MRE11-RAD50-NBS1 complex alterations and DNA damage response: implications for cancer treatment

CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs

(2019) Mohiuddin Mohiuddin et al.   NUCLEIC ACIDS RESEARCH

MRE11 as a predictive biomarker of outcome following radiotherapy in bladder cancer

(2019) Alexandra K. Walker et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Gene expression profiling of homologous recombination repair pathway indicates susceptibility for olaparib treatment in malignant pleural mesothelioma in vitro

(2019) Sabrina Borchert et al.   BMC CANCER

Decrease of Nibrin expression in chronic hypoxia is associated with hypoxia-induced chemoresistance in some brain tumour cells

(2019) Sophie Cowman et al.   BMC CANCER

Three new cases of ataxia‐telangiectasia‐like disorder: No impairment of the ATM pathway, but S‐phase checkpoint defect

(2019) Alice Fiévet et al.   HUMAN MUTATION

High expression of MRE11 correlates with poor prognosis in gastric carcinoma

(2019) Junqing Li et al.   Diagnostic Pathology

The MRE11–RAD50–NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair

(2018) Aleem Syed et al.   Annual Review of Biochemistry

Topoisomerases as anticancer targets

(2018) Justine L. Delgado et al.   BIOCHEMICAL JOURNAL

Genetic variants in ATM, H2AFX and MRE11 genes and susceptibility to breast cancer in the polish population

(2018) Marta Podralska et al.   BMC CANCER

Genetic testing for hereditary prostate cancer: Current status and limitations

(2018) Jun Tu Zhen et al.   CANCER

Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer

(2018) Matthew B. Yurgelun et al.   GENETICS IN MEDICINE

Distinct homologous recombination gene expression profiles after neoadjuvant chemotherapy associated with clinical outcome in patients with ovarian cancer

(2018) Roy Kessous et al.   GYNECOLOGIC ONCOLOGY

RAD50 germline mutations are associated with poor survival in BRCA1/2 -negative breast cancer patients

(2018) Cong Fan et al.   INTERNATIONAL JOURNAL OF CANCER

Breast cancer risk associated with genes encoding DNA repair MRN complex: a study from Punjab, Pakistan

(2018) Rabbia Tariq Khan et al.   Breast Cancer

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence, and angiogenic signaling

(2018) Cristina Espinosa-Diez et al.   Cell Death & Disease

Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition

(2018) Rania El Botty et al.   Oncotarget

Overexpression of the MRE11-RAD50-NBS1 (MRN) complex in rectal cancer correlates with poor response to neoadjuvant radiotherapy and prognosis

(2018) Vincent Ho et al.   BMC CANCER

MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors

(2018) Marialaura Petroni et al.   Cell Death & Disease

Genomic analysis of DNA repair genes and androgen signaling in prostate cancer

(2018) Kasey Jividen et al.   BMC CANCER

Aneuploid acute myeloid leukemia exhibits a signature of genomic alterations in the cell cycle and protein degradation machinery

(2018) Giorgia Simonetti et al.   CANCER

Role of the Mre11 Complex in Preserving Genome Integrity

(2018) Julyun Oh et al.   Genes

Spectrum and Prevalence of Pathogenic Variants in Ovarian Cancer Susceptibility Genes in a Group of 333 Patients

(2018) Magdalena Koczkowska et al.   Cancers

Targeting BRCA Deficiency in Breast Cancer: What are the Clinical Evidences and the Next Perspectives?

(2018) Emanuel Nicolas et al.   Cancers

Frequency of mutations in a large series of clinically ascertained ovarian cancer cases tested on multi-gene panels compared to reference controls

(2017) Jenna Lilyquist et al.   GYNECOLOGIC ONCOLOGY

Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma

(2017) Pablo García-Sanz et al.   INTERNATIONAL JOURNAL OF CANCER

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

Comprehensive Transcriptome and Mutational Profiling of Endemic Burkitt Lymphoma Reveals EBV Type–Specific Differences

(2017) Yasin Kaymaz et al.   MOLECULAR CANCER RESEARCH

Radiosensitization In Vivo by Histone Deacetylase Inhibition with No Increase in Early Normal Tissue Radiation Toxicity

(2017) Blaz Groselj et al.   MOLECULAR CANCER THERAPEUTICS

ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response

(2017) Andrew N. Blackford et al.   MOLECULAR CELL

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad50 ATPase activity is regulated by DNA ends and requires coordination of both active sites

(2017) Rajashree A. Deshpande et al.   NUCLEIC ACIDS RESEARCH

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Eukaryotic Rad50 functions as a rod-shaped dimer

(2017) Young Bong Park et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

(2017) Masatoshi Takagi et al.   JNCI-Journal of the National Cancer Institute

Associations Between Cancer Predisposition Testing Panel Genes and Breast Cancer

(2017) Fergus J. Couch et al.   JAMA Oncology

Early Postoperative Low Expression of RAD50 in Rectal Cancer Patients Associates with Disease-Free Survival

(2017) Vincent Ho et al.   Cancers

Combining Oncolytic Adenovirus with Radiation—A Paradigm for the Future of Radiosensitization

(2017) Sean M. O’Cathail et al.   Frontiers in Oncology

High Expression of MRE11–RAD50–NBS1 Is Associated with Poor Prognosis and Chemoresistance in Gastric Cancer

(2016) BOLAG LTAN et al.   ANTICANCER RESEARCH

Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

(2016) Lihong Chang et al.   BMC CANCER

Women at high risk of breast cancer: Molecular characteristics, clinical presentation and management

(2016) Zdenek Kleibl et al.   BREAST

Copy number deletion of RAD50 as predictive marker of BRCAness and PARP inhibitor response in BRCA wild type ovarian cancer

(2016) Min Zhang et al.   GYNECOLOGIC ONCOLOGY

Germline mutations of the DNA repair pathways in uterine serous carcinoma

(2016) Marina Frimer et al.   GYNECOLOGIC ONCOLOGY

Effect of combined treatment of radiation and tissue-specific recombinant oncolytic adenovirus on bladder cancer cells

(2016) Hongjuan Zhang et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

MRN, CtIP, and BRCA1 mediate repair of topoisomerase II–DNA adducts

(2016) Tomas Aparicio et al.   JOURNAL OF CELL BIOLOGY

Targeting Homologous Recombination by Pharmacological Inhibitors Enhances the Killing Response of Glioblastoma Cells Treated with Alkylating Drugs

(2016) N. Berte et al.   MOLECULAR CANCER THERAPEUTICS

Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes

(2016) Nguyen Ngoc Hoa et al.   MOLECULAR CELL

Nbs1 Converts the Human Mre11/Rad50 Nuclease Complex into an Endo/Exonuclease Machine Specific for Protein-DNA Adducts

(2016) Rajashree A. Deshpande et al.   MOLECULAR CELL

Directed Alternative Splicing in Nijmegen Breakage Syndrome: Proof of Principle Concerning Its Therapeutical Application

(2016) Bastian Salewsky et al.   MOLECULAR THERAPY

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

The structure of ends determines the pathway choice and Mre11 nuclease dependency of DNA double-strand break repair

(2016) Shuren Liao et al.   NUCLEIC ACIDS RESEARCH

Repair Pathway Choices and Consequences at the Double-Strand Break

(2016) Raphael Ceccaldi et al.   TRENDS IN CELL BIOLOGY

The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11

(2016) Constantia Pantelidou et al.   Oncotarget

MRE11 and ATM Expression Levels Predict Rectal Cancer Survival and Their Association with Radiotherapy Response

(2016) Vincent Ho et al.   PLoS One

Viral and Cellular Genomes Activate Distinct DNA Damage Responses

(2015) Govind A. Shah et al.   CELL

Nuclear organization in DNA end processing: Telomeres vs double-strand breaks

(2015) Isabella Marcomini et al.   DNA REPAIR

ATP‐dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex

(2015) Yaqi Liu et al.   EMBO JOURNAL

Detection of novel germline mutations for breast cancer in non-BRCA1/2families

(2015) Fatima Aloraifi et al.   FEBS Journal

Nijmegen breakage syndrome protein 1 (NBS1) modulates hypoxia inducible factor-1α (HIF-1α) stability and promotes in vitro migration and invasion under ionizing radiation

(2015) Yi-Chih Kuo et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Genetic variations in the homologous recombination repair pathway genes modify risk of glioma

(2015) Haishi Zhang et al.   JOURNAL OF NEURO-ONCOLOGY

DNA repair system and renal cell carcinoma prognosis: under the influence of NBS1

(2015) Alina Rosinha et al.   MEDICAL ONCOLOGY

Prognostic Significance and Molecular Features of Colorectal Mucinous Adenocarcinomas

