The gut microbiota modulates both browning of white adipose tissue and the activity of brown adipose tissue

Gut microbial metabolites in obesity, NAFLD and T2DM

(2019) Emanuel E. Canfora et al.   Nature Reviews Endocrinology

Neuregulin 4 Is a Novel Marker of Beige Adipocyte Precursor Cells in Human Adipose Tissue

(2019) Ferran Comas et al.   Frontiers in Physiology

Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue

(2019) Baoguo Li et al.   Cell Reports

Understanding the Role of the Gut Microbiome and Microbial Metabolites in Obesity and Obesity-Associated Metabolic Disorders: Current Evidence and Perspectives

(2019) Natalia Vallianou et al.   Current Obesity Reports

Human gut microbiome: hopes, threats and promises

(2018) Patrice D Cani   GUT

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism

(2018) Preeti Pathak et al.   HEPATOLOGY

Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

(2018) Amir Zarrinpar et al.   Nature Communications

Caloric Restriction and Diet-Induced Weight Loss Do Not Induce Browning of Human Subcutaneous White Adipose Tissue in Women and Men with Obesity

(2018) Valentin Barquissau et al.   Cell Reports

Homeobox a5 Promotes White Adipose Tissue Browning Through Inhibition of the Tenascin C/Toll-Like Receptor 4/Nuclear Factor Kappa B Inflammatory Signaling in Mice

(2018) Weina Cao et al.   Frontiers in Immunology

Huddling remodels gut microbiota to reduce energy requirements in a small mammal species during cold exposure

(2018) Xue-Ying Zhang et al.   Microbiome

Functional Gut Microbiota Remodeling Contributes to the Caloric Restriction-Induced Metabolic Improvements

(2018) Salvatore Fabbiano et al.   Cell Metabolism

Environment dominates over host genetics in shaping human gut microbiota

(2018) Daphna Rothschild et al.   NATURE

Comparative Effectiveness and Safety of Bariatric Procedures in Medicare-Eligible Patients

(2018) Orestis A. Panagiotou et al.   JAMA Surgery

9-PAHSA promotes browning of white fat via activating G-protein-coupled receptor 120 and inhibiting lipopolysaccharide / NF-kappa B pathway

(2018) Yan-Mei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibitory Effects of Toll-Like Receptor 4, NLRP3 Inflammasome, and Interleukin-1β on White Adipocyte Browning

(2017) Meshail Okla et al.   INFLAMMATION

Foxc2 coordinates inflammation and browning of white adipose by leptin-STAT3-PRDM16 signal in mice

(2017) L Gan et al.   INTERNATIONAL JOURNAL OF OBESITY

Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism

(2017) Preeti Pathak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity

(2017) José María Moreno-Navarrete et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesis

(2017) Anna Worthmann et al.   NATURE MEDICINE

Insulin action and resistance in obesity and type 2 diabetes

(2017) Michael P Czech   NATURE MEDICINE

Alternatively activated macrophages do not synthesize catecholamines or contribute to adipose tissue adaptive thermogenesis

(2017) Katrin Fischer et al.   NATURE MEDICINE

Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells

(2017) Nami Kim et al.   Scientific Reports

Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice

(2017) Karolin Weitkunat et al.   Scientific Reports

Intestinal Crosstalk between Bile Acids and Microbiota and Its Impact on Host Metabolism

(2016) Annika Wahlström et al.   Cell Metabolism

Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

(2016) Marika Ziętak et al.   Cell Metabolism

Akkermansia MuciniphilaProtects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation inApoe−/−MiceCLINICAL PERSPECTIVE

(2016) Jin Li et al.   CIRCULATION

Lipopolysaccharide-binding protein is a negative regulator of adipose tissue browning in mice and humans

(2016) Aleix Gavaldà-Navarro et al.   DIABETOLOGIA

Short-Chain Fatty Acid Acetate Stimulates Adipogenesis and Mitochondrial Biogenesis via GPR43 in Brown Adipocytes

(2016) Jiamiao Hu et al.   ENDOCRINOLOGY

Reprogramming of hepatic fat accumulation and 'browning' of adipose tissue by the short-chain fatty acid acetate

(2016) M Sahuri-Arisoylu et al.   INTERNATIONAL JOURNAL OF OBESITY

Acetate alters expression of genes involved in beige adipogenesis in 3T3-L1 cells and obese KK-Ay mice

(2016) Satoko Hanatani et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

(2016) Hubert Plovier et al.   NATURE MEDICINE

Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature

(2016) José María Moreno-Navarrete et al.   Obesity

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos

(2016) Felix Sommer et al.   Cell Reports

Short Chain Fatty Acids Prevent High-fat-diet-induced Obesity in Mice by Regulating G Protein-coupled Receptors and Gut Microbiota

