Microbiota Profile of Obese Diabetic Women Submitted to Roux-en-Y Gastric Bypass and Its Association with Food Intake and Postoperative Diabetes Remission

(2020) Karina Al Assal et al.   Nutrients

Resveratrol enhances brown adipose tissue activity and white adipose tissue browning in part by regulating bile acid metabolism via gut microbiota remodeling

(2020) Suocheng Hui et al.   INTERNATIONAL JOURNAL OF OBESITY

Grape Extract Activates Brown Adipose Tissue Through Pathway Involving the Regulation of Gut Microbiota and Bile Acid

(2020) Xue Han et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Statin therapy is associated with lower prevalence of gut microbiota dysbiosis

(2020) Sara Vieira-Silva et al.   NATURE

Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

(2020) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Two Bariatric Surgical Procedures Differentially Alter the Intestinal Microbiota in Obesity Patients

(2020) Guolin Chen et al.   OBESITY SURGERY

Impact of laparoscopic Roux-en-Y gastric bypass and sleeve gastrectomy on gut microbiota: a metagenomic comparative analysis

(2020) William Farin et al.   Surgery for Obesity and Related Diseases

Gut microbiota differs a decade after bariatric surgery relative to a nonsurgical comparison group

(2020) Jacob G. Mabey et al.   Surgery for Obesity and Related Diseases

Tryptophan Metabolic Pathways Are Altered in Obesity and Are Associated With Systemic Inflammation

(2020) Sofia Cussotto et al.   Frontiers in Immunology

Treatment with Anaerobutyricum soehngenii: a pilot study of safety and dose–response effects on glucose metabolism in human subjects with metabolic syndrome

(2020) Pim W. Gilijamse et al.   npj Biofilms and Microbiomes

Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives

(2020) Natalia Vallianou et al.   Current Obesity Reports

Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

(2020) Antonio Molinaro et al.   Molecular Metabolism

AhR activation defends gut barrier integrity against damage occurring in obesity

(2020) Bárbara G. Postal et al.   Molecular Metabolism

Weight Gain after Fecal Microbiota Transplantation in a Patient with Recurrent Underweight following Clinical Recovery from Anorexia Nervosa

(2019) Nicolien C. de Clercq et al.   PSYCHOTHERAPY AND PSYCHOSOMATICS

Comparative Evaluation of Microbiota Engraftment Following Fecal Microbiota Transfer in Mice Models: Age, Kinetic and Microbial Status Matter

(2019) Tiphaine Le Roy et al.   Frontiers in Microbiology

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

(2019) Baoguo Li et al.   Cell Reports

Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases

(2019) Serena Sanna et al.   NATURE GENETICS

Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles

(2019) Mohd Badrin Hanizam Abdul Rahim et al.   ACTA DIABETOLOGICA

Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity

(2019) Yi-Hsuan Lin et al.   INTERNATIONAL JOURNAL OF OBESITY

Impact of bariatric surgery on type 2 diabetes: contribution of inflammation and gut microbiome?

(2019) Jean Debédat et al.   Seminars in Immunopathology

Akkermansia muciniphila abundance is lower in severe obesity but its increased level after bariatric surgery is not associated with metabolic health improvement

(2019) Maria Carlota Dao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes?

(2019) Judith Aron-Wisnewsky et al.   Current Diabetes Reports

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study

(2019) Clara Depommier et al.   NATURE MEDICINE

The gut microbiota regulates white adipose tissue inflammation and obesity via a family of microRNAs

(2019) Anthony T. Virtue et al.   Science Translational Medicine

Roux-Y Gastric Bypass and Sleeve Gastrectomy directly change gut microbiota composition independent of surgery type

(2019) Fernanda L. Paganelli et al.   Scientific Reports

Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery

(2019) Jean Debédat et al.   Current Obesity Reports

Short-term dietary reduction of branched-chain amino acids reduces meal-induced insulin secretion and modifies microbiome composition in type 2 diabetes: a randomized controlled crossover trial

