Notch Signaling in Development, Tissue Homeostasis, and Disease

Compound Heterozygosity for Null Mutations and a Common Hypomorphic Risk Haplotype in TBX6 Causes Congenital Scoliosis

(2017) Kazuki Takeda et al.   HUMAN MUTATION

Fibroblastic niches prime T cell alloimmunity through Delta-like Notch ligands

(2017) Jooho Chung et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity

(2017) Vincent C. Luca et al.   SCIENCE

Genome-wide identification and characterization of Notch transcription complex–binding sequence-paired sites in leukemia cells

(2017) Eric Severson et al.   Science Signaling

TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling

(2017) Liam A. Hurst et al.   Nature Communications

Hairless-binding deficient Suppressor of Hairless alleles reveal Su(H) protein levels are dependent on complex formation with Hairless

(2017) Heiko Praxenthaler et al.   PLoS Genetics

Xylosylation of the Notch receptor preserves the balance between its activation by trans-Delta and inhibition by cis-ligands in Drosophila

(2017) Tom V. Lee et al.   PLoS Genetics

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

(2017) Graham J Britton et al.   eLife

O-GlcNAc on NOTCH1 EGF repeats regulates ligand-induced Notch signaling and vascular development in mammals

(2017) Shogo Sawaguchi et al.   eLife

Genome-wide identification and characterization of Notch transcription complex–binding sequence-paired sites in leukemia cells

(2017) Eric Severson et al.   Science Signaling

Reducing Timp3 or vitronectin ameliorates disease manifestations in CADASIL mice

(2016) Carmen Capone et al.   ANNALS OF NEUROLOGY

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

(2016) M. Y. Chiang et al.   BLOOD

Hajdu Cheney Syndrome; report of a novel NOTCH2 mutation and treatment with denosumab

(2016) Giovanni Adami et al.   BONE

Therapeutic NOTCH3 cysteine correction in CADASIL using exon skipping:in vitroproof of concept

(2016) Julie W. Rutten et al.   BRAIN

Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma

(2016) Eleni M. Rettig et al.   Cancer Prevention Research

The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis

(2016) L. Astudillo et al.   CANCER RESEARCH

Self-Organization of Embryonic Genetic Oscillators into Spatiotemporal Wave Patterns

(2016) Charisios D. Tsiairis et al.   CELL

Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits

(2016) Kole T. Roybal et al.   CELL

Engineering Customized Cell Sensing and Response Behaviors Using Synthetic Notch Receptors

(2016) Leonardo Morsut et al.   CELL

Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors

(2016) Kole T. Roybal et al.   CELL

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Hes1: the maestro in neurogenesis

(2016) Sivadasan Bindu Dhanesh et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Evidence of non-canonical NOTCH signaling: Delta-like 1 homolog (DLK1) directly interacts with the NOTCH1 receptor in mammals

(2016) Gunnhildur Ásta Traustadóttir et al.   CELLULAR SIGNALLING

Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial

(2016) R. Xu et al.   CLINICAL CANCER RESEARCH

Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy

(2016) T. Hayashi et al.   CLINICAL CANCER RESEARCH

Notch, lipids, and endothelial cells

(2016) Anaïs Briot et al.   CURRENT OPINION IN LIPIDOLOGY

DrosophilaCrumbs prevents ectopic Notch activation in developing wings by inhibiting ligand-independent endocytosis

(2016) Linda Nemetschke et al.   DEVELOPMENT

Notch: A multi-functional integrating system of microenvironmental signals

(2016) Bryce LaFoya et al.   DEVELOPMENTAL BIOLOGY

Complex regulation of HSC emergence by the Notch signaling pathway

(2016) Emerald Butko et al.   DEVELOPMENTAL BIOLOGY

A POGLUT1 mutation causes a muscular dystrophy with reduced Notch signaling and satellite cell loss

(2016) Emilia Servián‐Morilla et al.   EMBO Molecular Medicine

Genetic Diversity of Pancreatic Ductal Adenocarcinoma and Opportunities for Precision Medicine

(2016) Erik S. Knudsen et al.   GASTROENTEROLOGY

Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis

(2016) Hiromi Shimojo et al.   GENES & DEVELOPMENT

Notch signal reception is required in vascular smooth muscle cells for ductus arteriosus closure

(2016) Luke T. Krebs et al.   GENESIS

Identification of Domains for Efficient Notch Signaling Activity in Immobilized Notch Ligand Proteins

(2016) Ledi Liu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model

(2016) Oh-Joon Kwon et al.   JOURNAL OF CLINICAL INVESTIGATION

RBPJ maintains brain tumor–initiating cells through CDK9-mediated transcriptional elongation

(2016) Qi Xie et al.   JOURNAL OF CLINICAL INVESTIGATION

The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development

(2016) Mustafa Turkoz et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation

(2016) Christine Bernsmeier et al.   LABORATORY INVESTIGATION

Defining Single Molecular Forces Required for Notch Activation Using Nano Yoyo

(2016) Farhan Chowdhury et al.   NANO LETTERS

Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis

(2016) Peidong Han et al.   NATURE

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Sex hormones establish a reserve pool of adult muscle stem cells

(2016) Ji-Hoon Kim et al.   NATURE CELL BIOLOGY

NOTCH1 mediates a switch between two distinct secretomes during senescence

(2016) Matthew Hoare et al.   NATURE CELL BIOLOGY

Structural analysis of Notch-regulating Rumi reveals basis for pathogenic mutations

(2016) Hongjun Yu et al.   Nature Chemical Biology

Notch signalling in context

(2016) Sarah J. Bray   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Developmental signalling pathways in renal fibrosis: the roles of Notch, Wnt and Hedgehog

(2016) Maria Edeling et al.   Nature Reviews Nephrology

A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes

(2016) Franz Oswald et al.   NUCLEIC ACIDS RESEARCH

Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer

(2016) Q Su et al.   ONCOGENE

Cellular stress induces TRB3/USP9x-dependent Notch activation in cancer

(2016) J Izrailit et al.   ONCOGENE

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies

(2016) P Bernasconi-Elias et al.   ONCOGENE

Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer

(2016) Tanya Stoyanova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch3 drives development and progression of cholangiocarcinoma

(2016) Rachel V. Guest et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The many roles of Notch signaling during vertebrate somitogenesis

(2016) Kanu Wahi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Notch Signaling and Alloreactivity

(2016) Vedran Radojcic et al.   TRANSPLANTATION

Notch regulates BMP responsiveness and lateral branching in vessel networks via SMAD6

(2016) Kevin P. Mouillesseaux et al.   Nature Communications

Faster embryonic segmentation through elevated Delta-Notch signalling

(2016) Bo-Kai Liao et al.   Nature Communications

Notch signalling mediates reproductive constraint in the adult worker honeybee

(2016) Elizabeth J. Duncan et al.   Nature Communications

Notch-independent RBPJ controls angiogenesis in the adult heart

(2016) Ramón Díaz-Trelles et al.   Nature Communications

Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium

(2016) Bethany A. Kerr et al.   Nature Communications

Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment

(2016) Keisuke Katsushima et al.   Nature Communications

Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy

(2016) José M. García-Heredia et al.   Oncotarget

Notch signaling: its roles and therapeutic potential in hematological malignancies

(2016) Yisu Gu et al.   Oncotarget

PDCD4 is a CSL associated protein with a transcription repressive function in cancer associated fibroblast activation

(2016) Seung-Hee Jo et al.   Oncotarget

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

(2016) Sanaz Yahyanejad et al.   Oncotarget

NUMB negatively regulates the epithelial-mesenchymal transition of triple-negative breast cancer by antagonizing Notch signaling

(2016) Jianchao Zhang et al.   Oncotarget

Phosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells

(2016) Niina M. Santio et al.   Oncotarget

Radiation driven epithelial-mesenchymal transition is mediated by Notch signaling in breast cancer

(2016) Rae-Kwon Kim et al.   Oncotarget

The long non-coding RNA HOTAIR increases tumour growth and invasion in cervical cancer by targeting the Notch pathway

