Nicastrin regulates breast cancer stem cell properties and tumor growth in vitro and in vivo

Notch1 Inhibition Alters the CD44hi/CD24lo Population and Reduces the Formation of Brain Metastases from Breast Cancer

(2011) P. M. McGowan et al.   MOLECULAR CANCER RESEARCH

A Monoclonal Antibody against Human Notch1 Ligand-Binding Domain Depletes Subpopulation of Putative Breast Cancer Stem-like Cells

(2011) A. Sharma et al.   MOLECULAR CANCER THERAPEUTICS

Kinome screening for regulators of the estrogen receptor identifies LMTK3 as a new therapeutic target in breast cancer

(2011) Georgios Giamas et al.   NATURE MEDICINE

Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer

(2011) Dan R Robinson et al.   NATURE MEDICINE

Gamma-secretase inhibitors target tumor-initiating cells in a mouse model of ERBB2 breast cancer

(2011) M Kondratyev et al.   ONCOGENE

Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin

(2011) I Hayashi et al.   ONCOGENE

Novel Research Horizons for Presenilins and γ-Secretases in Cell Biology and Disease

(2010) Bart De Strooper et al.   Annual Review of Cell and Developmental Biology

Biological and clinical implications of nicastrin expression in invasive breast cancer

(2010) Aleksandra Filipović et al.   BREAST CANCER RESEARCH AND TREATMENT

The prognostic role of cancer stem cells in breast cancer: a meta-analysis of published literatures

(2010) Liheng Zhou et al.   BREAST CANCER RESEARCH AND TREATMENT

Synthetic Lethality through Combined Notch-Epidermal Growth Factor Receptor Pathway Inhibition in Basal-Like Breast Cancer

(2010) Y. Dong et al.   CANCER RESEARCH

Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch4 Receptor

(2010) H. Harrison et al.   CANCER RESEARCH

Epithelial-Mesenchymal Transition (EMT) in Tumor-Initiating Cells and Its Clinical Implications in Breast Cancer

(2010) Chad J. Creighton et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Evaluation of Selective  -Secretase Inhibitor PF-03084014 for Its Antitumor Efficacy and Gastrointestinal Safety to Guide Optimal Clinical Trial Design

(2010) P. Wei et al.   MOLECULAR CANCER THERAPEUTICS

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of γ-secretase induces G2/M arrest and triggers apoptosis in breast cancer cells

(2009) S Rasul et al.   BRITISH JOURNAL OF CANCER

Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion

(2009) J Chen et al.   BRITISH JOURNAL OF CANCER

Notch Activation Induces Akt Signaling via an Autocrine Loop to Prevent Apoptosis in Breast Epithelial Cells

(2009) O. Meurette et al.   CANCER RESEARCH

 -Secretase Inhibitors Abrogate Oxaliplatin-Induced Activation of the Notch-1 Signaling Pathway in Colon Cancer Cells Resulting in Enhanced Chemosensitivity

(2009) R. D. Meng et al.   CANCER RESEARCH

Targeted Knockdown of Notch1 Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator

(2009) B. Bin Hafeez et al.   CLINICAL CANCER RESEARCH

Role for notch signaling in salivary acinar cell growth and differentiation

(2009) Howard Dang et al.   DEVELOPMENTAL DYNAMICS

Single Chain Variable Fragment against Nicastrin Inhibits the γ-Secretase Activity

(2009) Ikuo Hayashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53-Dependent control of cell death by nicastrin: lack of requirement for presenilin-dependent γ-secretase complex

(2009) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF NEUROCHEMISTRY

Inhibition of Notch3 enhances sensitivity to gemcitabine in pancreatic cancer through an inactivation of PI3K/Akt-dependent pathway

(2009) Jun Yao et al.   MEDICAL ONCOLOGY

Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis

(2009) Suruchi Mittal et al.   Molecular Cancer

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab

(2008) M Pickl et al.   ONCOGENE