(2019) Yanislava Karusheva et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Obese Individuals with and without Type 2 Diabetes Show Different Gut Microbial Functional Capacity and Composition

(2019) Louise B. Thingholm et al.   Cell Host & Microbe

Alterations in Gut Microbiota by Statin Therapy and Possible Intermediate Effects on Hyperglycemia and Hyperlipidemia

(2019) Jiyeon Kim et al.   Frontiers in Microbiology

Glucagon-like peptide 1 (GLP-1)

(2019) T.D. Müller et al.   Molecular Metabolism

Palmitic acid damages gut epithelium integrity and initiates inflammatory cytokine production

(2019) Sara Ghezzal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The intestinal microbiota regulates host cholesterol homeostasis

(2019) Tiphaine Le Roy et al.   BMC BIOLOGY

Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention

(2019) Yan Liu et al.   Cell Metabolism

Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation

(2019) Lin-Hu Quan et al.   GUT

The gut microbiota modulates both browning of white adipose tissue and the activity of brown adipose tissue

(2019) José María Moreno-Navarrete et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss

(2019) Corey A. Rynders et al.   Nutrients

Effects of Macronutrients on the In Vitro Production of ClpB, a Bacterial Mimetic Protein of α-MSH and Its Possible Role in Satiety Signaling

(2019) Manon Dominique et al.   Nutrients

Gut Microbiota and Obesity: A Role for Probiotics

(2019) Ludovico Abenavoli et al.   Nutrients

Effect of multi-strain probiotic (UB0316) in weight management in overweight/obese adults: a 12-week double blind, randomised, placebo-controlled study

(2019) M. Ratna Sudha et al.   Beneficial Microbes

Hafnia alvei HA4597 Strain Reduces Food Intake and Body Weight Gain and Improves Body Composition, Glucose, and Lipid Metabolism in a Mouse Model of Hyperphagic Obesity

(2019) Nicolas Lucas et al.   Microorganisms

Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease

(2018) Allison Agus et al.   Cell Host & Microbe

Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids

(2018) Kristina Martinez-Guryn et al.   Cell Host & Microbe

Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

(2018) Elizabeth F. Sutton et al.   Cell Metabolism

DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates

(2018) David G. McLaren et al.   Cell Metabolism

The Science of Obesity Management: An Endocrine Society Scientific Statement

(2018) George A Bray et al.   ENDOCRINE REVIEWS

Major microbiota dysbiosis in severe obesity: fate after bariatric surgery

(2018) Judith Aron-Wisnewsky et al.   GUT

Differences in Obesity Prevalence by Demographic Characteristics and Urbanization Level Among Adults in the United States, 2013-2016

(2018) Craig M. Hales et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Dysregulation of Tryptophan Catabolism in Metabolic Syndrome

(2018) Neila Hiraishi Mallmann et al.   Metabolic Syndrome and Related Disorders

Genetic deficiency of indoleamine 2,3-dioxygenase promotes gut microbiota-mediated metabolic health

(2018) Ludivine Laurans et al.   NATURE MEDICINE

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

(2018) Karine Clément et al.   NATURE MEDICINE

Gut Microbes and Health: A Focus on the Mechanisms Linking Microbes, Obesity, and Related Disorders

(2018) Marialetizia Rastelli et al.   Obesity

Genetic and microbiome influence on lipid metabolism and dyslipidemia

(2018) Maria Luisa Matey-Hernandez et al.   PHYSIOLOGICAL GENOMICS

Metabolome and gut microbiota variation with long-term intake of Panax ginseng extracts on rats

(2018) Yifan Sun et al.   Food & Function

A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue

(2018) Ji Suk Chang et al.   Scientific Reports

Effect of atorvastatin on the gut microbiota of high fat diet-induced hypercholesterolemic rats