(2016) Maria Lee et al.   Oncotarget

Small molecule activation of NOTCH signaling inhibits acute myeloid leukemia

(2016) Qi Ye et al.   Scientific Reports

Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest

(2016) Xifu Shang et al.   Scientific Reports

Identification of a Paralog-Specific Notch1 Intracellular Domain Degron

(2016) Matthew R. Broadus et al.   Cell Reports

Notch Signaling Rescues Loss of Satellite Cells Lacking Pax7 and Promotes Brown Adipogenic Differentiation

(2016) Alessandra Pasut et al.   Cell Reports

Structure and Function of the Su(H)-Hairless Repressor Complex, the Major Antagonist of Notch Signaling in Drosophila melanogaster

(2016) Zhenyu Yuan et al.   PLOS BIOLOGY

BLOS2 negatively regulates Notch signaling during neural and hematopoietic stem and progenitor cell development

(2016) Wenwen Zhou et al.   eLife

Stage-specific effects of Notch activation during skeletal myogenesis

(2016) Pengpeng Bi et al.   eLife

Cytoplasmic NOTCH and membrane-derived β-catenin link cell fate choice to epithelial-mesenchymal transition during myogenesis

(2016) Daniel Sieiro et al.   eLife

Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

(2016) Joana Esteves de Lima et al.   eLife

Loss of CSL Unlocks a Hypoxic Response and Enhanced Tumor Growth Potential in Breast Cancer Cells

(2016) Eike-Benjamin Braune et al.   Stem Cell Reports

Hajdu-Cheney Syndrome, a Disease Associated with NOTCH2 Mutations

(2016) Ernesto Canalis et al.   Current Osteoporosis Reports

Notch Signaling Coordinates Progenitor Cell-Mediated Biliary Regeneration Following Partial Hepatectomy

(2016) Jie Lu et al.   Scientific Reports

Heterozygous Loss-of-Function Mutations in DLL4 Cause Adams-Oliver Syndrome

(2015) Josephina A.N. Meester et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome

(2015) Ender Karaca et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Notch Activation of Ca2+Signaling in the Development of Hypoxic Pulmonary Vasoconstriction and Pulmonary Hypertension

(2015) Kimberly A. Smith et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pericytes are involved in the pathogenesis of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

(2015) Mitrajit Ghosh et al.   ANNALS OF NEUROLOGY

Wnt16 Attenuates TGFβ-Induced Chondrogenic Transformation in Vascular Smooth MuscleSignificance

(2015) Kelly E. Beazley et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes

(2015) Claudio Giachino et al.   CANCER CELL

Usp28 Counteracts Fbw7 in Intestinal Homeostasis and Cancer

(2015) M. E. Diefenbacher et al.   CANCER RESEARCH

Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype

(2015) Natassia M. Vieira et al.   CELL

Integrative Clinical Genomics of Advanced Prostate Cancer

(2015) Dan Robinson et al.   CELL

A New Notch for Lung Stem Cells

(2015) Gianni Carraro et al.   Cell Stem Cell

Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations

(2015) Ana Pardo-Saganta et al.   Cell Stem Cell

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Endocardial Notch Signaling in Cardiac Development and Disease

(2015) Guillermo Luxán et al.   CIRCULATION RESEARCH

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

PEST Domain Mutations in Notch Receptors Comprise an Oncogenic Driver Segment in Triple-Negative Breast Cancer Sensitive to a  -Secretase Inhibitor

(2015) K. Wang et al.   CLINICAL CANCER RESEARCH

Evidence of cell-fate conversion from hepatocytes to cholangiocytes in the injured liver

(2015) Atsushi Suzuki   CURRENT OPINION IN GASTROENTEROLOGY

Sensory hair cell development and regeneration: similarities and differences

(2015) P. J. Atkinson et al.   DEVELOPMENT

A conserved role for Notch signaling in priming the cellular response to Shh through ciliary localisation of the key Shh transducer Smo

(2015) M. Stasiulewicz et al.   DEVELOPMENT

Notch3-Jagged signaling controls the pool of undifferentiated airway progenitors

(2015) M. Mori et al.   DEVELOPMENT

Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest

(2015) L. J. Manderfield et al.   DEVELOPMENT

The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis

(2015) Z. Liu et al.   DEVELOPMENT

Notch Activity Modulates the Responsiveness of Neural Progenitors to Sonic Hedgehog Signaling

(2015) Jennifer H. Kong et al.   DEVELOPMENTAL CELL

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch

(2015) Wendy R. Gordon et al.   DEVELOPMENTAL CELL

The molecular regulation of arteriovenous specification and maintenance

(2015) Jason E. Fish et al.   DEVELOPMENTAL DYNAMICS

Chromatin signatures at Notch-regulated enhancers reveal large-scale changes in H3K56ac upon activation

(2015) L. Skalska et al.   EMBO JOURNAL

Homozygous NOTCH3 null mutation and impaired NOTCH3 signaling in recessive early-onset arteriopathy and cavitating leukoencephalopathy

(2015) T. Pippucci et al.   EMBO Molecular Medicine

Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease

(2015) R. Sancho et al.   EMBO REPORTS

Loss of Notch2 and Notch3 in vascular smooth muscle causes patent ductus arteriosus

(2015) Jeremy T. Baeten et al.   GENESIS

Differential effects of targeting Notch receptors in a mouse model of liver cancer

(2015) Erik G. Huntzicker et al.   HEPATOLOGY

Jagged1 heterozygosity in mice results in a congenital cholangiopathy which is reversed by concomitant deletion of one copy ofPoglut1(Rumi)

(2015) Shakeel M. Thakurdas et al.   HEPATOLOGY

The PIAS-like Coactivator Zmiz1 Is a Direct and Selective Cofactor of Notch1 in T Cell Development and Leukemia

(2015) Nancy Pinnell et al.   IMMUNITY

Hajdu Cheney Mouse Mutants Exhibit Osteopenia, Increased Osteoclastogenesis, and Bone Resorption

(2015) Ernesto Canalis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rme-8 depletion perturbs Notch recycling and predisposes to pathogenic signaling

(2015) Maria J. Gomez-Lamarca et al.   JOURNAL OF CELL BIOLOGY

The Role of Notch Receptors in Transcriptional Regulation

(2015) Hongfang Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Epigenetic Mechanisms in Notch Signaling During Development

(2015) Ralf Schwanbeck   JOURNAL OF CELLULAR PHYSIOLOGY

Lineage fate of ductular reactions in liver injury and carcinogenesis

(2015) Simone Jörs et al.   JOURNAL OF CLINICAL INVESTIGATION

Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes

(2015) Xiao Zhang et al.   LABORATORY INVESTIGATION

Left ventricular non-compaction cardiomyopathy

(2015) Jeffrey A Towbin et al.   LANCET

Notch1 signaling regulates the epithelial–mesenchymal transition and invasion of breast cancer in a Slug-dependent manner

(2015) Shan Shao et al.   Molecular Cancer

Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung

(2015) Daniel Lafkas et al.   NATURE

The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3

(2015) Colleen A. McHugh et al.   NATURE

Parent stem cells can serve as niches for their daughter cells

(2015) Ana Pardo-Saganta et al.   NATURE

Comprehensive genomic profiles of small cell lung cancer

(2015) Julie George et al.   NATURE

Directed differentiation of cholangiocytes from human pluripotent stem cells

(2015) Mina Ogawa et al.   NATURE BIOTECHNOLOGY

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

(2015) Maria-Giuseppina Procopio et al.   NATURE CELL BIOLOGY

What are super-enhancers?

