MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency

(2017) Tinh-Hai Collet et al.   Molecular Metabolism

Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist

(2016) Jocelyn M Bischof et al.   BRITISH JOURNAL OF PHARMACOLOGY

Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist

(2016) Peter Kühnen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seven Novel DeleteriousLEPRMutations Found in Early-Onset Obesity: a ΔExon6–8 Shared by Subjects From Reunion Island, France, Suggests a Founder Effect

(2015) Hélène Huvenne et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

3-iodothyronamine differentially modulates  -2A-adrenergic receptor-mediated signaling

(2015) J. Dinter et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons

(2015) Masoud Ghamari-Langroudi et al.   NATURE

Investigational drugs in Phase II clinical trials for the treatment of obesity: implications for future development of novel therapies

(2014) V Margaret Jackson et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

20 YEARS OF LEPTIN: Human disorders of leptin action

(2014) I Sadaf Farooqi et al.   JOURNAL OF ENDOCRINOLOGY

Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design

(2013) J. Koehbach et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of a Lipid G Protein-Coupled Receptor

(2012) M. A. Hanson et al.   SCIENCE

Crystal structure of the β2 adrenergic receptor–Gs protein complex

(2011) Søren G. F. Rasmussen et al.   NATURE

Potent and Selective Agonism of the Melanocortin Receptor 4 With MK-0493 Does Not Induce Weight Loss in Obese Human Subjects: Energy Intake Predicts Lack of Weight Loss Efficacy

(2009) R Krishna et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Pertussis Toxin-sensitive Signaling of Melanocortin-4 Receptors in Hypothalamic GT1-7 Cells Defines Agouti-related Protein as a Biased Agonist

(2009) Thomas R. H. Büch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prevalence of Melanocortin-4 Receptor Deficiency in Europeans and Their Age-Dependent Penetrance in Multigenerational Pedigrees

(2008) F. Stutzmann et al.   DIABETES