(2018) Tariq Jamal Khan et al.   Scientific Reports

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

(2018) Valentin Barquissau et al.   Cell Reports

Gut Microbiome Associates With Lipid-Lowering Effect of Rosuvastatin in Vivo

(2018) Yinhui Liu et al.   Frontiers in Microbiology

Differential metabolic effects of oral butyrate treatment in lean versus metabolic syndrome subjects

(2018) KEC Bouter et al.   Clinical and Translational Gastroenterology

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

Effects of a 6-month multi-strain probiotics supplementation in endotoxemic, inflammatory and cardiometabolic status of T2DM patients: A randomized, double-blind, placebo-controlled trial

(2018) Shaun Sabico et al.   CLINICAL NUTRITION

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Depicting the composition of gut microbiota in a population with varied ethnic origins but shared geography

(2018) Mélanie Deschasaux et al.   NATURE MEDICINE

Metabolites as regulators of insulin sensitivity and metabolism

(2018) Qin Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dysbiosis signatures of gut microbiota in coronary artery disease

(2018) Qi Zhu et al.   PHYSIOLOGICAL GENOMICS

The gut microbiota promotes hepatic fatty acid desaturation and elongation in mice

(2018) Alida Kindt et al.   Nature Communications

Berberine alleviates insulin resistance by reducing peripheral branched-chain amino acids

(2018) Shi-Jun Yue et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Microbially Produced Imidazole Propionate Impairs Insulin Signaling through mTORC1

(2018) Ara Koh et al.   CELL

Quantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids

(2018) Michael D. Neinast et al.   Cell Metabolism

PGC-1α as a Pivotal Factor in Lipid and Metabolic Regulation

(2018) Ching-Feng Cheng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans

(2018) Robert A. Koeth et al.   JOURNAL OF CLINICAL INVESTIGATION

Resveratrol-Induced White Adipose Tissue Browning in Obese Mice by Remodeling Fecal Microbiota

(2018) Weiyao Liao et al.   MOLECULES

Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis

(2018) Wenjing Sun et al.   Biomed Research International

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

(2017) Emilie Catry et al.   GUT

European consensus conference on faecal microbiota transplantation in clinical practice

(2017) Giovanni Cammarota et al.   GUT

CIDE Family-Mediated Unique Lipid Droplet Morphology in White Adipose Tissue and Brown Adipose Tissue Determines the Adipocyte Energy Metabolism

(2017) Yuki Nishimoto et al.   Journal of Atherosclerosis and Thrombosis

Restoration of metabolic health by decreased consumption of branched-chain amino acids

(2017) Nicole E. Cummings et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of a multi-strain probiotic supplement for 12 weeks in circulating endotoxin levels and cardiometabolic profiles of medication naïve T2DM patients: a randomized clinical trial

(2017) Shaun Sabico et al.   Journal of Translational Medicine

Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity

(2017) José María Moreno-Navarrete et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention

(2017) Ruixin Liu et al.   NATURE MEDICINE

The gut microbiome in atherosclerotic cardiovascular disease

(2017) Zhuye Jie et al.   Nature Communications

A combination of quercetin and resveratrol reduces obesity in high-fat diet-fed rats by modulation of gut microbiota

(2017) Le Zhao et al.   Food & Function

Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults

(2017) John F. Trepanowski et al.   JAMA Internal Medicine

Effects of Gut Microbiota Manipulation by Antibiotics on Host Metabolism in Obese Humans: A Randomized Double-Blind Placebo-Controlled Trial

(2016) Dorien Reijnders et al.   Cell Metabolism

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans

(2016) Aleix Gavaldà-Navarro et al.   DIABETOLOGIA

Effect of multi-strain probiotics (multi-strain microbial cell preparation) on glycemic control and other diabetes-related outcomes in people with type 2 diabetes: a randomized controlled trial