(2015) Mo-Jin Wang et al.   MEDICINE

Targeting the DNA Damage Response in Cancer

(2015) Mark J. O’Connor   MOLECULAR CELL

Expression of DNA double-strand break repair proteins predicts the response and prognosis of colorectal cancer patients undergoing oxaliplatin-based chemotherapy

(2015) KEISUKE IHARA et al.   ONCOLOGY REPORTS

Microtubule-targeting agents augment the toxicity of DNA-damaging agents by disrupting intracellular trafficking of DNA repair proteins

(2015) Marianne S. Poruchynsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rad51 recombinase prevents Mre11 nuclease-dependent degradation and excessive PrimPol-mediated elongation of nascent DNA after UV irradiation

(2015) María Belén Vallerga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair

(2015) Julien Lafrance-Vanasse et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Heterozygous p.I171V mutation of the NBN gene as a risk factor for lung cancer development

(2015) EWELINA MARIA KAŁUŻNA et al.   Oncology Letters

Multigene Panel Testing in Oncology Practice

(2015) Allison W. Kurian et al.   JAMA Oncology

Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer

(2014) M. T. W. Teo et al.   ANNALS OF ONCOLOGY

Mechanistic relationships between hepatic genotoxicity and carcinogenicity in male B6C3F1 mice treated with polycyclic aromatic hydrocarbon mixtures

(2014) Tracie D. Phillips et al.   ARCHIVES OF TOXICOLOGY

Chromosomal instability portends superior response of rectal adenocarcinoma to chemoradiation therapy

(2014) Bassem I. Zaki et al.   CANCER

RAD50 targeting impairs DNA damage response and sensitizes human breast cancer cells to cisplatin therapy

(2014) Ali Flores-Pérez et al.   CANCER BIOLOGY & THERAPY

Dual Disruption of DNA Repair and Telomere Maintenance for the Treatment of Head and Neck Cancer

(2014) S. A. Lajud et al.   CLINICAL CANCER RESEARCH

Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks

(2014) Q. Wang et al.   EMBO JOURNAL

Next-generation sequencing for the diagnosis of hereditary breast and ovarian cancer using genomic capture targeting multiple candidate genes

(2014) Laurent Castéra et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Gemcitabine: Metabolism and molecular mechanisms of action, sensitivity and chemoresistance in pancreatic cancer

(2014) Lucas de Sousa Cavalcante et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cisplatin in cancer therapy: Molecular mechanisms of action

(2014) Shaloam Dasari et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis

(2014) R. Roset et al.   GENES & DEVELOPMENT

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress

(2014) Magtouf Gatei et al.   HUMAN MOLECULAR GENETICS

Mutations in the FHA-domain of ectopically expressed NBS1 lead to radiosensitization and to no increase in somatic mutation rates via a partial suppression of homologous recombination

(2014) Maki Ohara et al.   JOURNAL OF RADIATION RESEARCH

Targeting of DNA Damage Signaling Pathway Induced Senescence and Reduced Migration of Cancer cells

(2014) Ran Gao et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

MRE11A and SKP2 genes are associated with the increased cytotoxicity induced by the synergistic effects of cisplatin and gemcitabine in bladder cancer cells

(2014) Glenda Nicioli da Silva et al.   MOLECULAR BIOLOGY REPORTS

The functional polymorphism of NBS1 p.Glu185Gln is associated with an increased risk of lung cancer in Chinese populations: Case–control and a meta-analysis

(2014) Wenxiang Fang et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Development of Serous Ovarian Cancer is Associated with the Expression of Homologous Recombination Pathway Proteins

(2014) Qingqing Ye et al.   PATHOLOGY & ONCOLOGY RESEARCH

Effect of MRE11 Loss on PARP-Inhibitor Sensitivity in Endometrial Cancer In Vitro

(2014) Romana Koppensteiner et al.   PLoS One

MRE11-Deficiency Associated with Improved Long-Term Disease Free Survival and Overall Survival in a Subset of Stage III Colon Cancer Patients in Randomized CALGB 89803 Trial

(2014) Thomas Pavelitz et al.   PLoS One

Poly (ADP-ribose) polymerase inhibitor LT-626: Sensitivity correlates with MRE11 mutations and synergizes with platinums and irinotecan in colorectal cancer cells

(2013) Lisa A. McPherson et al.   CANCER LETTERS

Clinical Course of Two Italian Siblings with Ataxia-Telangiectasia-Like Disorder

(2013) Silvia Palmeri et al.   CEREBELLUM

DNA replication and homologous recombination factors: acting together to maintain genome stability

(2013) Antoine Aze et al.   CHROMOSOMA

Nibrin is a marker of clinical outcome in patients with advanced serous ovarian cancer treated in the phase III OVA-301 trial

(2013) Bradley J. Monk et al.   GYNECOLOGIC ONCOLOGY

Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms

(2013) Joshua A. Regal et al.   HUMAN MOLECULAR GENETICS

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks

(2013) Amit B. Shirode et al.   MOLECULAR CARCINOGENESIS

The Mre11 Complex Suppresses Oncogene-Driven Breast Tumorigenesis and Metastasis

(2013) Gaorav P. Gupta et al.   MOLECULAR CELL

DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities

(2013) Atsushi Shibata et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

FOXM1 targets NBS1 to regulate DNA damage-induced senescence and epirubicin resistance

(2013) P Khongkow et al.   ONCOGENE

Mutation Inactivation of Nijmegen Breakage Syndrome Gene (NBS1) in Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma

(2013) Yan Wang et al.   PLoS One

Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11

(2013) C. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking

(2013) T. Kondo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Mre11-Dependent Degradation of Stalled DNA Replication Forks Is Prevented by BRCA2 and PARP1

(2012) S. Ying et al.   CANCER RESEARCH

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

MRE11 Deficiency Increases Sensitivity to Poly(ADP-ribose) Polymerase Inhibition in Microsatellite Unstable Colorectal Cancers

(2011) E. Vilar et al.   CANCER RESEARCH

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Genetic Interactions in Cancer Progression and Treatment

(2011) Alan Ashworth et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma

(2011) Jian Zheng et al.   MOLECULAR CARCINOGENESIS

The MRE11 complex: starting from the ends

(2011) Travis H. Stracker et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular disruption of NBS1 with targeted gene delivery enhances chemosensitisation in head and neck cancer

(2010) K Araki et al.   BRITISH JOURNAL OF CANCER

Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery

(2010) S. Kuroda et al.   CANCER RESEARCH

MRE11 Expression Is Predictive of Cause-Specific Survival following Radical Radiotherapy for Muscle-Invasive Bladder Cancer

(2010) A. Choudhury et al.   CANCER RESEARCH

Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

(2010) Gareth J. Williams et al.   DNA REPAIR

Crystal Structure of the First Eubacterial Mre11 Nuclease Reveals Novel Features that May Discriminate Substrates During DNA Repair

(2010) Debanu Das et al.   JOURNAL OF MOLECULAR BIOLOGY

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder

(2009) Regina Waltes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Physical Interaction between Replication Protein A (RPA) and MRN: Involvement of RPA2 Phosphorylation and the N-Terminus of RPA1

(2009) Greg G. Oakley et al.   BIOCHEMISTRY

Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation

(2009) Maria Rajecki et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular disruption of RAD50 sensitizes human tumor cells to cisplatin-based chemotherapy

(2009) Waleed M. Abuzeid et al.   JOURNAL OF CLINICAL INVESTIGATION

Adenovirus E1B 55-Kilodalton Protein: Multiple Roles in Viral Infection and Cell Transformation

(2009) A. N. Blackford et al.   JOURNAL OF VIROLOGY

Distinct Requirements for the Rad32Mre11 Nuclease and Ctp1CtIP in the Removal of Covalently Bound Topoisomerase I and II from DNA

(2009) Edgar Hartsuiker et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Mre11 Dimers Coordinate DNA End Bridging and Nuclease Processing in Double-Strand-Break Repair

(2008) R. Scott Williams et al.   CELL

Mre11 Nuclease Activity Has Essential Roles in DNA Repair and Genomic Stability Distinct from ATM Activation

(2008) Jeffrey Buis et al.   CELL

Dancing on Damaged Chromatin: Functions of ATM and the RAD50/MRE11/NBS1 Complex in Cellular Responses to DNA Damage

(2008) Kenta IIJIMA et al.   JOURNAL OF RADIATION RESEARCH

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

ATM-like kinases and regulation of telomerase: lessons from yeast and mammals

(2008) Michelle Sabourin et al.   TRENDS IN CELL BIOLOGY