Targeting an Achilles’ heel of cancer with a WRN helicase inhibitor

The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold Attachment Factor B1 deficient mice

(2016) Sophie Lachapelle et al.   Aging-US

The Werner syndrome protein: linking the replication checkpoint response to genome stability

(2016) Pietro Pichierri et al.   Aging-US

Werner Syndrome Helicase Has a Critical Role in DNA Damage Responses in the Absence of a Functional Fanconi Anemia Pathway

(2013) M. Aggarwal et al.   CANCER RESEARCH

Fanconi anaemia and the repair of Watson and Crick DNA crosslinks

(2013) Molly C. Kottemann et al.   NATURE

Werner syndrome protein suppresses the formation of large deletions during the replication of human telomeric sequences

(2012) Rama Rao Damerla et al.   CELL CYCLE

Regulation of DNA cross-link repair by the Fanconi anemia/BRCA pathway

(2012) H. Kim et al.   GENES & DEVELOPMENT

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

(2012) Samuel F. Bunting et al.   MOLECULAR CELL

Targeting cancer-specific synthetic lethality in double-strand DNA break repair

(2011) Benjamin J. Moeller et al.   CELL CYCLE

Exploiting synthetic lethal interactions for targeted cancer therapy

(2011) H. Christian Reinhardt et al.   CELL CYCLE

Understanding the molecular basis of common fragile sites instability: Role of the proteins involved in the recovery of stalled replication forks

(2011) Annapaola Franchitto et al.   CELL CYCLE

Synthetic lethality of PARP inhibition in cancers lackingBRCA1andBRCA2mutations

(2011) Konstantin J. Dedes et al.   CELL CYCLE

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

G-quadruplex nucleic acids and human disease

(2010) Yuliang Wu et al.   FEBS Journal

WRN participates in translesion synthesis pathway through interaction with NBS1

(2010) Junya Kobayashi et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Dangerous Liaisons: Fanconi Anemia and Toxic Nonhomologous End Joining in DNA Crosslink Repair

(2010) Samuel F. Bunting et al.   MOLECULAR CELL

Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia

(2010) Adele Adamo et al.   MOLECULAR CELL

Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway

(2010) P. Pace et al.   SCIENCE

CHK1 inhibition as a strategy for targeting fanconi anemia (FA) DNA repair pathway deficient tumors

(2009) Clark C Chen et al.   Molecular Cancer

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD