Homologous-recombination-deficient tumours are dependent on Polθ-mediated repair

DNA Repair Pathway Gene Expression Score Correlates with Repair Proficiency and Tumor Sensitivity to Chemotherapy

(2014) S. P. Pitroda et al.   Science Translational Medicine

A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

(2014) Wouter Koole et al.   Nature Communications

PARP1-Driven Poly-ADP-Ribosylation Regulates BRCA1 Function in Homologous Recombination-Mediated DNA Repair

(2014) Y. Hu et al.   Cancer Discovery

The HsRAD51B–HsRAD51C stabilizes the HsRAD51 nucleoprotein filament

(2013) Ravindra Amunugama et al.   DNA REPAIR

Integrated genomic characterization of endometrial carcinoma

(2013) Gad Getz et al.   NATURE

Signatures of mutational processes in human cancer

(2013) Ludmil B. Alexandrov et al.   NATURE

Repair of Double-Strand Breaks by End Joining

(2013) K. K. Chiruvella et al.   Cold Spring Harbor Perspectives in Biology

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

DNA polymerase POLQ and cellular defense against DNA damage

(2012) Matthew J. Yousefzadeh et al.   DNA REPAIR

A DNA Repair Pathway–Focused Score for Prediction of Outcomes in Ovarian Cancer Treated With Platinum-Based Chemotherapy

(2012) Josephine Kang et al.   JNCI-Journal of the National Cancer Institute

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

(2011) Da Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Inhibition of Homologous Recombination by the PCNA-Interacting Protein PARI

(2011) George-Lucian Moldovan et al.   MOLECULAR CELL

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overlapping Mechanisms Promote Postsynaptic RAD-51 Filament Disassembly during Meiotic Double-Strand Break Repair

(2010) Jordan D. Ward et al.   MOLECULAR CELL

An essential role for CtIP in chromosomal translocation formation through an alternative end-joining pathway

(2010) Yu Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Synthesis-dependent microhomology-mediated end joining accounts for multiple types of repair junctions

(2010) Amy Marie Yu et al.   NUCLEIC ACIDS RESEARCH

DNA polymerase   up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

(2010) F. Lemee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1

(2010) Kalindi Parmar et al.   STEM CELLS

Dual Roles for DNA Polymerase Theta in Alternative End-Joining Repair of Double-Strand Breaks in Drosophila

(2010) Sze Ham Chan et al.   PLoS Genetics

RTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination

(2008) Louise J. Barber et al.   CELL

Caenorhabditis elegans POLQ-1 and HEL-308 function in two distinct DNA interstrand cross-link repair pathways

(2008) Diego M. Muzzini et al.   DNA REPAIR

HARP Is an ATP-Driven Annealing Helicase

(2008) T. Yusufzai et al.   SCIENCE

MMEJ repair of double-strand breaks (director’s cut): deleted sequences and alternative endings

(2008) Mitch McVey et al.   TRENDS IN GENETICS

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics

DNA polymerase θ (POLQ) can extend from mismatches and from bases opposite a (6-4) photoproduct

(2007) Mineaki Seki et al.   DNA REPAIR