Metabolites as regulators of insulin sensitivity and metabolism

Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

(2018) Ismail Syed et al.   Cell Metabolism

Role of carnitine and its derivatives in the development and management of type 2 diabetes

(2018) Judit Bene et al.   Nutrition & Diabetes

Short-Term Versus Long-Term Effects of Adipocyte Toll-Like Receptor 4 Activation on Insulin Resistance in Male Mice

(2017) Caroline Tao et al.   ENDOCRINOLOGY

Bile Acid Control of Metabolism and Inflammation in Obesity, Type 2 Diabetes, Dyslipidemia, and Nonalcoholic Fatty Liver Disease

(2017) Oscar Chávez-Talavera et al.   GASTROENTEROLOGY

DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation

(2017) Keyong Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of a High-fat Diet on Tissue Acyl-CoA and Histone Acetylation Levels

(2017) Alessandro Carrer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress

(2017) Baran A. Ersoy et al.   JOURNAL OF CLINICAL INVESTIGATION

Nutrient-sensing nuclear receptors PPARα and FXR control liver energy balance

(2017) Geoffrey A. Preidis et al.   JOURNAL OF CLINICAL INVESTIGATION

Stereochemistry of Endogenous Palmitic Acid Ester of 9-Hydroxystearic Acid and Relevance of Absolute Configuration to Regulation

(2017) Andrew T. Nelson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current role of the NLRP3 inflammasome on obesity and insulin resistance: A systematic review

(2017) Jakeline Rheinheimer et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The UPR ER : Sensor and Coordinator of Organismal Homeostasis

(2017) Ashley E. Frakes et al.   MOLECULAR CELL

Biochemical and cellular properties of insulin receptor signalling

(2017) Rebecca A. Haeusler et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Sphingolipids and their metabolism in physiology and disease

(2017) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Protein O-GlcNAcylation: emerging mechanisms and functions

(2017) Xiaoyong Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Epigenetic regulation of antagonistic receptors confers rice blast resistance with yield balance

(2017) Yiwen Deng et al.   SCIENCE

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

(2017) Max C. Petersen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a

(2017) Matteo Spinelli et al.   Nature Communications

Regulation of Serine-Threonine Kinase Akt Activation by NAD + -Dependent Deacetylase SIRT7

(2017) Jia Yu et al.   Cell Reports

β-Hydroxybutyrate Deactivates Neutrophil NLRP3 Inflammasome to Relieve Gout Flares

(2017) Emily L. Goldberg et al.   Cell Reports

Beta-adrenergic receptors are critical for weight loss but not for other metabolic adaptations to the consumption of a ketogenic diet in male mice

(2017) Nicholas Douris et al.   Molecular Metabolism

Targeting ceramide metabolism in obesity

(2016) Hanin Aburasayn et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Understanding the Physiology of FGF21

(2016) Ffolliott Martin Fisher et al.   Annual Review of Physiology

Branched Fatty Acid Esters of Hydroxy Fatty Acids Are Preferred Substrates of the MODY8 Protein Carboxyl Ester Lipase

(2016) Matthew J. Kolar et al.   BIOCHEMISTRY

Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species

(2016) Magdalene K. Montgomery et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The world of protein acetylation

(2016) Adrian Drazic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Adipocyte lipolysis and insulin resistance

(2016) Pauline Morigny et al.   BIOCHIMIE

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart FailureCLINICAL PERSPECTIVE

(2016) Haipeng Sun et al.   CIRCULATION

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain–Liver Connection

(2016) Heather A. Ferris et al.   DIABETES

Docosahexaenoic Acid–Derived Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) With Anti-inflammatory Properties

(2016) Ondrej Kuda et al.   DIABETES

Metabolic Effects of Monounsaturated Fatty Acid–Enriched Diets Compared With Carbohydrate or Polyunsaturated Fatty Acid–Enriched Diets in Patients With Type 2 Diabetes: A Systematic Review and Meta-analysis of Randomized Controlled Trials

(2016) Frank Qian et al.   DIABETES CARE

Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans

(2016) Bryan C. Bergman et al.   DIABETOLOGIA

Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice

(2016) Seung-Ah Lee et al.   HEPATOLOGY

Vertical sleeve gastrectomy activates GPBAR-1/TGR5 to sustain weight loss, improve fatty liver, and remit insulin resistance in mice