(2015) Sebastian Pott et al.   NATURE GENETICS

Control of peripheral tolerance by regulatory T cell–intrinsic Notch signaling

(2015) Louis-Marie Charbonnier et al.   NATURE IMMUNOLOGY

TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis

(2015) Nan Wu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas

(2015)   NEW ENGLAND JOURNAL OF MEDICINE

Potassium channelopathy-like defect underlies early-stage cerebrovascular dysfunction in a genetic model of small vessel disease

(2015) Fabrice Dabertrand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for Notch1 engagement of Delta-like 4

(2015) V. C. Luca et al.   SCIENCE

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

(2015) K. Hein et al.   Science Signaling

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region

(2015) Xiang Xu et al.   STRUCTURE

Intramyocardial Delivery ofNotchLigand-Containing Hydrogels Improves Cardiac Function and Angiogenesis Following Infarction

(2015) Archana V. Boopathy et al.   TISSUE ENGINEERING PART A

Alk1 and Alk5 inhibition by Nrp1 controls vascular sprouting downstream of Notch

(2015) Irene Maria Aspalter et al.   Nature Communications

A novel Monoclonal Antibody against Notch1 Targets Leukemia-associated Mutant Notch1 and Depletes Therapy Resistant Cancer Stem Cells in Solid Tumors

(2015) Ankur Sharma et al.   Scientific Reports

Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL and results in arteriovenous malformations

(2015) Natalie M. Kofler et al.   Scientific Reports

Anti-estrogen Resistance in Human Breast Tumors Is Driven by JAG1-NOTCH4-Dependent Cancer Stem Cell Activity

(2015) Bruno M. Simões et al.   Cell Reports

Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

(2015) Kristina Preuße et al.   PLoS Genetics

Haploinsufficiency of the NOTCH1 Receptor as a Cause of Adams–Oliver Syndrome With Variable Cardiac AnomaliesCLINICAL PERSPECTIVE

(2015) Laura Southgate et al.   Circulation-Cardiovascular Genetics

A balance of positive and negative regulators determines the pace of the segmentation clock

(2015) Guy Wiedermann et al.   eLife

Pericytes are progenitors for coronary artery smooth muscle

(2015) Katharina S Volz et al.   eLife

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response

(2015) K. Hein et al.   Science Signaling

Clinical Significance of Cerebral Microbleeds Locations in CADASIL with R544C NOTCH3 Mutation

(2015) Jung Seok Lee et al.   PLoS One

O-Fucosylation of DLL3 Is Required for Its Function during Somitogenesis

(2015) Katrin Serth et al.   PLoS One

Hepatocytes, Rather than Cholangiocytes, Can Be the Major Source of Primitive Ductules in the Chronically Injured Mouse Liver

(2014) Sayaka Sekiya et al.   AMERICAN JOURNAL OF PATHOLOGY

Signaling Pathways in the Specification of Arteries and Veins

(2014) Monica Corada et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Significance of glycosylation in Notch signaling

(2014) Hideyuki Takeuchi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Notch functions in developmental and tumour angiogenesis by diverse mechanisms1

(2014) Thaned Kangsamaksin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Notch4 reveals a novel mechanism regulating Notch signal transduction

(2014) A.C. James et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pressing the right buttons: signaling in lymphangiogenesis

(2014) S. Coso et al.   BLOOD

Latent NOTCH3 epitopes unmasked in CADASIL and regulated by protein redox state

(2014) Xiaojie Zhang et al.   BRAIN RESEARCH

Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells

(2014) Aleksandra Filipović et al.   BREAST CANCER RESEARCH AND TREATMENT

Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia

(2014) Thomas Trimarchi et al.   CELL

Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways

(2014) Mirjam C. Boelens et al.   CELL

Hippo Pathway Activity Influences Liver Cell Fate

(2014) Dean Yimlamai et al.   CELL

The Noncoding RNA Revolution—Trashing Old Rules to Forge New Ones

(2014) Thomas R. Cech et al.   CELL

Dynamic expression and roles of Hes factors in neural development

(2014) Ryoichiro Kageyama et al.   CELL AND TISSUE RESEARCH

PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner

(2014) Marika Sjöqvist et al.   CELL RESEARCH

Adult Hepatocytes Are Generated by Self-Duplication Rather than Stem Cell Differentiation

(2014) Kilangsungla Yanger et al.   Cell Stem Cell

Repair and Regeneration of the Respiratory System: Complexity, Plasticity, and Mechanisms of Lung Stem Cell Function

(2014) Brigid L.M. Hogan et al.   Cell Stem Cell

Stem/Progenitor Cells in Liver Development, Homeostasis, Regeneration, and Reprogramming

(2014) Atsushi Miyajima et al.   Cell Stem Cell

Bipotential Adult Liver Progenitors Are Derived from Chronically Injured Mature Hepatocytes

(2014) Branden D. Tarlow et al.   Cell Stem Cell

A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors

(2014) D. C. Smith et al.   CLINICAL CANCER RESEARCH

Notch signaling functions in lymphatic valve formation

(2014) A. Murtomaki et al.   DEVELOPMENT

Spatiotemporal oscillations of Notch1, Dll1 and NICD are coordinated across the mouse PSM

(2014) R. A. Bone et al.   DEVELOPMENT

Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock

(2014) C. Soza-Ried et al.   DEVELOPMENT

Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

(2014) J. Petrovic et al.   DEVELOPMENT

Repression of Sox9 by Jag1 Is Continuously Required to Suppress the Default Chondrogenic Fate of Vascular Smooth Muscle Cells

(2014) Anaïs Briot et al.   DEVELOPMENTAL CELL

MurineNotch1is required for lymphatic vascular morphogenesis during development

(2014) Anees Fatima et al.   DEVELOPMENTAL DYNAMICS

Pleiotropic roles of Notch signaling in normal, malignant, and developmental hematopoiesis in the human

(2014) R. Kushwah et al.   EMBO REPORTS

The Notch pathway: a novel target for myocardial remodelling therapy?

(2014) R. Ferrari et al.   EUROPEAN HEART JOURNAL

ADAM10 Regulates Notch Function in Intestinal Stem Cells of Mice

(2014) Yu-Hwai Tsai et al.   GASTROENTEROLOGY

The NOTCH pathway is recurrently mutated in diffuse large B-cell lymphoma associated with hepatitis C virus infection

(2014) L. Arcaini et al.   HAEMATOLOGICA

Emerging roles of Notch signaling in liver disease

(2014) Fabian Geisler et al.   HEPATOLOGY

Compound heterozygous mutations in RIPPLY2 associated with vertebral segmentation defects

(2014) Aideen M. McInerney-Leo et al.   HUMAN MOLECULAR GENETICS

Signaling Involved in Hair Follicle Morphogenesis and Development

(2014) Pisal Rishikaysh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Basal body proteins regulate Notch signaling through endosomal trafficking

(2014) C. C. Leitch et al.   JOURNAL OF CELL SCIENCE

The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer

(2014) Markus E. Diefenbacher et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of the Notch effector RBPJ promotes tumorigenesis

(2014) Iva Kulic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

Ikaros Regulates Notch Target Gene Expression in Developing Thymocytes

(2014) S. Chari et al.   JOURNAL OF IMMUNOLOGY

NOTCH1 Mutations Occur Early during Cutaneous Squamous Cell Carcinogenesis

(2014) Andrew P. South et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of genomic alterations in oesophageal squamous cell cancer

(2014) Yongmei Song et al.   NATURE

Endothelial Notch activity promotes angiogenesis and osteogenesis in bone

(2014) Saravana K. Ramasamy et al.   NATURE

The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis

(2014) Katie Bentley et al.   NATURE CELL BIOLOGY

Genetic landscape of esophageal squamous cell carcinoma

(2014) Yi-Bo Gao et al.   NATURE GENETICS

A new tumor suppressor role for the Notch pathway in bladder cancer

(2014) Theodoros Rampias et al.   NATURE MEDICINE

A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia

(2014) Daniel Herranz et al.   NATURE MEDICINE

Therapeutic modulation of Notch signalling — are we there yet?

