WRN-targeted therapy using inhibitors NSC 19630 and NSC 617145 induce apoptosis in HTLV-1-transformed adult T-cell leukemia cells

Clinical significance of microRNAs in chronic and acute human leukemia

(2016) Chien-Hung Yeh et al.   Molecular Cancer

Mutation of epigenetic regulators TET2 and MLL3 in patients with HTLV-I-induced acute adult T-cell leukemia

(2016) Chien-Hung Yeh et al.   Molecular Cancer

Targeting DNA repair, DNA metabolism and replication stress as anti-cancer strategies

(2015) Jordi Carreras Puigvert et al.   FEBS Journal

Small PARP inhibitor PJ-34 induces cell cycle arrest and apoptosis of adult T-cell leukemia cells

(2015) Xue Tao Bai et al.   Journal of Hematology & Oncology

Synthetic lethal targeting of oncogenic transcription factors in acute leukemia by PARP inhibitors

(2015) Maria Teresa Esposito et al.   NATURE MEDICINE

The Emerging Role of miRNAs in HTLV-1 Infection and ATLL Pathogenesis

(2015) Ramona Moles et al.   Viruses-Basel

Cell Death Signaling

(2015) Douglas R. Green et al.   Cold Spring Harbor Perspectives in Biology

STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I–Transformed and ATL Cells

(2015) Ramona Moles et al.   NEOPLASIA

Targeting DNA damage response in cancer therapy

(2014) Noriko Hosoya et al.   CANCER SCIENCE

Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions

(2014) Hassiba Chaib-Mezrag et al.   Molecular Cancer

Targeting an Achilles’ heel of cancer with a WRN helicase inhibitor

(2013) Monika Aggarwal et al.   CELL CYCLE

Therapeutic Options for Adult T-Cell Leukemia/Lymphoma

(2013) Ambroise Marçais et al.   Current Oncology Reports

MYC-Driven Tumorigenesis Is Inhibited by WRN Syndrome Gene Deficiency

(2012) R. Moser et al.   MOLECULAR CANCER RESEARCH

HTLV-I Tax Increases Genetic Instability by Inducing DNA Double Strand Breaks during DNA Replication and Switching Repair to NHEJ

(2012) Hicham H. Baydoun et al.   PLoS One

Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses

(2012) Nicolas Simonis et al.   Retrovirology

New insight into the oncogenic mechanism of the retroviral oncoprotein Tax

(2012) Hua Cheng et al.   Protein & Cell

HTLV Tax: A Fascinating Multifunctional Co-Regulator of Viral and Cellular Pathways

(2012) Robert Currer et al.   Frontiers in Microbiology

Epidemiological Aspects and World Distribution of HTLV-1 Infection

(2012) Antoine Gessain et al.   Frontiers in Microbiology

Complex role of microRNAs in HTLV-1 infections

(2012) Gavin C. Sampey et al.   Frontiers in Genetics

How I treat adult T-cell leukemia/lymphoma

(2011) A. Bazarbachi et al.   BLOOD

Molecular mechanisms of HTLV-1 infection and pathogenesis

(2011) Junichiro Yasunaga et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

(2011) M. Aggarwal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HTLV-1 and Innate Immunity

(2011) Chloé Journo et al.   Viruses-Basel

Long-term study of indolent adult T-cell leukemia-lymphoma

(2010) Y. Takasaki et al.   BLOOD

HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes

(2010) M. Bellon et al.   BLOOD

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Induction of Reactive Oxygen Species by Human T-Cell Leukemia Virus Type 1 Tax Correlates with DNA Damage and Expression of Cellular Senescence Marker

(2010) T. Kinjo et al.   JOURNAL OF VIROLOGY

Adult T-cell leukemia–lymphoma: current treatment strategies and novel immunological approaches

(2010) Ryuji Tanosaki et al.   Expert Review of Hematology

Up-regulation of WRN and DNA ligase III  in chronic myeloid leukemia: consequences for the repair of DNA double-strand breaks

(2008) A. Sallmyr et al.   BLOOD

HTLV-1 Tax Oncoprotein Subverts the Cellular DNA Damage Response via Binding to DNA-dependent Protein Kinase

(2008) Sarah S. Durkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

(2008) Kunihiro Tsukasaki et al.   JOURNAL OF CLINICAL ONCOLOGY