(2016) Lili Ding et al.   HEPATOLOGY

Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ

(2016) Amar Bahadur Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

(2016) Divya P. Kumar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses

(2016) Jennifer Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

(2016) Max C. Petersen et al.   JOURNAL OF CLINICAL INVESTIGATION

Antibiotic effects on gut microbiota and metabolism are host dependent

(2016) Shiho Fujisaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Mogat1deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2−/−) or obese (ob/ob) mice

(2016) Anil K. Agarwal et al.   JOURNAL OF LIPID RESEARCH

FFAR4 (GPR120) Signaling Is Not Required for Anti-Inflammatory and Insulin-Sensitizing Effects of Omega-3 Fatty Acids

(2016) Simone Isling Pærregaard et al.   MEDIATORS OF INFLAMMATION

A human model of dietary saturated fatty acid induced insulin resistance

(2016) Juraj Koska et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Human gut microbes impact host serum metabolome and insulin sensitivity

(2016) Helle Krogh Pedersen et al.   NATURE

Acetate mediates a microbiome–brain–β-cell axis to promote metabolic syndrome

(2016) Rachel J. Perry et al.   NATURE

AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs

(2016) William H Parsons et al.   Nature Chemical Biology

A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance

(2016) Cholsoon Jang et al.   NATURE MEDICINE

Dissociation of muscle insulin sensitivity from exercise endurance in mice by HDAC3 depletion

(2016) Sungguan Hong et al.   NATURE MEDICINE

Sphingolipids and phospholipids in insulin resistance and related metabolic disorders

(2016) Peter J. Meikle et al.   Nature Reviews Endocrinology

Decreased acylcarnitine content improves insulin sensitivity in experimental mice models of insulin resistance

(2016) Edgars Liepinsh et al.   PHARMACOLOGICAL RESEARCH

Fatty acylation of proteins: The long and the short of it

(2016) Marilyn D. Resh   PROGRESS IN LIPID RESEARCH

Cell Signaling and Stress Responses

(2016) Gökhan S. Hotamisligil et al.   Cold Spring Harbor Perspectives in Biology

Insulin-Sensitizing Effects of Omega-3 Fatty Acids: Lost in Translation?

(2016) Antigoni Lalia et al.   Nutrients

Saturated Fatty Acids Engage an IRE1α-Dependent Pathway to Activate the NLRP3 Inflammasome in Myeloid Cells

(2016) Megan M. Robblee et al.   Cell Reports

Effect of Insulin Resistance on Monounsaturated Fatty Acid Levels: A Multi-cohort Non-targeted Metabolomics and Mendelian Randomization Study

(2016) Christoph Nowak et al.   PLoS Genetics

Effects of Saturated Fat, Polyunsaturated Fat, Monounsaturated Fat, and Carbohydrate on Glucose-Insulin Homeostasis: A Systematic Review and Meta-analysis of Randomised Controlled Feeding Trials

(2016) Fumiaki Imamura et al.   PLOS MEDICINE

Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study

(2016) Nita G. Forouhi et al.   PLOS MEDICINE

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Chronic Uridine Administration Induces Fatty Liver and Pre-Diabetic Conditions in Mice

(2016) Yasuyo Urasaki et al.   PLoS One

Fat in flames: influence of cytokines and pattern recognition receptors on adipocyte lipolysis

(2015) Ryan W. Grant et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glut4 palmitoylation at Cys223 plays a critical role in Glut4 membrane trafficking

(2015) Wenying Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process

(2015) Liliana Perdomo et al.   Cardiovascular Diabetology

Hepatic Acetyl CoA Links Adipose Tissue Inflammation to Hepatic Insulin Resistance and Type 2 Diabetes

(2015) Rachel J. Perry et al.   CELL

Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism

(2015) Samantha J. Mentch et al.   Cell Metabolism

Glycolysis-Mediated Changes in Acetyl-CoA and Histone Acetylation Control the Early Differentiation of Embryonic Stem Cells

(2015) Arieh Moussaieff et al.   Cell Metabolism

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Integrated Metabolomics and Genomics

(2015) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Monounsaturated Fatty Acid–Enriched High-Fat Diets Impede Adipose NLRP3 Inflammasome–Mediated IL-1β Secretion and Insulin Resistance Despite Obesity

(2015) Orla M. Finucane et al.   DIABETES

SIRT3 Is Crucial for Maintaining Skeletal Muscle Insulin Action and Protects Against Severe Insulin Resistance in High-Fat–Fed Mice

(2015) Louise Lantier et al.   DIABETES

UCP1 is an essential mediator of the effects of methionine restriction on energy balance but not insulin sensitivity

(2015) Desiree Wanders et al.   FASEB JOURNAL

Acylcarnitines: potential implications for skeletal muscle insulin resistance

(2015) Céline Aguer et al.   FASEB JOURNAL

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FGF21 and the late adaptive response to starvation in humans

(2015) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of resolvin D2 receptor mediating resolution of infections and organ protection

(2015) Nan Chiang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Liver-specific loss of lipin-1-mediated phosphatidic acid phosphatase activity does not mitigate intrahepatic TG accumulation in mice

(2015) George G. Schweitzer et al.   JOURNAL OF LIPID RESEARCH

Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation

(2015) Matthew D. Hirschey et al.   MOLECULAR & CELLULAR PROTEOMICS

Inflammation and ER Stress Regulate Branched-Chain Amino Acid Uptake and Metabolism in Adipocytes

(2015) Joel S. Burrill et al.   MOLECULAR ENDOCRINOLOGY

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

(2015) Medha Priyadarshini et al.   MOLECULAR ENDOCRINOLOGY

Is Acetylation a Metabolic Rheostat that Regulates Skeletal Muscle Insulin Action?

(2015) Samuel LaBarge et al.   MOLECULES AND CELLS

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis

(2015) Courtney R Green et al.   Nature Chemical Biology

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

(2015) Yun-Hee Youm et al.   NATURE MEDICINE

Protein acetylation in metabolism — metabolites and cofactors

(2015) Keir J. Menzies et al.   Nature Reviews Endocrinology

Short-chain fatty acids in control of body weight and insulin sensitivity

(2015) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Compromised responses to dietary methionine restriction in adipose tissue but not liver ofob/obmice

(2015) Kirsten P. Stone et al.   Obesity

Elevation of branched-chain amino acid levels in diabetes and NAFL and changes with antidiabetic drug treatment

(2015) Motoh Iwasa et al.   Obesity Research & Clinical Practice

An in silico MS/MS library for automatic annotation of novel FAHFA lipids

(2015) Yan Ma et al.   Journal of Cheminformatics

Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?

(2015) Brian N. Finck et al.   Biomed Research International

Integrated Metabolomics and Genomics

(2015) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression

(2014) Amanda T. White et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PI3K/AKT signaling pathway and cancer: an updated review

(2014) Miriam Martini et al.   ANNALS OF MEDICINE

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

A SIRT7-Dependent Acetylation Switch of GABPβ1 Controls Mitochondrial Function

(2014) Dongryeol Ryu et al.   Cell Metabolism

Akt-Dependent Metabolic Reprogramming Regulates Tumor Cell Histone Acetylation

(2014) Joyce V. Lee et al.   Cell Metabolism

Obesity-Induced CerS6-Dependent C16:0 Ceramide Production Promotes Weight Gain and Glucose Intolerance

(2014) Sarah M. Turpin et al.   Cell Metabolism

CerS2 Haploinsufficiency Inhibits β-Oxidation and Confers Susceptibility to Diet-Induced Steatohepatitis and Insulin Resistance

(2014) Suryaprakash Raichur et al.   Cell Metabolism

Brain Insulin Lowers Circulating BCAA Levels by Inducing Hepatic BCAA Catabolism

(2014) Andrew C. Shin et al.   Cell Metabolism

SIRT7 Controls Hepatic Lipid Metabolism by Regulating the Ubiquitin-Proteasome Pathway

(2014) Tatsuya Yoshizawa et al.   Cell Metabolism

β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors

(2014) Lee D. Roberts et al.   Cell Metabolism

Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice

(2014) Kirsten P. Stone et al.   DIABETES

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

(2014) Gordon I. Smith et al.   DIABETES

Abrogating Monoacylglycerol Acyltransferase Activity in Liver Improves Glucose Tolerance and Hepatic Insulin Signaling in Obese Mice

(2014) A. M. Hall et al.   DIABETES

Lipid-Induced Insulin Resistance Is Associated With an Impaired Skeletal Muscle Protein Synthetic Response to Amino Acid Ingestion in Healthy Young Men

(2014) Francis B. Stephens et al.   DIABETES

Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults

(2014) Edward S Chambers et al.   GUT

The fish oil ingredient, docosahexaenoic acid, activates cytosolic phospholipase A2via GPR120 receptor to produce prostaglandin E2and plays an anti-inflammatory role in macrophages

(2014) Yueqin Liu et al.   IMMUNOLOGY

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Inhibited Insulin Signaling in Mouse Hepatocytes Is Associated with Increased Phosphatidic Acid but Not Diacylglycerol

(2014) Chongben Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ketogenesis prevents diet-induced fatty liver injury and hyperglycemia

(2014) David G. Cotter et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 Attenuates Polyinosinic-Polycytidylic Acid–Induced Inflammatory Signaling in Human Airway Epithelial Cells via TAK1

(2014) Hsi-Min Hsiao et al.   JOURNAL OF IMMUNOLOGY

Short-Chain Fatty Acids Enhance Adipocyte Differentiation in the Stromal Vascular Fraction of Porcine Adipose Tissue

(2014) Genlai Li et al.   JOURNAL OF NUTRITION

Monounsaturated fatty acids, olive oil and health status: a systematic review and meta-analysis of cohort studies

(2014) Lukas Schwingshackl et al.   Lipids in Health and Disease

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

The growing landscape of lysine acetylation links metabolism and cell signalling

(2014) Chunaram Choudhary et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

Adipose tissue monomethyl branched-chain fatty acids and insulin sensitivity: Effects of obesity and weight loss

(2014) Xiong Su et al.   Obesity

The Beneficial Effects of n-3 Polyunsaturated Fatty Acids on Diet Induced Obesity and Impaired Glucose Control Do Not Require Gpr120

(2014) Mikael Bjursell et al.   PLoS One

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

(2014) Julia Szendroedi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol-stimulated 3T3-L1 mature adipocytes

(2014) Nicola Aberdein et al.   Adipocyte

Diversity of lipid mediators in human adipose tissue depots

(2013) Joan Clària et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity

(2013) Denise E. Lackey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization

(2013) Sayanti Bhattacharya et al.   ATHEROSCLEROSIS

Ceramide synthases as potential targets for therapeutic intervention in human diseases

(2013) Joo-Won Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

LXRs Regulate ER Stress and Inflammation through Dynamic Modulation of Membrane Phospholipid Composition

(2013) Xin Rong et al.   Cell Metabolism

"Deficiency" of Mitochondria in Muscle Does Not Cause Insulin Resistance

(2013) J. O. Holloszy   DIABETES

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Skeletal muscle-specific overexpression of SIRT1 does not enhance whole-body energy expenditure or insulin sensitivity in young mice

(2013) A. T. White et al.   DIABETOLOGIA

Involvement of sphingosine 1-phosphate in palmitate-induced insulin resistance of hepatocytes via the S1P2 receptor subtype

(2013) Susann Fayyaz et al.   DIABETOLOGIA

Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4)

(2013) Xinzhi Li et al.   FASEB JOURNAL

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of uridine homeostasis links liver pyrimidine metabolism to lipid accumulation

(2013) Thuc T. Le et al.   JOURNAL OF LIPID RESEARCH

Adipose transplant for inborn errors of branched chain amino acid metabolism in mice

(2013) Heather A. Zimmerman et al.   MOLECULAR GENETICS AND METABOLISM

A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use

(2013) Sihao Liu et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

Evaluation of the relationship between GPR43 and adiposity in human

(2013) Evelyne M Dewulf et al.   Nutrition & Metabolism

Toll-Like Receptor 4 Knockout Mice Are Protected against Endoplasmic Reticulum Stress Induced by a High-Fat Diet

(2013) Nicolas Pierre et al.   PLoS One

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

SIRT7 Represses Myc Activity to Suppress ER Stress and Prevent Fatty Liver Disease

(2013) Jiyung Shin et al.   Cell Reports

SIRT1 metabolic actions: Integrating recent advances from mouse models

(2013) Marie Boutant et al.   Molecular Metabolism

Effect of Uridine on Energy Metabolism, LPO, and Antioxidant System in the Myocardium under Conditions of Acute Coronary Insufficiency

(2012) I. B. Krylova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

High-Fat Diet Triggers Inflammation-Induced Cleavage of SIRT1 in Adipose Tissue To Promote Metabolic Dysfunction

(2012) Angeliki Chalkiadaki et al.   Cell Metabolism

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Lipid-Induced Mitochondrial Stress and Insulin Action in Muscle

(2012) Deborah M. Muoio et al.   Cell Metabolism

A Ceramide-Centric View of Insulin Resistance

(2012) Jose A. Chavez et al.   Cell Metabolism

Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

(2012) Christopher B. Newgard   Cell Metabolism

Branched-Chain and Aromatic Amino Acids Are Predictors of Insulin Resistance in Young Adults

(2012) P. Wurtz et al.   DIABETES CARE

Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2

(2012) K. D. Copps et al.   DIABETOLOGIA

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Effects of an overnight intravenous lipid infusion on intramyocellular lipid content and insulin sensitivity in African–American versus Caucasian adolescents

(2012) SoJung Lee et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The Warburg Effect Dictates the Mechanism of Butyrate-Mediated Histone Acetylation and Cell Proliferation

(2012) Dallas R. Donohoe et al.   MOLECULAR CELL

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

(2012) Zheng Sun et al.   NATURE MEDICINE

Sirtuins as regulators of metabolism and healthspan

(2012) Riekelt H. Houtkooper et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

n–3 Fatty Acids and Cardiovascular Outcomes in Patients with Dysglycemia

(2012)   NEW ENGLAND JOURNAL OF MEDICINE

High levels of stearic acid, palmitoleic acid, and dihomo-γ-linolenic acid and low levels of linoleic acid in serum cholesterol ester are associated with high insulin resistance

(2012) Kayo Kurotani et al.   NUTRITION RESEARCH

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

(2012) Alexandra K. Leamy et al.   PROGRESS IN LIPID RESEARCH

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis

(2012) Pablo J. Fernandez-Marcos et al.   Scientific Reports

Proteomic analysis of protein palmitoylation in adipocytes

(2012) Wenying Ren et al.   Adipocyte

Differential effect of long-term leucine supplementation on skeletal muscle and adipose tissue in old rats: an insulin signaling pathway approach

(2011) Gilbert Zeanandin et al.   AGE

Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation

(2011) Ryan G. Holzer et al.   CELL

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Endoplasmic Reticulum Stress Promotes LIPIN2-Dependent Hepatic Insulin Resistance

(2011) D. Ryu et al.   DIABETES

SirT1 Regulates Adipose Tissue Inflammation

(2011) M. P. Gillum et al.   DIABETES

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Skeletal Muscle Triglycerides, Diacylglycerols, and Ceramides in Insulin Resistance: Another Paradox in Endurance-Trained Athletes?

(2011) F. Amati et al.   DIABETES

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

(2011) Sa’ad Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 decreases adipose tissue macrophage accumulation and improves insulin sensitivity in obese-diabetic mice

(2011) Jason Hellmann et al.   FASEB JOURNAL

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

(2011) Yu Li et al.   FASEB JOURNAL

Systemic SIRT1 insufficiency results in disruption of energy homeostasis and steroid hormone metabolism upon high-fat-diet feeding

(2011) Aparna Purushotham et al.   FASEB JOURNAL

Multiple Site Acetylation of Rictor Stimulates Mammalian Target of Rapamycin Complex 2 (mTORC2)-dependent Phosphorylation of Akt Protein

(2011) Emily J. Glidden et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Diet-induced Lethality Due to Deletion of theHdac3Gene in Heart and Skeletal Muscle

(2011) Zheng Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice

(2011) William L. Holland et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

(2011) Rui-Hong Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Resolvin D1 and Its Precursor Docosahexaenoic Acid Promote Resolution of Adipose Tissue Inflammation by Eliciting Macrophage Polarization toward an M2-Like Phenotype

(2011) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Acetyl-CoA Induces Cell Growth and Proliferation by Promoting the Acetylation of Histones at Growth Genes

(2011) Ling Cai et al.   MOLECULAR CELL

A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects

(2011) Jae Man Lee et al.   NATURE

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Metabolite profiles and the risk of developing diabetes

(2011) Thomas J Wang et al.   NATURE MEDICINE

Dietary Leucine - An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

(2011) Yazmin Macotela et al.   PLoS One

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

(2011) F. R. Jornayvaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Circadian Rhythm Orchestrated by Histone Deacetylase 3 Controls Hepatic Lipid Metabolism

(2011) D. Feng et al.   SCIENCE

Understanding protein palmitoylation: Biological significance and enzymology

(2011) XiaoMu Guan et al.   Science China-Chemistry

The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

(2011) N. R. Sundaresan et al.   Science Signaling

Differential Metabolic Impact of Gastric Bypass Surgery Versus Dietary Intervention in Obese Diabetic Subjects Despite Identical Weight Loss

(2011) B. Laferrere et al.   Science Translational Medicine

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

(2010) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Irs1 Serine 307 Promotes Insulin Sensitivity in Mice

(2010) Kyle D. Copps et al.   Cell Metabolism

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

(2010) Svati H. Shah et al.   Circulation-Cardiovascular Genetics

Increased Reactive Oxygen Species Production and Lower Abundance of Complex I Subunits and Carnitine Palmitoyltransferase 1B Protein Despite Normal Mitochondrial Respiration in Insulin-Resistant Human Skeletal Muscle

