The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

Complete Azoospermia Factor b Deletion of Y Chromosome in an Infertile Male With Severe Oligoasthenozoospermia: Case Report and Literature Review

(2017) Yong-Sheng Zhang et al.   UROLOGY

An updated meta-analysis of XRCC4 polymorphisms and cancer risk based on 31 case-control studies

(2017) Ning Shao et al.   Cancer Biomarkers

Dual TORK/DNA-PK inhibition blocks critical signaling pathways in chronic lymphocytic leukemia

(2016) R. Thijssen et al.   BLOOD

SCR7 is neither a selective nor a potent inhibitor of human DNA ligase IV

(2016) George E. Greco et al.   DNA REPAIR

A novel small molecule inhibitor of the DNA repair protein Ku70/80

(2016) Eric Weterings et al.   DNA REPAIR

Interplay between Fanconi anemia and homologous recombination pathways in genome integrity

(2016) Johanna Michl et al.   EMBO JOURNAL

Identification of PRKDC (Protein Kinase, DNA-Activated, Catalytic Polypeptide) as an essential gene for colorectal cancer (CRCs) cells

(2016) Shangfeng Sun et al.   GENE

DNA-PKcs Expression Is a Predictor of Biochemical Recurrence After Permanent Iodine 125 Interstitial Brachytherapy for Prostate Cancer

(2016) Sarah Molina et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Genetic effects of XRCC4 and ligase IV genes on human glioma

(2016) Keping Jiao et al.   NEUROREPORT

Expression and significance of Ku80 and PDGFR-α in nasal NK/T-cell lymphoma

(2016) Jun Li et al.   PATHOLOGY RESEARCH AND PRACTICE

Association between single-nucleotide polymorphisms in DNA double-strand break repair genes and prostate cancer aggressiveness in the Spanish population

(2016) L A Henríquez-Hernández et al.   PROSTATE CANCER AND PROSTATIC DISEASES

LIG4 mediates Wnt signalling-induced radioresistance

(2016) Sohee Jun et al.   Nature Communications

Expression of Interactive Genes Associated with Apoptosis and Their Prognostic Value for Ovarian Serous Adenocarcinoma

(2016) Heungyeol Kim et al.   Advances in Clinical and Experimental Medicine

Genomic landscape of DNA repair genes in cancer

(2016) Young Kwang Chae et al.   Oncotarget

Common genetic variations in cell cycle and DNA repair pathways associated with pediatric brain tumor susceptibility

(2016) Maral Adel Fahmideh et al.   Oncotarget

Increasing sensitivity to DNA damage is a potential driver for human ovarian cancer

(2016) Yimei Jin et al.   Oncotarget

The Expression Levels of XLF and Mutant P53 Are Inversely Correlated in Head and Neck Cancer Cells

(2016) Sizhe Feng et al.   Journal of Cancer

System-wide Clinical Proteomics of Breast Cancer Reveals Global Remodeling of Tissue Homeostasis

(2016) Yair Pozniak et al.   Cell Systems

Single Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis

(2016) Scooter Willis et al.   PLoS One

Structure-Based Virtual Ligand Screening on the XRCC4/DNA Ligase IV Interface

(2016) Grégory Menchon et al.   Scientific Reports

Chromothripsis: A New Mechanism for Rapid Karyotype Evolution

(2015) Mitchell L. Leibowitz et al.   Annual Review of Genetics

How cancer cells hijack DNA double-strand break repair pathways to gain genomic instability

(2015) P. A. Jeggo et al.   BIOCHEMICAL JOURNAL

DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis

(2015) Jonathan F. Goodwin et al.   CANCER CELL

DNA-PKcs plays role in cancer metastasis through regulation of secreted proteins involved in migration and invasion

(2015) Ewa Kotula et al.   CELL CYCLE

Defects in the Fanconi Anemia Pathway in Head and Neck Cancer Cells Stimulate Tumor Cell Invasion through DNA-PK and Rac1 Signaling

(2015) L. E. Romick-Rosendale et al.   CLINICAL CANCER RESEARCH

Association between single nucleotide polymorphisms of X-ray repair cross-complementing protein 4 gene and development of pancreatic cancer

