Cancer Stem Cells, Quo Vadis? The Notch Signaling Pathway in Tumor Initiation and Progression

Notch ligand Dll4 impairs cell recruitment to aortic clusters and limits blood stem cell generation

(2020) Cristina Porcheri et al.   EMBO JOURNAL

Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: Identification, Characterization and Clinical Implications

(2019) Peitzsch et al.   Cancers

Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation

(2018) Katharina F. Sonnen et al.   CELL

The NOTCH1/CD44 axis drives pathogenesis in a T cell acute lymphoblastic leukemia model

(2018) Marina García-Peydró et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting Notch1 and IKKa enhanced NF-κB activation in CD133+Skin Cancer Stem Cells

(2018) Xin Xin Quan et al.   MOLECULAR CANCER THERAPEUTICS

Notch signaling and non-small cell lung cancer (Review)

(2018) Bin Zou et al.   Oncology Letters

Impaired Notch Signaling Leads to a Decrease in p53 Activity and Mitotic Catastrophe in Aged Muscle Stem Cells

(2018) Ling Liu et al.   Cell Stem Cell

Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells

(2018) Erika López-Arribillaga et al.   Nature Communications

Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies

(2018) David A. Mahvi et al.   CA-A CANCER JOURNAL FOR CLINICIANS

γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma

(2017) Liang Mao et al.   INTERNATIONAL JOURNAL OF CANCER

Notch3 signaling-mediated melanoma–endothelial crosstalk regulates melanoma stem-like cell homeostasis and niche morphogenesis

(2017) Mei-Yu Hsu et al.   LABORATORY INVESTIGATION

Differential Routing of Mindbomb1 via Centriolar Satellites Regulates Asymmetric Divisions of Neural Progenitors

(2017) Samuel Tozer et al.   NEURON

Brain Cancer Stem Cells in Adults and Children: Cell Biology and Therapeutic Implications

(2017) Tamara J. Abou-Antoun et al.   Neurotherapeutics

Notch Signaling in Development, Tissue Homeostasis, and Disease

(2017) Chris Siebel et al.   PHYSIOLOGICAL REVIEWS

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

(2016) L. Astudillo et al.   CANCER RESEARCH

Notch4+ cancer stem-like cells promote the metastatic and invasive ability of melanoma

(2016) Xian Lin et al.   CANCER SCIENCE

Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial

(2016) R. Xu et al.   CLINICAL CANCER RESEARCH

RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

(2016) Qi Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch1-MAPK Signaling Axis Regulates CD133 + Cancer Stem Cell-Mediated Melanoma Growth and Angiogenesis

(2016) Dhiraj Kumar et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Notch 2 signaling contributes to cell growth, anti-apoptosis and metastasis in laryngeal squamous cell carcinoma

(2016) You Zou et al.   Molecular Medicine Reports

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Phase I study of the gamma secretase inhibitor PF-03084014 in combination with docetaxel in patients with advanced triple-negative breast cancer

(2016) Marzia A. Locatelli et al.   Oncotarget

HES1 mRNA expression is associated with survival in sinonasal squamous cell carcinoma

(2016) Markus Wirth et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

(2016) Eike-Benjamin Braune et al.   Stem Cell Reports

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

(2016) Zhi-Li Zhao et al.   Scientific Reports

Thymic expression of a T-cell receptor targeting a tumor-associated antigen coexpressed in the thymus induces T-ALL

(2015) Y. Cui et al.   BLOOD

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

(2015) Claudio Giachino et al.   CANCER CELL

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a  -Secretase Inhibitor

(2015) K. Wang et al.   CLINICAL CANCER RESEARCH

Notch signaling regulates gastric antral LGR5 stem cell function

(2015) E. S. Demitrack et al.   EMBO JOURNAL

ANOTCH1gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer

(2015) John J. Arcaroli et al.   INTERNATIONAL JOURNAL OF CANCER

APC is required for muscle stem cell proliferation and skeletal muscle tissue repair

(2015) Alice Parisi et al.   JOURNAL OF CELL BIOLOGY

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

(2015) Daniel Lafkas et al.   NATURE

Directional Notch trafficking in Sara endosomes during asymmetric cell division in the spinal cord

(2015) Sabine Kressmann et al.   NATURE CELL BIOLOGY

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

(2015) Maria-Giuseppina Procopio et al.   NATURE CELL BIOLOGY

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

American Brain Tumor Association Adolescent and Young Adult Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

(2015) S Zhang et al.   ONCOGENE

Epidermal Growth Factor Receptor Inhibition Reduces Angiogenesis via Hypoxia-Inducible Factor-1α and Notch1 in Head Neck Squamous Cell Carcinoma