(2010) N. Lefort et al.   DIABETES

Inhibition of De Novo Ceramide Synthesis Reverses Diet-Induced Insulin Resistance and Enhances Whole-Body Oxygen Consumption

(2010) J. R. Ussher et al.   DIABETES

Adipose triacylglycerol lipase is a major regulator of hepatic lipid metabolism but not insulin sensitivity in mice

(2010) S. M. Turpin et al.   DIABETOLOGIA

Lack of SIRT1 (Mammalian Sirtuin 1) Activity Leads to Liver Steatosis in the SIRT1+/−Mice: A Role of Lipid Mobilization and Inflammation

(2010) Fen Xu et al.   ENDOCRINOLOGY

Regulation of adipokine production in human adipose tissue by propionic acid

(2010) Sa’ad H. Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

De NovoLipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation

(2010) Xiaochao Wei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipose Tissue Branched Chain Amino Acid (BCAA) Metabolism Modulates Circulating BCAA Levels

(2010) Mark A. Herman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

(2010) J. Mark Brown et al.   JOURNAL OF LIPID RESEARCH

Lipid-induced insulin resistance: unravelling the mechanism

(2010) Varman T Samuel et al.   LANCET

Diacylglycerol-mediated insulin resistance

(2010) Derek M Erion et al.   NATURE MEDICINE

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin

(2010) William L Holland et al.   NATURE MEDICINE

Relationship Between Plasma Uridine and Insulin Resistance in Patients with Non-Insulin-Dependent Diabetes Mellitus

(2010) Tetsuya Yamamoto et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

(2009) Kristin R. Freeland et al.   BRITISH JOURNAL OF NUTRITION

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States

(2009) Jongsook Kim Kemper et al.   Cell Metabolism

TORC2 Regulates Hepatic Insulin Signaling via a Mammalian Phosphatidic Acid Phosphatase, LIPIN1

(2009) Dongryeol Ryu et al.   Cell Metabolism

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Plasma Membrane Subdomain Compartmentalization Contributes to Distinct Mechanisms of Ceramide Action on Insulin Signaling

(2009) C. M. Blouin et al.   DIABETES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance

(2009) A. O. Chavez et al.   DIABETES CARE

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

The c-Jun N-Terminal Kinase Mediates the Induction of Oxidative Stress and Insulin Resistance by Palmitate and Toll-like Receptor 2 and 4 Ligands in 3T3-L1 Adipocytes

(2009) J. Davis et al.   HORMONE AND METABOLIC RESEARCH

Resolvin E1 Receptor Activation Signals Phosphorylation and Phagocytosis

(2009) Taisuke Ohira et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Palmitate increases sphingosine-1-phosphate in C2C12 myotubes via upregulation of sphingosine kinase message and activity

(2009) Wei Hu et al.   JOURNAL OF LIPID RESEARCH

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

(2009) Kendle M. Maslowski et al.   NATURE

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Regulation of skeletal muscle mitochondrial fatty acid metabolism in lean and obese individuals

(2008) Graham P Holloway et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Targeting of PKCζ and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

(2008) Eric Hajduch et al.   BIOCHEMICAL JOURNAL

Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

(2008) Alexander V. Chibalin et al.   CELL

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

The Lipid Messenger OEA Links Dietary Fat Intake to Satiety

(2008) Gary J. Schwartz et al.   Cell Metabolism

SirT1 Gain of Function Increases Energy Efficiency and Prevents Diabetes in Mice

(2008) Alexander S. Banks et al.   Cell Metabolism

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

(2008) Andreas Schaeffler et al.   IMMUNOLOGY

The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP

(2008) Sungsoon Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

(2008) Gergana M. Deevska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Thematic Review Series: Glycerolipids.Phosphatidylcholine and choline homeostasis

(2008) Zhaoyu Li et al.   JOURNAL OF LIPID RESEARCH

A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange

(2008) Yi Liu et al.   NATURE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lipid signalling in disease

(2008) Matthias P. Wymann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis

(2008) B.-H. Ahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-fat diets cause insulin resistance despite an increase in muscle mitochondria

(2008) C. R. Hancock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sirt1 protects against high-fat diet-induced metabolic damage

(2008) P. T. Pfluger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dietary fats and prevention of type 2 diabetes

(2008) U RISERUS et al.   PROGRESS IN LIPID RESEARCH