(2016) Somayyeh Firouzi et al.   EUROPEAN JOURNAL OF NUTRITION

Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events

(2016) Rohan Khera et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Interaction between dietary lipids and gut microbiota regulates hepatic cholesterol metabolism

(2016) Robert Caesar et al.   JOURNAL OF LIPID RESEARCH

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Diet–microbiota interactions as moderators of human metabolism

(2016) Justin L. Sonnenburg et al.   NATURE

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

(2016) Bruno Lamas et al.   NATURE MEDICINE

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

The Human Intestinal Microbiome in Health and Disease

(2016) Susan V. Lynch et al.   NEW ENGLAND JOURNAL OF MEDICINE

Differential Changes in Gut Microbiota After Gastric Bypass and Sleeve Gastrectomy Bariatric Surgery Vary According to Diabetes Remission

(2016) Rinki Murphy et al.   OBESITY SURGERY

Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity

(2016) Alexandra Zhernakova et al.   SCIENCE

Population-level analysis of gut microbiome variation

(2016) Gwen Falony et al.   SCIENCE

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Roux-en-Y gastric bypass surgery of morbidly obese patients induces swift and persistent changes of the individual gut microbiota

(2016) Albert Palleja et al.   Genome Medicine

Insulin resistance is associated with altered amino acid metabolism and adipose tissue dysfunction in normoglycemic women

(2016) Petri Wiklund et al.   Scientific Reports

Interleukin-22: Immunobiology and Pathology

(2015) Jarrod A. Dudakov et al.   Annual Review of Immunology

Serotonin controlling feeding and satiety

(2015) Jörg-Peter Voigt et al.   BEHAVIOURAL BRAIN RESEARCH

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis

(2015) Zeneng Wang et al.   CELL

Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

(2015) Milena Monteiro-Sepulveda et al.   Cell Metabolism

Indoleamine 2,3-Dioxygenase Fine-Tunes Immune Homeostasis in Atherosclerosis and Colitis through Repression of Interleukin-10 Production

(2015) Sarvenaz Metghalchi et al.   Cell Metabolism

Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling

(2015) Robert Caesar et al.   Cell Metabolism

The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood LipidsNovelty and Significance

(2015) Jingyuan Fu et al.   CIRCULATION RESEARCH

Tryptophan-kynurenine pathway is dysregulated in inflammation and immune activation

(2015) Ming-Hui Zou   Frontiers in Bioscience-Landmark

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Kynurenines as predictors of acute coronary events in the Hordaland Health Study

(2015) Simone J.P.M. Eussen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

The gut microbiome, diet and links to cardiometabolic and chronic disorders

(2015) Judith Aron-Wisnewsky et al.   Nature Reviews Nephrology

The kynurenine pathway is activated in human obesity and shifted toward kynurenine monooxygenase activation

(2015) Marie Favennec et al.   Obesity

Weight Gain After Fecal Microbiota Transplantation

(2015) N. Alang et al.   Open Forum Infectious Diseases

The Characterization of Novel Tissue Microbiota Using an Optimized 16S Metagenomic Sequencing Pipeline

(2015) Jérôme Lluch et al.   PLoS One

Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet

(2015) Ellen E. Jackson et al.   PLoS One

Modulation of gut microbiota by berberine and metformin during the treatment of high-fat diet-induced obesity in rats

(2015) Xu Zhang et al.   Scientific Reports

Resveratrol increases brown adipose tissue thermogenesis markers by increasing SIRT1 and energy expenditure and decreasing fat accumulation in adipose tissue of mice fed a standard diet

(2014) João Marcus Oliveira Andrade et al.   EUROPEAN JOURNAL OF NUTRITION

Intestinal Epithelial Cell Toll-like Receptor 5 Regulates the Intestinal Microbiota to Prevent Low-Grade Inflammation and Metabolic Syndrome in Mice

(2014) Benoit Chassaing et al.   GASTROENTEROLOGY

Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity

(2014) Amandine Everard et al.   ISME Journal

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

Modulation of the Gut Microbiota by Nutrients with Prebiotic and Probiotic Properties

(2014) Céline Druart et al.   Advances in Nutrition

Bacterial Metabolite Indole Modulates Incretin Secretion from Intestinal Enteroendocrine L Cells

(2014) Catalin Chimerel et al.   Cell Reports

Bacterial ClpB heat-shock protein, an antigen-mimetic of the anorexigenic peptide α-MSH, at the origin of eating disorders

(2014) N Tennoune et al.   Translational Psychiatry

Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids

(2013) Gijs den Besten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

Dietary intervention impact on gut microbial gene richness

(2013) Aurélie Cotillard et al.   NATURE

Gut metagenome in European women with normal, impaired and diabetic glucose control

(2013) Fredrik H. Karlsson et al.   NATURE

Intestinal Microbial Metabolism of Phosphatidylcholine and Cardiovascular Risk

(2013) W.H. Wilson Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

ProbioticsL. plantarumandL. curvatusin Combination Alter Hepatic Lipid Metabolism and Suppress Diet-Induced Obesity

(2013) Sae-Rom Yoo et al.   Obesity

Obesity-related dysregulation of the Tryptophan-Kynurenine metabolism: Role of age and parameters of the metabolic syndrome

(2013) Harald Mangge et al.   Obesity

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Structural modulation of gut microbiota in life-long calorie-restricted mice

(2013) Chenhong Zhang et al.   Nature Communications

Effect of exercise training on metabolic flexibility in response to a high-fat diet in obese individuals

(2012) Gina M. Battaglia et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Tryptophan metabolism activation by indoleamine 2,3-dioxygenase in adipose tissue of obese women: an attempt to maintain immune homeostasis and vascular tone

(2012) Isabelle Wolowczuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Toll-like Receptor 4 Deficiency Promotes the Alternative Activation of Adipose Tissue Macrophages

(2012) J. S. Orr et al.   DIABETES

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

(2012) Robert Caesar et al.   GUT

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

(2012) Jorge Henao-Mejia et al.   NATURE

The importance of the gut microbiota after bariatric surgery

(2012) Judith Aron-Wisnewsky et al.   Nature Reviews Gastroenterology & Hepatology

Obesity, Whole Blood Serotonin and Sex Differences in Healthy Volunteers

(2012) Stephanie Hodge et al.   Obesity Facts

Metagenomic sequencing of the human gut microbiome before and after bariatric surgery in obese patients with type 2 diabetes: correlation with inflammatory and metabolic parameters

(2012) J Graessler et al.   PHARMACOGENOMICS JOURNAL

Midlife gene expressions identify modulators of aging through dietary interventions

(2012) B. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

(2011) J. Amar et al.   DIABETOLOGIA

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment

(2011) Jacques Amar et al.   EMBO Molecular Medicine

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

High-Fat Diet: Bacteria Interactions Promote Intestinal Inflammation Which Precedes and Correlates with Obesity and Insulin Resistance in Mouse

(2010) Shengli Ding et al.   PLoS One

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Lipoprotein lipase: from gene to obesity

(2009) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability

(2009) P. D. Cani et al.   GUT

The gut microbiota modulates host energy and lipid metabolism in mice

(2009) Vidya R. Velagapudi et al.   JOURNAL OF LIPID RESEARCH

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe

Elevated Toll-Like Receptor 4 Expression and Signaling in Muscle From Insulin-Resistant Subjects

(2008) S. M. Reyna et al.   DIABETES

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Tlr-4 Deficiency Selectively Protects Against Obesity Induced by Diets High in Saturated Fat

(2008) Jeremy E. Davis et al.   Obesity

Global Transcript Profiles of Fat in Monozygotic Twins Discordant for BMI: Pathways behind Acquired Obesity

(2008) Kirsi H Pietiläinen et al.   PLOS MEDICINE