Journal
ONCOLOGY LETTERS
Volume 15, Issue 3, Pages 3415-3421Publisher
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.7738
Keywords
apoptosis; cancer stem cells; non-small cell lung cancer; Notch signaling; proliferation; resistance
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Funding
- National Natural Science Foundation of China [81260024]
- Natural Science Foundation of China [81460065]
- Graduate Innovation Fund of Jiangxi Province [YC2015-B009]
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Lung cancer is the leading cause of cancer-associated mortality worldwide. Elucidation of the pathogenesis and biology of lung cancer is critical for the design of an effective treatment for patients. Non-small cell lung cancer (NSCLC) accounts for 80-85% of lung cancer cases. The abnormal expression of Notch signaling pathway members is a relatively frequent event in NSCLC. The Notch signaling pathway serves important roles in cell fate determination, proliferation, differentiation and apoptosis. Increasing evidence supports the association of Notch signaling dysregulation with various types of malignant tumor, including NSCLC. Several studies have demonstrated that members of the Notch signaling pathway may be potential biomarkers for predicting the progression and prognosis of patients with NSCLC. Furthermore, Notch signaling serves critical roles in the tumorigenesis and treatment resistance of NSCLC cells by promoting the proliferation or inhibiting the apoptosis of NSCLC cells. The present review provides a detailed summary of the roles of Notch signaling in NSCLC.
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