(2014) Emma R. Andersson et al.   NATURE REVIEWS DRUG DISCOVERY

Signalling dynamics in vertebrate segmentation

(2014) Alexis Hubaud et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain

(2014) Leda Dimou et al.   PHYSIOLOGICAL REVIEWS

Long-range enhancer activity determinesMycsensitivity to Notch inhibitors in T cell leukemia

(2014) Yumi Yashiro-Ohtani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch regulation of myogenic versus endothelial fates of cells that migrate from the somite to the limb

(2014) A. Mayeuf-Louchart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somites Without a Clock

(2014) A. S. Dias et al.   SCIENCE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

The Tumor Suppressor Ikaros Shapes the Repertoire of Notch Target Genes in T Cells

(2014) A.-S. Geimer Le Lay et al.   Science Signaling

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

(2014) C. A. Martz et al.   Science Signaling

Notch signal integration in the vasculature during remodeling

(2014) Bahman Rostama et al.   VASCULAR PHARMACOLOGY

NOTCH Decoys That Selectively Block DLL/NOTCH or JAG/NOTCH Disrupt Angiogenesis by Unique Mechanisms to Inhibit Tumor Growth

(2014) Thaned Kangsamaksin et al.   Cancer Discovery

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

Non-canonical Notch signaling represents an ancestral mechanism to regulate neural differentiation

(2014) Michael J Layden et al.   EvoDevo

RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking

(2014) Robert J. Lake et al.   PLoS Genetics

Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states

(2014) Lauren LeBon et al.   eLife

Non-Canonical Notch Signaling Drives Activation and Differentiation of Peripheral CD4+ T Cells

(2014) Anushka Dongre et al.   Frontiers in Immunology

Sequestration of latent TGF-β binding protein 1 into CADASIL-related Notch3-ECD deposits

(2014) Jessica Kast et al.   Acta Neuropathologica Communications

Non-Canonical Notch Signaling in Cancer and Immunity

(2014) Furkan Ayaz et al.   Frontiers in Oncology

A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis

(2013) Yee Him Cheung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutations in PDGFRB Cause Autosomal-Dominant Infantile Myofibromatosis

(2013) John A. Martignetti et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Mutation of HES7 in a large extended family with spondylocostal dysostosis and dextrocardia with situs inversus

(2013) Duncan B. Sparrow et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

CCR2 Deficiency, Dysregulation of Notch Signaling, and Spontaneous Pulmonary Arterial Hypertension

(2013) Yen-Rei A. Yu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Soluble Jagged1 Inhibits Pulmonary Hypertension by Attenuating Notch Signaling

(2013) Yongguang Xiao et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

γ-Secretase inhibitors and modulators

(2013) Todd E. Golde et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Endothelial RAF1/ERK activation regulates arterial morphogenesis

(2013) Y. Deng et al.   BLOOD

Notch controls generation and function of human effector CD8+ T cells

(2013) L. M. Kuijk et al.   BLOOD

Abnormal recruitment of extracellular matrix proteins by excess Notch3ECD: a new pathomechanism in CADASIL

(2013) Marie Monet-Leprêtre et al.   BRAIN

A phase I study of the combination of ro4929097 and cediranib in patients with advanced solid tumours (PJC-004/NCI 8503)

(2013) S Sahebjam et al.   BRITISH JOURNAL OF CANCER

A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas

(2013) Steffen Zender et al.   CANCER CELL

Loss of TGF-  Adaptor  2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma

(2013) S. Song et al.   CANCER RESEARCH

Activation of the NOTCH Pathway in Head and Neck Cancer

(2013) W. Sun et al.   CANCER RESEARCH

Cell Lineage Tracing Reveals a Biliary Origin of Intrahepatic Cholangiocarcinoma

(2013) R. V. Guest et al.   CANCER RESEARCH

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

Numb Localizes at Endosomes and Controls the Endosomal Sorting of Notch after Asymmetric Division in Drosophila

(2013) Lydie Couturier et al.   CURRENT BIOLOGY

Notch cooperates with Lozenge/Runx to lock haemocytes into a differentiation programme

(2013) A. Terriente-Felix et al.   DEVELOPMENT

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo

(2013) Yu Takahashi et al.   DEVELOPMENTAL BIOLOGY

ETS Factors Regulate Vegf-Dependent Arterial Specification

(2013) Joshua D. Wythe et al.   DEVELOPMENTAL CELL

The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development

(2013) Zhenyi Liu et al.   DEVELOPMENTAL CELL

Endothelio-Mesenchymal Interaction Controls runx1 Expression and Modulates the notch Pathway to Initiate Aortic Hematopoiesis

(2013) Charlotte Richard et al.   DEVELOPMENTAL CELL

Jagged1 is the major regulator of notch-dependent cell fate in proximal airways

(2013) Shubing Zhang et al.   DEVELOPMENTAL DYNAMICS

Autosomal recessive Adams–Oliver syndrome caused by homozygous mutation in EOGT, encoding an EGF domain-specific O-GlcNAc transferase

(2013) Idan Cohen et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The 4 Notch receptors play distinct and antagonistic roles in the proliferation and hepatocytic differentiation of liver progenitors

(2013) Sara Ortica et al.   FASEB JOURNAL

Yes-Associated Protein Up-regulates Jagged-1 and Activates the NOTCH Pathway in Human Hepatocellular Carcinoma

(2013) Darjus Felix Tschaharganeh et al.   GASTROENTEROLOGY

Roles of PINK1, mTORC2, and mitochondria in preserving brain tumor-forming stem cells in a noncanonical Notch signaling pathway

(2013) K.-S. Lee et al.   GENES & DEVELOPMENT

Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling

(2013) M. Kitade et al.   GENES & DEVELOPMENT

Dynamic binding of RBPJ is determined by Notch signaling status

(2013) D. Castel et al.   GENES & DEVELOPMENT

Robust cellular reprogramming occurs spontaneously during liver regeneration

(2013) K. Yanger et al.   GENES & DEVELOPMENT

Novel MIR143-NOTCH fusions in benign and malignant glomus tumors

(2013) Juan-Miguel Mosquera et al.   GENES CHROMOSOMES & CANCER

Canonical Notch2 signaling determines biliary cell fates of embryonic hepatoblasts and adult hepatocytes independent of Hes1

(2013) Petia Jeliazkova et al.   HEPATOLOGY

Autosomal dominant spondylocostal dysostosis is caused by mutation in TBX6

(2013) Duncan B. Sparrow et al.   HUMAN MOLECULAR GENETICS

miR-30a Regulates Endothelial Tip Cell Formation and Arteriolar Branching

(2013) Qiu Jiang et al.   HYPERTENSION

Lateral inhibition and neurogenesis: novel aspects in motion

(2013) Pau Formosa-Jordan et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

 -arrestin 1 (ARRDC1) and  -arrestins cooperate to mediate Notch degradation in mammals

(2013) L. Puca et al.   JOURNAL OF CELL SCIENCE

Blockade of individual Notch ligands and receptors controls graft-versus-host disease

(2013) Ivy T. Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Whole exome sequencing of adenoid cystic carcinoma

(2013) Philip J. Stephens et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice

(2013) Romina Fiorotto et al.   JOURNAL OF HEPATOLOGY

Notch signaling and new therapeutic options in liver disease

(2013) Carola Maria Morell et al.   JOURNAL OF HEPATOLOGY

Notch Signaling Regulates Follicular Helper T Cell Differentiation

(2013) F. Auderset et al.   JOURNAL OF IMMUNOLOGY

Notch-Regulated Periphery B Cell Differentiation Involves Suppression of E Protein Function

(2013) P. Zhang et al.   JOURNAL OF IMMUNOLOGY

NFIA Controls Telencephalic Progenitor Cell Differentiation through Repression of the Notch Effector Hes1

(2013) M. Piper et al.   JOURNAL OF NEUROSCIENCE

Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear

(2013) W. Pan et al.   JOURNAL OF NEUROSCIENCE

Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development

(2013) Masashi Kitagawa et al.   MECHANISMS OF DEVELOPMENT

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

The mutational landscape of adenoid cystic carcinoma

(2013) Allen S Ho et al.   NATURE GENETICS

Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy

(2013) Guillermo Luxán et al.   NATURE MEDICINE

Notch Inhibition Induces Cochlear Hair Cell Regeneration and Recovery of Hearing after Acoustic Trauma

(2013) Kunio Mizutari et al.   NEURON

The Different Role of Notch1 and Notch2 in Astrocytic Gliomas

(2013) Peng Xu et al.   PLoS One

The Significance of Notch1 Compared with Notch3 in High Metastasis and Poor Overall Survival in Hepatocellular Carcinoma

(2013) Liang Zhou et al.   PLoS One

Notch Signaling Maintains Neural Rosette Polarity

(2013) Heather Main et al.   PLoS One

Gauging NOTCH1 Activation in Cancer Using Immunohistochemistry

(2013) Michael J. Kluk et al.   PLoS One

Activation of Notch Signaling Is Required for Cholangiocarcinoma Progression and Is Enhanced by Inactivation of p53 In Vivo

(2013) Mona El Khatib et al.   PLoS One

Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development

(2013) N. Sacilotto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of somatic mutations and clonal evolution in mantle cell lymphoma

(2013) S. Bea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers

(2013) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brief Report: Blockade of Notch Signaling in Muscle Stem Cells Causes Muscular Dystrophic Phenotype and Impaired Muscle Regeneration

(2013) Shuibin Lin et al.   STEM CELLS

A Critical Role for Sox9 in Notch-Induced Astrogliogenesis and Stem Cell Maintenance

(2013) Simone Martini et al.   STEM CELLS

Hypoxia-Induced Arterial Differentiation Requires Adrenomedullin and Notch Signaling

(2013) Fredrik Lanner et al.   STEM CELLS AND DEVELOPMENT

Structure and Function of the CSL-KyoT2 Corepressor Complex: A Negative Regulator of Notch Signaling

(2013) Kelly J. Collins et al.   STRUCTURE

Regulation of Vascular Smooth Muscle Cell Phenotype in Three-Dimensional Coculture System by Jagged1-Selective Notch3 Signaling

(2013) Aparna Bhattacharyya et al.   TISSUE ENGINEERING PART A

RBPJ Mutations Identified in Two Families Affected by Adams-Oliver Syndrome

(2012) Susan J. Hassed et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Notch in the Intestine: Regulation of Homeostasis and Pathogenesis

(2012) Taeko K. Noah et al.   Annual Review of Physiology

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis

(2012) G. Bridge et al.   BLOOD

BMP9 and BMP10 are critical for postnatal retinal vascular remodeling

(2012) N. Ricard et al.   BLOOD

Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: A model of spondylocostal dysostosis and spondylothoracic dysostosis

(2012) Yuji Makino et al.   BONE

Endothelial cell metabolism and implications for cancer therapy

(2012) U Harjes et al.   BRITISH JOURNAL OF CANCER

Elevated Epidermal Thymic Stromal Lymphopoietin Levels Establish an Antitumor Environment in the Skin

(2012) Shadmehr Demehri et al.   CANCER CELL

Notch signalling in smooth muscle cells during development and disease

(2012) C. Fouillade et al.   CARDIOVASCULAR RESEARCH

A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis

(2012) Duncan B. Sparrow et al.   CELL

Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling

(2012) Bing Hu et al.   CELL

Current perspectives of the signaling pathways directing neural crest induction

(2012) Timothy J. Stuhlmiller et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition

(2012) E. Chrysostomou et al.   DEVELOPMENT

Different assemblies of Notch receptors coordinate the distribution of the major bronchial Clara, ciliated and neuroendocrine cells

(2012) M. Morimoto et al.   DEVELOPMENT

The role of Hes genes in intestinal development, homeostasis and tumor formation

(2012) T. Ueo et al.   DEVELOPMENT

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Patterning and cell fate in the inner ear: a case for Notch in the chicken embryo

(2012) Joana Neves et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Optical Tweezers Studies on Notch: Single-Molecule Interaction Strength Is Independent of Ligand Endocytosis

(2012) Bhupinder Shergill et al.   DEVELOPMENTAL CELL

Botch Promotes Neurogenesis by Antagonizing Notch

(2012) Zhikai Chi et al.   DEVELOPMENTAL CELL

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Single-Cell-Resolution Imaging of the Impact of Notch Signaling and Mitosis on Segmentation Clock Dynamics

(2012) Emilie A. Delaune et al.   DEVELOPMENTAL CELL

Notch Ligand Endocytosis Generates Mechanical Pulling Force Dependent on Dynamin, Epsins, and Actin

(2012) Laurence Meloty-Kapella et al.   DEVELOPMENTAL CELL

The Notch pathway controls fibrotic and regenerative repair in the adult heart

(2012) Mohamed Nemir et al.   EUROPEAN HEART JOURNAL

Notch Signaling Is Activated in Human Hepatocellular Carcinoma and Induces Tumor Formation in Mice

(2012) Augusto Villanueva et al.   GASTROENTEROLOGY

Liver Progenitor Cells Yield Functional Hepatocytes in Response to Chronic Liver Injury in Mice

(2012) Regina Español–Suñer et al.   GASTROENTEROLOGY

Constitutive Notch2 signaling induces hepatic tumors in mice

(2012) Michael T. Dill et al.   HEPATOLOGY

Notch Activation by the Metalloproteinase ADAM17 Regulates Myeloproliferation and Atopic Barrier Immunity by Suppressing Epithelial Cytokine Synthesis

(2012) Aditya Murthy et al.   IMMUNITY

The Ubiquitin-specific Protease 12 (USP12) Is a Negative Regulator of Notch Signaling Acting on Notch Receptor Trafficking toward Degradation

(2012) Julien Moretti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cholangiocarcinomas can originate from hepatocytes in mice

(2012) Biao Fan et al.   JOURNAL OF CLINICAL INVESTIGATION

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

(2012) Sayaka Sekiya et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

(2012) Marie Cherrier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Whole-genome sequencing identifies recurrent somaticNOTCH2mutations in splenic marginal zone lymphoma

(2012) Mark J. Kiel et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Programming of Regulatory T Cells from Pluripotent Stem Cells and Prevention of Autoimmunity

(2012) R. Haque et al.   JOURNAL OF IMMUNOLOGY

Epithelial Cell-Intrinsic Notch Signaling Plays an Essential Role in the Maintenance of Gut Immune Homeostasis

(2012) Y. Obata et al.   JOURNAL OF IMMUNOLOGY

Alzheimer's Disease: Presenilin 2-Sparing  -Secretase Inhibition Is a Tolerable A  Peptide-Lowering Strategy

(2012) T. Borgegard et al.   JOURNAL OF NEUROSCIENCE

Neurogenic Subventricular Zone Stem/Progenitor Cells Are Notch1-Dependent in Their Active But Not Quiescent State

(2012) O. Basak et al.   JOURNAL OF NEUROSCIENCE

miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia

(2012) Yuan-Lei Lou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

(2012) J. E. Grim et al.   MOLECULAR AND CELLULAR BIOLOGY

NOTCH1 Nuclear Interactome Reveals Key Regulators of Its Transcriptional Activity and Oncogenic Function

(2012) Ahmad Yatim et al.   MOLECULAR CELL

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia

(2012) Panagiotis Ntziachristos et al.   NATURE MEDICINE

BCL6 controls neurogenesis through Sirt1-dependent epigenetic repression of selective Notch targets

(2012) Luca Tiberi et al.   NATURE NEUROSCIENCE

Pericytes as a new target for pathological processes in CADASIL

(2012) Dorota Dziewulska et al.   NEUROPATHOLOGY

Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ

(2012) S Jin et al.   ONCOGENE

Overactivation of Notch1 Signaling Induces Ectopic Hair Cells in the Mouse Inner Ear in an Age-Dependent Manner

(2012) Zhiyong Liu et al.   PLoS One

Notch2 and Notch3 Function Together to Regulate Vascular Smooth Muscle Development

(2012) Qingqing Wang et al.   PLoS One

Loss of RBPj in Postnatal Excitatory Neurons Does Not Cause Neurodegeneration or Memory Impairments in Aged Mice

(2012) Chihiro Sato et al.   PLoS One

Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencing

(2012) J. G. Lohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation of vascular smooth muscle cells from local precursors during embryonic and adult arteriogenesis requires Notch signaling

(2012) L. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling

(2012) Yusuke Okubo et al.   Nature Communications

Comparative Genomic Analysis of Esophageal Adenocarcinoma and Squamous Cell Carcinoma

(2012) Nishant Agrawal et al.   Cancer Discovery

Accelerating the Tempo of the Segmentation Clock by Reducing the Number of Introns in the Hes7 Gene

(2012) Yukiko Harima et al.   Cell Reports

The loss of Hoxa5 function promotes Notch-dependent goblet cell metaplasia in lung airways

(2012) O. Boucherat et al.   Biology Open

Notch Induces Myofibroblast Differentiation of Alveolar Epithelial Cells via Transforming Growth Factor- -Smad3 Pathway

(2011) K. Aoyagi-Ikeda et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Soluble Jagged-1 Inhibits Neointima Formation by Attenuating Notch-Herp2 Signaling

(2011) Vincenza Caolo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

(2011) W. Zheng et al.   BLOOD

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

(2011) L. Scheppke et al.   BLOOD

Whole transcriptome sequencing reveals recurrent NOTCH1 mutations in mantle cell lymphoma

(2011) R. Kridel et al.   BLOOD

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

(2011) K. Niessen et al.   BLOOD

miR-27b controls venous specification and tip cell fate

(2011) D. Biyashev et al.   BLOOD

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

DLL4-Notch Signaling Mediates Tumor Resistance to Anti-VEGF Therapy In Vivo

(2011) J.-L. Li et al.   CANCER RESEARCH

Notch-Dependent Differentiation of Adult Airway Basal Stem Cells

(2011) Jason R. Rock et al.   Cell Stem Cell

Notch Activation of Jagged1 Contributes to the Assembly of the Arterial Wall

(2011) Lauren J. Manderfield et al.   CIRCULATION

Signaling During Epicardium and Coronary Vessel Development

(2011) José María Pérez-Pomares et al.   CIRCULATION RESEARCH

Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells

(2011) Thomas Grieskamp et al.   CIRCULATION RESEARCH

Differential Notch Signaling in the Epicardium Is Required for Cardiac Inflow Development and Coronary Vessel Morphogenesis

(2011) Gonzalo del Monte et al.   CIRCULATION RESEARCH

Identification of de novo mutations and rare variants in hypoplastic left heart syndrome

(2011) M Iascone et al.   CLINICAL GENETICS

Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism

(2011) J. Ahnfelt-Ronne et al.   DEVELOPMENT

Rbpj regulates development of prosensory cells in the mammalian inner ear

(2011) Norio Yamamoto et al.   DEVELOPMENTAL BIOLOGY

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas

(2011) Daniel Kopinke et al.   DEVELOPMENTAL BIOLOGY

Noncanonical notch function in motor axon guidance is mediated by Rac GTPase and the GEF1 domain of trio

(2011) Jeong K. Song et al.   DEVELOPMENTAL DYNAMICS

Dicer is required for the maintenance of notch signaling and gliogenic competence during mouse retinal development

(2011) Sean A. Georgi et al.   Developmental Neurobiology

Alagille syndrome: pathogenesis, diagnosis and management

(2011) Peter D Turnpenny et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Dll1- and Dll4-Mediated Notch Signaling Are Required for Homeostasis of Intestinal Stem Cells

(2011) Luca Pellegrinet et al.   GASTROENTEROLOGY

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

(2011) Toshiro Sato et al.   GASTROENTEROLOGY

Roles of Drosophila Deltex in Notch receptor endocytic trafficking and activation

(2011) Kenta Yamada et al.   GENES TO CELLS

Ductular reactions in human liver: Diversity at the interface

(2011) Annette S. H. Gouw et al.   HEPATOLOGY

Mutations in NOTCH2 in families with Hajdu-Cheney syndrome

(2011) Jacek Majewski et al.   HUMAN MUTATION

Notch2 Receptor Signaling Controls Functional Differentiation of Dendritic Cells in the Spleen and Intestine

(2011) Kanako L. Lewis et al.   IMMUNITY

Genetic Evidence That Intestinal Notch Functions Vary Regionally and Operate through a Common Mechanism of Math1 Repression

(2011) Tae-Hee Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The miR-143/145 Cluster Is a Novel Transcriptional Target of Jagged-1/Notch Signaling in Vascular Smooth Muscle Cells

(2011) Joshua M. Boucher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch1 loss of heterozygosity causes vascular tumors and lethal hemorrhage in mice

(2011) Zhenyi Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Fate tracing of mature hepatocytes in mouse liver homeostasis and regeneration

(2011) Yann Malato et al.   JOURNAL OF CLINICAL INVESTIGATION

Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans

(2011) Elly Sau-Wai Ngan et al.   JOURNAL OF CLINICAL INVESTIGATION

FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation

(2011) Roya Babaei-Jadidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway

(2011) Patrick Viatour et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Blockade of Notch Ligand Delta1 Promotes Allograft Survival by Inhibiting Alloreactive Th1 Cells and Cytotoxic T Cell Generation

(2011) L. V. Riella et al.   JOURNAL OF IMMUNOLOGY

Notch Ligand Delta-Like 4 Blockade Alleviates Experimental Autoimmune Encephalomyelitis by Promoting Regulatory T Cell Development

(2011) R. Bassil et al.   JOURNAL OF IMMUNOLOGY

Canonical Notch Signaling Is Not Necessary for Prosensory Induction in the Mouse Cochlea: Insights from a Conditional Mutant of RBPj 

(2011) M. L. Basch et al.   JOURNAL OF NEUROSCIENCE

Notch1 is an independent prognostic factor for patients with glioma

(2011) Jiang Li et al.   JOURNAL OF SURGICAL ONCOLOGY

The mouse notches up another success: understanding the causes of human vertebral malformation

(2011) Duncan B. Sparrow et al.   MAMMALIAN GENOME

A novel tumour-suppressor function for the Notch pathway in myeloid leukaemia

(2011) Apostolos Klinakis et al.   NATURE

Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia

(2011) Xose S. Puente et al.   NATURE

Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

(2011) Virginia Guarani et al.   NATURE

Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis

(2011) Bertrand Isidor et al.   NATURE GENETICS

Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss

(2011) Michael A Simpson et al.   NATURE GENETICS

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Activity-Induced Notch Signaling in Neurons Requires Arc/Arg3.1 and Is Essential for Synaptic Plasticity in Hippocampal Networks

(2011) Lavinia Alberi et al.   NEURON

Dual Roles of Notch in Regulation of Apically Restricted Mitosis and Apicobasal Polarity of Neuroepithelial Cells

(2011) Shinya Ohata et al.   NEURON

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

(2011) I Hayashi et al.   ONCOGENE

Acetylation controls Notch3 stability and function in T-cell leukemia

(2011) R Palermo et al.   ONCOGENE

Delta1 Expression, Cell Cycle Exit, and Commitment to a Specific Secretory Fate Coincide within a Few Hours in the Mouse Intestinal Stem Cell System

(2011) Despina Stamataki et al.   PLoS One

Rumi functions as both a protein O-glucosyltransferase and a protein O-xylosyltransferase

(2011) H. Takeuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypo- and hyperactivated Notch signaling induce a glycolytic switch through distinct mechanisms

(2011) S. K.- J. Landor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma

(2011) N. J. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

A Critical Requirement for Notch Signaling in Maintenance of the Quiescent Skeletal Muscle Stem Cell State

(2011) Philippos Mourikis et al.   STEM CELLS

Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells

(2011) Christopher R.R. Bjornson et al.   STEM CELLS

The Epigenetic Regulation of Stem Cell Factors in Hepatic Stellate Cells

(2011) Sven Reister et al.   STEM CELLS AND DEVELOPMENT

Notch Activation Enhances the Microglia-Mediated Inflammatory Response Associated With Focal Cerebral Ischemia

(2011) Zelan Wei et al.   STROKE

Proliferating Reactive Astrocytes Are Regulated by Notch-1 in the Peri-Infarct Area After Stroke

(2011) Issei S. Shimada et al.   STROKE

Association of JAG1 with Bone Mineral Density and Osteoporotic Fractures: A Genome-wide Association Study and Follow-up Replication Studies

(2010) Annie W.C. Kung et al.   AMERICAN JOURNAL OF HUMAN GENETICS

New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

(2010) H. Sheldon et al.   BLOOD

Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease

(2010) Y. Zhang et al.   BLOOD

Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis and Inhibits Tumor Growth in Lung Cancer

(2010) L. Lin et al.   CANCER RESEARCH

Quiescent and Active Hippocampal Neural Stem Cells with Distinct Morphologies Respond Selectively to Physiological and Pathological Stimuli and Aging

