Notch3 signaling-mediated melanoma–endothelial crosstalk regulates melanoma stem-like cell homeostasis and niche morphogenesis

Self-renewal of CD133hi cells by IL6/Notch3 signalling regulates endocrine resistance in metastatic breast cancer

(2016) Pasquale Sansone et al.   Nature Communications

Induction of Vasculogenic Mimicry Overrides VEGF-A Silencing and Enriches Stem-like Cancer Cells in Melanoma

(2015) C. I. Schnegg et al.   CANCER RESEARCH

Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency

(2015) W.-C. Yen et al.   CLINICAL CANCER RESEARCH

Notch3-specific inhibition using siRNA knockdown or GSI sensitizes paclitaxel-resistant ovarian cancer cells

(2015) Haeyoun Kang et al.   MOLECULAR CARCINOGENESIS

Notch3 functions as a regulator of cell self-renewal by interacting with the β-catenin pathway in hepatocellular carcinoma

(2015) Qingyu Zhang et al.   Oncotarget

CD133-Targeted Niche-Dependent Therapy in Cancer

(2014) Anthony B. Mak et al.   AMERICAN JOURNAL OF PATHOLOGY

Developmental pathways activated in melanocytes and melanoma

(2014) Jianglan Liu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Notch signaling: switching an oncogene to a tumor suppressor

(2014) C. Lobry et al.   BLOOD

Phase 2 study of RO4929097, a gamma-secretase inhibitor, in metastatic melanoma: SWOG 0933

(2014) Sylvia M. Lee et al.   CANCER

EGFR Blockade Enriches for Lung Cancer Stem-like Cells through Notch3-Dependent Signaling

(2014) R. R. Arasada et al.   CANCER RESEARCH

NOTCH3 Signaling Regulates MUSASHI-1 Expression in Metastatic Colorectal Cancer Cells

(2014) A. Pasto et al.   CANCER RESEARCH

Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence

(2013) H. Cui et al.   CANCER RESEARCH

“Take it up a NOTCH

(2013) Stefanie L. Morgan et al.   CELL CYCLE

Notch signaling mediates melanoma-endothelial cell communication and melanoma cell migration

(2013) Jason D. Howard et al.   Pigment Cell & Melanoma Research

A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-Initiating Cells

(2013) Norihiko Saito et al.   STEM CELLS

CD133+ Melanoma Subpopulations Contribute to Perivascular Niche Morphogenesis and Tumorigenicity through Vasculogenic Mimicry

(2012) C.-Y. Lai et al.   CANCER RESEARCH

Cancer Stem Cells: Distinct Entities or Dynamically Regulated Phenotypes?

(2012) Y. Li et al.   CANCER RESEARCH

The involvement of Notch signaling in melanoma vasculogenic mimicry

(2012) Amalia Vartanian et al.   CLINICAL AND EXPERIMENTAL MEDICINE

Acquired cancer stem cell phenotypes through Oct4-mediated dedifferentiation

(2012) S M Kumar et al.   ONCOGENE

Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy

(2012) S. M. McAuliffe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integration of Genotypic and Phenotypic Screening Reveals Molecular Mediators of Melanoma-Stromal Interaction

(2011) M. J. Stine et al.   CANCER RESEARCH

Notch signaling: simplicity in design, versatility in function

(2011) E. R. Andersson et al.   DEVELOPMENT

Inhibition of NOTCH3 signalling significantly enhances sensitivity to cisplatin in EBV-associated nasopharyngeal carcinoma

(2011) Cheuk-Him Man et al.   JOURNAL OF PATHOLOGY

Notch Signaling Modulates Hypoxia-Induced Neuroendocrine Differentiation of Human Prostate Cancer Cells

(2011) G. Danza et al.   MOLECULAR CANCER RESEARCH

Sorting through the many opportunities for melanoma therapy

(2011) Meenhard Herlyn et al.   Pigment Cell & Melanoma Research

The Novel Gamma Secretase Inhibitor RO4929097 Reduces the Tumor Initiating Potential of Melanoma

(2011) Chanh Huynh et al.   PLoS One

c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype

(2011) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Notch3 Overexpression Is Related to the Recurrence of Ovarian Cancer and Confers Resistance to Carboplatin

(2010) Joon Tae Park et al.   AMERICAN JOURNAL OF PATHOLOGY

Notch3 in Human Breast Cancer Cell Lines Regulates Osteoblast-Cancer Cell Interactions and Osteolytic Bone Metastasis

(2010) Zhiyuan Zhang et al.   AMERICAN JOURNAL OF PATHOLOGY

Regulation of the Embryonic Morphogen Nodal by Notch4 Facilitates Manifestation of the Aggressive Melanoma Phenotype

(2010) K. M. Hardy et al.   CANCER RESEARCH

A Temporarily Distinct Subpopulation of Slow-Cycling Melanoma Cells Is Required for Continuous Tumor Growth

(2010) Alexander Roesch et al.   CELL

Glioblastoma cancer stem cells: heterogeneity, microenvironment and related therapeutic strategies

(2010) Tetyana Denysenko et al.   CELL BIOCHEMISTRY AND FUNCTION

Cross-talk between Tumor and Endothelial Cells Involving the Notch3-Dll4 Interaction Marks Escape from Tumor Dormancy

(2009) Stefano Indraccolo et al.   CANCER RESEARCH

Biology of glioma cancer stem cells

(2009) Deric M. Park et al.   MOLECULES AND CELLS

Therapeutic Targets in Malignant Glioblastoma Microenvironment

(2009) Mary Helen Barcellos-Hoff et al.   SEMINARS IN RADIATION ONCOLOGY