The essential kinase ATR: ensuring faithful duplication of a challenging genome

Moonlighting at replication forks - a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51

(2017) Arun Mouli Kolinjivadi et al.   FEBS LETTERS

PHF11 promotes DSB resection, ATR signaling, and HR

(2017) Yi Gong et al.   GENES & DEVELOPMENT

Coupling of Homologous Recombination and the Checkpoint by ATR

(2017) Rémi Buisson et al.   MOLECULAR CELL

Telomeres in cancer: tumour suppression and genome instability

(2017) John Maciejowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response

(2016) Yuan-Cho Lee et al.   CURRENT BIOLOGY

A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis

(2016) Heike Duda et al.   DEVELOPMENTAL CELL

Phosphopeptide binding by Sld3 links Dbf4‐dependent kinase to MCM replicative helicase activation

(2016) Tom D Deegan et al.   EMBO JOURNAL

ATM/ATR‐mediated phosphorylation of PALB2 promotes RAD51 function

(2016) Johanna K Ahlskog et al.   EMBO REPORTS

The Dimeric Architecture of Checkpoint Kinases Mec1ATRand Tel1ATMReveal a Common Structural Organization

(2016) Marta Sawicka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

(2016) Sergio Ruiz et al.   MOLECULAR CELL

Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppression

(2016) Antoine Aze et al.   NATURE CELL BIOLOGY

ETAA1 acts at stalled replication forks to maintain genome integrity

(2016) Thomas E. Bass et al.   NATURE CELL BIOLOGY

Activation of the ATR kinase by the RPA-binding protein ETAA1

(2016) Peter Haahr et al.   NATURE CELL BIOLOGY

Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint

(2016) Laura A. Lindsey-Boltz   PHOTOCHEMISTRY AND PHOTOBIOLOGY

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

(2016) Hui Zhang et al.   Cell Reports

Signaling from Mus81-Eme2-Dependent DNA Damage Elicited by Chk1 Deficiency Modulates Replication Fork Speed and Origin Usage

(2016) Hervé Técher et al.   Cell Reports

RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling

(2015) Laura A Lindsey-Boltz et al.   CELL CYCLE

Molecular Pathways: Targeting ATR in Cancer Therapy

(2015) L. M. Karnitz et al.   CLINICAL CANCER RESEARCH

IncreasedRrm2gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

(2015) Andres J. Lopez-Contreras et al.   GENES & DEVELOPMENT

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

ATR-Mediated Phosphorylation of FANCI Regulates Dormant Origin Firing in Response to Replication Stress

(2015) Yu-Hung Chen et al.   MOLECULAR CELL

PLEKHM1: A Multiprotein Adaptor for the Endolysosomal System

(2015) Moran Rawet-Slobodkin et al.   MOLECULAR CELL

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

Phosphoproteomics Reveals Distinct Modes of Mec1/ATR Signaling during DNA Replication

(2015) Francisco Meirelles Bastos de Oliveira et al.   MOLECULAR CELL

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

(2015) Rémi Buisson et al.   MOLECULAR CELL

Regulated eukaryotic DNA replication origin firing with purified proteins

(2015) Joseph T. P. Yeeles et al.   NATURE

DNA replication origin activation in space and time

(2015) Michalis Fragkos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved Polϵ binding module in Ctf18-RFC is required for S-phase checkpoint activation downstream of Mec1

(2015) Luis J. García-Rodríguez et al.   NUCLEIC ACIDS RESEARCH

EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair

(2015) Yuehan Wu et al.   PLoS Genetics

ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress

(2014) Amit Kumar et al.   CELL

Fork reversal, too much of a good thing

(2014) Frank B Couch et al.   CELL CYCLE

SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway

(2014) C.-S. Wu et al.   GENES & DEVELOPMENT

Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

(2014) Anar K. Murphy et al.   JOURNAL OF CELL BIOLOGY

PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage

(2014) Stuart G. Jarrett et al.   MOLECULAR CELL

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress

(2014) Giorgia Basile et al.   NUCLEIC ACIDS RESEARCH

MUS81-EME2 Promotes Replication Fork Restart

(2014) Alessandra Pepe et al.   Cell Reports

ATR-Dependent Phosphorylation of FANCM at Serine 1045 Is Essential for FANCM Functions