(2010) Sebastian Lugert et al.   Cell Stem Cell

Notch1 signaling is mediated by importins alpha 3, 4, and 7

(2010) Kerstin Huenniger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of Notch1-Dependent Cardiomyogenesis Leads to a Dilated Myopathy in the Neonatal Heart

(2010) Konrad Urbanek et al.   CIRCULATION RESEARCH

Notch3 Is Critical for Proper Angiogenesis and Mural Cell Investment

(2010) Hua Liu et al.   CIRCULATION RESEARCH

Endocytic Internalization Routes Required for Delta/Notch Signaling

(2010) Sarah L. Windler et al.   CURRENT BIOLOGY

Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion

(2010) X. Feng et al.   DEVELOPMENT

Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome

(2010) J. J. Hofmann et al.   DEVELOPMENT

Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression

(2010) U. Marklund et al.   DEVELOPMENT

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

Dynamic Filopodia Transmit Intermittent Delta-Notch Signaling to Drive Pattern Refinement during Lateral Inhibition

(2010) Michael Cohen et al.   DEVELOPMENTAL CELL

The Notch signaling pathway: Molecular basis of cell context dependency

(2010) Ralf Schwanbeck et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Regulation of skeletal myogenesis by Notch

(2010) Matthew F. Buas et al.   EXPERIMENTAL CELL RESEARCH

Atonal Homolog 1 Is Required for Growth and Differentiation Effects of Notch/γ-Secretase Inhibitors on Normal and Cancerous Intestinal Epithelial Cells

(2010) Avedis Kazanjian et al.   GASTROENTEROLOGY

F-box and WD Repeat Domain-Containing 7 Regulates Intestinal Cell Lineage Commitment and Is a Haploinsufficient Tumor Suppressor

(2010) Rocio Sancho et al.   GASTROENTEROLOGY

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex

(2010) R. Liefke et al.   GENES & DEVELOPMENT

Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis

(2010) A. V. Pinho et al.   GUT

Notch inhibition by the ligand Delta-Like 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis

(2010) Gavin Chapman et al.   HUMAN MOLECULAR GENETICS

Hes1 Is a Critical but Context-Dependent Mediator of Canonical Notch Signaling in Lymphocyte Development and Transformation

(2010) Agnieszka A. Wendorff et al.   IMMUNITY

Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

(2010) Kohei Yamamizu et al.   JOURNAL OF CELL BIOLOGY

Control of Notch-ligand endocytosis by ligand-receptor interaction

(2010) E. M. Hansson et al.   JOURNAL OF CELL SCIENCE

Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation

(2010) Luis Luna-Zurita et al.   JOURNAL OF CLINICAL INVESTIGATION

Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease

(2010) Anne Joutel et al.   JOURNAL OF CLINICAL INVESTIGATION

Notch2 Signaling Is Required for Potent Antitumor Immunity In Vivo

(2010) K. Sugimoto et al.   JOURNAL OF IMMUNOLOGY

RBPJ -Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

(2010) O. Ehm et al.   JOURNAL OF NEUROSCIENCE

Notch Activity Levels Control the Balance between Quiescence and Recruitment of Adult Neural Stem Cells

(2010) P. Chapouton et al.   JOURNAL OF NEUROSCIENCE

Notch1 Is Required for Maintenance of the Reservoir of Adult Hippocampal Stem Cells

(2010) J. L. Ables et al.   JOURNAL OF NEUROSCIENCE

Essential Roles of Notch Signaling in Maintenance of Neural Stem Cells in Developing and Adult Brains

(2010) I. Imayoshi et al.   JOURNAL OF NEUROSCIENCE

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

(2010) David Sprinzak et al.   NATURE

Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal

(2010) Adan Aguirre et al.   NATURE

Nemo-like kinase suppresses Notch signalling by interfering with formation of the Notch active transcriptional complex

(2010) Tohru Ishitani et al.   NATURE CELL BIOLOGY

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

(2010) Kelly L Arnett et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of Notch1 Antibodies That Inhibit Signaling of Both Normal and Mutated Notch1 Receptors

(2010) Miguel Aste-Amézaga et al.   PLoS One

Atopic Dermatitis-Like Disease and Associated Lethal Myeloproliferative Disorder Arise from Loss of Notch Signaling in the Murine Skin

(2010) Alexis Dumortier et al.   PLoS One

Activated Notch1 Target Genes during Embryonic Cell Differentiation Depend on the Cellular Context and Include Lineage Determinants and Inhibitors

(2010) Franziska Meier-Stiegen et al.   PLoS One

Notch and MAML-1 Complexation Do Not Detectably Alter the DNA Binding Specificity of the Transcription Factor CSL

(2010) Cristina Del Bianco et al.   PLoS One

Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear

(2010) B. H. Hartman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal Stroke in Mice Causes Long-Term Changes in Neuronal Notch-2 Expression That May Contribute to Prolonged Injury

(2010) L. Alberi et al.   STROKE

γ-Secretase-Dependent Cleavage Initiates Notch Signaling from the Plasma Membrane

(2010) Erika B. Sorensen et al.   TRAFFIC

Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors

(2010) Johan H. van Es et al.   Nature Communications

The spectra of clinical phenotypes in aplasia cutis congenita and terminal transverse limb defects

(2009) Katie M.G. Snape et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Notch1 Signaling in FIZZ1 Induction of Myofibroblast Differentiation

(2009) Tianju Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes

(2009) Eve Gazave et al.   BMC EVOLUTIONARY BIOLOGY

Congruence between NOTCH3 mutations and GOM in 131 CADASIL patients

(2009) Saara Tikka et al.   BRAIN

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

Heterozygosity for Hypoxia Inducible Factor 1  Decreases the Incidence of Thymic Lymphomas in a p53 Mutant Mouse Model

(2009) J. A. Bertout et al.   CANCER RESEARCH

A hierarchical cascade activated by non-canonical Notch signaling and the mTOR–Rictor complex regulates neglect-induced death in mammalian cells

(2009) L R Perumalsamy et al.   CELL DEATH AND DIFFERENTIATION

Smooth Muscle Notch1 Mediates Neointimal Formation After Vascular Injury

(2009) Yuxin Li et al.   CIRCULATION

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

Tumor-Initiating Cells of HER2-Positive Carcinoma Cell Lines Express the Highest Oncoprotein Levels and Are Sensitive to Trastuzumab

(2009) A. Magnifico et al.   CLINICAL CANCER RESEARCH

Notch signaling controls liver development by regulating biliary differentiation

(2009) Y. Zong et al.   DEVELOPMENT

Notch signaling controls the balance of ciliated and secretory cell fates in developing airways

(2009) P.-N. Tsao et al.   DEVELOPMENT

Notch signaling promotes airway mucous metaplasia and inhibits alveolar development

(2009) J. S. Guseh et al.   DEVELOPMENT

Committed Neuronal Precursors Confer Astrocytic Potential on Residual Neural Precursor Cells

(2009) Masakazu Namihira et al.   DEVELOPMENTAL CELL

The Vacuolar Proton Pump, V-ATPase, Is Required for Notch Signaling and Endosomal Trafficking in Drosophila

(2009) Yan Yan et al.   DEVELOPMENTAL CELL

Interactions between Notch- and hypoxia-induced transcriptomes in embryonic stem cells

(2009) Heather Main et al.   EXPERIMENTAL CELL RESEARCH

Notch Signaling as Gatekeeper of Rat Acinar-to-β-Cell Conversion in Vitro

(2009) Luc Baeyens et al.   GASTROENTEROLOGY

Presenilins, Notch dose control the fate of pancreatic endocrine progenitors during a narrow developmental window

(2009) C. Cras-Meneur et al.   GENES & DEVELOPMENT

MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury

(2009) M. Xin et al.   GENES & DEVELOPMENT

Notch signaling regulates formation of the three-dimensional architecture of intrahepatic bile ducts in mice

(2009) Erin E. Sparks et al.   HEPATOLOGY

Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice

(2009) Jan S. Tchorz et al.   HEPATOLOGY

Differences in hydroxylation and binding of Notch and HIF-1α demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1)