(2015) Y. Ding et al.   GENETICS AND MOLECULAR RESEARCH

Chromothripsis in cancer cells: An update

(2015) Agata Rode et al.   INTERNATIONAL JOURNAL OF CANCER

The role of XRCC6/Ku70 in nasopharyngeal carcinoma

(2015) C.-Y. Huang et al.   INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY

XRCC4 deficiency in human subjects causes a marked neurological phenotype but no overt immunodeficiency

(2015) Chaowan Guo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator–dependent autoimmunity

(2015) Anne-Laure Mathieu et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Association Between the XRCC6 Polymorphisms and Cancer Risks

(2015) Jing Jia et al.   MEDICINE

The Ku heterodimer: Function in DNA repair and beyond

(2015) Victoria L. Fell et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Phosphorylation of Ku dictates DNA double-strand break (DSB) repair pathway choice in S phase

(2015) Kyung-Jong Lee et al.   NUCLEIC ACIDS RESEARCH

Spontaneous tumor development in bone marrow-rescued DNA-PKcs3A/3A mice due to dysfunction of telomere leading strand deprotection

(2015) S Zhang et al.   ONCOGENE

Expression of DNA ligase IV is linked to poor prognosis and characterizes a subset of prostate cancers harboring TMPRSS2:ERG fusion and PTEN deletion

(2015) KATHARINA GRUPP et al.   ONCOLOGY REPORTS

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Castration radiosensitizes prostate cancer tissue by impairing DNA double-strand break repair

(2015) Firas L. Tarish et al.   Science Translational Medicine

Whole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets

(2015) Agnieszka K. Witkiewicz et al.   Nature Communications

Genetic variants of the DNA damage repair genes XRCC4 and RAD51 are associated with susceptibility to esophageal cancer

(2015) Sun Ming-zhong et al.   Clinics and Research in Hepatology and Gastroenterology

Invasive oral cancer stem cells display resistance to ionising radiation

(2015) Emilios Gemenetzidis et al.   Oncotarget

Common cancer-associated imbalances in the DNA damage response confer sensitivity to single agent ATR inhibition

(2015) Fiona K. Middleton et al.   Oncotarget

Loss of expression of the double strand break repair protein ATM is associated with worse prognosis in colorectal cancer and loss of Ku70 expression is associated with CIN

(2015) Andrew D Beggs et al.   Oncotarget

A recessive variant of XRCC4 predisposes to non- BRCA1/2 breast cancer in chinese women and impairs the DNA damage response via dysregulated nuclear localization

(2015) Min He et al.   Oncotarget

Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population-based prognostic study

(2014) Angeline S. Andrew et al.   BJU INTERNATIONAL

DNA-PK--A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival

(2014) L. Cornell et al.   CLINICAL CANCER RESEARCH

Non-homologous end joining: Emerging themes and unanswered questions

(2014) Sarvan Kumar Radhakrishnan et al.   DNA REPAIR

DNA-PK: A dynamic enzyme in a versatile DSB repair pathway

(2014) Anthony J. Davis et al.   DNA REPAIR

Novel role for non-homologous end joining in the formation of double minutes in methotrexate-resistant colon cancer cells

(2014) Xiangning Meng et al.   JOURNAL OF MEDICAL GENETICS

Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

(2014) Hind Ghezraoui et al.   MOLECULAR CELL

Significant association of XRCC4 single nucleotide polymorphisms with prostate cancer susceptibility in Taiwanese males

(2014) Chao-Hsiang Chang et al.   Molecular Medicine Reports

Downregulated Ku70 and ATM associated to poor prognosis in colorectal cancer among Chinese patients

(2014) Yuanming Lu et al.   OncoTargets and Therapy

The fidelity of the ligation step determines how ends are resolved during nonhomologous end joining

(2014) Crystal A. Waters et al.   Nature Communications

From Breaking Bad to Worse: Exploiting Homologous DNA Repair Deficiency in Cancer

(2014) M. T. Hemann   Cancer Discovery

Relevance of LIG4 gene polymorphisms with cancer susceptibility: Evidence from a meta-analysis

