Novel Developments in the Use of Antimetabolites

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors

(2013) Noboru Yamamoto et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Metabolism, mechanism of action and sensitivity profile of fluorocyclopentenylcytosine (RX-3117; TV-1360)

(2013) Godefridus J. Peters et al.   INVESTIGATIONAL NEW DRUGS

New Challenges and Inspired Answers for Anticancer Drug Discovery and Development

(2013) T. Utsugi   JAPANESE JOURNAL OF CLINICAL ONCOLOGY

Randomized, Multicenter, Phase II Study of CO-101 Versus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: Including a Prospective Evaluation of the Role of hENT1 in Gemcitabine or CO-101 Sensitivity

(2013) Elizabeth Poplin et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I study of TAS-102 treatment in Japanese patients with advanced solid tumours

(2012) T Doi et al.   BRITISH JOURNAL OF CANCER

Molecular Targets of Gemcitabine Action: Rationale for Development of Novel Drugs and Drug Combinations

(2012) Maha Elnaggar et al.   CURRENT PHARMACEUTICAL DESIGN

Fluorocyclopentenyl-cytosine with Broad Spectrum and Potent Antitumor Activity

(2012) Won Jun Choi et al.   JOURNAL OF MEDICINAL CHEMISTRY

TAS-102 monotherapy for pretreated metastatic colorectal cancer: a double-blind, randomised, placebo-controlled phase 2 trial

(2012) Takayuki Yoshino et al.   LANCET ONCOLOGY

Thymidine phosphorylase in cancer cells stimulates human endothelial cell migration and invasion by the secretion of angiogenic factors

(2011) I V Bijnsdorp et al.   BRITISH JOURNAL OF CANCER

A phase I-II study of elacytarabine (CP-4055) in the treatment of patients with ovarian cancer resistant or refractory to platinum therapy

(2011) S. Pignata et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Phase I Study of Oral Gemcitabine Prodrug (LY2334737) Alone and in Combination with Erlotinib in Patients with Advanced Solid Tumors

(2011) Stijn L.W. Koolen et al.   CLINICAL CANCER RESEARCH

Phosphoramidate ProTides of the Anticancer Agent FUDR Successfully Deliver the Preformed Bioactive Monophosphate in Cells and Confer Advantage over the Parent Nucleoside

(2011) Christopher McGuigan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipophilic Prodrugs and Formulations of Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer

(2011) Godefridus J. Peters et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Accumulation of thymidine-derived sugars in thymidine phosphorylase overexpressing cells

(2010) I.V. Bijnsdorp et al.   BIOCHEMICAL PHARMACOLOGY

Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma

(2010) Raphaël Maréchal et al.   CANCER

Antiproliferative activity, mechanism of action and oral antitumor activity of CP-4126, a fatty acid derivative of gemcitabine, in in vitro and in vivo tumor models

(2010) Andries M. Bergman et al.   INVESTIGATIONAL NEW DRUGS

Mechanism of Inactivation of Human Ribonucleotide Reductase with p53R2 by Gemcitabine 5′-Diphosphate

(2009) Jun Wang et al.   BIOCHEMISTRY

Innovations and Opportunities to Improve Conventional (Deoxy)Nucleoside and Fluoropyrimidine Analogs in Cancer

(2009) A. Adema et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, Crystallization, and Biological Evaluation of an Orally Active Prodrug of Gemcitabine

(2009) David M. Bender et al.   JOURNAL OF MEDICINAL CHEMISTRY

The dual role of thymidine phosphorylase in cancer development and chemotherapy

(2009) Annelies Bronckaers et al.   MEDICINAL RESEARCH REVIEWS

A History of Cancer Chemotherapy

(2008) Vincent T. DeVita et al.   CANCER RESEARCH

Oral Administration of Gemcitabine in Patients with Refractory Tumors: A Clinical and Pharmacologic Study

(2008) S. A. Veltkamp et al.   CLINICAL CANCER RESEARCH

SLC28 genes and concentrative nucleoside transporter (CNT) proteins

(2008) M. Pastor-Anglada et al.   XENOBIOTICA

Will cyclopentenyl cytosine (CPEC) ever have a future in the clinic?

(2007) Chris van Bree et al.   LEUKEMIA RESEARCH