(2016) Yuanyuan Lu et al.   Scientific Reports

Gut Microbiota Orchestrates Energy Homeostasis during Cold

(2015) Claire Chevalier et al.   CELL

The Bile Acid Chenodeoxycholic Acid Increases Human Brown Adipose Tissue Activity

(2015) Evie P.M. Broeders et al.   Cell Metabolism

Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations

(2015) Kristin I. Stanford et al.   DIABETES

Association of Lipopolysaccharide-Binding Protein With Aging-Related Adiposity Change and Prediabetes Among African Ancestry Men

(2015) Curtis M. Tilves et al.   DIABETES CARE

Lipopolysaccharide binding protein is an adipokine involved in the resilience of the mouse adipocyte to inflammation

(2015) José María Moreno-Navarrete et al.   DIABETOLOGIA

Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity

(2015) Injae Hwang et al.   FASEB JOURNAL

Akkermansia muciniphilaand improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology

(2015) Maria Carlota Dao et al.   GUT

Activation of Toll-like Receptor 4 (TLR4) Attenuates Adaptive Thermogenesis via Endoplasmic Reticulum Stress

(2015) Meshail Okla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis

(2015) Labros Sidossis et al.   JOURNAL OF CLINICAL INVESTIGATION

PRDM16 sustains white fat gene expression profile in human adipocytes in direct relation with insulin action

(2015) José María Moreno-Navarrete et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

(2015) Sungsoon Fang et al.   NATURE MEDICINE

Microbiota depletion promotes browning of white adipose tissue and reduces obesity

(2015) Nicolas Suárez-Zamorano et al.   NATURE MEDICINE

Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity

(2015) L. -G. Hersoug et al.   Obesity Reviews

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction

(2015) Changtao Jiang et al.   Nature Communications

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

(2015) Marc Schneeberger et al.   Scientific Reports

Shc depletion stimulates brown fat activityin vivoandin vitro

(2014) Alexey Tomilov et al.   AGING CELL

Eosinophils and Type 2 Cytokine Signaling in Macrophages Orchestrate Development of Functional Beige Fat

(2014) Yifu Qiu et al.   CELL

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Lipopolysaccharide binding protein, obesity status and incidence of metabolic syndrome: a prospective study among middle-aged and older Chinese

(2014) Xin Liu et al.   DIABETOLOGIA

Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

(2014) Changtao Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gastrectomy Increases the Expression of Hepatic Cytochrome P450 3A by Increasing Lithocholic Acid-Producing Enteric Bacteria in Mice

(2013) Makoto Ishii et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction

(2013) José María Moreno-Navarrete et al.   DIABETOLOGIA

Inducible Brown Adipose Tissue, or Beige Fat, Is Anabolic for the Skeleton

(2013) Sima Rahman et al.   ENDOCRINOLOGY

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

(2013) Gijs den Besten et al.   JOURNAL OF LIPID RESEARCH

Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity

(2013) A. Everard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetatifactor muris gen. nov., sp. nov., a novel bacterium isolated from the intestine of an obese mouse

(2012) Nora Pfeiffer et al.   ARCHIVES OF MICROBIOLOGY

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

(2012) Véronique Ouellet et al.   JOURNAL OF CLINICAL INVESTIGATION

Functional interactions between the gut microbiota and host metabolism

(2012) Valentina Tremaroli et al.   NATURE

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

Circulating lipopolysaccharide-binding protein (LBP) as a marker of obesity-related insulin resistance

(2011) J M Moreno-Navarrete et al.   INTERNATIONAL JOURNAL OF OBESITY

Gut Microbiota Modulate the Metabolism of Brown Adipose Tissue in Mice

(2011) Renaud Mestdagh et al.   JOURNAL OF PROTEOME RESEARCH

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

(2011) Khoa D. Nguyen et al.   NATURE

Adipose Depots Possess Unique Developmental Gene Signatures

(2010) Yuji Yamamoto et al.   Obesity

Switch from Stress Response to Homeobox Transcription Factors in Adipose Tissue After Profound Fat Loss

(2010) Simon N. Dankel et al.   PLoS One

Histochemical demonstration of monocarboxylate transporters in mouse brown adipose tissue

(2009) Toshihiko Iwanaga et al.   BIOMEDICAL RESEARCH-TOKYO

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

(2009) Helena M. Feldmann et al.   Cell Metabolism

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diet-Induced Obesity Is Linked to Marked but Reversible Alterations in the Mouse Distal Gut Microbiome

(2008) Peter J. Turnbaugh et al.   Cell Host & Microbe