(2009) Sarah E. Wilkins et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Numb Regulates Post-endocytic Trafficking and Degradation of Notch1

(2009) Melanie A. McGill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Notch Effector Hey1 Associates with Myogenic Target Genes to Repress Myogenesis

(2009) Matthew F. Buas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

YB-1 Acts as a Ligand for Notch-3 Receptors and Modulates Receptor Activation

(2009) Thomas Rauen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rbpj Cell Autonomous Regulation of Retinal Ganglion Cell and Cone Photoreceptor Fates in the Mouse Retina

(2009) A. N. Riesenberg et al.   JOURNAL OF NEUROSCIENCE

CADASIL

(2009) Hugues Chabriat et al.   LANCET NEUROLOGY

Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors

(2009) Fang Gao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

Notch3 signaling promotes the development of pulmonary arterial hypertension

(2009) Xiaodong Li et al.   NATURE MEDICINE

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

(2009) Marie Carlén et al.   NATURE NEUROSCIENCE

Generating specificity and diversity in the transcriptional response to hypoxia

(2009) Urban Lendahl et al.   NATURE REVIEWS GENETICS

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Differential Expression of Notch Family Members in Astrocytomas and Medulloblastomas

(2009) Peng Xu et al.   PATHOLOGY & ONCOLOGY RESEARCH

Alterations of the Notch pathway in lung cancer

(2009) Britta Westhoff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thermodynamic and structural insights into CSL-DNA complexes

(2009) David R. Friedmann et al.   PROTEIN SCIENCE

Direct Response to Notch Activation: Signaling Crosstalk and Incoherent Logic

(2009) A. Krejci et al.   Science Signaling

The transcription factor RBP-J is essential for retinal cell differentiation and lamination

(2009) Min-Hua Zheng et al.   Molecular Brain

Mutations in the MESP2 Gene Cause Spondylothoracic Dysostosis/Jarcho-Levin Syndrome

(2008) Alberto S. Cornier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Down-regulation of the Notch Pathway in Human Airway Epithelium in Association with Smoking and Chronic Obstructive Pulmonary Disease

(2008) Ann E. Tilley et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Beta-catenin modulates the level and transcriptional activity of Notch1/NICD through its direct interaction

(2008) Yun Hye Jin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

An early decrease in Notch activation is required for human TCR-   lineage differentiation at the expense of TCR-   T cells

(2008) I. Van de Walle et al.   BLOOD

Notch signaling is required for proliferation but not for differentiation at a well-defined  -selection checkpoint during human T-cell development

(2008) T. Taghon et al.   BLOOD

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches

(2008) P. Rizzo et al.   CANCER RESEARCH

Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling

(2008) Melih Acar et al.   CELL

MicroRNA Regulation of Cell Lineages in Mouse and Human Embryonic Stem Cells

(2008) Kathryn N. Ivey et al.   Cell Stem Cell

Notch Signaling Regulates Platelet-Derived Growth Factor Receptor-β Expression in Vascular Smooth Muscle Cells

(2008) Shaobo Jin et al.   CIRCULATION RESEARCH

Developmental origin of smooth muscle cells in the descending aorta in mice

(2008) P. Wasteson et al.   DEVELOPMENT

Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus

(2008) Massimo Nichane et al.   DEVELOPMENTAL BIOLOGY

Multiple Roles of Notch Signaling in the Regulation of Epidermal Development

(2008) Mariko Moriyama et al.   DEVELOPMENTAL CELL

Drosophila HOPS and AP-3 Complex Genes Are Required for a Deltex-Regulated Activation of Notch in the Endosomal Trafficking Pathway

(2008) Marian Wilkin et al.   DEVELOPMENTAL CELL

Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos

(2008) Ho Kim et al.   DEVELOPMENTAL DYNAMICS

Notch2 is required for the proliferation of cardiac neural crest-derived smooth muscle cells

(2008) Prajakta Varadkar et al.   DEVELOPMENTAL DYNAMICS

Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27Kip1 and p57Kip2

(2008) Orbicia Riccio et al.   EMBO REPORTS

Cbf11 and Cbf12, the fission yeast CSL proteins, play opposing roles in cell adhesion and coordination of cell and nuclear division

(2008) Martin Převorovský et al.   EXPERIMENTAL CELL RESEARCH

Notch Signaling Is Required for Exocrine Regeneration After Acute Pancreatitis

(2008) Jens T. Siveke et al.   GASTROENTEROLOGY

A nonclassical bHLH Rbpj transcription factor complex is required for specification of GABAergic neurons independent of Notch signaling

(2008) K. Hori et al.   GENES & DEVELOPMENT

In vitro validation of  -secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia

(2008) K. De Keersmaecker et al.   HAEMATOLOGICA

NOTCH2 mutations in marginal zone lymphoma

(2008) G. Troen et al.   HAEMATOLOGICA

β-Catenin deletion in hepatoblasts disrupts hepatic morphogenesis and survival during mouse development

(2008) Xinping Tan et al.   HEPATOLOGY

Liver-specific inactivation ofNotch2, but notNotch1, compromises intrahepatic bile duct development in mice

(2008) Fabian Geisler et al.   HEPATOLOGY

Interaction of master mind, big brain, neuralized and Notch genes of Droso-phila melanogaster as expressed in adult morphology

(2008) PETTER PORTIN et al.   HEREDITAS

Activating NOTCH3 mutation in a patient with small-vessel-disease of the Brain

(2008) Charles Fouillade et al.   HUMAN MUTATION

O-LinkedN-Acetylglucosamine Is Present on the Extracellular Domain of Notch Receptors

(2008) Aiko Matsuura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3

(2008) Kang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Secretase Activation of Notch Signaling Regulates the Balance of Proximal and Distal Fates in Progenitor Cells of the Developing Lung

(2008) Po-Nien Tsao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex

(2008) David R. Friedmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endosomal entry regulates Notch receptor activation inDrosophila melanogaster

(2008) Thomas Vaccari et al.   JOURNAL OF CELL BIOLOGY

Inhibition of myogenesis by Notch: Evidence for multiple pathways

(2008) Matthew F. Buas et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Control of the adaptive response of the heart to stress via the Notch1 receptor pathway

(2008) Adrien Croquelois et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Notch1 Signaling in Pyramidal Neurons Regulates Synaptic Connectivity and Experience-Dependent Modifications of Acuity in the Visual Cortex

(2008) M. Dahlhaus et al.   JOURNAL OF NEUROSCIENCE

FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias

(2008) Jee Hoon Song et al.   LEUKEMIA RESEARCH

ETO, but Not Leukemogenic Fusion Protein AML1/ETO, Augments RBP-J /SHARP-Mediated Repression of Notch Target Genes

(2008) D. Salat et al.   MOLECULAR AND CELLULAR BIOLOGY

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE

γ-secretase inhibitors reverse glucocorticoid resistance in T cell acute lymphoblastic leukemia

(2008) Pedro J Real et al.   NATURE MEDICINE

Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition

(2008) Ryoichiro Kageyama et al.   NATURE NEUROSCIENCE

Mind Bomb 1-Expressing Intermediate Progenitors Generate Notch Signaling to Maintain Radial Glial Cells

(2008) Ki-Jun Yoon et al.   NEURON

Oscillations in Notch Signaling Regulate Maintenance of Neural Progenitors

(2008) Hiromi Shimojo et al.   NEURON

Rbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesis

(2008) A Raafat et al.   ONCOGENE

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Notch Signalling Synchronizes the Zebrafish Segmentation Clock but Is Not Needed To Create Somite Boundaries

(2008) Ertuğrul M. Özbudak et al.   PLoS Genetics

Notch Signaling Regulates Bile Duct Morphogenesis in Mice

(2008) Julie Lozier et al.   PLoS One

Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways

(2008) X. Zheng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

(2008) F. A. High et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch signaling mediates hypoxia-induced tumor cell migration and invasion

(2008) C. Sahlgren et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular separation of two signaling pathways for the receptor, Notch

(2007) Maude Le Gall et al.   DEVELOPMENTAL BIOLOGY

Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis

(2007) Soline Estrach et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY