Loss of DNA Damage Response in Neuroblastoma and Utility of a PARP Inhibitor

Genome instability model of metastatic neuroblastoma tumorigenesis by a dictionary learning algorithm

(2015) Salvatore Masecchia et al.   BMC Medical Genomics

Involvement of ATM in homologous recombination after end resection and RAD51 nucleofilament formation

(2015) A. Bakr et al.   NUCLEIC ACIDS RESEARCH

Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer

(2015) N. J. Roberts et al.   Cancer Discovery

Ataxia-telangiectasia mutated (ATM) silencing promotes neuroblastoma progression through a MYCN independent mechanism

(2015) Stefano J. Mandriota et al.   Oncotarget

Growing recognition of the role for rare missense substitutions in breast cancer susceptibility

(2014) Sean V Tavtigian et al.   Biomarkers in Medicine

Novel 1p tumour suppressor Dnmt1-associated protein 1 regulates MYCN/ataxia telangiectasia mutated/p53 pathway

(2014) Yohko Yamaguchi et al.   EUROPEAN JOURNAL OF CANCER

ATM-dependent DNA damage-response pathway as a determinant in chronic myelogenous leukemia

(2013) Masatoshi Takagi et al.   DNA REPAIR

The genetic landscape of high-risk neuroblastoma

(2013) Trevor J Pugh et al.   NATURE GENETICS

Preclinical evaluation of the PARP inhibitor, olaparib, in combination with cytotoxic chemotherapy in pediatric solid tumors

(2013) Robin E. Norris et al.   PEDIATRIC BLOOD & CANCER

Biallelic ATM Inactivation Significantly Reduces Survival in Patients Treated on the United Kingdom Leukemia Research Fund Chronic Lymphocytic Leukemia 4 Trial

(2012) Anna Skowronska et al.   JOURNAL OF CLINICAL ONCOLOGY

Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes

(2012) Jan J. Molenaar et al.   NATURE

Variant ataxia-telangiectasia presenting as primary-appearing dystonia in Canadian Mennonites

(2012) R. Saunders-Pullman et al.   NEUROLOGY

Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance

(2012) Stefano Campaner et al.   Cell Division

New mutations in the ATM gene and clinical data of 25 AT patients

(2011) Ilja Demuth et al.   NEUROGENETICS

ATM Mutations in Patients with Hereditary Pancreatic Cancer

(2011) Nicholas J. Roberts et al.   Cancer Discovery

GISTIC2.0 facilitates sensitive and confident localization of the targets of focal somatic copy-number alteration in human cancers

(2011) Craig H Mermel et al.   GENOME BIOLOGY

The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo

(2010) V. J. Weston et al.   BLOOD

Pre-clinical and clinical evaluation of PARP inhibitors as tumour-specific radiosensitisers

(2010) C. Powell et al.   CANCER TREATMENT REVIEWS

Multiple synchronous tumors in a child with Fanconi anemia

(2010) Alessia Compostella et al.   JOURNAL OF PEDIATRIC SURGERY

Integrative genomics identifies LMO1 as a neuroblastoma oncogene

(2010) Kai Wang et al.   NATURE

Recent Advances in Neuroblastoma

(2010) John M. Maris   NEW ENGLAND JOURNAL OF MEDICINE

Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage

(2010) Lina Guerra et al.   PLoS One

ATM is down-regulated by N-Myc-regulated microRNA-421

(2010) H. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2

(2009) Andrea Beucher et al.   EMBO JOURNAL

Common variations in BARD1 influence susceptibility to high-risk neuroblastoma

(2009) Mario Capasso et al.   NATURE GENETICS

CADM1 is a strong neuroblastoma candidate gene that maps within a 3.72 Mb critical region of loss on 11q23

(2008) Evi Michels et al.   BMC CANCER

Expression ofTSLC1, a candidate tumor suppressor gene mapped to chromosome 11q23, is downregulated in unfavorable neuroblastoma without promoter hypermethylation

(2008) Kiyohiro Ando et al.   INTERNATIONAL JOURNAL OF CANCER

Identification of ALK as a major familial neuroblastoma predisposition gene

(2008) Yaël P. Mossé et al.   NATURE

Oncogenic mutations of ALK kinase in neuroblastoma

(2008) Yuyan Chen et al.   NATURE

Chromosome 6p22 Locus Associated with Clinically Aggressive Neuroblastoma

(2008) John M. Maris et al.   NEW ENGLAND JOURNAL OF MEDICINE