Restoration of metabolic health by decreased consumption of branched-chain amino acids

Liver BCATm transgenic mouse model reveals the important role of the liver in maintaining BCAA homeostasis

(2017) Elitsa A. Ananieva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Branched Chain Amino Acids Are Associated with Insulin Resistance Independent of Leptin and Adiponectin in Subjects with Varying Degrees of Glucose Tolerance

(2017) Margery A. Connelly et al.   Metabolic Syndrome and Related Disorders

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice

(2017) Takashi Honda et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Repletion of branched chain amino acids reverses mTORC1 signaling but not improved metabolism during dietary protein dilution

(2017) Adriano Maida et al.   Molecular Metabolism

Low protein-induced increases in FGF21 drive UCP1-dependent metabolic but not thermoregulatory endpoints

(2017) Cristal M. Hill et al.   Scientific Reports

Direct comparison of methionine restriction with leucine restriction on the metabolic health of C57BL/6J mice

(2017) Emma K. Lees et al.   Scientific Reports

Defining the Nutritional and Metabolic Context of FGF21 Using the Geometric Framework

(2016) Samantha M. Solon-Biet et al.   Cell Metabolism

Caloric Restriction Leads to Browning of White Adipose Tissue through Type 2 Immune Signaling

(2016) Salvatore Fabbiano et al.   Cell Metabolism

Pancreatic β-Cells From Mice Offset Age-Associated Mitochondrial Deficiency With Reduced KATPChannel Activity

(2016) Trillian Gregg et al.   DIABETES

A liver stress-endocrine nexus promotes metabolic integrity during dietary protein dilution

(2016) Adriano Maida et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological management of nonalcoholic fatty liver disease

(2016) Diana Barb et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The lipid sensor GPR120 promotes brown fat activation and FGF21 release from adipocytes

(2016) Tania Quesada-López et al.   Nature Communications

Decreased Consumption of Branched-Chain Amino Acids Improves Metabolic Health

(2016) Luigi Fontana et al.   Cell Reports

Metabolic Responses to Dietary Protein Restriction Require an Increase in FGF21 that Is Delayed by the Absence of GCN2

(2016) Thomas Laeger et al.   Cell Reports

Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export

(2016) Phillip J. White et al.   Molecular Metabolism

Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system

(2015) Sebastian I. Arriola Apelo et al.   AGING CELL

Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice

(2015) Emma L. Baar et al.   AGING CELL

GCN2 is required to increase fibroblast growth factor 21 and maintain hepatic triglyceride homeostasis during asparaginase treatment

(2015) Gabriel J. Wilson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Metabolic responses to dietary leucine restriction involve remodeling of adipose tissue and enhanced hepatic insulin signaling

(2015) Desiree Wanders et al.   BIOFACTORS

Promoting Health and Longevity through Diet: From Model Organisms to Humans

(2015) Luigi Fontana et al.   CELL

Central Fibroblast Growth Factor 21 Browns White Fat via Sympathetic Action in Male Mice

(2015) Nicholas Douris et al.   ENDOCRINOLOGY

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

Glucagon-Like Peptide-1 Regulates Cholecystokinin Production in β-Cells to Protect From Apoptosis

(2015) Amelia K. Linnemann et al.   MOLECULAR ENDOCRINOLOGY

A single-islet microplate assay to measure mouse and human islet insulin secretion

(2015) Nathan A Truchan et al.   Islets

Discrete Aspects of FGF21 In Vivo Pharmacology Do Not Require UCP1

(2015) Ricardo J. Samms et al.   Cell Reports

Dietary Protein to Carbohydrate Ratio and Caloric Restriction: Comparing Metabolic Outcomes in Mice

(2015) Samantha M. Solon-Biet et al.   Cell Reports

Methionine restriction restores a younger metabolic phenotype in adult mice with alterations in fibroblast growth factor 21

(2014) Emma K. Lees et al.   AGING CELL

FGF21 Acts Centrally to Induce Sympathetic Nerve Activity, Energy Expenditure, and Weight Loss

(2014) Bryn M. Owen et al.   Cell Metabolism

The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice

(2014) Samantha M. Solon-Biet et al.   Cell Metabolism

Low Protein Intake Is Associated with a Major Reduction in IGF-1, Cancer, and Overall Mortality in the 65 and Younger but Not Older Population

(2014) Morgan E. Levine et al.   Cell Metabolism

Mechanisms of Increased In Vivo Insulin Sensitivity by Dietary Methionine Restriction in Mice

(2014) Kirsten P. Stone et al.   DIABETES

Circulating FGF21 Is Liver Derived and Enhances Glucose Uptake During Refeeding and Overfeeding

(2014) K. R. Markan et al.   DIABETES

Interplay between FGF21 and insulin action in the liver regulates metabolism

(2014) Brice Emanuelli et al.   JOURNAL OF CLINICAL INVESTIGATION

FGF21 is an endocrine signal of protein restriction

(2014) Thomas Laeger et al.   JOURNAL OF CLINICAL INVESTIGATION

Effects of individual branched-chain amino acids deprivation on insulin sensitivity and glucose metabolism in mice

(2014) Fei Xiao et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Branched-chain amino acids in metabolic signalling and insulin resistance

(2014) Christopher J. Lynch et al.   Nature Reviews Endocrinology

The Development of Diet-Induced Obesity and Glucose Intolerance in C57Bl/6 Mice on a High-Fat Diet Consists of Distinct Phases

(2014) Lynda M. Williams et al.   PLoS One

Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

(2014) Ildiko Kasza et al.   PLoS Genetics

Prevention and reversal of hepatic steatosis with a high-protein diet in mice

(2013) Sonia C. Garcia-Caraballo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness

(2013) Bryan C. Batch et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

An Instrument to Measure Adherence to Weight Loss Programs: The Compliance Praxis Survey-Diet (COMPASS-Diet)

(2013) Monika Janda et al.   Nutrients

UCP1 in Brite/Beige Adipose Tissue Mitochondria Is Functionally Thermogenic

(2013) Irina G. Shabalina et al.   Cell Reports

Activating transcription factor 4-dependent induction of FGF21 during amino acid deprivation

(2012) Ana Luísa De Sousa-Coelho et al.   BIOCHEMICAL JOURNAL

BMP8B Increases Brown Adipose Tissue Thermogenesis through Both Central and Peripheral Actions

(2012) Andrew J. Whittle et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

FGF21 regulates PGC-1  and browning of white adipose tissues in adaptive thermogenesis

(2012) f. M. Fisher et al.   GENES & DEVELOPMENT

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

(2011) S. H. Shah et al.   DIABETOLOGIA

Lipid droplets: size matters

(2011) M. Suzuki et al.   Microscopy

Surrogate measures of insulin resistance: of rats, mice, and men

(2009) Kieren Mather   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

(2009) Christopher B. Newgard et al.   Cell Metabolism

Dietary Intake of Total, Animal, and Vegetable Protein and Risk of Type 2 Diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-NL Study

(2009) I. Sluijs et al.   DIABETES CARE

Fibroblast Growth Factor 21 Controls Glycemia via Regulation of Hepatic Glucose Flux and Insulin Sensitivity

(2009) Eric D. Berglund et al.   ENDOCRINOLOGY