(2014) Shang Xie et al.   Scientific Reports

Knock-In Reporter Mice Demonstrate that DNA Repair by Non-homologous End Joining Declines with Age

(2014) Amita Vaidya et al.   PLoS Genetics

Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

(2014) Mireille Bétermier et al.   PLoS Genetics

Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising

(2014) Christian Jekimovs et al.   Frontiers in Oncology

Clinicopathological significance of KU70/KU80, a key DNA damage repair protein in breast cancer

(2013) Alaa T. Alshareeda et al.   BREAST CANCER RESEARCH AND TREATMENT

Deregulation of DNA-dependent protein kinase catalytic subunit contributes to human hepatocarcinogenesis development and has a putative prognostic value

(2013) M Evert et al.   BRITISH JOURNAL OF CANCER

Castration Therapy Results in Decreased Ku70 Levels in Prostate Cancer

(2013) F. L. T. Al-Ubaidi et al.   CLINICAL CANCER RESEARCH

Genetic Polymorphisms in DNA Repair Genes XRCC4 and XRCC5 and Aflatoxin B1–related Hepatocellular Carcinoma

(2013) Xi-Dai Long et al.   EPIDEMIOLOGY

Nonreciprocal chromosomal translocations in renal cancer involve multiple DSBs and NHEJ associated with breakpoint inversion but not necessarily with transcription

(2013) Hanif Ali et al.   GENES CHROMOSOMES & CANCER

Association Between the XRCC6 Promoter rs2267437 Polymorphism and Cancer Risk: Evidence Based on the Current Literature

(2013) Haitao Xu et al.   Genetic Testing and Molecular Biomarkers

Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer

(2013) Christine Kuhmann et al.   HUMAN MOLECULAR GENETICS

Extreme Growth Failure is a Common Presentation of Ligase IV Deficiency

(2013) Jennie E. Murray et al.   HUMAN MUTATION

A preliminary study on the radiation-resistance mechanism in ovarian cancer

(2013) Yu-bing Chen et al.   Journal of Cancer Research and Therapeutics

PRKDC mutations in a SCID patient with profound neurological abnormalities

(2013) Lisa Woodbine et al.   JOURNAL OF CLINICAL INVESTIGATION

Association of XRCC3 and XRCC4 gene polymorphisms, family history of cancer and tobacco smoking with non-small-cell lung cancer in a Chinese population: a case–control study

(2013) Fei He et al.   JOURNAL OF HUMAN GENETICS

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Identification of the DNA Repair Defects in a Case of Dubowitz Syndrome

(2013) Jingyin Yue et al.   PLoS One

Correction: Nuclear Survivin and Its Relationship to DNA Damage Repair Genes in Non-Small Cell Lung Cancer Investigated Using Tissue Array

(2013) Songliu Hu et al.   PLoS One

Therapeutic Targeting of a Robust Non-Oncogene Addiction to PRKDC in ATM-Defective Tumors

(2013) A. Riabinska et al.   Science Translational Medicine

Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma

(2013) Wei Li   WORLD JOURNAL OF GASTROENTEROLOGY

Mutual regulation between DNA-PKcs and snail1 leads to increased genomic instability and aggressive tumor characteristics

(2013) B-J Pyun et al.   Cell Death & Disease

Expression of DNA-PKcs and BRCA1 as prognostic indicators in nasopharyngeal carcinoma following intensity-modulated radiation therapy

(2013) JIAO YANG et al.   Oncology Letters

Ku Protein Levels, Localization and Association to Replication Origins in Different Stages of Breast Tumor Progression

(2013) Khalil Abdelbaqi et al.   Journal of Cancer

XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair

(2012) Brandi L. Mahaney et al.   Biochemistry and Cell Biology

Impact of genomic stability on protein expression in endometrioid endometrial cancer

(2012) M I Lomnytska et al.   BRITISH JOURNAL OF CANCER

An Inhibitor of Nonhomologous End-Joining Abrogates Double-Strand Break Repair and Impedes Cancer Progression

(2012) Mrinal Srivastava et al.   CELL

DNA repair and replication proteins as prognostic markers in melanoma

(2012) Liang Song et al.   HISTOPATHOLOGY

Role of non-homologous end joining in V(D)J recombination

(2012) Shruti Malu et al.   IMMUNOLOGIC RESEARCH

Interaction between Polymorphisms of DNA Repair Genes Significantly Modulated Bladder Cancer Risk

(2012) Yi Zhi et al.   International Journal of Medical Sciences

DNA-PKcs Expression Predicts Response to Radiotherapy in Prostate Cancer

(2012) Patrick Bouchaert et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Ku80 is highly expressed in lung adenocarcinoma and promotes cisplatin resistance

(2012) Qingshan Ma et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Chemosensitization of Cancer Cells by KU-0060648, a Dual Inhibitor of DNA-PK and PI-3K

(2012) J. M. Munck et al.   MOLECULAR CANCER THERAPEUTICS

A functional polymorphism C-1310G in the promoter region ofKu70/XRCC6is associated with risk of renal cell carcinoma

(2012) Wei Wang et al.   MOLECULAR CARCINOGENESIS

Analysis and results of Ku and XRCC4 expression in hypopharyngeal cancer tissues treated with chemoradiotherapy

(2012) JYUNICHI HAYASHI et al.   Oncology Letters

Waldenström’s macroglobulinemia harbors a unique proteome where Ku70 is severely underexpressed as compared with other B-lymphoproliferative disorders

(2012) A Perrot et al.   Blood Cancer Journal

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Genetic polymorphisms of DNA double strand break gene Ku70 and gastric cancer in Taiwan

(2011) Mei-Due Yang et al.   BMC CANCER

The association of DNA-dependent protein kinase activity of peripheral blood lymphocytes with prognosis of cancer

(2011) M Someya et al.   BRITISH JOURNAL OF CANCER

Genetic polymorphisms in DNA double-strand break repair genes XRCC5 , XRCC6 and susceptibility to hepatocellular carcinoma

(2011) Rui Li et al.   CARCINOGENESIS

Massive Genomic Rearrangement Acquired in a Single Catastrophic Event during Cancer Development

(2011) Philip J. Stephens et al.   CELL

DNA Repair Biomarker Profiling of Head and Neck Cancer: Ku80 Expression Predicts Locoregional Failure and Death following Radiotherapy

(2011) B. J. Moeller et al.   CLINICAL CANCER RESEARCH

Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair

(2011) Shichuan Zhang et al.   JOURNAL OF CELL BIOLOGY

The Ku70 −1310C/G promoter polymorphism is associated with breast cancer susceptibility in Chinese Han population

(2011) Wenshan He et al.   MOLECULAR BIOLOGY REPORTS

DNA double-strand break repair pathways, chromosomal rearrangements and cancer

(2011) Torben R. Kasparek et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer

(2011) Jia-Qi Li   WORLD JOURNAL OF GASTROENTEROLOGY

The Mechanism of Double-Strand DNA Break Repair by the Nonhomologous DNA End-Joining Pathway

(2010) Michael R. Lieber   Annual Review of Biochemistry

Polymorphic Variants of DNA Repair Gene XRCC3 and XRCC7 and Risk of Prostate Cancer: A Study from North Indian Population

(2010) Raju K. Mandal et al.   DNA AND CELL BIOLOGY

Coping with DNA double strand breaks

(2010) Kevin Hiom   DNA REPAIR

Expression of TRF1, TRF2, TIN2, TERT, KU70, and BRCA1 proteins is associated with telomere shortening and may contribute to multistage carcinogenesis of gastric cancer

(2010) Hua Hu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4–ligase IV during chromosomal translocation formation

(2010) Deniz Simsek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

(2010) Joellen M. Schildkraut et al.   PLoS One

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

Genomic rearrangements in inherited disease and cancer

(2010) Jian-Min Chen et al.   SEMINARS IN CANCER BIOLOGY

Radioresistant cervical cancer shows upregulation of the NHEJ proteins DNA-PKcs, Ku70 and Ku86

(2009) C Beskow et al.   BRITISH JOURNAL OF CANCER

Lung cancer susceptibility and prognosis associated with polymorphisms in the nonhomologous end-joining pathway genes

(2009) Ruo-Chia Tseng et al.   CANCER

Nuclear Receptor-Induced Chromosomal Proximity and DNA Breaks Underlie Specific Translocations in Cancer

(2009) Chunru Lin et al.   CELL

Associations between Single Nucleotide Polymorphisms in Double-Stranded DNA Repair Pathway Genes and Familial Breast Cancer

(2009) M. E. Sehl et al.   CLINICAL CANCER RESEARCH

A polymorphism in the promoter region of Ku70/XRCC6, associated with breast cancer risk and oestrogen exposure

(2009) Petra Willems et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

A novel splice variant of the DNA-PKcs gene is associated with clinical and cellular radiosensitivity in a patient with xeroderma pigmentosum

(2009) F. Abbaszadeh et al.   JOURNAL OF MEDICAL GENETICS

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Association between DNA double strand break gene Ku80 polymorphisms and oral cancer susceptibility

(2009) Chia-Fang Hsu et al.   ORAL ONCOLOGY

Ku86 represses lethal telomere deletion events in human somatic cells

(2009) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eukaryotic DNA Ligases: Structural and Functional Insights

(2008) Tom Ellenberger et al.   Annual Review of Biochemistry

Prognostic significance ofataxia-telangiectasia mutated, DNA-dependent protein kinase catalytic subunit, and Ku heterodimeric regulatory complex 86-kD subunit expression in patients with nonsmall cell lung cancer

(2008) Jinliang Xing et al.   CANCER

Genetic Susceptibility to Renal Cell Carcinoma: The Role of DNA Double-Strand Break Repair Pathway

(2008) V. Margulis et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Rational Design of Human DNA Ligase Inhibitors that Target Cellular DNA Replication and Repair

(2008) X. Chen et al.   CANCER RESEARCH

Transient Inhibition of ATM Kinase Is Sufficient to Enhance Cellular Sensitivity to Ionizing Radiation

(2008) M. D. Rainey et al.   CANCER RESEARCH

DNA-Dependent Protein Kinase Is a Therapeutic Target and an Indicator of Poor Prognosis in B-Cell Chronic Lymphocytic Leukemia

(2008) E. Willmore et al.   CLINICAL CANCER RESEARCH

Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer

(2008) Miguel Angel Pavón et al.   INTERNATIONAL JOURNAL OF CANCER

Genetic variants of the XRCC7 gene involved in DNA repair and risk of human bladder cancer

(2008) Shou-Yu Wang et al.   INTERNATIONAL JOURNAL OF UROLOGY

A DNA-PKcs mutation in a radiosensitive T–B– SCID patient inhibits Artemis activation and nonhomologous end-joining

(2008) Mirjam van der Burg et al.   JOURNAL OF CLINICAL INVESTIGATION

Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas

(2008) Cui-Jie Shao et al.   JOURNAL OF NEURO-ONCOLOGY

Lymphocyte-Specific Compensation for XLF/Cernunnos End-Joining Functions in V(D)J Recombination

(2008) Gang Li et al.   MOLECULAR CELL

Single-nucleotide polymorphisms in DNA double-strand break repair genes: Association with head and neck cancer and interaction with tobacco use and alcohol consumption

(2008) Joke Werbrouck et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

XLF-Cernunnos promotes DNA ligase IV–XRCC4 re-adenylation following ligation

(2008) Enriqueta Riballo et al.   NUCLEIC ACIDS RESEARCH

Oral cancer and genetic polymorphism of DNA double strand break gene Ku70 in Taiwan

(2008) Da-Tian Bau et al.   ORAL ONCOLOGY

A novel single nucleotide polymorphism in XRCC4 gene is associated with oral cancer susceptibility in Taiwanese patients

(2008) Chang-Fang Chiu et al.   ORAL ONCOLOGY

Ku70, an essential gene, modulates the frequency of rAAV-mediated gene targeting in human somatic cells

(2008) F. J. Fattah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA