Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tumor-Suppressive Activity of Lunatic Fringe in Prostate through Differential Modulation of Notch Receptor Activation

(2015) Shubing Zhang et al.   NEOPLASIA

The Notch Pathway Inhibits TGF  Signaling in Breast Cancer through HEYL-Mediated Crosstalk

(2014) L. Han et al.   CANCER RESEARCH

Tumor-Infiltrating Myeloid Cells Activate Dll4/Notch/TGF-  Signaling to Drive Malignant Progression

(2014) H. Ohnuki et al.   CANCER RESEARCH

Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer

(2014) M. Schiavone et al.   Disease Models & Mechanisms

Opposing role of Notch1 and Notch2 in a KrasG12D-driven murine non-small cell lung cancer model

(2014) A Baumgart et al.   ONCOGENE

Conversion of Human Pancreatic Acinar Cells Toward a Ductal-Mesenchymal Phenotype and the Role of Transforming Growth Factor β and Activin Signaling

(2014) Evelien De Waele et al.   PANCREAS

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas

(2014) Irene Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGF  signaling to specify V2b interneurons in the spinal cord

(2013) K. Misra et al.   DEVELOPMENT

Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression

(2013) Helen Court et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of Canonical Smad4 Signaling Promotes KRAS Driven Malignant Transformation of Human Pancreatic Duct Epithelial Cells and Metastasis

(2013) Lisa Leung et al.   PLoS One

Lunatic Fringe Deficiency Cooperates with the Met/Caveolin Gene Amplicon to Induce Basal-like Breast Cancer

(2012) Keli Xu et al.   CANCER CELL

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

TGF-  and  v 6 Integrin Act in a Common Pathway to Suppress Pancreatic Cancer Progression

(2012) A. F. Hezel et al.   CANCER RESEARCH

Notch and TGFβ Form a Reciprocal Positive Regulatory Loop that Suppresses Murine Prostate Basal Stem/Progenitor Cell Activity

(2012) Joseph M. Valdez et al.   Cell Stem Cell

A Notch-dependent molecular circuitry initiates pancreatic endocrine and ductal cell differentiation

(2012) H. P. Shih et al.   DEVELOPMENT

Targeting notch pathway enhances rapamycin antitumor activity in pancreas cancers through PTEN phosphorylation

(2012) Kevin Vo et al.   Molecular Cancer

Notch1 Is Not Required for Acinar-to-Ductal Metaplasia in a Model of Kras-Induced Pancreatic Ductal Adenocarcinoma

(2012) Jacqueline L. Avila et al.   PLoS One

Notch3 and Hey-1 as Prognostic Biomarkers in Pancreatic Adenocarcinoma

(2012) Christopher D. Mann et al.   PLoS One

Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas

(2011) Daniel Kopinke et al.   DEVELOPMENTAL BIOLOGY

Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

(2011) Eleni Maniati et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1

(2011) Hendrik Ungefroren et al.   Molecular Cancer

Notch1 Functions as a Tumor Suppressor in a Model of K-ras–Induced Pancreatic Ductal Adenocarcinoma

(2010) Linda Hanlon et al.   CANCER RESEARCH

Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma

(2010) P. K. Mazur et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lunatic Fringe-mediated Notch signaling is required for lung alveogenesis

(2009) Keli Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

MFng Is Dispensable for Mouse Pancreas Development and Function

(2009) P. Svensson et al.   MOLECULAR AND CELLULAR BIOLOGY

Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas

(2009) M. Rovira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA