Short-chain fatty acids in control of body weight and insulin sensitivity

Short-Chain Fatty Acids Protect Against High-Fat Diet–Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation

(2015) Gijs den Besten et al.   DIABETES

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

(2015) Laurence Macia et al.   Nature Communications

Microbiota-Generated Metabolites Promote Metabolic Benefits via Gut-Brain Neural Circuits

(2014) Filipe De Vadder et al.   CELL

Insights Into the Role of the Microbiome in Obesity and Type 2 Diabetes

(2014) Annick V. Hartstra et al.   DIABETES CARE

Intestinal glucose metabolism revisited

(2014) Gilles Mithieux et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents

(2014) A Psichas et al.   INTERNATIONAL JOURNAL OF OBESITY

Short-Chain Fatty Acids Enhance Adipocyte Differentiation in the Stromal Vascular Fraction of Porcine Adipose Tissue

(2014) Genlai Li et al.   JOURNAL OF NUTRITION

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

(2014) Gerald I. Shulman   NEW ENGLAND JOURNAL OF MEDICINE

The impact of oligofructose on stimulation of gut hormones, appetite regulation and adiposity

(2014) Norlida M. Daud et al.   Obesity

Inulin propionate ester increases satiety and decreases appetite but does not affect gastric emptying in healthy humans

(2014) H. Alhabeeb et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism

(2014) Gary Frost et al.   Nature Communications

Immune Cell Toll-like Receptor 4 Mediates the Development of Obesity- and Endotoxemia-Associated Adipose Tissue Fibrosis

(2014) Isabelle K. Vila et al.   Cell Reports

Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis

(2014) G Frost et al.   Nutrition & Diabetes

Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans

(2014) J Fernandes et al.   Nutrition & Diabetes

Butyrate and other short-chain fatty acids increase the rate of lipolysis in 3T3-L1 adipocytes

(2014) John M. Rumberger et al.   PeerJ

Sodium acetate decreases phosphorylation of hormone sensitive lipase in isoproterenol-stimulated 3T3-L1 mature adipocytes

(2014) Nicola Aberdein et al.   Adipocyte

Gut hormone release and appetite regulation in healthy non-obese participants following oligofructose intake. A dose-escalation study

(2013) Camilla Pedersen et al.   APPETITE

Effect of polydextrose and soluble maize fibre on energy metabolism, metabolic profile and appetite control in overweight men and women

(2013) Ellen Konings et al.   BRITISH JOURNAL OF NUTRITION

Microbial Modulation of Energy Availability in the Colon Regulates Intestinal Transit

(2013) Anita Wichmann et al.   Cell Host & Microbe

Butyrate Attenuates Inflammation and Lipolysis Generated by the Interaction of Adipocytes and Macrophages

(2013) Hideo Ohira et al.   Journal of Atherosclerosis and Thrombosis

Increased brain uptake and oxidation of acetate in heavy drinkers

(2013) Lihong Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Control of inflammation by integration of environmental cues by regulatory T cells

(2013) Ashutosh Chaudhry et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of oral vancomycin on gut microbiota, bile acid metabolism, and insulin sensitivity

(2013) Anne Vrieze et al.   JOURNAL OF HEPATOLOGY

A Mixture of trans-Galactooligosaccharides Reduces Markers of Metabolic Syndrome and Modulates the Fecal Microbiota and Immune Function of Overweight Adults

(2013) Jelena Vulevic et al.   JOURNAL OF NUTRITION

Short-Chain Fatty Acids Activate AMP-Activated Protein Kinase and Ameliorate Ethanol-Induced Intestinal Barrier Dysfunction in Caco-2 Cell Monolayers

(2013) Elhaseen E. Elamin et al.   JOURNAL OF NUTRITION

Improvement Effect of Resistant Maltodextrin in Humans with Metabolic Syndrome by Continuous Administration

(2013) Chieko HASHIZUME et al.   JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

(2013) Yukihiro Furusawa et al.   NATURE

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

(2013) Nicholas Arpaia et al.   NATURE

The gut microbiota and obesity: from correlation to causality

(2013) Liping Zhao   NATURE REVIEWS MICROBIOLOGY

Evaluation of the relationship between GPR43 and adiposity in human

(2013) Evelyne M Dewulf et al.   Nutrition & Metabolism

Impact of dietary fiber intake on glycemic control, cardiovascular risk factors and chronic kidney disease in Japanese patients with type 2 diabetes mellitus: the Fukuoka Diabetes Registry

(2013) Hiroki Fujii et al.   Nutrition Journal

Butyrate-Producing Probiotics Reduce Nonalcoholic Fatty Liver Disease Progression in Rats: New Insight into the Probiotics for the Gut-Liver Axis

(2013) Hitoshi Endo et al.   PLoS One

Acetic Acid Activates the AMP-Activated Protein Kinase Signaling Pathway to Regulate Lipid Metabolism in Bovine Hepatocytes

(2013) Xinwei Li et al.   PLoS One

Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation

(2013) Jennifer L. Pluznick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

(2013) V. K. Ridaura et al.   SCIENCE

The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43

(2013) Ikuo Kimura et al.   Nature Communications

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide-Dependent Mechanism

(2012) W. Chai et al.   DIABETES

Intravenous acetate elicits a greater free fatty acid rebound in normal than hyperinsulinaemic humans

(2012) J Fernandes et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Transfer of Intestinal Microbiota From Lean Donors Increases Insulin Sensitivity in Individuals With Metabolic Syndrome

(2012) Anne Vrieze et al.   GASTROENTEROLOGY

Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women

(2012) Evelyne M Dewulf et al.   GUT

Gut Hormones and Appetite Control: A Focus on PYY and GLP-1 as Therapeutic Targets in Obesity

(2012) Akila De Silva et al.   Gut and Liver

Short-Chain Fatty Acids Suppress Lipopolysaccharide-Induced Production of Nitric Oxide and Proinflammatory Cytokines Through Inhibition of NF-κB Pathway in RAW264.7 Cells

(2012) Tengfei Liu et al.   INFLAMMATION

Bacteria, Colonic Fermentation, and Gastrointestinal Health

(2012) George T. Macfarlane et al.   JOURNAL OF AOAC INTERNATIONAL

Significance of Short Chain Fatty Acid Transport by Members of the Monocarboxylate Transporter Family (MCT)

(2012) Ivano Moschen et al.   NEUROCHEMICAL RESEARCH

Butyrate and Propionate Protect against Diet-Induced Obesity and Regulate Gut Hormones via Free Fatty Acid Receptor 3-Independent Mechanisms

(2012) Hua V. Lin et al.   PLoS One

Fish oil combined with SCFA synergistically prevent tissue accumulation of NEFA during weight loss in obese mice

(2011) Maiken H. Pedersen et al.   BRITISH JOURNAL OF NUTRITION

Short-Chain Fatty Acids Stimulate Glucagon-Like Peptide-1 Secretion via the G-Protein-Coupled Receptor FFAR2

(2011) G. Tolhurst et al.   DIABETES

Bacterial monocultures, propionate, butyrate and H2O2 modulate the expression, secretion and structure of the fasting-induced adipose factor in gut epithelial cell lines

(2011) Charlotte Grootaert et al.   ENVIRONMENTAL MICROBIOLOGY

Propionic acid affects immune status and metabolism in adipose tissue from overweight subjects

(2011) Sa’ad Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Relevance of protein fermentation to gut health

(2011) Karen Windey et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Short-chain fatty acids and ketones directly regulate sympathetic nervous system via G protein-coupled receptor 41 (GPR41)

(2011) I. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of adipokine production in human adipose tissue by propionic acid

(2010) Sa’ad H. Al-Lahham et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Roles of GPR41 and GPR43 in leptin secretory responses of murine adipocytes to short chain fatty acids

(2010) Mohamed S. Zaibi et al.   FEBS LETTERS

Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models

(2010) E F Murphy et al.   GUT

Redundant Control of Adipogenesis by Histone Deacetylases 1 and 2

(2010) Michael Haberland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice

(2010) Evelyne M. Dewulf et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The endocannabinoid system links gut microbiota to adipogenesis

(2010) Giulio G Muccioli et al.   Molecular Systems Biology

Probiotics lower plasma glucose in the high-fat fed C57BL/6J mouse

(2010) U. Andersson et al.   Beneficial Microbes

Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults

(2009) Jill A Parnell et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal

(2009) Patrice D Cani et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Expression of short-chain fatty acid receptor GPR41 in the human colon

(2009) Hideaki Tazoe et al.   BIOMEDICAL RESEARCH-TOKYO

Vinegar Intake Reduces Body Weight, Body Fat Mass, and Serum Triglyceride Levels in Obese Japanese Subjects

(2009) Tomoo KONDO et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Effects of Acetate on Lipid Metabolism in Muscles and Adipose Tissues of Type 2 Diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) Rats

(2009) Hiromi YAMASHITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Acute effects of intravenous and rectal acetate on glucagon-like peptide-1, peptide YY, ghrelin, adiponectin and tumour necrosis factor-α

(2009) Kristin R. Freeland et al.   BRITISH JOURNAL OF NUTRITION

GPR109A Is a G-protein-Coupled Receptor for the Bacterial Fermentation Product Butyrate and Functions as a Tumor Suppressor in Colon

(2009) M. Thangaraju et al.   CANCER RESEARCH

AMPK: An Emerging Drug Target for Diabetes and the Metabolic Syndrome

(2009) Bei B. Zhang et al.   Cell Metabolism

Short chain fatty acids exchange across the gut and liver in humans measured at surgery

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Short chain fatty acids exchange: Is the cirrhotic, dysfunctional liver still able to clear them?

(2009) Johanne G. Bloemen et al.   CLINICAL NUTRITION

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

(2009) N. N. Mehta et al.   DIABETES

Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice

(2009) Z. Gao et al.   DIABETES

Acetic Acid Upregulates the Expression of Genes for Fatty Acid Oxidation Enzymes in Liver To Suppress Body Fat Accumulation

(2009) Tomoo Kondo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Human P-selectin glycoprotein ligand-1 is a functional receptor for enterovirus 71

(2009) Yorihiro Nishimura et al.   NATURE MEDICINE

Microbiota and SCFA in Lean and Overweight Healthy Subjects

(2009) Andreas Schwiertz et al.   Obesity

Metabolic flexibility in the development of insulin resistance and type 2 diabetes: effects of lifestyle

(2009) E. Corpeleijn et al.   Obesity Reviews

Short-chain fatty acids act as antiinflammatory mediatorsby regulating prostaglandin E2 and cytokines

(2009) Mary Ann Cox et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents

(2008) June Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Adipose Macrophage Infiltration Is Associated With Insulin Resistance and Vascular Endothelial Dysfunction in Obese Subjects

(2008) Caroline M. Apovian et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Physiological concentrations of short-chain fatty acids immediately suppress colonic epithelial permeability

(2008) Takuya Suzuki et al.   BRITISH JOURNAL OF NUTRITION

Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

(2008) Timothy R. Koves et al.   Cell Metabolism

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

(2008) Mathieu Membrez et al.   FASEB JOURNAL

A core gut microbiome in obese and lean twins

(2008) Peter J. Turnbaugh et al.   NATURE

Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41

(2008) B. S. Samuel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance

(2007) Gijs H. Goossens   PHYSIOLOGY & BEHAVIOR