(2015) Wei-Ming Wang et al.   PLoS One

Notch signal strength controls cell fate in the haemogenic endothelium

(2015) Leonor Gama-Norton et al.   Nature Communications

Lateral inhibition of Notch signaling in neoplastic cells

(2015) Kah Jing Lim et al.   Oncotarget

Signaling Pathways in the Specification of Arteries and Veins

(2014) Monica Corada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch functions in developmental and tumour angiogenesis by diverse mechanisms1

(2014) Thaned Kangsamaksin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Epithelial Notch signaling is a limiting step for pancreatic carcinogenesis

(2014) Marsha M Thomas et al.   BMC CANCER

From Fly Wings to Targeted Cancer Therapies: A Centennial for Notch Signaling

(2014) Panagiotis Ntziachristos et al.   CANCER CELL

Abstract 410: Elevated Jagged-1 and Notch-1 expression in high grade and metastatic prostate cancers.

(2014) He Zhu et al.   CANCER RESEARCH

Dynamic expression and roles of Hes factors in neural development

(2014) Ryoichiro Kageyama et al.   CELL AND TISSUE RESEARCH

A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

(2014) D. C. Smith et al.   CLINICAL CANCER RESEARCH

WNT Signaling: an Emerging Mediator of Cancer Cell Metabolism?

(2014) Victoria Sherwood   MOLECULAR AND CELLULAR BIOLOGY

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut

(2014) Maia Chanrion et al.   Nature Communications

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

Hes1 is involved in the self-renewal and tumourigenicity of stem-like cancer cells in colon cancer

(2014) Fei Gao et al.   Scientific Reports

Notch3/Jagged1 Circuitry Reinforces Notch Signaling and Sustains T-ALL

(2014) Maria Pelullo et al.   NEOPLASIA

Oncogenic somatic events in tissue-specific stem cells: A role in cancer recurrence?

(2013) F.P. Hartwig et al.   AGEING RESEARCH REVIEWS

Regulation of angiogenesis via Notch signaling in breast cancer and cancer stem cells

(2013) Weiqiang Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Apc regulates the function of hematopoietic stem cells largely through  -catenin-dependent mechanisms

(2013) W. Li et al.   BLOOD

A Rare Population of CD24+ITGB4+Notchhi Cells Drives Tumor Propagation in NSCLC and Requires Notch3 for Self-Renewal

(2013) Yanyan Zheng et al.   CANCER CELL

Oscillatory links of Fgf signaling and Hes7 in the segmentation clock

(2013) Yukiko Harima et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Stem cells living with a Notch

(2013) U. Koch et al.   DEVELOPMENT

The Art of Choreographing Asymmetric Cell Division

(2013) Rong Li   DEVELOPMENTAL CELL

Notch1-dependent regulation of p27 determines cell fate in colorectal cancer

(2013) NEVYANA R. HRISTOVA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Invasive cancers are not necessarily from preformedin situtumours - an alternative way of carcinogenesis from misplaced stem cells

(2013) Rui-An Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming

(2013) Henry F. Frierson et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch pathway activation targets AML-initiating cell homeostasis and differentiation

(2013) Camille Lobry et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The pathological significance of Notch1 in oral squamous cell carcinoma

(2013) Ryoji Yoshida et al.   LABORATORY INVESTIGATION

Notch signaling in acute promyelocytic leukemia

(2013) N R Grieselhuber et al.   LEUKEMIA

Notch3 overexpression associates with poor prognosis in human non-small-cell lung cancer

(2013) Yuan-zi Ye et al.   MEDICAL ONCOLOGY

Intestinal label-retaining cells are secretory precursors expressing Lgr5

(2013) Simon J. A. Buczacki et al.   NATURE

Differential patterns of NOTCH1-4 receptor expression are markers of glioma cell differentiation

(2013) P. Dell'Albani et al.   NEURO-ONCOLOGY

Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation

(2013) C. Tomasetti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oscillatory Control of Factors Determining Multipotency and Fate in Mouse Neural Progenitors

(2013) I. Imayoshi et al.   SCIENCE

Brief Report: Blockade of Notch Signaling in Muscle Stem Cells Causes Muscular Dystrophic Phenotype and Impaired Muscle Regeneration

(2013) Shuibin Lin et al.   STEM CELLS

Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis

(2013) Michael G. Poulos et al.   Cell Reports

TNFα enhances cancer stem cell-like phenotype via Notch-Hes1 activation in oral squamous cell carcinoma cells

