Mitotic catastrophe: a mechanism for avoiding genomic instability

p53 represses the polyploidization of primary mammary epithelial cells by activating apoptosis

(2011) Laura Senovilla et al.   CELL CYCLE

Phosphorylation of survivin at threonine 34 inhibits its mitotic function and enhances its cytoprotective activity

(2011) Rachel M.A. Barrett et al.   CELL CYCLE

Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5

(2011) Santiago Rello-Varona et al.   CELL CYCLE

Anaphase Catastrophe Is a Target for Cancer Therapy

(2011) Fabrizio Galimberti et al.   CLINICAL CANCER RESEARCH

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Cell death assays for drug discovery

(2011) Oliver Kepp et al.   NATURE REVIEWS DRUG DISCOVERY

HDAC inhibition synergistically enhances alkylator-induced DNA damage responses and apoptosis in multiple myeloma cells

(2010) Choon-Kee Lee et al.   CANCER LETTERS

Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function

(2010) Han-Zhang Xu et al.   CELL CYCLE

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

(2010) P Karna et al.   CELL DEATH AND DIFFERENTIATION

Prolonged Prometaphase Blocks Daughter Cell Proliferation Despite Normal Completion of Mitosis

(2010) Yumi Uetake et al.   CURRENT BIOLOGY

Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos

(2010) Ilio Vitale et al.   EMBO JOURNAL

Phosphorylation of Mcl-1 by CDK1–cyclin B1 initiates its Cdc20-dependent destruction during mitotic arrest

(2010) Margaret E Harley et al.   EMBO JOURNAL

Aurora B Interacts with NIR-p53, Leading to p53 Phosphorylation in Its DNA-binding Domain and Subsequent Functional Suppression

(2010) Liming Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of the E2 ubiquitin–conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation

(2010) Janine H. van Ree et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Proliferation of aneuploid human cells is limited by a p53-dependent mechanism

(2010) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

Welcome to a new kind of tension: translating kinetochore mechanics into a wait-anaphase signal

(2010) Thomas J. Maresca et al.   JOURNAL OF CELL SCIENCE

Aurora Kinase Inhibitors - Rising Stars in Cancer Therapeutics?

(2010) A. A. Dar et al.   MOLECULAR CANCER THERAPEUTICS

Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function

(2010) Nicholas Kwiatkowski et al.   Nature Chemical Biology

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stochastic Competition between Mechanistically Independent Slippage and Death Pathways Determines Cell Fate during Mitotic Arrest

(2010) Hsiao-Chun Huang et al.   PLoS One

Death by releasing the breaks: CHK1 inhibitors as cancer therapeutics

(2010) Cynthia X. Ma et al.   TRENDS IN MOLECULAR MEDICINE

An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe

(2010) S Rello-Varona et al.   Cell Death & Disease

Kinesin motor proteins as targets for cancer therapy

(2009) Dennis Huszar et al.   CANCER AND METASTASIS REVIEWS

Survivin: A new target for anti-cancer therapy

(2009) Bríd M. Ryan et al.   CANCER TREATMENT REVIEWS

Restraint of apoptosis during mitosis through interdomain phosphorylation of caspase-2

(2009) Joshua L Andersen et al.   EMBO JOURNAL

Inhibition of KSP by ARRY-520 induces cell cycle block and cell death via the mitochondrial pathway in AML cells

(2009) B Z Carter et al.   LEUKEMIA

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

(2009) Y.-F. Huang et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

p31comet Induces Cellular Senescence through p21 Accumulation and Mad2 Disruption

(2009) M. Yun et al.   MOLECULAR CANCER RESEARCH

Length of mitotic arrest induced by microtubule-stabilizing drugs determines cell death after mitotic exit

(2009) M. E. Bekier et al.   MOLECULAR CANCER THERAPEUTICS

Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis

(2009) Andrew J. Holland et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

A tumor suppressor function for caspase-2

(2009) L. H. Ho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells

(2009) Aniek Janssen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An HDAC inhibitor, trichostatin A, induces a delay at G2/M transition, slippage of spindle checkpoint, and cell death in a transcription-dependent manner

(2008) Eun Joo Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancer

(2008) N Bucher et al.   BRITISH JOURNAL OF CANCER

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Impaired Bub1 Function In vivo Compromises Tension-Dependent Checkpoint Function Leading to Aneuploidy and Tumorigenesis

(2008) M. Schliekelman et al.   CANCER RESEARCH

The enigma of caspase-2: the laymen's view

(2008) G Krumschnabel et al.   CELL DEATH AND DIFFERENTIATION

Death through a tragedy: mitotic catastrophe

(2008) H Vakifahmetoglu et al.   CELL DEATH AND DIFFERENTIATION

Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009

(2008) G Kroemer et al.   CELL DEATH AND DIFFERENTIATION

Linking Kinetochore-Microtubule Binding to the Spindle Checkpoint

(2008) Daniel J. Burke et al.   DEVELOPMENTAL CELL

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Spindle assembly checkpoint and p53 deficiencies cooperate for tumorigenesis in mice

(2008) Ya-Hui Chi et al.   INTERNATIONAL JOURNAL OF CANCER

Examining the link between chromosomal instability and aneuploidy in human cells

(2008) Sarah L. Thompson et al.   JOURNAL OF CELL BIOLOGY

The consequences of tetraploidy and aneuploidy

(2008) Z. Storchova et al.   JOURNAL OF CELL SCIENCE

Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

(2008) J. D. Orth et al.   MOLECULAR CANCER THERAPEUTICS

Autophagic cell death: the story of a misnomer

(2008) Guido Kroemer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aneuploidy Affects Proliferation and Spontaneous Immortalization in Mammalian Cells

(2008) B. R. Williams et al.   SCIENCE

Concerning the Origin of Malignant Tumours by Theodor Boveri. Translated and annotated by Henry Harris

(2007) T. Boveri   JOURNAL OF CELL SCIENCE