The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The Enigmatic Function of PARP1: From PARylation Activity to PAR Readers
Authors
Keywords
-
Journal
Cells
Volume 8, Issue 12, Pages 1625
Publisher
MDPI AG
Online
2019-12-13
DOI
10.3390/cells8121625
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Suppression of cell cycle progression by poly(ADP-ribose) polymerase inhibitor PJ34 in neural stem/progenitor cells
- (2019) Suguru Kurokawa et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Regulating Immunity via ADP-Ribosylation: Therapeutic Implications and Beyond
- (2019) Friedrich A. Kunze et al. TRENDS IN IMMUNOLOGY
- The CHD6 chromatin remodeler is an oxidative DNA damage response factor
- (2019) Shaun Moore et al. Nature Communications
- Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1
- (2019) Luis M. Polo et al. Cell Reports
- GFP-Fragment Reassembly Screens for the Functional Characterization of Variants of Uncertain Significance in Protein Interaction Domains of the BRCA1 and BRCA2 Genes
- (2019) Laura Caleca et al. Cancers
- Poly(ADP-ribosyl)ation by PARP1: reaction mechanism and regulatory proteins
- (2019) Elizaveta E Alemasova et al. NUCLEIC ACIDS RESEARCH
- Targeting dePARylation selectively suppresses DNA repair–defective and PARP inhibitor–resistant malignancies
- (2019) Shih-Hsun Chen et al. Science Advances
- PARP Inhibitors as a Therapeutic Agent for Homologous Recombination Deficiency in Breast Cancers
- (2019) Man Keung et al. Journal of Clinical Medicine
- Cell-Penetrating Function of the Poly(ADP-Ribose) (PAR)-Binding Motif Derived from the PAR-Dependent E3 Ubiquitin Ligase Iduna
- (2018) Ja-Hyun Koo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition
- (2018) Yasin Pourfarjam et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PARP-1–dependent recruitment of cold-inducible RNA-binding protein promotes double-strand break repair and genome stability
- (2018) Jung-Kuei Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural basis for the interaction between the cell polarity proteins Par3 and Par6
- (2018) Fabian A. Renschler et al. Science Signaling
- The PARP1-Siah1 Axis Controls HIV-1 Transcription and Expression of Siah1 Substrates
- (2018) Dan Yu et al. Cell Reports
- Structural basis for the interaction between the cell polarity proteins Par3 and Par6
- (2018) Fabian A. Renschler et al. Science Signaling
- PARP2 mediates branched poly ADP-ribosylation in response to DNA damage
- (2018) Qian Chen et al. Nature Communications
- PARP family enzymes: regulation and catalysis of the poly(ADP-ribose) posttranslational modification
- (2018) Marie-France Langelier et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- PARPs and ADP-ribosylation: recent advances linking molecular functions to biological outcomes
- (2017) Rebecca Gupte et al. GENES & DEVELOPMENT
- Therapeutic Targeting of Poly(ADP-Ribose) Polymerase-1 (PARP1) in Cancer: Current Developments, Therapeutic Strategies, and Future Opportunities
- (2017) Jyotika Rajawat et al. MEDICINAL RESEARCH REVIEWS
- Serine ADP-Ribosylation Depends on HPF1
- (2017) Juan José Bonfiglio et al. MOLECULAR CELL
- Poly-ADP ribosylation in DNA damage response and cancer therapy
- (2017) Wei-Hsien Hou et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
- (2017) Arnab Ray Chaudhuri et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Kinetics of poly(ADP-ribosyl)ation, but not PARP1 itself, determines the cell fate in response to DNA damage in vitro and in vivo
- (2017) Harald Schuhwerk et al. NUCLEIC ACIDS RESEARCH
- The role of poly ADP-ribosylation in the first wave of DNA damage response
- (2017) Chao Liu et al. NUCLEIC ACIDS RESEARCH
- Structural conservation of the PIN domain active site across all domains of life
- (2017) M. Senissar et al. PROTEIN SCIENCE
- PARPing for balance in the homeostasis of poly(ADP-ribosyl)ation
- (2017) Harald Schuhwerk et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- The conserved macrodomains of the non-structural proteins of Chikungunya virus and other pathogenic positive strand RNA viruses function as mono-ADP-ribosylhydrolases
- (2017) Laura Eckei et al. Scientific Reports
- Macrodomains: Structure, Function, Evolution, and Catalytic Activities
- (2016) Johannes Gregor Matthias Rack et al. Annual Review of Biochemistry
- The PARP family: insights into functional aspects of poly (ADP-ribose) polymerase-1 in cell growth and survival
- (2016) T. Jubin et al. CELL PROLIFERATION
- ADPriboDB: The database of ADP-ribosylated proteins
- (2016) Christina A. Vivelo et al. NUCLEIC ACIDS RESEARCH
- Functions of PARylation in DNA Damage Repair Pathways
- (2016) Huiting Wei et al. GENOMICS PROTEOMICS & BIOINFORMATICS
- Nuclear ADP-Ribosylation and Its Role in Chromatin Plasticity, Cell Differentiation, and Epigenetics
- (2015) Michael O. Hottiger Annual Review of Biochemistry
- ADP-Ribosyltransferases and Poly ADP-Ribosylation
- (2015) Chao Liu et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function
- (2015) Felix Y. Feng et al. MOLECULAR CELL
- C2H2 zinc finger proteins greatly expand the human regulatory lexicon
- (2015) Hamed S Najafabadi et al. NATURE BIOTECHNOLOGY
- The PIN domain of EXO1 recognizes poly(ADP-ribose) in DNA damage response
- (2015) Feng Zhang et al. NUCLEIC ACIDS RESEARCH
- Readers of poly(ADP-ribose): designed to be fit for purpose
- (2015) Federico Teloni et al. NUCLEIC ACIDS RESEARCH
- Branching of poly(ADP-ribose): Synthesis of the Core Motif
- (2015) Hans A. V. Kistemaker et al. ORGANIC LETTERS
- Poly(ADP-ribose) polymerase-13 and RNA regulation in immunity and cancer
- (2015) Tanya Todorova et al. TRENDS IN MOLECULAR MEDICINE
- Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)
- (2015) Matthias Altmeyer et al. Nature Communications
- Poly(ADP-Ribose) Mediates the BRCA2-Dependent Early DNA Damage Response
- (2015) Feng Zhang et al. Cell Reports
- Conformational Activation of Poly(ADP-ribose) Polymerase-1 upon DNA Binding Revealed by Small-Angle X-ray Scattering
- (2014) Steven O. Mansoorabadi et al. BIOCHEMISTRY
- Poly(ADP-ribose) polymerases in double-strand break repair: Focus on PARP1, PARP2 and PARP3
- (2014) Carole Beck et al. EXPERIMENTAL CELL RESEARCH
- A Quantitative Assay Reveals Ligand Specificity of the DNA Scaffold Repair Protein XRCC1 and Efficient Disassembly of Complexes of XRCC1 and the Poly(ADP-ribose) Polymerase 1 by Poly(ADP-ribose) Glycohydrolase
- (2014) In-Kwon Kim et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Poly(ADP-ribose): An organizer of cellular architecture
- (2014) Anthony K.L. Leung JOURNAL OF CELL BIOLOGY
- Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
- (2014) Paul A. DaRosa et al. NATURE
- How Structure Defines Affinity in Protein-Protein Interactions
- (2014) Ariel Erijman et al. PLoS One
- The oligonucleotide/oligosaccharide-binding fold motif is a poly(ADP-ribose)-binding domain that mediates DNA damage response
- (2014) F. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD + Depletion
- (2014) Elise Fouquerel et al. Cell Reports
- RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination
- (2013) Meredith B. Metzger et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation
- (2013) Mo Li et al. CANCER CELL
- The FHA and BRCT domains recognize ADP-ribosylation during DNA damage response
- (2013) M. Li et al. GENES & DEVELOPMENT
- The novel PAR-1-binding protein MTCL1 has crucial roles in organizing microtubules in polarizing epithelial cells
- (2013) Y. Sato et al. JOURNAL OF CELL SCIENCE
- PARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage
- (2013) Stuart L. Rulten et al. NUCLEIC ACIDS RESEARCH
- Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation
- (2013) WooKee Min et al. Nature Communications
- Recognition of the iso-ADP-ribose moiety in poly(ADP-ribose) by WWE domains suggests a general mechanism for poly(ADP-ribosyl)ation-dependent ubiquitination
- (2012) Z. Wang et al. GENES & DEVELOPMENT
- On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1
- (2012) X. Luo et al. GENES & DEVELOPMENT
- CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation
- (2012) Lisa Kashima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation
- (2012) M. Isabelle et al. JOURNAL OF CELL SCIENCE
- The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
- (2012) Ammar A E Ali et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- CHFR is important for the first wave of ubiquitination at DNA damage sites
- (2012) Chao Liu et al. NUCLEIC ACIDS RESEARCH
- PARP activation regulates the RNA-binding protein NONO in the DNA damage response to DNA double-strand breaks
- (2012) Jana Krietsch et al. NUCLEIC ACIDS RESEARCH
- PARP-1 Activation--Bringing the Pieces Together
- (2012) J.-P. Gagne et al. SCIENCE
- Structural Basis for DNA Damage-Dependent Poly(ADP-ribosyl)ation by Human PARP-1
- (2012) M.-F. Langelier et al. SCIENCE
- Ring finger protein 146/Iduna is a Poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase
- (2012) Zhi-dong Zhou et al. Cell Adhesion & Migration
- Regulation of chromatin structure by poly(ADP-ribosyl)ation
- (2012) Sascha Beneke Frontiers in Genetics
- PARP-1 Inhibition Increases Mitochondrial Metabolism through SIRT1 Activation
- (2011) Péter Bai et al. Cell Metabolism
- Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA
- (2011) Marie-France Langelier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase
- (2011) Dea Slade et al. NATURE
- RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling
- (2011) Yue Zhang et al. NATURE CELL BIOLOGY
- Iduna protects the brain from glutamate excitotoxicity and stroke by interfering with poly(ADP-ribose) polymer-induced cell death
- (2011) Shaida A Andrabi et al. NATURE MEDICINE
- Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage
- (2011) H. C. Kang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression
- (2011) C. Boehler et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)
- (2011) Y. Wang et al. Science Signaling
- Structural studies of the PARP-1 BRCT domain
- (2011) Paul A Loeffler et al. BMC STRUCTURAL BIOLOGY
- Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression
- (2011) Magdalena Murawska et al. PLoS Genetics
- High-Affinity Interaction of Poly(ADP-ribose) and the Human DEK Oncoprotein Depends upon Chain Length
- (2010) Jörg Fahrer et al. BIOCHEMISTRY
- The Zn3 Domain of Human Poly(ADP-ribose) Polymerase-1 (PARP-1) Functions in Both DNA-dependent Poly(ADP-ribose) Synthesis Activity and Chromatin Compaction
- (2010) Marie-France Langelier et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PARP1 deficiency exacerbates diet-induced obesity in mice
- (2010) Kishor Devalaraja-Narashimha et al. JOURNAL OF ENDOCRINOLOGY
- The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets
- (2010) Raga Krishnakumar et al. MOLECULAR CELL
- Structure and identification of ADP-ribose recognition motifs of APLF and role in the DNA damage response
- (2010) G.-Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential
- (2009) WooKee Min Frontiers in Bioscience-Landmark
- PARP-1 Deficiency Increases the Severity of Disease in a Mouse Model of Multiple Sclerosis
- (2009) Vimal Selvaraj et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
- (2009) Gyula Timinszky et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Molecular mechanism of poly(ADP-ribosyl)ation by PARP1 and identification of lysine residues as ADP-ribose acceptor sites
- (2009) Matthias Altmeyer et al. NUCLEIC ACIDS RESEARCH
- Structure/Function Analysis of PARP-1 in Oxidative and Nitrosative Stress-Induced Monomeric ADPR Formation
- (2009) Ben Buelow et al. PLoS One
- Poly(ADP-ribose) Binds to the Splicing Factor ASF/SF2 and Regulates Its Phosphorylation by DNA Topoisomerase I
- (2008) Maria Malanga et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- APLF (C2orf13) Is a Novel Component of Poly(ADP-Ribose) Signaling in Mammalian Cells
- (2008) S. L. Rulten et al. MOLECULAR AND CELLULAR BIOLOGY
- Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
- (2008) Ivan Ahel et al. NATURE
- Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes
- (2008) Jean-Philippe Gagné et al. NUCLEIC ACIDS RESEARCH
- Structure and Function of the Phosphothreonine-Specific FHA Domain
- (2008) A. Mahajan et al. Science Signaling
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now