(2012) Sung Hee Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sending the right signal: Notch and stem cells

(2012) Carolina N. Perdigoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

(2012) M. Y. Chiang et al.   BLOOD

Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL

(2012) Maura M. Hannon et al.   BRITISH JOURNAL OF HAEMATOLOGY

Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer

(2012) Keli Xu et al.   CANCER CELL

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

(2012) Bing Hu et al.   CELL

Biomarker and Pharmacologic Evaluation of the  -Secretase Inhibitor PF-03084014 in Breast Cancer Models

(2012) C. C. Zhang et al.   CLINICAL CANCER RESEARCH

Dose-dependent roles for canonical Wnt signalling in de novo crypt formation and cell cycle properties of the colonic epithelium

(2012) A. Hirata et al.   DEVELOPMENT

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial

(2012) S Jenkinson et al.   LEUKEMIA

MEDI0639: A Novel Therapeutic Antibody Targeting Dll4 Modulates Endothelial Cell Function and Angiogenesis In Vivo

(2012) D. W. Jenkins et al.   MOLECULAR CANCER THERAPEUTICS

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species

(2012) Vincenzo Giambra et al.   NATURE MEDICINE

Intralineage Directional Notch Signaling Regulates Self-Renewal and Differentiation of Asymmetrically Dividing Radial Glia

(2012) Zhiqiang Dong et al.   NEURON

Prognostic impact of δ-like ligand 4 and Notch1 in acute myeloid leukemia

(2012) JINGRU ZHANG et al.   ONCOLOGY REPORTS

NOTCH1 Signaling Promotes Human T-Cell Acute Lymphoblastic Leukemia Initiating Cell Regeneration in Supportive Niches

(2012) Wenxue Ma et al.   PLoS One

Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

(2012) Y. Lombardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy

(2012) Gregg L. Semenza   TRENDS IN PHARMACOLOGICAL SCIENCES

Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal Tract

(2012) A. Schepers et al.   Cold Spring Harbor Perspectives in Biology

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells

(2011) Simone Brabletz et al.   EMBO JOURNAL

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Genetic Evidence That Intestinal Notch Functions Vary Regionally and Operate through a Common Mechanism of Math1 Repression

(2011) Tae-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma

(2011) Cheuk-Him Man et al.   JOURNAL OF PATHOLOGY

Notch1 is an independent prognostic factor for patients with glioma

(2011) Jiang Li et al.   JOURNAL OF SURGICAL ONCOLOGY

Notch3-mediated regulation of MKP-1 levels promotes survival of T acute lymphoblastic leukemia cells

(2011) M Masiero et al.   LEUKEMIA

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Asymmetric cell divisions promote Notch-dependent epidermal differentiation

(2011) Scott E. Williams et al.   NATURE

Microenvironmental regulation of stem cells in intestinal homeostasis and cancer

(2011) Jan Paul Medema et al.   NATURE

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

(2011) I Hayashi et al.   ONCOGENE

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gamma-secretase inhibitor enhances the cytotoxic effect of bortezomib in multiple myeloma

(2011) Feng Chen et al.   CELLULAR ONCOLOGY

Association of High Levels of Jagged-1 and Notch-1 Expression with Poor Prognosis in Head and Neck Cancer

(2010) Jen-Tsun Lin et al.   ANNALS OF SURGICAL ONCOLOGY

Prognostic impact of Notch ligands and receptors in nonsmall cell lung cancer

(2010) Tom Donnem et al.   CANCER

NOTCH Signaling Is Required for Formation and Self-Renewal of Tumor-Initiating Cells and for Repression of Secretory Cell Differentiation in Colon Cancer

(2010) S. S. Sikandar et al.   CANCER RESEARCH

Aldehyde Dehydrogenase Activity Selects for Lung Adenocarcinoma Stem Cells Dependent on Notch Signaling

(2010) J. P. Sullivan et al.   CANCER RESEARCH

Downregulation of Notch Pathway by a  -Secretase Inhibitor Attenuates AKT/Mammalian Target of Rapamycin Signaling and Glucose Uptake in an ERBB2 Transgenic Breast Cancer Model

(2010) C. L. Efferson et al.   CANCER RESEARCH

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Activation of Notch signaling in human tongue carcinoma

(2010) Tong-Han Zhang et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

(2010) H Ling et al.   ONCOGENE

Expression of Stat3 and Notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma

(2010) Fu   ONCOLOGY REPORTS

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

(2009) S Rasul et al.   BRITISH JOURNAL OF CANCER

Epidermal Notch1 Loss Promotes Skin Tumorigenesis by Impacting the Stromal Microenvironment

(2009) Shadmehr Demehri et al.   CANCER CELL

Cross-talk between Tumor and Endothelial Cells Involving the Notch3-Dll4 Interaction Marks Escape from Tumor Dormancy

(2009) Stefano Indraccolo et al.   CANCER RESEARCH

Up-regulation of miR-200 and let-7 by Natural Agents Leads to the Reversal of Epithelial-to-Mesenchymal Transition in Gemcitabine-Resistant Pancreatic Cancer Cells

(2009) Y. Li et al.   CANCER RESEARCH

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

Notch signaling in the hematopoietic system

(2009) Ashley R Sandy et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Down-regulation of Notch-1 increases co-cultured Jurkat cell sensitivity to chemotherapy

(2009) Dongmei Guo et al.   LEUKEMIA & LYMPHOMA

Aldehyde Dehydrogenase 1 Is a Tumor Stem Cell-Associated Marker in Lung Cancer

(2009) F. Jiang et al.   MOLECULAR CANCER RESEARCH

Directional Delta and Notch trafficking in Sara endosomes during asymmetric cell division

(2009) F. Coumailleau et al.   NATURE

A side population of cells from a human pancreatic carcinoma cell line harbors cancer stem cell characteristics

(2009) Y. WANG et al.   NEOPLASMA

Relationship between vascular endothelial growth factor and Notch1 expression and lymphatic metastasis in tongue cancer

(2009) Young-Hoon Joo et al.   OTOLARYNGOLOGY-HEAD AND NECK SURGERY

Differential Expression of Notch Family Members in Astrocytomas and Medulloblastomas

(2009) Peng Xu et al.   PATHOLOGY & ONCOLOGY RESEARCH

MicroRNA miR-34 Inhibits Human Pancreatic Cancer Tumor-Initiating Cells

(2009) Qing Ji et al.   PLoS One

Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

(2009) V. Rodilla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine

(2009) S. Fre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Increasing Complexity of the Cancer Stem Cell Paradigm

(2009) J. M. Rosen et al.   SCIENCE

Notch Promotes Radioresistance of Glioma Stem Cells

(2009) Jialiang Wang et al.   STEM CELLS

Skin-Derived TSLP Triggers Progression from Epidermal-Barrier Defects to Asthma

(2009) Shadmehr Demehri et al.   PLOS BIOLOGY

The role of NOTCH1 signaling in T-ALL

(2009) A. A. Ferrando   Hematology-American Society of Hematology Education Program

Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

(2008) Ann E. Tilley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Notch Signaling in Leukemia

(2008) Jon C. Aster et al.   Annual Review of Pathology-Mechanisms of Disease

Stem cell concepts renew cancer research

(2008) J. E. Dick   BLOOD

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Transcriptome Analysis of the Normal Human Mammary Cell Commitment and Differentiation Process

(2008) Afshin Raouf et al.   Cell Stem Cell

Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

(2008) Toula Bouras et al.   Cell Stem Cell

An overview of cancer multidrug resistance: a still unsolved problem

(2008) H. Lage   CELLULAR AND MOLECULAR LIFE SCIENCES

Epidermal Notch signalling: differentiation, cancer and adhesion

(2008) Fiona M Watt et al.   CURRENT OPINION IN CELL BIOLOGY

Neurogenesis and asymmetric cell division

(2008) Weimin Zhong et al.   CURRENT OPINION IN NEUROBIOLOGY

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Slug is a direct Notch target required for initiation of cardiac cushion cellularization

(2008) Kyle Niessen et al.   JOURNAL OF CELL BIOLOGY

Photoexposition discriminates Notch 1 expression in human cutaneous squamous cell carcinoma

(2008) John Panelos et al.   MODERN PATHOLOGY

Notch Inhibits Expression of the Kruppel-Like Factor 4 Tumor Suppressor in the Intestinal Epithelium

(2008) A. M. Ghaleb et al.   MOLECULAR CANCER RESEARCH

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis

(2008) A Raafat et al.   ONCOGENE

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Global epidemiology of oral and oropharyngeal cancer

(2008) Saman Warnakulasuriya   ORAL ONCOLOGY

Notch-Deficient Skin Induces a Lethal Systemic B-Lymphoproliferative Disorder by Secreting TSLP, a Sentinel for Epidermal Integrity

(2008) Shadmehr Demehri et al.   PLOS BIOLOGY

Notch signaling is activated by TLR stimulation and regulates macrophage functions

(2007) Tanapat Palaga et al.   EUROPEAN JOURNAL OF IMMUNOLOGY