(2013) T. R. Singh et al.   CANCER RESEARCH

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

(2013) Luis Ignacio Toledo et al.   CELL

hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity

(2013) Li Wan et al.   EMBO REPORTS

Lagging strand maturation factor Dna2 is a component of the replication checkpoint initiation machinery

(2013) S. Kumar et al.   GENES & DEVELOPMENT

ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing

(2013) H. Royo et al.   GENES & DEVELOPMENT

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cells

(2013) R. L. Ragland et al.   GENES & DEVELOPMENT

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Controlling DNA replication origins in response to DNA damage - inhibit globally, activate locally

(2013) M. Yekezare et al.   JOURNAL OF CELL SCIENCE

ATM- and ATR-Mediated Phosphorylation of XRCC3 Regulates DNA Double-Strand Break-Induced Checkpoint Activation and Repair

(2013) Kumar Somyajit et al.   MOLECULAR AND CELLULAR BIOLOGY

The Mre11-Rad50-Nbs1 (MRN) complex has a specific role in the activation of Chk1 in response to stalled replication forks

(2013) Joon Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Coordinated Actions of SLX1-SLX4 and MUS81-EME1 for Holliday Junction Resolution in Human Cells

(2013) Haley D.M. Wyatt et al.   MOLECULAR CELL

PrimPol Bypasses UV Photoproducts during Eukaryotic Chromosomal DNA Replication

(2013) Julie Bianchi et al.   MOLECULAR CELL

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

FANCD2 Binds MCM Proteins and Controls Replisome Function upon Activation of S Phase Checkpoint Signaling

(2013) Gérald Lossaint et al.   MOLECULAR CELL

PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry

(2013) Alexandre Maréchal et al.   MOLECULAR CELL

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Repriming of DNA synthesis at stalled replication forks by human PrimPol

(2013) Silvana Mourón et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

DNA Damage Response: Three Levels of DNA Repair Regulation

(2013) B. M. Sirbu et al.   Cold Spring Harbor Perspectives in Biology

An Essential Function for the ATR-Activation-Domain (AAD) of TopBP1 in Mouse Development and Cellular Senescence

(2013) Zhong-Wei Zhou et al.   PLoS Genetics

Survival of the Replication Checkpoint Deficient Cells Requires MUS81-RAD52 Function

(2013) Ivana Murfuni et al.   PLoS Genetics

Stepwise Activation of the ATR Signaling Pathway upon Increasing Replication Stress Impacts Fragile Site Integrity

(2013) Stéphane Koundrioukoff et al.   PLoS Genetics

Function and Regulation of Yeast Ribonucleotide Reductase: Cell Cycle, Genotoxic Stress, and Iron Bioavailability

(2013) Sergi Puig et al.   Biomedical Journal

Cyclin F-Mediated Degradation of Ribonucleotide Reductase M2 Controls Genome Integrity and DNA Repair

(2012) Vincenzo D'Angiolella et al.   CELL

Mechanisms of replication fork protection: a safeguard for genome stability

(2012) Alessia Errico et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

The DNA translocase activity of FANCM protects stalled replication forks

(2012) Andrew N. Blackford et al.   HUMAN MOLECULAR GENETICS

Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

(2012) Giacomo De Piccoli et al.   MOLECULAR CELL

FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response

(2012) Jenny Xie et al.   PLoS Genetics

Cell-cycle-specific activators of the Mec1/ATR checkpoint kinase

(2011) Vasundhara M. Navadgi-Patil et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Activation of ATR and related PIKKs

(2011) Daniel A. Mordes et al.   CELL CYCLE

The effect of the intra-S-phase checkpoint on origins of replication in human cells

(2011) Neerja Karnani et al.   GENES & DEVELOPMENT

Thr-1989 Phosphorylation Is a Marker of Active Ataxia Telangiectasia-mutated and Rad3-related (ATR) Kinase

(2011) Edward A. Nam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease

(2011) Raquel Domínguez-Kelly et al.   JOURNAL OF CELL BIOLOGY

ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage

(2011) Thomas Göhler et al.   JOURNAL OF CELL BIOLOGY

WRN helicase regulates the ATR-CHK1-induced S-phase checkpoint pathway in response to topoisomerase-I-DNA covalent complexes

(2011) B. S. Patro et al.   JOURNAL OF CELL SCIENCE

ATR Autophosphorylation as a Molecular Switch for Checkpoint Activation

(2011) Shizhou Liu et al.   MOLECULAR CELL

Structure-Specific DNA Endonuclease Mus81/Eme1 Generates DNA Damage Caused by Chk1 Inactivation

(2011) Josep V. Forment et al.   PLoS One

A DNA Damage Response Screen Identifies RHINO, a 9-1-1 and TopBP1 Interacting Protein Required for ATR Signaling

(2011) C. Cotta-Ramusino et al.   SCIENCE

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

ATR activation and replication fork restart are defective in FANCM-deficient cells

(2010) Rebekka A Schwab et al.   EMBO JOURNAL

Stable Interaction between the Human Proliferating Cell Nuclear Antigen Loader Complex Ctf18-Replication Factor C (RFC) and DNA Polymerase ϵ Is Mediated by the Cohesion-specific Subunits, Ctf18, Dcc1, and Ctf8

(2010) Takeshi Murakami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels

(2010) Alexander M. Thomson et al.   JOURNAL OF CELL BIOLOGY

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories

(2010) Xin Quan Ge et al.   JOURNAL OF CELL BIOLOGY

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control

(2010) Zihua Gong et al.   MOLECULAR CELL

Damage-induced phosphorylation of Sld3 is important to block late origin firing

(2010) Jaime Lopez-Mosqueda et al.   NATURE

Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation

(2010) Philip Zegerman et al.   NATURE

Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint

(2010) Han Liu et al.   NATURE

Analysis of replication profiles reveals key role of RFC-Ctf18 in yeast replication stress response

(2010) Laure Crabbé et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Rad51 protects nascent DNA from Mre11-dependent degradation and promotes continuous DNA synthesis

(2010) Yoshitami Hashimoto et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Chk1 promotes replication fork progression by controlling replication initiation

(2010) E. Petermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining replication origin efficiency using DNA fiber assays

(2009) Sandie Tuduri et al.   CHROMOSOME RESEARCH

TopBP1 and DNA polymerase-α directly recruit the 9-1-1 complex to stalled DNA replication forks

(2009) Shan Yan et al.   JOURNAL OF CELL BIOLOGY

Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stress

(2009) V. M. Vassin et al.   JOURNAL OF CELL SCIENCE

Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

(2009) A. Blastyak et al.   MOLECULAR AND CELLULAR BIOLOGY

The Unstructured C-Terminal Tail of the 9-1-1 Clamp Subunit Ddc1 Activates Mec1/ATR via Two Distinct Mechanisms

(2009) Vasundhara M. Navadgi-Patil et al.   MOLECULAR CELL

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

(2009) Matilde Murga et al.   NATURE GENETICS

Cyclin A-Cdk1 regulates the origin firing program in mammalian cells

(2009) Y. Katsuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plx1 is required for chromosomal DNA replication under stressful conditions

(2008) Kristina Trenz et al.   EMBO JOURNAL

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

(2008) D. A. Mordes et al.   GENES & DEVELOPMENT

Yeast DNA Replication Protein Dpb11 Activates the Mec1/ATR Checkpoint Kinase

(2008) Vasundhara M. Navadgi-Patil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATR and H2AX Cooperate in Maintaining Genome Stability under Replication Stress

(2008) Rebecca A. Chanoux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

(2008) Jeremy A. Daniel et al.   JOURNAL OF CELL BIOLOGY

Checkpoint-Dependent Regulation of Origin Firing and Replication Fork Movement in Response to DNA Damage in Fission Yeast

(2008) S. Kumar et al.   MOLECULAR AND CELLULAR BIOLOGY

FANCM and FAAP24 Function in ATR-Mediated Checkpoint Signaling Independently of the Fanconi Anemia Core Complex

(2008) Spencer J. Collis et al.   MOLECULAR CELL

ATR: an essential regulator of genome integrity

(2008) Karlene A. Cimprich et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dpb11 activates the Mec1-Ddc2 complex

(2008) D. A. Mordes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA