NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia

(2012) Jinghui Zhang et al.   NATURE

Reverse engineering of TLX oncogenic transcriptional networks identifies RUNX1 as tumor suppressor in T-ALL

(2012) Giusy Della Gatta et al.   NATURE MEDICINE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL

(2011) J. Tatarek et al.   BLOOD

The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

(2011) A. Gutierrez et al.   BLOOD

Integrated Transcript and Genome Analyses Reveal NKX2-1 and MEF2C as Potential Oncogenes in T Cell Acute Lymphoblastic Leukemia

(2011) Irene Homminga et al.   CANCER CELL

Prognostic relevance of RUNX1 mutations in T-cell acute lymphoblastic leukemia

(2011) V. Grossmann et al.   HAEMATOLOGICA

Regulation of reactive oxygen species in stem cells and cancer stem cells

(2011) Chiharu I. Kobayashi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Expression of CD34 and CD7 on human T-cell acute lymphoblastic leukemia discriminates functionally heterogeneous cell populations

(2011) B Gerby et al.   LEUKEMIA

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells

(2011) H. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

(2010) P. P. L. Chiu et al.   BLOOD

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes

(2010) M. Tremblay et al.   GENES & DEVELOPMENT

Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss

(2009) H. Medyouf et al.   BLOOD

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia

(2009) Elaine Coustan-Smith et al.   LANCET ONCOLOGY

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation

(2009) Edward Owusu-Ansah et al.   NATURE

NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity

(2008) F. Armstrong et al.   BLOOD

Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras–initiated leukemia

(2008) Mark Y. Chiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation

(2008) Wei Guo et al.   NATURE

An integrated software system for analyzing ChIP-chip and ChIP-seq data

(2008) Hongkai Ji et al.   NATURE BIOTECHNOLOGY

Protein kinase C-θ regulates KIT expression and proliferation in gastrointestinal stromal tumors

(2008) W-b Ou et al.   ONCOGENE