γ-Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

(2017) Frederick Arce Vargas et al.   IMMUNITY

B7-H4 expression indicates poor prognosis of oral squamous cell carcinoma

(2016) Lei Wu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages

(2016) Jun-Long Zhao et al.   CANCER RESEARCH

Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling

(2016) D. Peng et al.   CANCER RESEARCH

Association of Notch pathway down-regulation with Triple Negative/Basal-like breast carcinomas and high tumor-infiltrating FOXP3+ Tregs

(2016) Fernando Ortiz-Martínez et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

CD45 Phosphatase Inhibits STAT3 Transcription Factor Activity in Myeloid Cells and Promotes Tumor-Associated Macrophage Differentiation

(2016) Vinit Kumar et al.   IMMUNITY

Myeloid-derived suppressor cells as effectors of immune suppression in cancer

(2016) Athalia Rachel Pyzer et al.   INTERNATIONAL JOURNAL OF CANCER

Development of immuno-oncology drugs — from CTLA4 to PD1 to the next generations

(2016) Axel Hoos   NATURE REVIEWS DRUG DISCOVERY

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

Targeting STAT3 signaling reduces immunosuppressive myeloid cells in head and neck squamous cell carcinoma

(2016) Lin-Lin Bu et al.   OncoImmunology

CTLA4 blockade reduces immature myeloid cells in head and neck squamous cell carcinoma

(2016) Guang-Tao Yu et al.   OncoImmunology

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell

(2016) Zhi-Li Zhao et al.   Scientific Reports

ROR1C Regulates Differentiation of Myeloid-Derived Suppressor Cells

(2015) Dmitry Gabrilovich et al.   CANCER CELL

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Notch signaling: An emerging therapeutic target for cancer treatment

(2015) Xun Yuan et al.   CANCER LETTERS

The Notch pathway in colorectal cancer

(2015) Kaitlyn E. Vinson et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive genomic characterization of head and neck squamous cell carcinomas

(2015)   NATURE

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

(2015) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

(2015) James Larkin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Notch1 Mutations Are Drivers of Oral Tumorigenesis

(2014) E. Izumchenko et al.   Cancer Prevention Research

Endothelial Cell-Secreted EGF Induces Epithelial to Mesenchymal Transition and Endows Head and Neck Cancer Cells with Stem-like Phenotype

(2014) Z. Zhang et al.   CANCER RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses

(2014) Nicolas Fasnacht et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mouse and human Notch-1 regulate mucosal immune responses

(2014) D R Mathern et al.   Mucosal Immunology

Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens

(2014) Matthew M. Gubin et al.   NATURE

The cellular and molecular origin of tumor-associated macrophages

(2014) R. A. Franklin et al.   SCIENCE

MicroRNA-135b acts as a tumor promoter by targeting the hypoxia-inducible factor pathway in genetically defined mouse model of head and neck squamous cell carcinoma

(2013) Lu Zhang et al.   CANCER LETTERS

Effects of Notch Signaling on Regulation of Myeloid Cell Differentiation in Cancer

(2013) P. Cheng et al.   CANCER RESEARCH

Tumor-Specific T-cell Help Is Associated with Improved Survival in Melanoma

(2013) K. Woods et al.   CLINICAL CANCER RESEARCH

Common and Complex Notch1 Mutations in Chinese Oral Squamous Cell Carcinoma

(2013) Xiaomeng Song et al.   CLINICAL CANCER RESEARCH

Integrative Genomic Characterization of Oral Squamous Cell Carcinoma Identifies Frequent Somatic Drivers

(2013) C. R. Pickering et al.   Cancer Discovery

Chemopreventive and Chemotherapeutic Actions of mTOR Inhibitor in Genetically Defined Head and Neck Squamous Cell Carcinoma Mouse Model

(2012) Z.-J. Sun et al.   CLINICAL CANCER RESEARCH

The tumor microenvironment is a dominant force in multidrug resistance

(2012) Ana Luísa Correia et al.   DRUG RESISTANCE UPDATES

Autocrine and paracrine loops between cancer cells and macrophages promote lymph node metastasisviaCCR4/CCL22 in head and neck squamous cell carcinoma

(2012) Takahiro Tsujikawa et al.   INTERNATIONAL JOURNAL OF CANCER

Cytoreduction surgery reduces systemic myeloid suppressor cell populations and restores intratumoral immunotherapy effectiveness

(2012) Jarrod D Predina et al.   Journal of Hematology & Oncology

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion

(2011) Sheinei J. Saleem et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cooperative Regulation of NOTCH1 Protein-Phosphatidylinositol 3-Kinase (PI3K) Signaling by NOD1, NOD2, and TLR2 Receptors Renders Enhanced Refractoriness to Transforming Growth Factor-β (TGF-β)- or Cytotoxic T-lymphocyte Antigen 4 (CTLA-4)-mediated Impairment of Human Dendritic Cell Maturation

(2011) Devram Sampat Ghorpade et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation

(2011) Y Bian et al.   ONCOGENE

Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1

(2011) N. Agrawal et al.   SCIENCE

The Mutational Landscape of Head and Neck Squamous Cell Carcinoma

(2011) N. Stransky et al.   SCIENCE

Notch Signaling Determines the M1 versus M2 Polarization of Macrophages in Antitumor Immune Responses

(2010) Yao-Chun Wang et al.   CANCER RESEARCH